indomethacin has been researched along with Brain Swelling in 30 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats." | 5.28 | Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990) |
| "At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns." | 5.27 | Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988) |
| "A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)." | 5.27 | Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986) |
| "The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied." | 3.68 | Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits. ( Sande, MA; Täuber, MG; Tureen, JH, 1991) |
| " The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas." | 3.67 | Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986) |
| "Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats." | 1.28 | Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990) |
| "At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns." | 1.27 | Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988) |
| "With indomethacin there was an initial decrease immediately following the drug, and at 60 minutes there was a rise in the insulted left hemisphere, more than the right one." | 1.27 | An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure. ( Drummond, JC; James, HE; Moore, S; Tung, H, 1986) |
| "A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)." | 1.27 | Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986) |
| "Focal cerebral ischemia initiates multiple detrimental effects in the brain." | 1.27 | Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985) |
| "Pretreatment with indomethacin improved cortical reperfusion but did not influence cortical pO2 and electrocorticographic activity." | 1.26 | Recovery from global cerebral ischemia in rabbits: influence of indomethacin. ( Boulu, RG; Gueniau, C; Plotkine, M; Sofeir, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (53.33) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, A | 1 |
| Castellani, RJ | 1 |
| Smith, MA | 1 |
| Muresanu, DF | 1 |
| Dey, PK | 1 |
| Sharma, HS | 2 |
| Girgis, H | 1 |
| Palmier, B | 1 |
| Croci, N | 1 |
| Soustrat, M | 1 |
| Plotkine, M | 2 |
| Marchand-Leroux, C | 1 |
| Irimia, P | 1 |
| Barbosa, C | 1 |
| Martinez-Vila, E | 1 |
| Matsui, T | 1 |
| Basugi, N | 1 |
| Asano, T | 2 |
| Takakura, K | 2 |
| Pappius, HM | 1 |
| Wolfe, LS | 1 |
| Baethmann, A | 1 |
| Maier-Hauff, K | 1 |
| Kempski, O | 1 |
| Unterberg, A | 1 |
| Wahl, M | 1 |
| Boulu, RG | 1 |
| Gueniau, C | 1 |
| Sofeir, M | 1 |
| Yamamoto, N | 1 |
| Yokota, K | 1 |
| Yamashita, A | 1 |
| Oda, M | 1 |
| Harrigan, MR | 1 |
| Tuteja, S | 1 |
| Neudeck, BL | 1 |
| Dunn-Meynell, AA | 1 |
| Hassanain, M | 1 |
| Levin, BE | 1 |
| Zhang, W | 1 |
| Smith, C | 1 |
| Monette, R | 1 |
| Hutchison, J | 1 |
| Stanimirovic, DB | 1 |
| Chung, C | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Robert, B | 1 |
| Petit, JY | 2 |
| Grimaud, N | 1 |
| Jugé, M | 2 |
| Welin, L | 2 |
| Olsson, Y | 1 |
| Pettersson, A | 1 |
| Cervos-Navarro, J | 1 |
| Tureen, JH | 1 |
| Täuber, MG | 1 |
| Sande, MA | 1 |
| Ohnishi, T | 2 |
| Sher, PB | 1 |
| Posner, JB | 1 |
| Shapiro, WR | 2 |
| Katayama, Y | 2 |
| Shimizu, J | 2 |
| Suzuki, S | 2 |
| Memezawa, H | 1 |
| Kashiwagi, F | 1 |
| Kamiya, T | 1 |
| Terashi, A | 2 |
| Ting, P | 1 |
| Hayakawa, T | 1 |
| Arita, N | 1 |
| Mogami, H | 1 |
| Ushio, Y | 1 |
| Johshita, H | 1 |
| Hanamura, T | 1 |
| Walker, V | 1 |
| Pickard, JD | 1 |
| Yen, MH | 1 |
| Lee, SH | 1 |
| Sanchez, RY | 1 |
| Pineau, A | 1 |
| Shapira, Y | 1 |
| Davidson, E | 1 |
| Weidenfeld, Y | 1 |
| Cotev, S | 1 |
| Shohami, E | 1 |
| Minamisawa, H | 1 |
| Sugimoto, S | 1 |
| Reichman, HR | 1 |
| Farrell, CL | 1 |
| Del Maestro, RF | 1 |
| Tung, H | 1 |
| James, HE | 1 |
| Drummond, JC | 1 |
| Moore, S | 1 |
| Gamache, DA | 1 |
| Ellis, EF | 1 |
| Shigeno, T | 1 |
| Shigeno, S | 1 |
| Brock, M | 1 |
| Dempsey, RJ | 1 |
| Roy, MW | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
2 reviews available for indomethacin and Brain Swelling
| Article | Year |
|---|---|
Indomethacin in the management of elevated intracranial pressure: a review.
Topics: Animals; Body Temperature; Brain Edema; Cerebrovascular Circulation; Clinical Trials as Topic; Crani | 1997 |
Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease.
Topics: Animals; Arachidonic Acids; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Cerebro | 1985 |
28 other studies available for indomethacin and Brain Swelling
| Article | Year |
|---|---|
5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
Topics: 5-Hydroxytryptophan; Albumins; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; C | 2019 |
Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Behavior, Animal; Blotting, Western; Brain; Brain Edema; Brai | 2013 |
Paroxysmal hemicrania after carotid aneurysm embolization.
Topics: Aneurysm; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Carotid Artery Diseases; Embolizatio | 2005 |
The effect of indomethacin on ischemic brain edema. A study using cat middle cerebral artery occlusion combined with recirculation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Fe | 1984 |
Functional disturbances in brain following injury: search for underlying mechanisms.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Brain Edema; Brain Injuries; Dexamethasone; Glu | 1983 |
Therapeutic considerations in blood-brain barrier disturbances.
Topics: Animals; Barbiturates; Blood-Brain Barrier; Brain Diseases; Brain Edema; Brain Injuries; Humans; Ind | 1983 |
Recovery from global cerebral ischemia in rabbits: influence of indomethacin.
Topics: Animals; Brain Edema; Cerebral Cortex; Indomethacin; Ischemic Attack, Transient; Male; Oxygen Consum | 1981 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; G | 1996 |
Norepinephrine and traumatic brain injury: a possible role in post-traumatic edema.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brain Concus | 1998 |
Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.
Topics: Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chemokines; Cyclosp | 2000 |
Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis.
Topics: 6-Ketoprostaglandin F1 alpha; Ammonia; Animals; Body Water; Brain; Brain Edema; Glutamine; Indometha | 2001 |
Effect of clonidine on experimental brain edema in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Clonidine; Copper; Dexamethasone; Indomethacin; Male; P | 1992 |
Release of endogenous neurochemicals may increase vascular permeability, induce edema and influence cell changes in trauma to the spinal cord.
Topics: Animals; Blood Pressure; Body Water; Brain Edema; Capillary Permeability; Carbon Dioxide; Fenclonine | 1992 |
Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits.
Topics: Animals; Brain Edema; Dinoprostone; Disease Models, Animal; Indomethacin; Meningitis, Pneumococcal; | 1991 |
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema; | 1990 |
Role of arachidonic acid metabolism on ischemic brain edema and metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Brain Edema; Brain Ischemia; Energy M | 1990 |
Indomethacin attenuates early postischemic vasogenic edema and cerebral injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Ci | 1990 |
[Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action].
Topics: Animals; Biological Factors; Brain Edema; Brain Neoplasms; Capillary Permeability; Dexamethasone; Gl | 1989 |
Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circ | 1989 |
Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Body Water; Brain Edema; Cyclooxygenase Inhibitors; El | 1987 |
[Effects of an anti-inflammatory agent of benzamide structure, dexamethasone and indomethacin on experimental cerebral edema induced by phospholipase 2 in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Benzamides; Brain Edema; Copper | 1988 |
Dexamethasone and indomethacin do not affect brain edema following head injury in rats.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Craniocerebral Trauma; Dexamethasone; Indomethacin; Mal | 1988 |
[Involvement of arachidonic acid cascade in brain edema and cerebral energy metabolism after reperfusion].
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Body Water; Brain; Brain Edema; Dexamethasone; E | 1987 |
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm | 1986 |
An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure.
Topics: Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Indomethacin; Intracranial Pr | 1986 |
Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Capillary Permeability; Carrageenan; Cerebrovascular | 1986 |
Effect of indomethacin in focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Indomethacin | 1986 |
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P | 1985 |