indomethacin has been researched along with Bronchial Spasm in 28 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interaction of threshold doses of bradykinin (BK) and substance P (SP) with acetylcholine (ACh)-induced bronchospasm was investigated in anaesthetized guinea-pigs." | 7.67 | Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig. ( Brunelli, G; Daffonchio, L; Hernandez, A; Omini, C, 1989) |
| "The term "aspirin intolerance" is defined as acute urticaria-angioedema, bronchospasm, severe rhinitis, or shock occurring within three hours of aspirin ingestion." | 4.76 | Adverse reactions of aspirin and related drugs. ( Settipane, GA, 1981) |
| " Using an animal model of diabetes (alloxan-induced hyperglycaemia in mice), a model of gastric ulcer (indomethacin-induced gastric lesion in rats), and a model of bronchial asthma (ovalbumin-induced allergic bronchospasm in guinea pigs), a potential therapeutic effect was tested in known antioxidant drugs (alpha-tocopherol, ubiquinone), the thio-compound mesna, and drugs with a possible antioxidant effect (substances derived from the ergoline structure: 6-hydroxynicotinic acid and 4-hydroxypyridine)." | 3.70 | Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). ( Grossmann, V; Stetinová, V, 2000) |
| "The interaction of threshold doses of bradykinin (BK) and substance P (SP) with acetylcholine (ACh)-induced bronchospasm was investigated in anaesthetized guinea-pigs." | 3.67 | Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig. ( Brunelli, G; Daffonchio, L; Hernandez, A; Omini, C, 1989) |
| "Indomethacin pretreatment decreased adenosine hyperresponsiveness and shifted the dose-response curves of adenosine challenge to the right with a geometric mean PD20 of 1." | 2.66 | Effect of indomethacin on adenosine-induced bronchoconstriction. ( Crimi, N; Maccarrone, C; Mistretta, A; Oliveri, R; Palermo, B; Palermo, F; Polosa, R, 1989) |
| "Chlorpheniramine pretreatment prevented death, delayed the onset of respiratory symptoms and decreased the severity of the hypersensitivity reaction." | 1.27 | Use of a simple in vivo technique to investigate components of the immediate hypersensitivity reaction in conscious guinea pigs. ( Hammerbeck, DM; Swingle, KF, 1984) |
| "FPL 55712 was nonselective since it inhibited prostaglandin D2 and histamine-induced bronchoconstriction as well as LTC4-induced bronchoconstriction." | 1.27 | Mediators of C5a-induced bronchoconstriction in the guinea pig. ( Bell, RL; Regal, JF, 1987) |
| " Aerosol pretreatment with the cyclooxygenase inhibitor indomethacin had no significant effect on either LTC4 or LTD4 dose-response curves; however, at the highest doses of these agonists a notable, nonsignificant inhibition of effects on both Rp and Cdyn was seen." | 1.27 | Pharmacology of aerosol leukotriene C4- and D4-induced alteration of pulmonary mechanics in anesthetized cynomolgus monkeys. ( Giles, RE; Krell, RD; Williams, JC, 1986) |
| " Salicylamide, an analgesic without effect on the prostaglandin synthesis was in the oral exposition test of 18 patients with proved analgesics-asthma-syndrome in the dosage of 500 mg subjectively and objectively tolerated without reaction." | 1.26 | [Salicylamide-- a potential pain-remedy alternative in the analgesic asthma syndrome]. ( Hummel, S; Jäger, L; Slapke, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (96.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weichman, BM | 1 |
| Muccitelli, RM | 1 |
| Osborn, RR | 1 |
| Holden, DA | 1 |
| Gleason, JG | 1 |
| Wasserman, MA | 1 |
| Hammerbeck, DM | 1 |
| Swingle, KF | 1 |
| Abraham, WM | 1 |
| Oliver, W | 1 |
| King, MM | 1 |
| Yerger, L | 1 |
| Wanner, A | 1 |
| Andersson, P | 1 |
| Fairfax, AJ | 1 |
| Hanson, JM | 1 |
| Morley, J | 1 |
| Settipane, GA | 1 |
| Ogilvy, CS | 1 |
| DuBois, AB | 1 |
| Douglas, JS | 1 |
| Butler, KD | 1 |
| Smith, JR | 1 |
| Stetinová, V | 1 |
| Grossmann, V | 1 |
| Vaage, J | 1 |
| Slapke, J | 1 |
| Hummel, S | 1 |
| Jäger, L | 1 |
| Pasargiklian, M | 1 |
| Bianco, S | 1 |
| Allegra, L | 1 |
| Schachter, EN | 1 |
| Kreisman, H | 1 |
| Bouhuys, A | 1 |
| Omini, C | 1 |
| Brunelli, G | 1 |
| Hernandez, A | 1 |
| Daffonchio, L | 1 |
| Fügner, A | 1 |
| Crimi, N | 1 |
| Palermo, F | 1 |
| Polosa, R | 1 |
| Oliveri, R | 1 |
| Maccarrone, C | 1 |
| Palermo, B | 1 |
| Mistretta, A | 1 |
| Ford-Hutchinson, AW | 1 |
| Hamel, R | 1 |
| McFarlane, CS | 1 |
| Freed, AN | 1 |
| Wang, D | 1 |
| Menkes, HA | 1 |
| Payne, AN | 1 |
| Whittle, BJ | 1 |
| Kurachi, M | 1 |
| Hongoh, K | 1 |
| Watanabe, A | 1 |
| Aihara, H | 1 |
| Chiariello, M | 1 |
| Campana, G | 1 |
| Delfanti, G | 1 |
| Capuano, D | 1 |
| Regal, JF | 1 |
| Bell, RL | 1 |
| Krell, RD | 1 |
| Williams, JC | 1 |
| Giles, RE | 1 |
| Adams, GK | 1 |
| Lichtenstein, LM | 1 |
| Liebig, R | 1 |
| Bernauer, W | 1 |
| Peskar, BA | 1 |
| Stotland, LM | 1 |
| Share, NN | 1 |
| Buttinoni, A | 1 |
| Cuttica, A | 1 |
| Franceschini, J | 1 |
| Mandelli, V | 1 |
| Orsini, G | 1 |
| Passerini, N | 1 |
| Turba, C | 1 |
| Tommasini, R | 1 |
| Barron, DI | 1 |
| Copley, AR | 1 |
| Vallance, DK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass (the OPTIMAL Study)[NCT03782350] | Phase 4 | 3,079 participants (Actual) | Interventional | 2018-12-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Bronchial Spasm
| Article | Year |
|---|---|
Adverse reactions of aspirin and related drugs.
Topics: Aspirin; Bronchial Spasm; Drug Hypersensitivity; Humans; Ibuprofen; Indomethacin; Prostaglandins; Ur | 1981 |
3 trials available for indomethacin and Bronchial Spasm
| Article | Year |
|---|---|
Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2alpha, E1, and E2.
Topics: Adult; Aerosols; Airway Resistance; Allergens; Asthma; Bronchial Spasm; Bronchitis; Clinical Trials | 1976 |
Prostaglandin-synthesis inhibition and exercise bronchospasm.
Topics: Aspirin; Bronchial Spasm; Clinical Trials as Topic; Double-Blind Method; Humans; Indomethacin; Physi | 1978 |
Effect of indomethacin on adenosine-induced bronchoconstriction.
Topics: Adenosine; Adolescent; Adult; Bronchial Spasm; Double-Blind Method; Female; Forced Expiratory Volume | 1989 |
24 other studies available for indomethacin and Bronchial Spasm
| Article | Year |
|---|---|
In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig.
Topics: Animals; Arachidonic Acids; Bronchial Spasm; Guinea Pigs; Histamine; In Vitro Techniques; Indomethac | 1982 |
Use of a simple in vivo technique to investigate components of the immediate hypersensitivity reaction in conscious guinea pigs.
Topics: Aerosols; Anaphylaxis; Animals; Atropine; Bronchial Spasm; Chlorpheniramine; Chromones; Guinea Pigs; | 1984 |
Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep.
Topics: Airway Resistance; Animals; Antigens; Ascaris; Atropine; Bronchial Spasm; Chlorpheniramine; Chromone | 1981 |
Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anaesthetized guinea-pigs.
Topics: Anaphylaxis; Anesthesia; Animals; Bronchial Spasm; Guinea Pigs; Histamine; Immunoglobulin E; Immunog | 1982 |
The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.
Topics: Adolescent; Adult; Allergens; Arachidonic Acids; Asthma; Bronchial Provocation Tests; Bronchial Spas | 1983 |
Effects of ascorbic acid and indomethacin on the airways of healthy male subjects with and without induced bronchoconstriction.
Topics: Airway Resistance; Ascorbic Acid; Bronchial Spasm; Humans; Indomethacin; Male; Methacholine Compound | 1981 |
Mechanisms of Forssman-induced bronchospasm and their inhibition.
Topics: Animals; Aspirin; Blood Platelets; Bronchial Spasm; Complement System Proteins; Forssman Antigen; Gu | 1981 |
Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm).
Topics: Alloxan; Animals; Antioxidants; Bronchial Spasm; Diabetes Mellitus, Experimental; Disease Models, An | 2000 |
Vagal reflexes in the bronchoconstriction occurring after induced intravascular platelet aggregation.
Topics: Animals; Atropine; Bronchi; Bronchial Spasm; Cats; Collagen; Hydrogen-Ion Concentration; Indomethaci | 1976 |
[Salicylamide-- a potential pain-remedy alternative in the analgesic asthma syndrome].
Topics: Analgesics; Animals; Antipyrine; Asthma; Bronchial Spasm; Cyclooxygenase Inhibitors; Female; Guinea | 1979 |
Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig.
Topics: Acetylcholine; Animals; Bradykinin; Bronchi; Bronchial Spasm; Cyclooxygenase Inhibitors; Drug Synerg | 1989 |
Formation of oedema and accumulation of eosinophils in the guinea pig lung. Inhibition by inhaled beta-stimulants.
Topics: Acetylcholine; Animals; Benzimidazoles; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Capillary Per | 1989 |
Pulmonary responses to exogenous leukotrienes.
Topics: Allergens; Animals; Arachidonic Acids; Ascaris; Bronchi; Bronchial Provocation Tests; Bronchial Spas | 1985 |
Dry air-induced constriction: effects of pharmacological intervention and temperature.
Topics: Air; Airway Resistance; Animals; Atropine; Bronchial Spasm; Cyclooxygenase Inhibitors; Dogs; Humidit | 1987 |
Potent cyclo-oxygenase-mediated bronchoconstrictor effects of endothelin in the guinea-pig in vivo.
Topics: Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchi; Bronchial | 1988 |
Suppression of bronchial response to platelet activating factor following taurine administration.
Topics: Animals; Bronchial Spasm; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Mice; Mice, In | 1987 |
[Bradykinin bronchospasm in guinea pigs: effects of indomethacin and verbenone].
Topics: Animals; Bicyclic Monoterpenes; Bradykinin; Bronchial Spasm; Guinea Pigs; Indomethacin; Male; Terpen | 1986 |
Mediators of C5a-induced bronchoconstriction in the guinea pig.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Bronchial Spasm; Chromones; Complement C5; Guinea Pigs; H | 1987 |
Pharmacology of aerosol leukotriene C4- and D4-induced alteration of pulmonary mechanics in anesthetized cynomolgus monkeys.
Topics: Aerosols; Airway Resistance; Anesthesia; Animals; Bronchial Spasm; Chromones; Dose-Response Relation | 1986 |
Indomethacin enhances response of human bronchus to antigen.
Topics: Anaphylaxis; Antigens; Biomechanical Phenomena; Bronchi; Bronchial Spasm; Histamine; Humans; In Vitr | 1985 |
Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines.
Topics: Anaphylaxis; Animals; Bronchial Spasm; Constriction; Epinephrine; Female; Guinea Pigs; Histamine Rel | 1974 |
Pharmacological studies on active bronchial anaphylaxis in the rat.
Topics: Aluminum Hydroxide; Anaphylaxis; Animals; Atropine; Bordetella pertussis; Bronchial Spasm; Cromolyn | 1974 |
Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Behavi | 1973 |
Anti-inflammatory and related properties of 4-(p-biphenylyl)-3-hydroxybutyric acid.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Biphenyl Compounds; Blood Pressure; Bronchial | 1968 |