indomethacin has been researched along with Bronchiectasis in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Bronchiectasis: Persistent abnormal dilatation of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bronchiectasis is associated with sputum containing high levels of the proteolytic enzyme elastase, which is thought to be involved in the pathogenesis of the disease." | 5.29 | In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion. ( Hill, SL; Johnson, MM; Llewellyn-Jones, CG; Mitchell, JL; Okafor, VC; Pye, A; Stockley, RA, 1995) |
| "Indomethacin suppository and aspirin inhalation reduced the amounts of sputum in the patients with bronchiectasis and chronic bronchitis." | 3.68 | Effect of cyclooxygenase inhibitor on excessive sputum. ( Aizawa, H; Ikeda, T; Inoue, H; Koto, H; Miyagawa, Y; Shigematsu, N, 1991) |
| "To determine whether the involvement of thromboxane A2 in bronchial hyperresponsiveness (BHR) is specific to asthma, we examined the effects of a selective inhibitor of thromboxane synthetase (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial responsiveness to methacholine in normal subjects and patients with chronic bronchitis, diffuse bronchiectasis, and intrinsic bronchial asthma." | 3.68 | Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. ( Fujimura, M; Matsuda, T; Sakamoto, S, 1990) |
| "Bronchiectasis is associated with sputum containing high levels of the proteolytic enzyme elastase, which is thought to be involved in the pathogenesis of the disease." | 1.29 | In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion. ( Hill, SL; Johnson, MM; Llewellyn-Jones, CG; Mitchell, JL; Okafor, VC; Pye, A; Stockley, RA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Folco, G | 1 |
| Bolla, M | 1 |
| Santinelli, E | 1 |
| Bianco, S | 1 |
| Sestini, P | 1 |
| Mezzetti, M | 1 |
| Sala, A | 1 |
| Llewellyn-Jones, CG | 1 |
| Johnson, MM | 1 |
| Mitchell, JL | 1 |
| Pye, A | 1 |
| Okafor, VC | 1 |
| Hill, SL | 1 |
| Stockley, RA | 1 |
| Tamaoki, J | 1 |
| Chiyotani, A | 1 |
| Kobayashi, K | 1 |
| Sakai, N | 1 |
| Kanemura, T | 1 |
| Takizawa, T | 1 |
| Inoue, H | 1 |
| Aizawa, H | 1 |
| Koto, H | 1 |
| Miyagawa, Y | 1 |
| Ikeda, T | 1 |
| Shigematsu, N | 1 |
| Fujimura, M | 1 |
| Sakamoto, S | 1 |
| Matsuda, T | 1 |
| Syabbalo, NC | 1 |
1 trial available for indomethacin and Bronchiectasis
| Article | Year |
|---|---|
Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis.
Topics: Adult; Aged; Bronchi; Bronchiectasis; Bronchitis; Chronic Disease; Double-Blind Method; Female; Huma | 1992 |
5 other studies available for indomethacin and Bronchiectasis
| Article | Year |
|---|---|
Furosemide attenuates bronchial responsiveness to antigen challenge "in vitro".
Topics: Acetophenones; Acetylcholine; Bronchi; Bronchiectasis; Carcinoma, Bronchogenic; Dicarboxylic Acids; | 1995 |
In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bronchiectasis; Chemotaxis, Leukocyte; Female; | 1995 |
Effect of cyclooxygenase inhibitor on excessive sputum.
Topics: Adult; Aged; Bronchiectasis; Bronchitis; Cyclooxygenase Inhibitors; Depression, Chemical; Female; Hu | 1991 |
Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma.
Topics: Acrylates; Asthma; Bronchi; Bronchial Provocation Tests; Bronchiectasis; Bronchitis; Female; Forced | 1990 |
Medical management of hemoptysis.
Topics: Bronchiectasis; Cimetidine; Hemoptysis; Humans; Indomethacin; Tuberculosis, Pulmonary | 1989 |