indomethacin has been researched along with Brain Neoplasms in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma." | 9.14 | Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide. ( Bähr, O; Bamberg, M; Gorlia, T; Hartmann, C; Herrlinger, U; Meyermann, R; Tatagiba, M; von Deimling, A; Weiler, M; Weller, M; Wick, W; Wiewrodt, D, 2010) |
| "This study compares the effect of gamma-linolenic acid (GLA) and its precursor linoleic acid (LA) on survival of 36B10 malignant rat astrocytoma cells and 'normal' rat astrocytes." | 7.70 | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. ( Davis, CS; McCaw, R; Robbins, ME; Spector, AA; Vartak, S, 1998) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 7.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| "Gliomas are the most common and devastating tumors of the central nervous system." | 5.35 | Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 5.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| "To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma." | 5.14 | Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide. ( Bähr, O; Bamberg, M; Gorlia, T; Hartmann, C; Herrlinger, U; Meyermann, R; Tatagiba, M; von Deimling, A; Weiler, M; Weller, M; Wick, W; Wiewrodt, D, 2010) |
| "In this study we investigated the expression of COX-1, COX-2 and COX-3 mRNA in C6 glioblastoma and normal brain tissues and the effects of acetaminophen, indomethacin or metamizole treatments on the development of C6 glioblastoma in relation with COX inhibition." | 3.83 | Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma. ( Atalar, F; Bilir, A; Oksuz, E; Shahzadi, A; Tanırverdi, G; Yazici, Z, 2016) |
| "The authors studied eight patients subjected to craniotomy under propofol-fentanyl anesthesia for supratentorial brain tumors." | 3.76 | Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors. ( Christensen, SM; Cold, GE; Gyldensted, C; Jónsdóttir, KY; Juul, N; Rasmussen, M; Vestergaard-Poulsen, P; Østergaard, L, 2010) |
| "This study compares the effect of gamma-linolenic acid (GLA) and its precursor linoleic acid (LA) on survival of 36B10 malignant rat astrocytoma cells and 'normal' rat astrocytes." | 3.70 | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. ( Davis, CS; McCaw, R; Robbins, ME; Spector, AA; Vartak, S, 1998) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 3.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| " The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas." | 3.67 | Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986) |
| "Levels of indomethacin-sensitive, glass-adherent, preculture-sensitive, and lymphocyte-mediated immunoregulatory activity were measured in peripheral blood mononuclear cells from 12 patients with intracranial astrocytomas." | 3.66 | Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas. ( Braun, DP; Flannery, AM; Harris, JE; Penn, RD, 1982) |
| "Indomethacin was given before induction of anaesthesia and the infusion was terminated after opening of the dura." | 2.71 | The effects of indomethacin on intracranial pressure and cerebral haemodynamics in patients undergoing craniotomy: a randomised prospective study. ( Cold, GE; Rasmussen, M; Tankisi, A, 2004) |
| "Gliomas are the most common and devastating tumors of the central nervous system." | 1.35 | Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 1.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernardi, A | 2 |
| Frozza, RL | 2 |
| Hoppe, JB | 1 |
| Salbego, C | 2 |
| Pohlmann, AR | 3 |
| Battastini, AM | 2 |
| Guterres, SS | 3 |
| Oksuz, E | 1 |
| Atalar, F | 1 |
| Tanırverdi, G | 1 |
| Bilir, A | 1 |
| Shahzadi, A | 1 |
| Yazici, Z | 1 |
| Rodrigues, SF | 1 |
| Fiel, LA | 1 |
| Shimada, AL | 1 |
| Pereira, NR | 1 |
| Farsky, SH | 1 |
| Weiler, M | 1 |
| Hartmann, C | 1 |
| Wiewrodt, D | 1 |
| Herrlinger, U | 1 |
| Gorlia, T | 1 |
| Bähr, O | 1 |
| Meyermann, R | 1 |
| Bamberg, M | 1 |
| Tatagiba, M | 1 |
| von Deimling, A | 1 |
| Weller, M | 1 |
| Wick, W | 1 |
| Rasmussen, M | 3 |
| Juul, N | 2 |
| Christensen, SM | 1 |
| Jónsdóttir, KY | 1 |
| Gyldensted, C | 2 |
| Vestergaard-Poulsen, P | 1 |
| Cold, GE | 4 |
| Østergaard, L | 2 |
| Robbins, MS | 1 |
| Grosberg, BM | 1 |
| Tankisi, A | 1 |
| Benyahia, B | 1 |
| Huguet, S | 1 |
| Declèves, X | 1 |
| Mokhtari, K | 1 |
| Crinière, E | 1 |
| Bernaudin, JF | 1 |
| Scherrmann, JM | 1 |
| Delattre, JY | 1 |
| Poulsen, PV | 1 |
| Hwang, SL | 1 |
| Lee, KS | 1 |
| Lin, CL | 1 |
| Lieu, AS | 1 |
| Cheng, CY | 1 |
| Loh, JK | 1 |
| Hwang, YF | 1 |
| Su, YF | 1 |
| Howng, SL | 1 |
| Wang, M | 1 |
| Yoshida, D | 1 |
| Liu, S | 1 |
| Teramoto, A | 1 |
| Sun, JJ | 1 |
| Wang, ZY | 1 |
| Liu, B | 1 |
| Zhong, YF | 1 |
| Du, J | 1 |
| Chen, YY | 1 |
| Ma, CC | 1 |
| Chen, XD | 1 |
| Jäger, E | 1 |
| Figueiró, F | 1 |
| Bavaresco, L | 1 |
| Roszman, TL | 1 |
| Brooks, WH | 1 |
| Elliott, LH | 1 |
| Braun, DP | 1 |
| Penn, RD | 1 |
| Flannery, AM | 1 |
| Harris, JE | 1 |
| Aas, AT | 1 |
| Tønnessen, TI | 1 |
| Brun, A | 1 |
| Salford, LG | 1 |
| Alexandrov, VA | 1 |
| Bespalov, VG | 1 |
| Petrov, AS | 1 |
| Troyan, DN | 1 |
| Singh, IN | 1 |
| Sorrentino, G | 1 |
| Sitar, DS | 1 |
| Kanfer, JN | 1 |
| Bundgaard, H | 1 |
| Jensen, KA | 1 |
| Bergholt, B | 1 |
| Frederiksen, RO | 1 |
| Pless, S | 1 |
| Vartak, S | 1 |
| McCaw, R | 1 |
| Davis, CS | 1 |
| Robbins, ME | 1 |
| Spector, AA | 1 |
| Taniguchi, Y | 1 |
| Ono, K | 1 |
| Yoshida, S | 1 |
| Tanaka, R | 1 |
| Giese, A | 1 |
| Hagel, C | 1 |
| Kim, EL | 1 |
| Zapf, S | 1 |
| Djawaheri, J | 1 |
| Berens, ME | 1 |
| Westphal, M | 1 |
| Medina, JL | 1 |
| Ohnishi, T | 2 |
| Sher, PB | 1 |
| Posner, JB | 1 |
| Shapiro, WR | 2 |
| Hayakawa, T | 1 |
| Arita, N | 1 |
| Mogami, H | 1 |
| Ushio, Y | 1 |
| Reichman, HR | 1 |
| Farrell, CL | 1 |
| Del Maestro, RF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor[NCT01642147] | 60 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358] | Phase 1 | 49 participants (Actual) | Interventional | 2019-03-23 | Terminated (stopped due to Study terminated because of COVID19 pandemics.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01642147)
Timeframe: 120min after extubation
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 69.7 |
| Abdominal Surgery Group | 59.2 |
(NCT01642147)
Timeframe: 30min after extubation
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 82.5 |
| Abdominal Surgery Group | 62.0 |
(NCT01642147)
Timeframe: 60min after extubation
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 77.0 |
| Abdominal Surgery Group | 61.2 |
(NCT01642147)
Timeframe: 90min after extubation
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 72.8 |
| Abdominal Surgery Group | 60.1 |
(NCT01642147)
Timeframe: after surgery at extubation (average surgery duration: craniotomy group 214min, abdominal group 207min)
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 95.7 |
| Abdominal Surgery Group | 63.6 |
It was the baseline mean blood flow velocity in middle cerebral artery. (NCT01642147)
Timeframe: before general anesthesia
| Intervention | cm/s (Mean) |
|---|---|
| Craniotomy Group | 63.7 |
| Abdominal Surgery Group | 61.8 |
(NCT01642147)
Timeframe: 120min after extubation
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 66.9 |
(NCT01642147)
Timeframe: 30min after extubation
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 77.0 |
(NCT01642147)
Timeframe: 60min after extubation
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 71.8 |
(NCT01642147)
Timeframe: 90min after extubation
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 68.8 |
(NCT01642147)
Timeframe: at extubation
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 81.4 |
(NCT01642147)
Timeframe: before general anesthesia
| Intervention | percentage of oxygen saturation (Mean) |
|---|---|
| Craniotomy Group | 60.9 |
3 trials available for indomethacin and Brain Neoplasms
| Article | Year |
|---|---|
Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Brain Neopl | 2010 |
The effects of indomethacin on intracranial pressure and cerebral haemodynamics in patients undergoing craniotomy: a randomised prospective study.
Topics: Adult; Aged; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; | 2004 |
[Effect of indomethacin on the intracranial pressure].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Neoplasms; Cerebrovascular Circul | 1997 |
23 other studies available for indomethacin and Brain Neoplasms
| Article | Year |
|---|---|
The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways.
Topics: Analysis of Variance; Animals; beta Catenin; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Glioblas | 2013 |
Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma.
Topics: Acetaminophen; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cyclooxygenase 1; | 2016 |
Lipid-Core Nanocapsules Act as a Drug Shuttle Through the Blood Brain Barrier and Reduce Glioblastoma After Intravenous or Oral Administration.
Topics: Administration, Oral; Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Diseas | 2016 |
Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors.
Topics: Adolescent; Adult; Aged; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Volume; Brain; B | 2010 |
Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors.
Topics: Adolescent; Adult; Aged; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Volume; Brain; B | 2010 |
Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors.
Topics: Adolescent; Adult; Aged; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Volume; Brain; B | 2010 |
Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors.
Topics: Adolescent; Adult; Aged; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Blood Volume; Brain; B | 2010 |
Hemicrania continua-like headache from metastatic lung cancer.
Topics: Adenocarcinoma; Brain Neoplasms; Female; Headache; Humans; Indomethacin; Lung Neoplasms; Magnetic Re | 2010 |
Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Ne | 2004 |
Do indomethacin and propofol cause cerebral ischemic damage? Diffusion-weighted magnetic resonance imaging in patients undergoing craniotomy for brain tumors.
Topics: Adult; Aged; Brain Ischemia; Brain Neoplasms; Craniotomy; Diffusion; Female; Humans; Indomethacin; M | 2004 |
Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Dinoprostone; Dose-Response Relat | 2004 |
Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Brain Neoplasms; Cell Line, Tumor; Cell M | 2005 |
[Inhibiting cerebral glioma growth with continuous low-dose chemotherapy and cyclooxygenase-2 inhibitor in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumo | 2006 |
Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Brain Neoplasms; Cell Count | 2008 |
Immunobiology of primary intracranial tumors. VI. Suppressor cell function and lectin-binding lymphocyte subpopulations in patients with cerebral tumors.
Topics: Adult; Aged; Brain Neoplasms; Cell Separation; Concanavalin A; Female; Flow Cytometry; Humans; Immun | 1982 |
Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; DNA; Glioblastoma; Humans; Immunity, Cellular; Indomethac | 1982 |
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; | 1995 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous S | 1996 |
Indomethacin and nordihydroguaiaretic acid inhibition of amyloid beta protein (25-35) activation of phospholipases A2 and D of LA-N-2 cells.
Topics: Amyloid beta-Protein Precursor; Brain Neoplasms; Dose-Response Relationship, Drug; Humans; Indometha | 1997 |
Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes.
Topics: alpha-Linolenic Acid; Animals; Antineoplastic Agents; Antioxidants; Astrocytes; Astrocytoma; Brain N | 1998 |
Antigen-presenting capability of glial cells under glioma-harboring conditions and the effect of glioma-derived factors on antigen presentation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antigen-Presenting Cells; Astrocytes; | 2000 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; | 1999 |
Organic headaches mimicking chronic paroxysmal hemicrania.
Topics: Adult; Brain Neoplasms; Diagnosis, Differential; Female; Frontal Lobe; Headache; Humans; Indomethaci | 1992 |
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema; | 1990 |
[Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action].
Topics: Animals; Biological Factors; Brain Edema; Brain Neoplasms; Capillary Permeability; Dexamethasone; Gl | 1989 |
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm | 1986 |