Page last updated: 2024-10-29

indomethacin and Brain Ischemia

indomethacin has been researched along with Brain Ischemia in 68 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
" The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model."7.81Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015)
"We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils."7.72Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003)
"Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus."7.70Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998)
"Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia."7.68Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991)
"The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats divided equally into nine groups subjected to 10 minutes of forebrain ischemia."7.67Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats. ( Bose, R; Lesiuk, H; Sima, AA; Sutherland, G, 1988)
"Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats."5.28Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990)
" The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model."3.81Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015)
"We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils."3.72Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003)
"Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus."3.70Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998)
"The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion."3.69Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994)
"Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia."3.68Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991)
"This study addresses the question of whether the cyclooxygenase inhibitors indomethacin and diclofenac and the glucocorticosteroid dexamethasone ameliorate neuronal necrosis following cerebral ischemia."3.67Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. ( Koide, T; Siesjö, BK; Wieloch, TW, 1986)
"The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats divided equally into nine groups subjected to 10 minutes of forebrain ischemia."3.67Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats. ( Bose, R; Lesiuk, H; Sima, AA; Sutherland, G, 1988)
"The purpose of our experiment was to examine whether the cyclooxygenase inhibitor indomethacin ameliorates neuronal injury in the gerbil hippocampal CA1 sector following 5 minutes of forebrain ischemia."3.67Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector. ( Kirino, T; Nakagomi, T; Noguchi, M; Saito, I; Sasaki, T; Takakura, K; Tamura, A, 1988)
"The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test."1.43Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016)
"Indomethacin treatment reduced microglia activation and the number of ED1+ cells in both 8 and 14 days post injury as compared with controls."1.43Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. ( Barbosa, MS; Cardoso, MM; DA Silva, MC; Ferreira, EM; Freire, MA; Gomes-Leal, W; Lima, RR; Lopes, RS; Sampaio, AO; Souza, CC, 2016)
"Each center approached implementation of the practices differently."1.32Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants. ( Boyle, D; Buchanan, DS; Carteaux, P; Check, J; Clark, SE; Cohen, H; George, JA; Klein, SA; McKinley, P; McLendon, D; Michael, L; Moehring, J; Okuno-Jones, S; Secrest, JW; Whitfield, JM, 2003)
"Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats."1.28Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990)
"Under conditions of bilateral cerebral ischemia, in which both carotid arteries were clamped, only irreversible ischemia (60 min) followed by reflow, was associated with highly significant damage to cerebral Na+, K+-ATPase."1.27Classification of ischemic-induced damage to Na+, K+-ATPase in gerbil forebrain. Modification by therapeutic agents. ( Callahan, AS; Christie-Pope, BC; Eddy, LJ; Palmer, GC; Palmer, SJ; Taylor, MD, 1985)
"Focal cerebral ischemia initiates multiple detrimental effects in the brain."1.27Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985)
"of complete cerebral ischemia with Aortic occlusion balloon catheter and followed by 120 min."1.26[Cerebral blood flow after total cerebral ischemia in dog (author's transl)]. ( Tabuse, H, 1981)

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-199026 (38.24)18.7374
1990's19 (27.94)18.2507
2000's18 (26.47)29.6817
2010's3 (4.41)24.3611
2020's2 (2.94)2.80

Authors

AuthorsStudies
Wang, H1
Cui, E1
Li, J1
Ma, X1
Jiang, X1
Du, S1
Qian, S1
Du, L1
Revuelta, M1
Zamarrón, A1
Fortes, J1
Rodríguez-Boto, G1
Gutiérrez-González, R1
Sandu, RE1
Uzoni, A1
Coman, C1
Popa-Wagner, A1
Matsuura, W1
Harada, S1
Tokuyama, S1
Lopes, RS1
Cardoso, MM1
Sampaio, AO1
Barbosa, MS1
Souza, CC1
DA Silva, MC1
Ferreira, EM1
Freire, MA1
Lima, RR1
Gomes-Leal, W1
Lenti, L1
Zimmermann, A1
Kis, D1
Oláh, O1
Tóth, GK1
Hegyi, O1
Busija, DW3
Bari, F5
Domoki, F2
Perciaccante, JV1
Puskar, M1
Lorenzo Fernández, P1
Miyamoto, O1
Tamae, K1
Kasai, H1
Hirakawa, H1
Hayashida, Y1
Konishi, R1
Itano, T1
McLendon, D1
Check, J1
Carteaux, P1
Michael, L1
Moehring, J1
Secrest, JW1
Clark, SE1
Cohen, H1
Klein, SA1
Boyle, D1
George, JA1
Okuno-Jones, S1
Buchanan, DS1
McKinley, P1
Whitfield, JM1
Sasaki, T2
Kitagawa, K1
Sugiura, S1
Omura-Matsuoka, E1
Tanaka, S1
Yagita, Y1
Okano, H1
Matsumoto, M1
Hori, M1
Nechipurenko, NI1
Kotova, SG1
Shal'kevich, VB1
Vlasiuk, PA1
Griboedova, TV1
Rasmussen, M1
Østergaard, L1
Juul, N1
Gyldensted, C1
Poulsen, PV1
Cold, GE3
Gjedde, A1
Johannsen, P1
Ostergaard, L1
Godoy, DA1
Biestro, A1
Puppo, C1
Chechneva, O1
Dinkel, K1
Cavaliere, F1
Martinez-Sanchez, M1
Reymann, KG1
Wang, ZJ1
Liang, CL1
Li, GM1
Yu, CY1
Yin, M1
Johnston, MV1
Hagberg, H1
Institoris, A1
Farkas, E1
Berczi, S1
Sule, Z1
Agostoni, A1
Matsui, T1
Basugi, N1
Asano, T2
Takakura, K3
Okabe, T1
Meyer, JS1
Amano, T1
Okayasu, H1
Mortel, K1
Mossakowski, MJ3
Kwiatkowska-Patzer, B1
Hallenbeck, JM2
Leitch, DR1
Dutka, AJ2
Greenbaum, LJ1
McKee, AE1
Siesjö, BK2
Rehncrona, S1
Smith, D1
Crockard, HA1
Bhakoo, KK1
Lascelles, PT1
Boulu, RG1
Plotkine, M1
Gueniau, C1
Sofeir, M1
Wiernsperger, N1
Tabuse, H1
Tasdemiroglu, E1
Christenberry, PD1
Ardell, JL1
Chronister, RB1
Taylor, AE1
Hansen, PA1
Knudsen, F1
Jacobsen, M1
Haase, J1
Bartholdy, N1
Phillis, JW1
Smith-Barbour, M1
Perkins, LM1
O'Regan, MH1
Zuckerman, SL1
Mirro, R1
Armstead, WM2
Shibata, M2
Leffler, CW2
Pomphrey, MA1
Zuckerman, S1
Yamamoto, N1
Yokota, K1
Yamashita, A1
Oda, M1
Bundgaard, H1
Jensen, K1
Bergholt, B1
Frederiksen, R1
Pless, S1
Louis, TM1
Beasley, TC2
Thore, C2
Thrikawala, N2
Louis, T2
Busija, D2
Shadid, M1
Moison, R1
Steendijk, P1
Hiltermann, L1
Berger, HM1
van Bel, F1
Sacco, S1
Agnello, D1
Sottocorno, M1
Lozza, G1
Monopoli, A1
Villa, P1
Ghezzi, P1
Koponen, S1
Keinänen, R1
Roivainen, R1
Hirvonen, T1
Närhi, M1
Chan, PH1
Koistinaho, J1
Rossi, DJ1
Oshima, T1
Attwell, D1
Bordet, R1
Deplanque, D1
Maboudou, P1
Puisieux, F1
Pu, Q1
Robin, E1
Martin, A1
Bastide, M1
Leys, D1
Lhermitte, M1
Dupuis, B1
Zhang, W1
Smith, C1
Monette, R1
Hutchison, J1
Stanimirovic, DB1
Kimura, S1
Katayama, Y2
Terashi, A2
Deluga, KS1
Plötz, FB1
Betz, AL1
Hemler, RJ1
Hoogeveen, JH1
Kraaier, V1
Van Huffelen, AC1
Wieneke, GH1
Hijman, R1
Glerum, JH1
Shimizu, J1
Suzuki, S1
Memezawa, H1
Kashiwagi, F1
Kamiya, T1
Haddad, J1
Messer, J1
Casanova, R1
Simeoni, U1
Willard, D1
Ting, P1
Petersen, EN1
Johshita, H1
Hanamura, T1
Blomqvist, P1
Lindvall, O1
Stenevi, U1
Wieloch, T1
Palmer, GC1
Palmer, SJ1
Christie-Pope, BC1
Callahan, AS1
Taylor, MD1
Eddy, LJ1
Walker, V1
Pickard, JD1
Koide, T1
Wieloch, TW1
Sutherland, G1
Lesiuk, H1
Bose, R1
Sima, AA1
Nakagomi, T1
Kirino, T1
Tamura, A1
Noguchi, M1
Saito, I1
Kochanek, PM1
Kumaroo, KK1
Gadamski, R2
Chemtob, S1
Laudignon, N1
Aranda, JV1
Masuda, Y1
Ochi, Y2
Kadokawa, T1
Symon, L1
Gisvold, SE1
Steen, PA1
Shigeno, T1
Shigeno, S1
Brock, M1
Dempsey, RJ1
Roy, MW1
Meyer, KL1
Donaldson, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087]Phase 448 participants (Actual)Interventional2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for indomethacin and Brain Ischemia

ArticleYear
Sex and the pathogenesis of cerebral palsy.
    Developmental medicine and child neurology, 2007, Volume: 49, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebral Palsy; Estrogens;

2007
Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease.
    Advances and technical standards in neurosurgery, 1985, Volume: 12

    Topics: Animals; Arachidonic Acids; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Cerebro

1985
Drug therapy in hypoxic-ischemic cerebral insults and intraventricular hemorrhage of the newborn.
    Clinics in perinatology, 1987, Volume: 14, Issue:4

    Topics: Asphyxia Neonatorum; Barbiturates; Brain Ischemia; Cerebral Hemorrhage; Female; Fetal Hypoxia; Human

1987
Flow thresholds in brain ischaemia and the effects of drugs.
    British journal of anaesthesia, 1985, Volume: 57, Issue:1

    Topics: Animals; Barbiturates; Brain Ischemia; Calcium; Calcium Channel Blockers; Cell Survival; Cerebrovasc

1985
Drug therapy in brain ischaemia.
    British journal of anaesthesia, 1985, Volume: 57, Issue:1

    Topics: Adrenal Cortex Hormones; Anesthetics; Animals; Anticonvulsants; Brain Ischemia; Calcium Channel Bloc

1985

Trials

2 trials available for indomethacin and Brain Ischemia

ArticleYear
Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:9

    Topics: Adult; Algorithms; Blood Gas Analysis; Brain Chemistry; Brain Ischemia; Capillaries; Cerebrovascular

2005
Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumors.
    Journal of neurosurgical anesthesiology, 1996, Volume: 8, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebrovascular Circula

1996

Other Studies

61 other studies available for indomethacin and Brain Ischemia

ArticleYear
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
    European journal of medicinal chemistry, 2022, Nov-05, Volume: 241

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazol

2022
Neuroprotective effect of indomethacin in normal perfusion pressure breakthrough phenomenon.
    Scientific reports, 2020, 09-22, Volume: 10, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain Ischemia; Cerebrovascul

2020
Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment.
    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2015, Volume: 56, Issue:3

    Topics: Aging; Animals; Anti-Inflammatory Agents; Antigens, Nuclear; Brain Ischemia; Cell Proliferation; Cer

2015
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico

2016
Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia.
    Journal of biosciences, 2016, Volume: 41, Issue:3

    Topics: Animals; Brain Ischemia; Cell Proliferation; Corpus Striatum; Doublecortin Protein; Endothelin-1; Hu

2016
PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs.
    Brain research, 2009, Aug-04, Volume: 1283

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Brain Ischemia; Cere

2009
Effects of hypothermia on neuronal-vascular function after cerebral ischemia in piglets.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:6

    Topics: Animals; Arterioles; Brain; Brain Ischemia; Cerebral Arteries; Female; Hypothermia, Induced; Indomet

2002
[Neuroprotection by aspirin in cerebrovascular pathology].
    Anales de la Real Academia Nacional de Medicina, 2002, Volume: 119, Issue:2

    Topics: Adenosine Triphosphate; Algorithms; Amino Acid Transport System X-AG; Animals; Aspirin; Brain Ischem

2002
Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia.
    European journal of pharmacology, 2003, Jan-17, Volume: 459, Issue:2-3

    Topics: Animals; Brain Ischemia; Cell Count; Cell Death; DNA; DNA Damage; Gerbillinae; Hyperemia; Indomethac

2003
Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants.
    Pediatrics, 2003, Volume: 111, Issue:4 Pt 2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Body Temperature; Brain Ischemia; Cooperative

2003
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
    Journal of neuroscience research, 2003, May-15, Volume: 72, Issue:4

    Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Division; Cyclooxygenase 2; Cyclooxy

2003
[Experimental basis and clinical evaluation of indomethacin efficacy in patients with ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Issue:Suppl 2

    Topics: Animals; Brain; Brain Ischemia; Cyclooxygenase Inhibitors; Hemodynamics; Indomethacin; Rabbits

2001
Do indomethacin and propofol cause cerebral ischemic damage? Diffusion-weighted magnetic resonance imaging in patients undergoing craniotomy for brain tumors.
    Anesthesiology, 2004, Volume: 101, Issue:4

    Topics: Adult; Aged; Brain Ischemia; Brain Neoplasms; Craniotomy; Diffusion; Female; Humans; Indomethacin; M

2004
Does indomethacin cause cerebral ischemia?
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Hypoxia; Cerebrovascular Circ

2005
Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis.
    Neurobiology of disease, 2006, Volume: 23, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Division; Cytokines; Disease

2006
Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices.
    Chemico-biological interactions, 2006, Nov-07, Volume: 163, Issue:3

    Topics: Animals; Arachidonic Acid; Benzhydryl Compounds; Benzoquinones; Brain Ischemia; Catalase; Cyclohexim

2006
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
    European journal of pharmacology, 2007, Nov-21, Volume: 574, Issue:1

    Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, An

2007
[Current status of medical treatment].
    Minerva medica, 1980, Jul-31, Volume: 71, Issue:29

    Topics: Aminophylline; Animals; Anticoagulants; Aspirin; Barbiturates; Brain Ischemia; Cerebrovascular Disor

1980
The effect of indomethacin on ischemic brain edema. A study using cat middle cerebral artery occlusion combined with recirculation.
    Neurologia medico-chirurgica, 1984, Volume: 24, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Fe

1984
Prostaglandin inhibition and cerebrovascular hemodynamics in normal and ischemic human brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1983, Volume: 3, Issue:1

    Topics: Adult; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Revascularization; Cerebrovascular C

1983
[Effect of indomethacin on ischemic brain damage in Mongolian gerbils (Meriones unguiculatus)].
    Neuropatologia polska, 1983, Volume: 21, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Gerbillinae; Indomethacin; Male; Region

1983
Prostaglandin I2, indomethacin, and heparin promote postischemic neuronal recovery in dogs.
    Annals of neurology, 1982, Volume: 12, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dogs; Drug Therapy, Combinati

1982
Neuronal cell damage in the brain: possible involvement of oxidative mechanisms.
    Acta physiologica Scandinavica. Supplementum, 1980, Volume: 492

    Topics: Animals; Brain Diseases; Brain Ischemia; Cerebrovascular Circulation; Hypoglycemia; Hypoxia; Indomet

1980
Regional prostaglandin levels in cerebral ischaemia.
    Journal of neurochemistry, 1982, Volume: 38, Issue:5

    Topics: Animals; Brain; Brain Ischemia; Dexamethasone; Dinoprost; Dinoprostone; Gerbillinae; Indomethacin; M

1982
Effect of indomethacin in experimental cerebral ischemia.
    Pathologie-biologie, 1982, Volume: 30, Issue:5

    Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Indomethacin; Male; Rabbits

1982
[Cerebral blood flow after total cerebral ischemia in dog (author's transl)].
    No to shinkei = Brain and nerve, 1981, Volume: 33, Issue:11

    Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Dogs; Electroencephalography; Indomethacin

1981
Effects of antioxidants on the blood-brain barrier and postischemic hyperemia.
    Acta neurochirurgica, 1994, Volume: 131, Issue:3-4

    Topics: Animals; Antioxidants; Blood Flow Velocity; Blood-Brain Barrier; Brain; Brain Ischemia; Capillary Pe

1994
Indomethacin in controlling "normal perfusion pressure breakthrough" in a case of large cerebral arteriovenous malformation.
    Journal of neurosurgical anesthesiology, 1995, Volume: 7, Issue:2

    Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Combined Modality Therapy; Embolization, Therape

1995
Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex.
    Brain research, 1994, Aug-01, Volume: 652, Issue:2

    Topics: Adenosine; Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cell Death; Cerebral Cortex; Elec

1994
Indomethacin reduces ischemia-induced alteration of blood-brain barrier transport in piglets.
    The American journal of physiology, 1994, Volume: 266, Issue:6 Pt 2

    Topics: Animals; Animals, Newborn; Biological Transport; Blood Volume; Blood-Brain Barrier; Brain Ischemia;

1994
Effect of indomethacin on piglet cerebral blood flow following total cerebral ischemia.
    Journal of the Tennessee Medical Association, 1994, Volume: 87, Issue:5

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Ischemia; Female; Humans; Indomethacin;

1994
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
    European journal of pharmacology, 1996, Feb-22, Volume: 297, Issue:3

    Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; G

1996
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
    Stroke, 1997, Volume: 28, Issue:6

    Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit

1997
Cerebral ischemia/reperfusion increases endothelial nitric oxide synthase levels by an indomethacin-sensitive mechanism.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:1

    Topics: Animals; Animals, Newborn; Brain Ischemia; Cyclooxygenase Inhibitors; Indomethacin; Nitric Oxide Syn

1998
Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets.
    Brain research. Developmental brain research, 1998, Jan-14, Volume: 105, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Female; Heat-Sho

1998
The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain.
    Pediatric research, 1998, Volume: 44, Issue:1

    Topics: Allopurinol; Animals; Animals, Newborn; Antioxidants; Asphyxia Neonatorum; Brain; Brain Ischemia; Cy

1998
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.
    Journal of neurochemistry, 1998, Volume: 71, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Brain; Brain Ischemia; En

1998
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
    Neuroscience, 1999, Volume: 93, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreadin

1999
Glutamate release in severe brain ischaemia is mainly by reversed uptake.
    Nature, 2000, Jan-20, Volume: 403, Issue:6767

    Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport;

2000
Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:8

    Topics: Adaptation, Physiological; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cycloheximide; Dexam

2000
Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chemokines; Cyclosp

2000
Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury.
    Brain research, 2001, Aug-10, Volume: 910, Issue:1-2

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Benzimidaz

2001
[Effect of indomethacin on delayed neuronal death of hippocampal CA1 sector in gerbil under different levels of controlled cranial temperatures].
    Nihon Ika Daigaku zasshi, 1992, Volume: 59, Issue:4

    Topics: Animals; Body Temperature; Brain Ischemia; Cell Survival; Gerbillinae; Hippocampus; Indomethacin; Ma

1992
Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil.
    Stroke, 1991, Volume: 22, Issue:10

    Topics: Animals; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Edema; Gerbillinae; Indomethacin;

1991
A pharmacological model of cerebral ischemia. The effects of indomethacin on cerebral blood flow velocity, quantitative EEG and cognitive functions.
    Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:9

    Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Cognition; Electroencephalography; Humans; Indom

1990
Role of arachidonic acid metabolism on ischemic brain edema and metabolism.
    Advances in neurology, 1990, Volume: 52

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Brain Edema; Brain Ischemia; Energy M

1990
Indomethacin and ischemic brain injury in neonates.
    The Journal of pediatrics, 1990, Volume: 116, Issue:5

    Topics: Brain Ischemia; Diseases in Twins; Encephalomalacia; Female; Humans; Indomethacin; Infant, Newborn;

1990
Indomethacin attenuates early postischemic vasogenic edema and cerebral injury.
    Advances in neurology, 1990, Volume: 52

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Ci

1990
Anti-ischaemic effects of indomethacin and ketamine on hippocampus neurones in Mongolian gerbils.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:4

    Topics: Animals; Brain Ischemia; Carotid Arteries; Female; Gerbillinae; Hippocampus; Indomethacin; Ketamine;

1989
Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats.
    Stroke, 1989, Volume: 20, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circ

1989
Cyclic AMP concentrations in rat neocortex and hippocampus during and following incomplete ischemia: effects of central noradrenergic neurons, prostaglandins, and adenosine.
    Journal of neurochemistry, 1985, Volume: 44, Issue:5

    Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cyclic AMP; Energy Metabolism; Fatty Acids, Non

1985
Classification of ischemic-induced damage to Na+, K+-ATPase in gerbil forebrain. Modification by therapeutic agents.
    Neuropharmacology, 1985, Volume: 24, Issue:6

    Topics: Adenosine Triphosphatases; Allopurinol; Animals; Brain; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Calciu

1985
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:4

    Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; D

1986
Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats.
    Stroke, 1988, Volume: 19, Issue:5

    Topics: Animals; Brain Ischemia; Drug Combinations; Indomethacin; Male; Mannitol; Nimodipine; Rats; Rats, In

1988
Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector.
    Stroke, 1988, Volume: 19, Issue:11

    Topics: Animals; Brain Ischemia; Cell Count; Cell Survival; Gerbillinae; Hippocampus; Indomethacin; Neurons

1988
Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain.
    Stroke, 1988, Volume: 19, Issue:6

    Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Dogs; Epoprostenol; Evoked Potentials, Somatos

1988
[Effect of prostacyclin PGI2 and indomethacin on ischemic damage of sector CA1 of Ammon's horn in the Mongolian gerbil].
    Neuropatologia polska, 1987, Volume: 25, Issue:1

    Topics: Animals; Brain Ischemia; Epoprostenol; Female; Gerbillinae; Hippocampus; Indomethacin

1987
A possible role of endogenously formed cerebral prostaglandins in the development of adaptive protection against cerebral hypoxia/ischemia in mice.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:11

    Topics: 6-Ketoprostaglandin F1 alpha; Adaptation, Physiological; Animals; Brain; Brain Ischemia; Electroshoc

1987
[Effect of indomethacin on ischemic damage of sector CA1 of the horn of Ammon in Mongolian gerbils].
    Neuropatologia polska, 1985, Volume: 23, Issue:4

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Gerbillinae; Hippocampus; Indomethacin; Male

1985
Effect of indomethacin in focal cerebral ischemia.
    Journal of neurosurgery, 1986, Volume: 64, Issue:4

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Indomethacin

1986
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
    Journal of neurosurgery, 1985, Volume: 62, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P

1985