indomethacin has been researched along with Burns in 59 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The administration of antiinflammatory drugs resulted at some laser intensities in increased scores of maximum wound area, healing time, cumulated wound area, fibrosis, hydroxyproline, and hydroxylysine, being mostly pronounced for indomethacin at 0." | 3.68 | Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model. ( Haedersdal, M; Poulsen, T; Wulf, HC, 1993) |
| " We studied the effect of combination interleukin 1 beta and indomethacin sodium therapy on macrophage hyperactivity and survival after sepsis in a murine burn model." | 3.68 | Modulation of macrophage hyperactivity improves survival in a burn-sepsis model. ( Collins, KH; Mannick, JA; O'Riordain, MG; Pilz, M; Rodrick, ML; Saporoschetz, IB, 1992) |
| " Significant inhibition of oedema formation caused by thermal injury was observed for calcium carbaspirin, phenylbutazone, hydrocortisone, cryogenine and indomethacin when given daily beginning 2 days prior to thermal exposure and afterwards." | 3.65 | Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus. ( Malone, MH; Trottier, RW, 1973) |
| "The oedema has distinct borders to the surrounding connective tissue and is separated and removed easily for further analysis." | 1.31 | A new technique for the analysis of endogenous mediators released following thermal injury. ( Cassuto, J; Lindblom, L; Löwhagen, PH; Nilsson, U; Räntfors, J; Tarnow, P; Yregård, L, 2001) |
| "Indomethacin-treated animals had CSA values 244% those of untreated burn-infected animals (p = 0." | 1.29 | Marrow granulocyte-macrophage progenitor cell response to burn injury as modified by endotoxin and indomethacin. ( Gamelli, RL; He, LK; Liu, H, 1994) |
| "Indomethacin was tested extensively in a wide range of concentrations in groups of six or more animals each." | 1.27 | Failure of topical prostaglandin inhibitors to improve wound healing following deep partial-thickness burns. ( Alexander, JW; Austin, LS; Fang, C; MacMillan, BG, 1983) |
| "Circular burns were inflicted on anaesthetized animals which were killed 30 min, 2 h or 4 h after burning." | 1.26 | On the enzymatic response to injury and its mediators. ( Nieminen, L; Raekallio, J, 1979) |
| "Indomethacin was administered intravenously 30 minutes before the scald; RISA was injected intravenously 30 min before termination of the study." | 1.26 | Effect of inhibiting prostaglandin synthesis on edema formation and albumin leakage during thermal trauma in the rat. ( Brouhard, BH; Carvajal, HF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (66.10) | 18.7374 |
| 1990's | 16 (27.12) | 18.2507 |
| 2000's | 4 (6.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choudhry, MA | 2 |
| Mao, H | 1 |
| Haque, F | 2 |
| Khan, M | 1 |
| Fazal, N | 2 |
| Sayeed, MM | 2 |
| Boykin, JV | 1 |
| Eriksson, E | 1 |
| Sholley, MM | 1 |
| Pittman, RN | 1 |
| Ninnemann, JL | 1 |
| Stockland, AE | 1 |
| Condie, JT | 1 |
| Maghsudi, M | 1 |
| Miller, CL | 1 |
| Hansbrough, J | 1 |
| Peterson, V | 1 |
| Zapata-Sirvent, R | 1 |
| Claman, HN | 1 |
| Ehrlich, HP | 3 |
| Needle, AL | 1 |
| Rajaratnam, J | 1 |
| White, ME | 1 |
| White, BS | 1 |
| Sloan, KB | 1 |
| Selk, S | 1 |
| Haslam, J | 1 |
| Caldwell, L | 1 |
| Shaffer, R | 1 |
| Fang, C | 1 |
| Alexander, JW | 2 |
| MacMillan, BG | 1 |
| Austin, LS | 1 |
| Hilton, JG | 1 |
| Mathieu, J | 1 |
| Masson, I | 1 |
| Chancerelle, Y | 1 |
| Chanaud, B | 1 |
| Strazlko, S | 1 |
| De Sousa, M | 1 |
| Kergonou, JF | 1 |
| Giroud, JP | 1 |
| Florentin, I | 1 |
| Molloy, RG | 2 |
| Holzheimer, R | 2 |
| Nestor, M | 2 |
| Collins, K | 2 |
| Mannick, JA | 6 |
| Rodrick, ML | 6 |
| Ogle, CK | 2 |
| Guo, X | 1 |
| Szczur, K | 1 |
| Hartmann, S | 1 |
| Ogle, JD | 1 |
| Gamelli, RL | 1 |
| He, LK | 1 |
| Liu, H | 1 |
| O'Riordain, M | 1 |
| Haedersdal, M | 1 |
| Poulsen, T | 1 |
| Wulf, HC | 1 |
| Tarnow, P | 2 |
| Cassuto, J | 2 |
| Jönsson, A | 1 |
| Nellgård, P | 1 |
| Bennett, A | 1 |
| Tavares, IA | 1 |
| Yamamoto, H | 1 |
| Siltharm, S | 1 |
| deSerres, S | 1 |
| Hultman, CS | 1 |
| Meyer, AA | 1 |
| Caldwell, FT | 1 |
| Graves, DB | 1 |
| Wallace, BH | 1 |
| Gregory, MS | 1 |
| Duffner, LA | 1 |
| Hahn, EL | 1 |
| Tai, HH | 1 |
| Faunce, DE | 1 |
| Kovacs, EJ | 1 |
| Yregård, L | 1 |
| Löwhagen, PH | 1 |
| Nilsson, U | 1 |
| Lindblom, L | 1 |
| Räntfors, J | 1 |
| Namak, SY | 1 |
| Ravindranath, T | 1 |
| Barac, G | 1 |
| Van Caneghem, P | 1 |
| Deby, C | 1 |
| Salomon, JC | 1 |
| Cha, CJ | 1 |
| Henry, WL | 1 |
| Clowes, GH | 1 |
| Raekallio, J | 1 |
| Nieminen, L | 1 |
| Jonsson, CE | 3 |
| Shimizu, Y | 1 |
| Fredholm, BB | 1 |
| Granström, E | 1 |
| Oliw, E | 1 |
| Del Beccaro, EJ | 2 |
| Heggers, JP | 2 |
| Robson, MC | 2 |
| Brouhard, BH | 1 |
| Carvajal, HF | 1 |
| Bronaugh, RL | 1 |
| Roller, RG | 1 |
| Cargill, R | 1 |
| Yamada, K | 1 |
| Aizawa, Y | 1 |
| Smit, JJ | 1 |
| Teodorczyk-Injeyan, JA | 2 |
| Sparkes, BG | 2 |
| Lalani, S | 1 |
| Peters, WJ | 2 |
| Mills, GB | 1 |
| O'Riordain, MG | 1 |
| Collins, KH | 1 |
| Pilz, M | 1 |
| Saporoschetz, IB | 1 |
| Grbic, JT | 2 |
| Gough, DB | 1 |
| Rockwell, WB | 1 |
| Miller-Graziano, CL | 1 |
| Szabo, G | 1 |
| Kodys, K | 1 |
| Griffey, K | 1 |
| Gadd, MA | 1 |
| Hansbrough, JF | 1 |
| Horgan, PG | 1 |
| Dubravec, DB | 1 |
| Waymack, JP | 1 |
| Guzman, RF | 1 |
| Burleson, DG | 1 |
| McManus, AT | 1 |
| Mason, AD | 1 |
| Pruitt, BA | 1 |
| Gerry, K | 1 |
| Falk, RE | 1 |
| Saito, H | 1 |
| Trocki, O | 1 |
| Haugan, A | 1 |
| Kirkebø, A | 1 |
| Proctor, KG | 1 |
| Shatkin, S | 1 |
| Kaminski, PM | 1 |
| Falck, JR | 1 |
| Capdevila, JH | 1 |
| Bjornson, AB | 1 |
| Knippenberg, RW | 1 |
| Bjornson, HS | 1 |
| Wood, JJ | 1 |
| Jordan, A | 1 |
| Latter, DA | 1 |
| Tchervenkov, JI | 1 |
| Nohr, CW | 1 |
| Christou, NV | 1 |
| Odessey, R | 1 |
| Arturson, G | 3 |
| Garcia Leme, J | 1 |
| Hamamura, L | 1 |
| Leite, MP | 1 |
| Rocha e Silva, M | 1 |
| Houck, JC | 1 |
| Johnston, J | 1 |
| Jacob, RA | 1 |
| Iizuka, Y | 1 |
| Tanaka, K | 1 |
| Holmes, L | 1 |
| Lewis, GP | 2 |
| Peters, J | 1 |
| White, AM | 1 |
| Malone, MH | 1 |
| Trottier, RW | 1 |
| Butler, K | 1 |
| Ryan, GB | 1 |
| Hurley, JV | 1 |
| Walters, MN | 1 |
| Willoughby, DA | 1 |
1 review available for indomethacin and Burns
| Article | Year |
|---|---|
Burn shock.
Topics: Animals; Blood Circulation; Burns; Capillary Permeability; Catecholamines; Dextrans; Dogs; Edema; He | 1974 |
58 other studies available for indomethacin and Burns
| Article | Year |
|---|---|
Role of NFAT and AP-1 in PGE2-mediated T cell suppression in burn injury.
Topics: Animals; Burns; Dinoprostone; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Indomethac | 2002 |
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami | 1980 |
Induction of prostaglandin synthesis-dependent suppressor cells with endotoxin: occurrence in patients with thermal injuries.
Topics: Adult; Burns; Endotoxins; Escherichia coli; Humans; Indomethacin; Isoantigens; Lipopolysaccharides; | 1983 |
The immunomodulating effect of TP5 and indomethacin in burn-induced hypoimmunity.
Topics: Animals; Burns; Female; Guinea Pigs; Hemolytic Plaque Technique; Hormones; Immune Tolerance; Indomet | 1984 |
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity | 1984 |
The role of prostacyclin and thromboxane in rat burn and freeze injuries.
Topics: Animals; Blood Vessels; Burns; Epoprostenol; Freezing; Indomethacin; Male; Prostaglandins; Rats; Rat | 1983 |
Acyloxyamines as prodrugs of anti-inflammatory carboxylic acids for improved delivery through skin.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Burns; Carboxylic Acids; Chemical Phenom | 1984 |
Promotion of vascular patency in dermal burns with ibuprofen.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Vessels; Body Fluids; Burns; Fibrinolysis; Freezing; Ib | 1984 |
Failure of topical prostaglandin inhibitors to improve wound healing following deep partial-thickness burns.
Topics: Administration, Topical; Animals; Burns; Female; Guinea Pigs; Indomethacin; Prostaglandin Antagonist | 1983 |
Effects of alterations of polyunsaturated fatty acid metabolism upon plasma volume loss induced by thermal trauma.
Topics: Animals; Burns; Catalase; Dogs; Fatty Acids, Unsaturated; Hemodynamics; Indomethacin; Plasma Volume; | 1980 |
Restoration of postburn impaired lymphocyte responsiveness by nonsteroidal anti-inflammatory drugs is independent of prostaglandin E2 inhibition.
Topics: Administration, Oral; Amino Acid Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1994 |
Granulocyte-macrophage colony-stimulating factor modulates immune function and improves survival after experimental thermal injury.
Topics: Animals; Burns; Cell Division; Dose-Response Relationship, Drug; Drug Therapy, Combination; Granuloc | 1995 |
Production of tumor necrosis factor, interleukin-6 and prostaglandin E2 by LPS-stimulated rat bone marrow macrophages after thermal injury: effect of indomethacin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Burns; Cytokines; Dinoprostone; Indomethacin; Interleukin-6 | 1994 |
Marrow granulocyte-macrophage progenitor cell response to burn injury as modified by endotoxin and indomethacin.
Topics: Animals; Bone Marrow; Burns; Cell Division; Colony-Forming Units Assay; Endotoxins; Granulocytes; He | 1994 |
Mechanism of increased tumor necrosis factor production after thermal injury. Altered sensitivity to PGE2 and immunomodulation with indomethacin.
Topics: Animals; Burns; Dinoprostone; Indomethacin; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred A; | 1993 |
Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model.
Topics: Administration, Oral; Animals; Burns; Cicatrix; Dose-Response Relationship, Radiation; Female; Fibro | 1993 |
Effects of D-myo-Inositol-1,2,6-triphosphate on eicosanoid formation in burned skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Eicosanoids; Indomethacin; Inositol Phospha | 1996 |
Effect of cyclo-oxygenase inhibition on in vitro B-cell function after burn injury.
Topics: Animals; Antibody Specificity; Antigens, Bacterial; B-Lymphocytes; Burns; Cell Division; Cyclooxygen | 1996 |
The effect of indomethacin on the cytokine cascade and body temperature following burn injury in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Surface Area; Body Temp | 1999 |
Differential production of prostaglandin E(2) in male and female mice subjected to thermal injury contributes to the gender difference in immune function: possible role for 15-hydroxyprostaglandin dehydrogenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cell Division; Cells, Cultured; Cyclooxygen | 2000 |
A new technique for the analysis of endogenous mediators released following thermal injury.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Dinoprostone; Disease Models, Ani | 2001 |
PGE2 suppresses intestinal T cell function in thermal injury: a cause of enhanced bacterial translocation.
Topics: Animals; Bacterial Translocation; Burns; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Inte | 2001 |
Proceedings: Prostaglandins in burn induced acute oligo-anuria and oedema.
Topics: Animals; Anuria; Burns; Dogs; Edema; Female; Indomethacin; Inflammation; Male; Oliguria; Prostagland | 1975 |
Collagen synthesis and prostaglandin inhibition in burns.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Collagen; Dinoprostone; Indomethacin; | 1978 |
On the enzymatic response to injury and its mediators.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Burns; | 1979 |
Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury.
Topics: Animals; Burns; Cyclic AMP; Diclofenac; Hindlimb; Indomethacin; Lymph; Prostaglandins E; Prostagland | 1979 |
Preventing the prostaglandin effect on dermal ischemia in the burn wound.
Topics: Animals; Aspirin; Burns; Female; Guinea Pigs; Indomethacin; Ischemia; Methylprednisolone; Prostaglan | 1978 |
The effect of prostaglandins on the dermal microcirculation after burning, and the inhibition of the effect by specific pharmacological agents.
Topics: Animals; Aspirin; Burns; Female; Guinea Pigs; Indomethacin; Methylprednisolone; Microcirculation; Ni | 1979 |
Effect of inhibiting prostaglandin synthesis on edema formation and albumin leakage during thermal trauma in the rat.
Topics: Albumins; Animals; Body Water; Burns; Capillary Permeability; Drug Evaluation, Preclinical; Edema; F | 1979 |
The evaluation of topical anti-inflammatory activity on rat ears subjected to thermal injury.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Burns; Dexamethasone; Dose-Response Rela | 1978 |
[Influence of inflammation on prostaglandin metabolism in rat skin (author's transl)].
Topics: Animals; Arachidonic Acids; Burns; Dinitrochlorobenzene; Indomethacin; Inflammation; Male; Prostagla | 1977 |
[Letter: Cold water as first aid in burns].
Topics: Burns; Cold Temperature; Humans; Indomethacin; Phenylbutazone; Water | 1975 |
IL-2 regulation of soluble IL-2 receptor levels following thermal injury.
Topics: Adult; Aged; Antigens, CD; Burns; Calcimycin; Calcium; CD5 Antigens; Colforsin; Humans; In Vitro Tec | 1992 |
Modulation of macrophage hyperactivity improves survival in a burn-sepsis model.
Topics: Animals; Burns; Indomethacin; Interleukin-1; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred A; | 1992 |
The role of prostaglandin E2 in immune suppression following injury.
Topics: Adolescent; Adult; Aged; Burns; Dinoprostone; Endotoxins; Escherichia coli; Female; Humans; Ibuprofe | 1991 |
An ibuprofen-antagonized plasmin inhibitor released by human endothelial cells.
Topics: Antifibrinolytic Agents; Burns; Cells, Cultured; Cicatrix; Endothelium; Fibrinolysis; Hot Temperatur | 1991 |
Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome.
Topics: Adult; Aged; Burns; Cell Separation; Humans; Immune Tolerance; Indomethacin; Middle Aged; Monocytes; | 1990 |
Postburn suppression of murine lymphocyte and neutrophil functions is not reversed by prostaglandin blockade.
Topics: Animals; Burns; Cell Division; Dietary Fats, Unsaturated; Dinoprostone; Female; Fish Oils; Indometha | 1990 |
Effect of low dose recombinant interleukin 2 plus indomethacin on mortality after sepsis in a murine burn model.
Topics: Animals; Bacterial Infections; Burns; Disease Models, Animal; Drug Therapy, Combination; Indomethaci | 1990 |
Effect of prostaglandin E in multiple experimental models. VI. Effect on T-cell subsets.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Burns; Disease Models, Animal; Indomethacin; Leukocyte Coun | 1989 |
Prostaglandin E-related impaired expression of interleukin-2 receptor in the burn patient.
Topics: Adult; Burns; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Immune Tolerance; Indomethacin; Inter | 1987 |
The importance of lipid type in the diet after burn injury.
Topics: Animals; Body Weight; Burns; Complement C3; Dietary Fats; Dinoprostone; Eicosapentaenoic Acid; Energ | 1986 |
Local renal ischemia during burn shock in rat effected by thromboxane A2 and serotonin.
Topics: Animals; Blood Pressure; Burns; Indomethacin; Ischemia; Ketanserin; Kidney Cortex; Male; Phentolamin | 1986 |
Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Arterioles | 1988 |
Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Bactericidal A | 1988 |
Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis.
Topics: Animals; Burns; Disease Models, Animal; Flurbiprofen; Indomethacin; Interleukin-2; Lymphocyte Activa | 1987 |
The effect of indomethacin on burn-induced immunosuppression.
Topics: Abscess; Animals; Burns; Hypersensitivity, Delayed; Immune Tolerance; Indomethacin; Male; Rats; Rats | 1987 |
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniqu | 1985 |
Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Carrageenan; Edema; Histamine H1 Antagonists; Ind | 1973 |
Effects of O-(beta-hydroxyethyl)-rutosides (HR) and indomethacin on transcapillary macromolecular transport and prostaglandins following scalding injury.
Topics: Animals; Biological Assay; Burns; Capillary Permeability; Depression, Chemical; Dextrans; Dogs; Etha | 1973 |
Chemical biology of in vivo and in vitro wounds.
Topics: Animals; Burns; Collagen; Croton Oil; Fucose; Glucuronidase; Glycoproteins; Histamine; Hot Temperatu | 1968 |
][A new method for screening of analgesics applied to heat induced inflammatory pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab | 1974 |
Proceedings: Effect of hydrocortisone and indomethacin on changes in LDH isoenzymes in skin after thermal injury.
Topics: Animals; Burns; Cats; Hydrocortisone; Indomethacin; Isoenzymes; L-Lactate Dehydrogenase; Rabbits; Sk | 1972 |
Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzocaine; Bradykinin; Burns; Chlorpromazine; Dose-Re | 1973 |
Effects of indomethacin on the transcapillary leakage of macromolecules and the efflux of prostaglandins in the paw lymph following experimental scalding injury.
Topics: Animals; Biological Transport; Blood Proteins; Burns; Capillary Permeability; Depression, Chemical; | 1973 |
The effect of anti-inflammatory agents on the changes in local lymph after thermal injury.
Topics: Alanine Transaminase; Animals; Burns; Capillary Permeability; Glucuronidase; Hindlimb; Hydrocortison | 1972 |
The drug inhibition of increased vascular permeability.
Topics: Animals; Blood Vessels; Burns; Capillary Permeability; Chlorpromazine; Digoxin; Diphenhydramine; Ind | 1968 |
Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool.
Topics: Animals; Anti-Inflammatory Agents; Burns; Guinea Pigs; Hemolysin Proteins; In Vitro Techniques; Indo | 1965 |