indomethacin has been researched along with Bronchial Hyperreactivity in 25 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs." | 9.09 | Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses. ( Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1999) |
| " To investigate whether prostaglandin production could also modulate the bronchial antireactive activity of this diuretic drug, we investigated the effect of inhaled lysine acetylsalicylate (162 mg) and of furosemide (18 mg), alone and in combination, on the bronchial obstructive response to ultrasonically nebulized water in asthmatic patients." | 9.07 | Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate. ( Berni, F; Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1993) |
| "The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects." | 9.07 | Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. ( Christie, PE; Hawksworth, R; Lee, TH; Spur, BW, 1992) |
| "We studied the effects of inhaled furosemide (40 mg) on bronchial responsiveness to acetylcholine (ACh) in patients with chronic congestive heart failure who had been premedicated with indomethacin (75 mg/day) for five days." | 7.69 | [Effects of inhaled furosemide after indomethacin premedication on bronchial hyperresponsiveness in patients with chronic congestive heart failure]. ( Ishizaki, T; Kanamori, K; Mifune, J; Miyabo, S; Nakai, T; Saitoh, Y; Sakai, T; Sasaki, F, 1994) |
| "Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs." | 5.09 | Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses. ( Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1999) |
| " In study 1, 15 non-aspirin sensitive patients with mild asthma attended on four occasions and inhaled 5 ml of lysine aspirin (L-aspirin) 900 mg, indomethacin 50 mg, sodium salicylate 800 mg, or saline 20 minutes before an inhaled MBS challenge." | 5.08 | Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma. ( Knox, A; Pavord, I; Tattersfield, A; Wang, M; Wisniewski, A, 1996) |
| " To investigate whether prostaglandin production could also modulate the bronchial antireactive activity of this diuretic drug, we investigated the effect of inhaled lysine acetylsalicylate (162 mg) and of furosemide (18 mg), alone and in combination, on the bronchial obstructive response to ultrasonically nebulized water in asthmatic patients." | 5.07 | Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate. ( Berni, F; Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1993) |
| "The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects." | 5.07 | Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. ( Christie, PE; Hawksworth, R; Lee, TH; Spur, BW, 1992) |
| " To determine the beneficial effects of statins on the airway hyperresponsiveness, a characteristic feature of allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced bronchial smooth muscle hyperresponsiveness was investigated in mice." | 3.74 | Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice. ( Chiba, Y; Misawa, M; Sato, S, 2008) |
| "We studied the effects of inhaled furosemide (40 mg) on bronchial responsiveness to acetylcholine (ACh) in patients with chronic congestive heart failure who had been premedicated with indomethacin (75 mg/day) for five days." | 3.69 | [Effects of inhaled furosemide after indomethacin premedication on bronchial hyperresponsiveness in patients with chronic congestive heart failure]. ( Ishizaki, T; Kanamori, K; Mifune, J; Miyabo, S; Nakai, T; Saitoh, Y; Sakai, T; Sasaki, F, 1994) |
| "The anti-asthmatic effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a specific thromboxane A2 (TXA2) synthase inhibitor, were investigated in the ovalbumin-sensitized guinea pig asthmatic model." | 3.68 | Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. ( Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T, 1993) |
| "Treatment with indomethacin reduced IP response in the hyper-reactive model, and did not produce any change in diabetic model with hyper-reactive airways, indicating further disruption of the COX pathway." | 1.43 | Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs. ( Bano, S; Kambadur, M; Mohammad, F; Swati, O, 2016) |
| "Indomethacin pretreatment did not modify the spasmogen responses of the explant." | 1.33 | Organ-cultured airway explants: a new model of airway hyperresponsiveness. ( Brayden, J; Morin, C; Proteau, S; Rousseau, E, 2005) |
| "In human non-smokers without airway obstruction, increased BAT was correlated with bronchial hyperreactivity." | 1.33 | Bronchial hyperreactivity is correlated with increased baseline airway tone. ( Bergner, A; Fischer, R; Gamarra, F; Huber, RM; Kellner, J; Kemp da Silva, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (64.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riley, JP | 1 |
| Fuchs, B | 1 |
| Sjöberg, L | 1 |
| Nilsson, GP | 1 |
| Karlsson, L | 1 |
| Dahlén, SE | 1 |
| Rao, NL | 1 |
| Adner, M | 1 |
| Bano, S | 1 |
| Swati, O | 1 |
| Kambadur, M | 1 |
| Mohammad, F | 1 |
| Chiba, Y | 1 |
| Sato, S | 1 |
| Misawa, M | 1 |
| Sharma, P | 1 |
| Ryu, MH | 1 |
| Basu, S | 1 |
| Maltby, SA | 1 |
| Yeganeh, B | 1 |
| Mutawe, MM | 1 |
| Mitchell, RW | 1 |
| Halayko, AJ | 1 |
| Morin, C | 1 |
| Proteau, S | 1 |
| Rousseau, E | 1 |
| Brayden, J | 1 |
| Bergner, A | 1 |
| Kellner, J | 1 |
| Kemp da Silva, A | 1 |
| Fischer, R | 1 |
| Gamarra, F | 1 |
| Huber, RM | 1 |
| Knight, DA | 1 |
| Stewart, GA | 1 |
| Lai, ML | 1 |
| Thompson, PJ | 1 |
| Saitoh, Y | 1 |
| Sasaki, F | 1 |
| Sakai, T | 1 |
| Ishizaki, T | 1 |
| Nakai, T | 1 |
| Miyabo, S | 1 |
| Kanamori, K | 1 |
| Mifune, J | 1 |
| Bianco, S | 2 |
| Vaghi, A | 2 |
| Pieroni, MG | 2 |
| Robuschi, M | 2 |
| Refini, RM | 2 |
| Berni, F | 1 |
| Sestini, P | 2 |
| Yamaguchi, T | 1 |
| Mukaiyama, O | 1 |
| Itoh, K | 1 |
| Satoh, Y | 1 |
| Terada, A | 1 |
| Iizuka, Y | 1 |
| Wang, M | 1 |
| Wisniewski, A | 1 |
| Pavord, I | 1 |
| Knox, A | 1 |
| Tattersfield, A | 1 |
| Nally, JE | 1 |
| Bunton, DC | 1 |
| Martin, D | 1 |
| Thomson, NC | 1 |
| Nagase, T | 1 |
| Ishii, S | 1 |
| Katayama, H | 1 |
| Fukuchi, Y | 1 |
| Ouchi, Y | 1 |
| Shimizu, T | 1 |
| Janssen, LJ | 1 |
| McGrogan, I | 1 |
| Wattie, J | 1 |
| O'Byrne, PM | 1 |
| Daniel, EE | 1 |
| Pennings, HJ | 1 |
| Kramer, K | 1 |
| Bast, A | 1 |
| Buurman, WA | 1 |
| Wouters, EF | 1 |
| Molimard, M | 1 |
| Naline, E | 1 |
| Boichot, E | 1 |
| Devillier, P | 1 |
| Lagente, V | 1 |
| Bégaud, B | 1 |
| Advenier, C | 1 |
| Tohda, Y | 1 |
| Muraki, M | 1 |
| Kubo, H | 1 |
| Itoh, M | 1 |
| Haraguchi, R | 1 |
| Nakajima, S | 1 |
| Fukuoka, M | 1 |
| Ishiura, Y | 1 |
| Fujimura, M | 2 |
| Myou, S | 1 |
| Nobata, K | 1 |
| Liu, Q | 1 |
| Yamamori, C | 1 |
| Amemiya, T | 1 |
| Davis, MS | 1 |
| McCulloch, S | 1 |
| Myers, T | 1 |
| Freed, AN | 1 |
| Christie, PE | 1 |
| Hawksworth, R | 1 |
| Spur, BW | 1 |
| Lee, TH | 1 |
| Yeadon, M | 1 |
| Wilkinson, D | 1 |
| Darley-Usmar, V | 1 |
| O'Leary, VJ | 1 |
| Payne, AN | 1 |
| Asano, M | 1 |
| Inamura, N | 1 |
| Nakahara, K | 1 |
| Nagayoshi, A | 1 |
| Isono, T | 1 |
| Hamada, K | 1 |
| Oku, T | 1 |
| Notsu, Y | 1 |
| Kohsaka, M | 1 |
| Ono, T | 1 |
| Saito, M | 1 |
| Sakamoto, S | 1 |
| Miyake, Y | 1 |
| Shintani, H | 1 |
| Yasui, M | 1 |
| Matsuda, T | 1 |
| Foster, A | 1 |
| Chan, CC | 1 |
4 trials available for indomethacin and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1993 |
Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Anti-Inflammatory Agents, Non-Steroidal; | 1996 |
Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; A | 1999 |
Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Hi | 1992 |
21 other studies available for indomethacin and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs.
Topics: Acetylcholine; Animals; Antigens, Bacterial; Bacterial Proteins; Bronchial Hyperreactivity; Bronchoc | 2016 |
Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice.
Topics: Acetylcholine; Animals; Antigens; Asthma; Atropine; Bronchial Hyperreactivity; Bronchodilator Agents | 2008 |
Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bronchial Hyperreactivity; Bronchoconstricti | 2012 |
Organ-cultured airway explants: a new model of airway hyperresponsiveness.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biomechanica | 2005 |
Bronchial hyperreactivity is correlated with increased baseline airway tone.
Topics: Acetylcholine; Airway Obstruction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Bronc | 2006 |
Epithelium-derived inhibitory prostaglandins modulate human bronchial smooth muscle responses to histamine.
Topics: Acetylcholine; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Bronchial Hyperreactivity; Cy | 1995 |
[Effects of inhaled furosemide after indomethacin premedication on bronchial hyperresponsiveness in patients with chronic congestive heart failure].
Topics: Administration, Inhalation; Aged; Aged, 80 and over; Bronchial Hyperreactivity; Chronic Disease; Fem | 1994 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyper | 1993 |
The role of cyclooxygenase and 5-lipoxygenase metabolites in potentiated endothelin-1-evoked contractions in bovine bronchi.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bronchial Hyperreactivity; Cattle; Cyclooxyg | 1996 |
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene | 1997 |
Myogenic and neurogenic mechanisms and arachidonate metabolites in bronchial muscle response to allergen.
Topics: Allergens; Animals; Arachidonic Acids; Ascaris suum; Bronchi; Bronchial Hyperreactivity; Carbachol; | 1997 |
Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro.
Topics: Airway Resistance; Animals; Azepines; Bronchial Hyperreactivity; Culture Techniques; Dose-Response R | 1998 |
In vitro-induced human airway hyperresponsiveness to bradykinin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Ketoprostaglandin F1 alpha; Ag | 1998 |
Role of chemical mediators in airway hyperresponsiveness in an asthmatic model.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response | 2001 |
In vivo airway eosinophil accumulation induced by polymyxin-B reduces bronchial responsiveness in guinea pigs.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Hyperreactivity; Bronchoa | 2001 |
Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs.
Topics: Air; Airway Obstruction; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dizocilpi | 2002 |
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: Adenine Nucleotides; Animals; Ascorbic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstrictio | 1992 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans | 1992 |
Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) in guinea pigs.
Topics: Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationshi | 1992 |
Peptide leukotriene involvement in pulmonary eosinophil migration upon antigen challenge in the actively sensitized guinea pig.
Topics: Animals; Bronchial Hyperreactivity; Cell Movement; Cimetidine; Eosinophils; Guinea Pigs; Indomethaci | 1991 |