Page last updated: 2024-10-29

indomethacin and Brain Swelling

indomethacin has been researched along with Brain Swelling in 30 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats."5.28Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990)
"At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns."5.27Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988)
"A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)."5.27Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986)
"The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied."3.68Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits. ( Sande, MA; Täuber, MG; Tureen, JH, 1991)
" The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas."3.67Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986)
"Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats."1.28Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990)
"At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns."1.27Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988)
"With indomethacin there was an initial decrease immediately following the drug, and at 60 minutes there was a rise in the insulted left hemisphere, more than the right one."1.27An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure. ( Drummond, JC; James, HE; Moore, S; Tung, H, 1986)
"A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)."1.27Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986)
"Focal cerebral ischemia initiates multiple detrimental effects in the brain."1.27Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985)
"Pretreatment with indomethacin improved cortical reperfusion but did not influence cortical pO2 and electrocorticographic activity."1.26Recovery from global cerebral ischemia in rabbits: influence of indomethacin. ( Boulu, RG; Gueniau, C; Plotkine, M; Sofeir, M, 1981)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199016 (53.33)18.7374
1990's9 (30.00)18.2507
2000's3 (10.00)29.6817
2010's2 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sharma, A1
Castellani, RJ1
Smith, MA1
Muresanu, DF1
Dey, PK1
Sharma, HS2
Girgis, H1
Palmier, B1
Croci, N1
Soustrat, M1
Plotkine, M2
Marchand-Leroux, C1
Irimia, P1
Barbosa, C1
Martinez-Vila, E1
Matsui, T1
Basugi, N1
Asano, T2
Takakura, K2
Pappius, HM1
Wolfe, LS1
Baethmann, A1
Maier-Hauff, K1
Kempski, O1
Unterberg, A1
Wahl, M1
Boulu, RG1
Gueniau, C1
Sofeir, M1
Yamamoto, N1
Yokota, K1
Yamashita, A1
Oda, M1
Harrigan, MR1
Tuteja, S1
Neudeck, BL1
Dunn-Meynell, AA1
Hassanain, M1
Levin, BE1
Zhang, W1
Smith, C1
Monette, R1
Hutchison, J1
Stanimirovic, DB1
Chung, C1
Gottstein, J1
Blei, AT1
Robert, B1
Petit, JY2
Grimaud, N1
Jugé, M2
Welin, L2
Olsson, Y1
Pettersson, A1
Cervos-Navarro, J1
Tureen, JH1
Täuber, MG1
Sande, MA1
Ohnishi, T2
Sher, PB1
Posner, JB1
Shapiro, WR2
Katayama, Y2
Shimizu, J2
Suzuki, S2
Memezawa, H1
Kashiwagi, F1
Kamiya, T1
Terashi, A2
Ting, P1
Hayakawa, T1
Arita, N1
Mogami, H1
Ushio, Y1
Johshita, H1
Hanamura, T1
Walker, V1
Pickard, JD1
Yen, MH1
Lee, SH1
Sanchez, RY1
Pineau, A1
Shapira, Y1
Davidson, E1
Weidenfeld, Y1
Cotev, S1
Shohami, E1
Minamisawa, H1
Sugimoto, S1
Reichman, HR1
Farrell, CL1
Del Maestro, RF1
Tung, H1
James, HE1
Drummond, JC1
Moore, S1
Gamache, DA1
Ellis, EF1
Shigeno, T1
Shigeno, S1
Brock, M1
Dempsey, RJ1
Roy, MW1
Meyer, KL1
Donaldson, DL1

Reviews

2 reviews available for indomethacin and Brain Swelling

ArticleYear
Indomethacin in the management of elevated intracranial pressure: a review.
    Journal of neurotrauma, 1997, Volume: 14, Issue:9

    Topics: Animals; Body Temperature; Brain Edema; Cerebrovascular Circulation; Clinical Trials as Topic; Crani

1997
Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease.
    Advances and technical standards in neurosurgery, 1985, Volume: 12

    Topics: Animals; Arachidonic Acids; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Cerebro

1985

Other Studies

28 other studies available for indomethacin and Brain Swelling

ArticleYear
5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
    International review of neurobiology, 2019, Volume: 146

    Topics: 5-Hydroxytryptophan; Albumins; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; C

2019
Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice.
    Brain research, 2013, Jan-23, Volume: 1491

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Behavior, Animal; Blotting, Western; Brain; Brain Edema; Brai

2013
Paroxysmal hemicrania after carotid aneurysm embolization.
    Cephalalgia : an international journal of headache, 2005, Volume: 25, Issue:11

    Topics: Aneurysm; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Carotid Artery Diseases; Embolizatio

2005
The effect of indomethacin on ischemic brain edema. A study using cat middle cerebral artery occlusion combined with recirculation.
    Neurologia medico-chirurgica, 1984, Volume: 24, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Fe

1984
Functional disturbances in brain following injury: search for underlying mechanisms.
    Neurochemical research, 1983, Volume: 8, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Brain Edema; Brain Injuries; Dexamethasone; Glu

1983
Therapeutic considerations in blood-brain barrier disturbances.
    Acta neuropathologica. Supplementum, 1983, Volume: 8

    Topics: Animals; Barbiturates; Blood-Brain Barrier; Brain Diseases; Brain Edema; Brain Injuries; Humans; Ind

1983
Recovery from global cerebral ischemia in rabbits: influence of indomethacin.
    European neurology, 1981, Volume: 20, Issue:3

    Topics: Animals; Brain Edema; Cerebral Cortex; Indomethacin; Ischemic Attack, Transient; Male; Oxygen Consum

1981
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
    European journal of pharmacology, 1996, Feb-22, Volume: 297, Issue:3

    Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; G

1996
Norepinephrine and traumatic brain injury: a possible role in post-traumatic edema.
    Brain research, 1998, Aug-03, Volume: 800, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brain Concus

1998
Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chemokines; Cyclosp

2000
Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis.
    Hepatology (Baltimore, Md.), 2001, Volume: 34, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Ammonia; Animals; Body Water; Brain; Brain Edema; Glutamine; Indometha

2001
Effect of clonidine on experimental brain edema in the rat.
    Agents and actions, 1992, Volume: 37, Issue:3-4

    Topics: Animals; Blood Pressure; Brain; Brain Edema; Clonidine; Copper; Dexamethasone; Indomethacin; Male; P

1992
Release of endogenous neurochemicals may increase vascular permeability, induce edema and influence cell changes in trauma to the spinal cord.
    Progress in brain research, 1992, Volume: 91

    Topics: Animals; Blood Pressure; Body Water; Brain Edema; Capillary Permeability; Carbon Dioxide; Fenclonine

1992
Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits.
    The Journal of infectious diseases, 1991, Volume: 163, Issue:3

    Topics: Animals; Brain Edema; Dinoprostone; Disease Models, Animal; Indomethacin; Meningitis, Pneumococcal;

1991
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
    Journal of neurosurgery, 1990, Volume: 72, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema;

1990
Role of arachidonic acid metabolism on ischemic brain edema and metabolism.
    Advances in neurology, 1990, Volume: 52

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Brain Edema; Brain Ischemia; Energy M

1990
Indomethacin attenuates early postischemic vasogenic edema and cerebral injury.
    Advances in neurology, 1990, Volume: 52

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Ci

1990
[Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action].
    No to shinkei = Brain and nerve, 1989, Volume: 41, Issue:11

    Topics: Animals; Biological Factors; Brain Edema; Brain Neoplasms; Capillary Permeability; Dexamethasone; Gl

1989
Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats.
    Stroke, 1989, Volume: 20, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circ

1989
Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats.
    European journal of pharmacology, 1987, Dec-15, Volume: 144, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Body Water; Brain Edema; Cyclooxygenase Inhibitors; El

1987
[Effects of an anti-inflammatory agent of benzamide structure, dexamethasone and indomethacin on experimental cerebral edema induced by phospholipase 2 in rats].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1988, Volume: 307, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Benzamides; Brain Edema; Copper

1988
Dexamethasone and indomethacin do not affect brain edema following head injury in rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:3

    Topics: Animals; Blood Pressure; Brain; Brain Edema; Craniocerebral Trauma; Dexamethasone; Indomethacin; Mal

1988
[Involvement of arachidonic acid cascade in brain edema and cerebral energy metabolism after reperfusion].
    No to shinkei = Brain and nerve, 1987, Volume: 39, Issue:4

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Body Water; Brain; Brain Edema; Dexamethasone; E

1987
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
    Journal of neurosurgery, 1986, Volume: 65, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm

1986
An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure.
    Brain research bulletin, 1986, Volume: 17, Issue:3

    Topics: Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Indomethacin; Intracranial Pr

1986
Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation.
    Journal of neurosurgery, 1986, Volume: 65, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Capillary Permeability; Carrageenan; Cerebrovascular

1986
Effect of indomethacin in focal cerebral ischemia.
    Journal of neurosurgery, 1986, Volume: 64, Issue:4

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Indomethacin

1986
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
    Journal of neurosurgery, 1985, Volume: 62, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P

1985