indomethacin has been researched along with Brain Ischemia in 68 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model." | 7.81 | Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015) |
| "We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils." | 7.72 | Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003) |
| "Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus." | 7.70 | Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 7.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| "The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats divided equally into nine groups subjected to 10 minutes of forebrain ischemia." | 7.67 | Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats. ( Bose, R; Lesiuk, H; Sima, AA; Sutherland, G, 1988) |
| "Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats." | 5.28 | Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990) |
| " The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model." | 3.81 | Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015) |
| "We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils." | 3.72 | Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003) |
| "Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus." | 3.70 | Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998) |
| "The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion." | 3.69 | Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 3.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| "This study addresses the question of whether the cyclooxygenase inhibitors indomethacin and diclofenac and the glucocorticosteroid dexamethasone ameliorate neuronal necrosis following cerebral ischemia." | 3.67 | Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. ( Koide, T; Siesjö, BK; Wieloch, TW, 1986) |
| "The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats divided equally into nine groups subjected to 10 minutes of forebrain ischemia." | 3.67 | Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats. ( Bose, R; Lesiuk, H; Sima, AA; Sutherland, G, 1988) |
| "The purpose of our experiment was to examine whether the cyclooxygenase inhibitor indomethacin ameliorates neuronal injury in the gerbil hippocampal CA1 sector following 5 minutes of forebrain ischemia." | 3.67 | Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector. ( Kirino, T; Nakagomi, T; Noguchi, M; Saito, I; Sasaki, T; Takakura, K; Tamura, A, 1988) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "Indomethacin treatment reduced microglia activation and the number of ED1+ cells in both 8 and 14 days post injury as compared with controls." | 1.43 | Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. ( Barbosa, MS; Cardoso, MM; DA Silva, MC; Ferreira, EM; Freire, MA; Gomes-Leal, W; Lima, RR; Lopes, RS; Sampaio, AO; Souza, CC, 2016) |
| "Each center approached implementation of the practices differently." | 1.32 | Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants. ( Boyle, D; Buchanan, DS; Carteaux, P; Check, J; Clark, SE; Cohen, H; George, JA; Klein, SA; McKinley, P; McLendon, D; Michael, L; Moehring, J; Okuno-Jones, S; Secrest, JW; Whitfield, JM, 2003) |
| "Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats." | 1.28 | Role of arachidonic acid metabolism on ischemic brain edema and metabolism. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Memezawa, H; Shimizu, J; Suzuki, S; Terashi, A, 1990) |
| "Under conditions of bilateral cerebral ischemia, in which both carotid arteries were clamped, only irreversible ischemia (60 min) followed by reflow, was associated with highly significant damage to cerebral Na+, K+-ATPase." | 1.27 | Classification of ischemic-induced damage to Na+, K+-ATPase in gerbil forebrain. Modification by therapeutic agents. ( Callahan, AS; Christie-Pope, BC; Eddy, LJ; Palmer, GC; Palmer, SJ; Taylor, MD, 1985) |
| "Focal cerebral ischemia initiates multiple detrimental effects in the brain." | 1.27 | Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985) |
| "of complete cerebral ischemia with Aortic occlusion balloon catheter and followed by 120 min." | 1.26 | [Cerebral blood flow after total cerebral ischemia in dog (author's transl)]. ( Tabuse, H, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (38.24) | 18.7374 |
| 1990's | 19 (27.94) | 18.2507 |
| 2000's | 18 (26.47) | 29.6817 |
| 2010's | 3 (4.41) | 24.3611 |
| 2020's | 2 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Cui, E | 1 |
| Li, J | 1 |
| Ma, X | 1 |
| Jiang, X | 1 |
| Du, S | 1 |
| Qian, S | 1 |
| Du, L | 1 |
| Revuelta, M | 1 |
| Zamarrón, A | 1 |
| Fortes, J | 1 |
| Rodríguez-Boto, G | 1 |
| Gutiérrez-González, R | 1 |
| Sandu, RE | 1 |
| Uzoni, A | 1 |
| Coman, C | 1 |
| Popa-Wagner, A | 1 |
| Matsuura, W | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Lopes, RS | 1 |
| Cardoso, MM | 1 |
| Sampaio, AO | 1 |
| Barbosa, MS | 1 |
| Souza, CC | 1 |
| DA Silva, MC | 1 |
| Ferreira, EM | 1 |
| Freire, MA | 1 |
| Lima, RR | 1 |
| Gomes-Leal, W | 1 |
| Lenti, L | 1 |
| Zimmermann, A | 1 |
| Kis, D | 1 |
| Oláh, O | 1 |
| Tóth, GK | 1 |
| Hegyi, O | 1 |
| Busija, DW | 3 |
| Bari, F | 5 |
| Domoki, F | 2 |
| Perciaccante, JV | 1 |
| Puskar, M | 1 |
| Lorenzo Fernández, P | 1 |
| Miyamoto, O | 1 |
| Tamae, K | 1 |
| Kasai, H | 1 |
| Hirakawa, H | 1 |
| Hayashida, Y | 1 |
| Konishi, R | 1 |
| Itano, T | 1 |
| McLendon, D | 1 |
| Check, J | 1 |
| Carteaux, P | 1 |
| Michael, L | 1 |
| Moehring, J | 1 |
| Secrest, JW | 1 |
| Clark, SE | 1 |
| Cohen, H | 1 |
| Klein, SA | 1 |
| Boyle, D | 1 |
| George, JA | 1 |
| Okuno-Jones, S | 1 |
| Buchanan, DS | 1 |
| McKinley, P | 1 |
| Whitfield, JM | 1 |
| Sasaki, T | 2 |
| Kitagawa, K | 1 |
| Sugiura, S | 1 |
| Omura-Matsuoka, E | 1 |
| Tanaka, S | 1 |
| Yagita, Y | 1 |
| Okano, H | 1 |
| Matsumoto, M | 1 |
| Hori, M | 1 |
| Nechipurenko, NI | 1 |
| Kotova, SG | 1 |
| Shal'kevich, VB | 1 |
| Vlasiuk, PA | 1 |
| Griboedova, TV | 1 |
| Rasmussen, M | 1 |
| Østergaard, L | 1 |
| Juul, N | 1 |
| Gyldensted, C | 1 |
| Poulsen, PV | 1 |
| Cold, GE | 3 |
| Gjedde, A | 1 |
| Johannsen, P | 1 |
| Ostergaard, L | 1 |
| Godoy, DA | 1 |
| Biestro, A | 1 |
| Puppo, C | 1 |
| Chechneva, O | 1 |
| Dinkel, K | 1 |
| Cavaliere, F | 1 |
| Martinez-Sanchez, M | 1 |
| Reymann, KG | 1 |
| Wang, ZJ | 1 |
| Liang, CL | 1 |
| Li, GM | 1 |
| Yu, CY | 1 |
| Yin, M | 1 |
| Johnston, MV | 1 |
| Hagberg, H | 1 |
| Institoris, A | 1 |
| Farkas, E | 1 |
| Berczi, S | 1 |
| Sule, Z | 1 |
| Agostoni, A | 1 |
| Matsui, T | 1 |
| Basugi, N | 1 |
| Asano, T | 2 |
| Takakura, K | 3 |
| Okabe, T | 1 |
| Meyer, JS | 1 |
| Amano, T | 1 |
| Okayasu, H | 1 |
| Mortel, K | 1 |
| Mossakowski, MJ | 3 |
| Kwiatkowska-Patzer, B | 1 |
| Hallenbeck, JM | 2 |
| Leitch, DR | 1 |
| Dutka, AJ | 2 |
| Greenbaum, LJ | 1 |
| McKee, AE | 1 |
| Siesjö, BK | 2 |
| Rehncrona, S | 1 |
| Smith, D | 1 |
| Crockard, HA | 1 |
| Bhakoo, KK | 1 |
| Lascelles, PT | 1 |
| Boulu, RG | 1 |
| Plotkine, M | 1 |
| Gueniau, C | 1 |
| Sofeir, M | 1 |
| Wiernsperger, N | 1 |
| Tabuse, H | 1 |
| Tasdemiroglu, E | 1 |
| Christenberry, PD | 1 |
| Ardell, JL | 1 |
| Chronister, RB | 1 |
| Taylor, AE | 1 |
| Hansen, PA | 1 |
| Knudsen, F | 1 |
| Jacobsen, M | 1 |
| Haase, J | 1 |
| Bartholdy, N | 1 |
| Phillis, JW | 1 |
| Smith-Barbour, M | 1 |
| Perkins, LM | 1 |
| O'Regan, MH | 1 |
| Zuckerman, SL | 1 |
| Mirro, R | 1 |
| Armstead, WM | 2 |
| Shibata, M | 2 |
| Leffler, CW | 2 |
| Pomphrey, MA | 1 |
| Zuckerman, S | 1 |
| Yamamoto, N | 1 |
| Yokota, K | 1 |
| Yamashita, A | 1 |
| Oda, M | 1 |
| Bundgaard, H | 1 |
| Jensen, K | 1 |
| Bergholt, B | 1 |
| Frederiksen, R | 1 |
| Pless, S | 1 |
| Louis, TM | 1 |
| Beasley, TC | 2 |
| Thore, C | 2 |
| Thrikawala, N | 2 |
| Louis, T | 2 |
| Busija, D | 2 |
| Shadid, M | 1 |
| Moison, R | 1 |
| Steendijk, P | 1 |
| Hiltermann, L | 1 |
| Berger, HM | 1 |
| van Bel, F | 1 |
| Sacco, S | 1 |
| Agnello, D | 1 |
| Sottocorno, M | 1 |
| Lozza, G | 1 |
| Monopoli, A | 1 |
| Villa, P | 1 |
| Ghezzi, P | 1 |
| Koponen, S | 1 |
| Keinänen, R | 1 |
| Roivainen, R | 1 |
| Hirvonen, T | 1 |
| Närhi, M | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
| Rossi, DJ | 1 |
| Oshima, T | 1 |
| Attwell, D | 1 |
| Bordet, R | 1 |
| Deplanque, D | 1 |
| Maboudou, P | 1 |
| Puisieux, F | 1 |
| Pu, Q | 1 |
| Robin, E | 1 |
| Martin, A | 1 |
| Bastide, M | 1 |
| Leys, D | 1 |
| Lhermitte, M | 1 |
| Dupuis, B | 1 |
| Zhang, W | 1 |
| Smith, C | 1 |
| Monette, R | 1 |
| Hutchison, J | 1 |
| Stanimirovic, DB | 1 |
| Kimura, S | 1 |
| Katayama, Y | 2 |
| Terashi, A | 2 |
| Deluga, KS | 1 |
| Plötz, FB | 1 |
| Betz, AL | 1 |
| Hemler, RJ | 1 |
| Hoogeveen, JH | 1 |
| Kraaier, V | 1 |
| Van Huffelen, AC | 1 |
| Wieneke, GH | 1 |
| Hijman, R | 1 |
| Glerum, JH | 1 |
| Shimizu, J | 1 |
| Suzuki, S | 1 |
| Memezawa, H | 1 |
| Kashiwagi, F | 1 |
| Kamiya, T | 1 |
| Haddad, J | 1 |
| Messer, J | 1 |
| Casanova, R | 1 |
| Simeoni, U | 1 |
| Willard, D | 1 |
| Ting, P | 1 |
| Petersen, EN | 1 |
| Johshita, H | 1 |
| Hanamura, T | 1 |
| Blomqvist, P | 1 |
| Lindvall, O | 1 |
| Stenevi, U | 1 |
| Wieloch, T | 1 |
| Palmer, GC | 1 |
| Palmer, SJ | 1 |
| Christie-Pope, BC | 1 |
| Callahan, AS | 1 |
| Taylor, MD | 1 |
| Eddy, LJ | 1 |
| Walker, V | 1 |
| Pickard, JD | 1 |
| Koide, T | 1 |
| Wieloch, TW | 1 |
| Sutherland, G | 1 |
| Lesiuk, H | 1 |
| Bose, R | 1 |
| Sima, AA | 1 |
| Nakagomi, T | 1 |
| Kirino, T | 1 |
| Tamura, A | 1 |
| Noguchi, M | 1 |
| Saito, I | 1 |
| Kochanek, PM | 1 |
| Kumaroo, KK | 1 |
| Gadamski, R | 2 |
| Chemtob, S | 1 |
| Laudignon, N | 1 |
| Aranda, JV | 1 |
| Masuda, Y | 1 |
| Ochi, Y | 2 |
| Kadokawa, T | 1 |
| Symon, L | 1 |
| Gisvold, SE | 1 |
| Steen, PA | 1 |
| Shigeno, T | 1 |
| Shigeno, S | 1 |
| Brock, M | 1 |
| Dempsey, RJ | 1 |
| Roy, MW | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indomethacin and Brain Ischemia
| Article | Year |
|---|---|
Sex and the pathogenesis of cerebral palsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebral Palsy; Estrogens; | 2007 |
Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease.
Topics: Animals; Arachidonic Acids; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Cerebro | 1985 |
Drug therapy in hypoxic-ischemic cerebral insults and intraventricular hemorrhage of the newborn.
Topics: Asphyxia Neonatorum; Barbiturates; Brain Ischemia; Cerebral Hemorrhage; Female; Fetal Hypoxia; Human | 1987 |
Flow thresholds in brain ischaemia and the effects of drugs.
Topics: Animals; Barbiturates; Brain Ischemia; Calcium; Calcium Channel Blockers; Cell Survival; Cerebrovasc | 1985 |
Drug therapy in brain ischaemia.
Topics: Adrenal Cortex Hormones; Anesthetics; Animals; Anticonvulsants; Brain Ischemia; Calcium Channel Bloc | 1985 |
2 trials available for indomethacin and Brain Ischemia
| Article | Year |
|---|---|
Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition.
Topics: Adult; Algorithms; Blood Gas Analysis; Brain Chemistry; Brain Ischemia; Capillaries; Cerebrovascular | 2005 |
Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumors.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebrovascular Circula | 1996 |
61 other studies available for indomethacin and Brain Ischemia
| Article | Year |
|---|---|
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazol | 2022 |
Neuroprotective effect of indomethacin in normal perfusion pressure breakthrough phenomenon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain Ischemia; Cerebrovascul | 2020 |
Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antigens, Nuclear; Brain Ischemia; Cell Proliferation; Cer | 2015 |
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia.
Topics: Animals; Brain Ischemia; Cell Proliferation; Corpus Striatum; Doublecortin Protein; Endothelin-1; Hu | 2016 |
PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Brain Ischemia; Cere | 2009 |
Effects of hypothermia on neuronal-vascular function after cerebral ischemia in piglets.
Topics: Animals; Arterioles; Brain; Brain Ischemia; Cerebral Arteries; Female; Hypothermia, Induced; Indomet | 2002 |
[Neuroprotection by aspirin in cerebrovascular pathology].
Topics: Adenosine Triphosphate; Algorithms; Amino Acid Transport System X-AG; Animals; Aspirin; Brain Ischem | 2002 |
Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Count; Cell Death; DNA; DNA Damage; Gerbillinae; Hyperemia; Indomethac | 2003 |
Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Body Temperature; Brain Ischemia; Cooperative | 2003 |
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Division; Cyclooxygenase 2; Cyclooxy | 2003 |
[Experimental basis and clinical evaluation of indomethacin efficacy in patients with ischemic stroke].
Topics: Animals; Brain; Brain Ischemia; Cyclooxygenase Inhibitors; Hemodynamics; Indomethacin; Rabbits | 2001 |
Do indomethacin and propofol cause cerebral ischemic damage? Diffusion-weighted magnetic resonance imaging in patients undergoing craniotomy for brain tumors.
Topics: Adult; Aged; Brain Ischemia; Brain Neoplasms; Craniotomy; Diffusion; Female; Humans; Indomethacin; M | 2004 |
Does indomethacin cause cerebral ischemia?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Hypoxia; Cerebrovascular Circ | 2005 |
Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Division; Cytokines; Disease | 2006 |
Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices.
Topics: Animals; Arachidonic Acid; Benzhydryl Compounds; Benzoquinones; Brain Ischemia; Catalase; Cyclohexim | 2006 |
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, An | 2007 |
[Current status of medical treatment].
Topics: Aminophylline; Animals; Anticoagulants; Aspirin; Barbiturates; Brain Ischemia; Cerebrovascular Disor | 1980 |
The effect of indomethacin on ischemic brain edema. A study using cat middle cerebral artery occlusion combined with recirculation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Fe | 1984 |
Prostaglandin inhibition and cerebrovascular hemodynamics in normal and ischemic human brain.
Topics: Adult; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Revascularization; Cerebrovascular C | 1983 |
[Effect of indomethacin on ischemic brain damage in Mongolian gerbils (Meriones unguiculatus)].
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Gerbillinae; Indomethacin; Male; Region | 1983 |
Prostaglandin I2, indomethacin, and heparin promote postischemic neuronal recovery in dogs.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dogs; Drug Therapy, Combinati | 1982 |
Neuronal cell damage in the brain: possible involvement of oxidative mechanisms.
Topics: Animals; Brain Diseases; Brain Ischemia; Cerebrovascular Circulation; Hypoglycemia; Hypoxia; Indomet | 1980 |
Regional prostaglandin levels in cerebral ischaemia.
Topics: Animals; Brain; Brain Ischemia; Dexamethasone; Dinoprost; Dinoprostone; Gerbillinae; Indomethacin; M | 1982 |
Effect of indomethacin in experimental cerebral ischemia.
Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Indomethacin; Male; Rabbits | 1982 |
[Cerebral blood flow after total cerebral ischemia in dog (author's transl)].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Dogs; Electroencephalography; Indomethacin | 1981 |
Effects of antioxidants on the blood-brain barrier and postischemic hyperemia.
Topics: Animals; Antioxidants; Blood Flow Velocity; Blood-Brain Barrier; Brain; Brain Ischemia; Capillary Pe | 1994 |
Indomethacin in controlling "normal perfusion pressure breakthrough" in a case of large cerebral arteriovenous malformation.
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Combined Modality Therapy; Embolization, Therape | 1995 |
Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex.
Topics: Adenosine; Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cell Death; Cerebral Cortex; Elec | 1994 |
Indomethacin reduces ischemia-induced alteration of blood-brain barrier transport in piglets.
Topics: Animals; Animals, Newborn; Biological Transport; Blood Volume; Blood-Brain Barrier; Brain Ischemia; | 1994 |
Effect of indomethacin on piglet cerebral blood flow following total cerebral ischemia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Ischemia; Female; Humans; Indomethacin; | 1994 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; G | 1996 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit | 1997 |
Cerebral ischemia/reperfusion increases endothelial nitric oxide synthase levels by an indomethacin-sensitive mechanism.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cyclooxygenase Inhibitors; Indomethacin; Nitric Oxide Syn | 1998 |
Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Female; Heat-Sho | 1998 |
The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain.
Topics: Allopurinol; Animals; Animals, Newborn; Antioxidants; Asphyxia Neonatorum; Brain; Brain Ischemia; Cy | 1998 |
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Brain; Brain Ischemia; En | 1998 |
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreadin | 1999 |
Glutamate release in severe brain ischaemia is mainly by reversed uptake.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; | 2000 |
Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance.
Topics: Adaptation, Physiological; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cycloheximide; Dexam | 2000 |
Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.
Topics: Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chemokines; Cyclosp | 2000 |
Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Benzimidaz | 2001 |
[Effect of indomethacin on delayed neuronal death of hippocampal CA1 sector in gerbil under different levels of controlled cranial temperatures].
Topics: Animals; Body Temperature; Brain Ischemia; Cell Survival; Gerbillinae; Hippocampus; Indomethacin; Ma | 1992 |
Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil.
Topics: Animals; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Edema; Gerbillinae; Indomethacin; | 1991 |
A pharmacological model of cerebral ischemia. The effects of indomethacin on cerebral blood flow velocity, quantitative EEG and cognitive functions.
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Cognition; Electroencephalography; Humans; Indom | 1990 |
Role of arachidonic acid metabolism on ischemic brain edema and metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Brain Edema; Brain Ischemia; Energy M | 1990 |
Indomethacin and ischemic brain injury in neonates.
Topics: Brain Ischemia; Diseases in Twins; Encephalomalacia; Female; Humans; Indomethacin; Infant, Newborn; | 1990 |
Indomethacin attenuates early postischemic vasogenic edema and cerebral injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Ci | 1990 |
Anti-ischaemic effects of indomethacin and ketamine on hippocampus neurones in Mongolian gerbils.
Topics: Animals; Brain Ischemia; Carotid Arteries; Female; Gerbillinae; Hippocampus; Indomethacin; Ketamine; | 1989 |
Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circ | 1989 |
Cyclic AMP concentrations in rat neocortex and hippocampus during and following incomplete ischemia: effects of central noradrenergic neurons, prostaglandins, and adenosine.
Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cyclic AMP; Energy Metabolism; Fatty Acids, Non | 1985 |
Classification of ischemic-induced damage to Na+, K+-ATPase in gerbil forebrain. Modification by therapeutic agents.
Topics: Adenosine Triphosphatases; Allopurinol; Animals; Brain; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Calciu | 1985 |
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; D | 1986 |
Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Drug Combinations; Indomethacin; Male; Mannitol; Nimodipine; Rats; Rats, In | 1988 |
Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector.
Topics: Animals; Brain Ischemia; Cell Count; Cell Survival; Gerbillinae; Hippocampus; Indomethacin; Neurons | 1988 |
Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Dogs; Epoprostenol; Evoked Potentials, Somatos | 1988 |
[Effect of prostacyclin PGI2 and indomethacin on ischemic damage of sector CA1 of Ammon's horn in the Mongolian gerbil].
Topics: Animals; Brain Ischemia; Epoprostenol; Female; Gerbillinae; Hippocampus; Indomethacin | 1987 |
A possible role of endogenously formed cerebral prostaglandins in the development of adaptive protection against cerebral hypoxia/ischemia in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adaptation, Physiological; Animals; Brain; Brain Ischemia; Electroshoc | 1987 |
[Effect of indomethacin on ischemic damage of sector CA1 of the horn of Ammon in Mongolian gerbils].
Topics: Animals; Brain Ischemia; Cerebral Infarction; Gerbillinae; Hippocampus; Indomethacin; Male | 1985 |
Effect of indomethacin in focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Indomethacin | 1986 |
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P | 1985 |