indomethacin has been researched along with Brain Injuries in 46 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight." | 8.02 | Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation. ( Adie, MA; Daspal, S; Dorling, J; Kandraju, H; Kanungo, J; Lee, KS; Lee, SK; Shah, PS; Ye, XY, 2021) |
| "To evaluate the impact of prophylactic indomethacin on early death (<10 days after birth) or severe neurologic injury and on early death or spontaneous intestinal perforation by completed weeks of gestational age in neonates born <29 weeks of gestation." | 4.02 | Gestational Age-Dependent Variations in Effects of Prophylactic Indomethacin on Brain Injury and Intestinal Injury. ( Abdelgadir, D; Afifi, J; Aziz, K; Crossman, SC; Mohammad, K; Piedboeuf, B; Qureshi, M; Shah, PS; Taylor, B; Ye, XY; Yuen, R, 2021) |
| "To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight." | 4.02 | Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation. ( Adie, MA; Daspal, S; Dorling, J; Kandraju, H; Kanungo, J; Lee, KS; Lee, SK; Shah, PS; Ye, XY, 2021) |
| "The effect of indomethacin, a cyclooxygenase inhibitor, was studied in the treatment of 10 patients with head injury and one patient with spontaneous subarachnoid hemorrhage, each of whom presented with high intracranial pressure (ICP) (34." | 3.69 | Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. ( Alberti, RA; Biestro, AA; Borovich, B; Cancela, M; Puppo, CB; Soca, AE, 1995) |
| "Indomethacin was administrated as a load plus continuous infusion." | 2.73 | Indomethacin and cerebral autoregulation in severe head injured patients: a transcranial Doppler study. ( Biestro, A; Caragna, E; Farina, G; Iturralde, A; Lopez, L; Moraes, L; Puppo, C, 2007) |
| "Indomethacin is a non-selective cyclooxygenase inhibitor." | 2.43 | Treatment of elevated intracranial pressure with indomethacin: friend or foe? ( Rasmussen, M, 2005) |
| "Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients." | 2.40 | Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999) |
| "In an attempt to prevent postoperative recurrence of ossification, 100 mg of indomethacin was administered daily after surgery for 6 weeks." | 1.30 | Operative treatment of heterotopic hip ossification in patients with coma after brain injury. ( Caterini, R; Farsetti, P; Formisano, R; Ippolito, E; Penta, F, 1999) |
| "Indomethacin was effective in reducing temperature in 10 of 11 cases which showed a dipyrone-resistant hyperthermia developing in the first 24 hours after brain damage, while no significant antipyretic effect was seen in hyperthermic cases developing more than 72 hours after cranial trauma or brain surgery." | 1.27 | Indomethacin is effective against neurogenic hyperthermia following cranial trauma or brain surgery. ( Benedek, G; Colner-Sasi, K; Hortobágyi, A; Janáky, J; Obál, F; Tóth-Daru, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (19.57) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 9 (19.57) | 29.6817 |
| 2010's | 7 (15.22) | 24.3611 |
| 2020's | 6 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Mohammad, K | 2 |
| Momin, S | 1 |
| Murthy, P | 1 |
| Zein, H | 1 |
| Scott, JN | 1 |
| Mehrem, AA | 1 |
| Ghosh, A | 1 |
| Javadyan, A | 1 |
| Awad, EA | 1 |
| Venkata, SKRG | 1 |
| Paul, R | 1 |
| Rombough, B | 1 |
| Bolderheij, L | 1 |
| Dossani, S | 1 |
| Montpetit, J | 1 |
| Eshemokhai, P | 1 |
| Fiedrich, E | 1 |
| Thomas, S | 1 |
| Shukla, VV | 1 |
| Klinger, A | 1 |
| Yazdi, S | 1 |
| Rahman, AKMF | 1 |
| Wright, S | 1 |
| Barganier, A | 1 |
| Ambalavanan, N | 1 |
| Carlo, WA | 1 |
| Ramani, M | 1 |
| Razak, A | 1 |
| Patel, W | 1 |
| Durrani, NUR | 1 |
| Pullattayil, AK | 1 |
| Qureshi, M | 1 |
| Shah, PS | 2 |
| Abdelgadir, D | 1 |
| Ye, XY | 2 |
| Afifi, J | 1 |
| Yuen, R | 1 |
| Crossman, SC | 1 |
| Taylor, B | 1 |
| Piedboeuf, B | 1 |
| Aziz, K | 1 |
| Kandraju, H | 1 |
| Kanungo, J | 1 |
| Lee, KS | 1 |
| Daspal, S | 1 |
| Adie, MA | 1 |
| Dorling, J | 1 |
| Lee, SK | 1 |
| Jobe, AH | 1 |
| Pedersen, AL | 1 |
| Brownrout, JL | 1 |
| Saldanha, CJ | 1 |
| Kuczynski, A | 1 |
| Crawford, S | 1 |
| Bodell, L | 1 |
| Dewey, D | 1 |
| Barlow, KM | 1 |
| Godoy, DA | 1 |
| Alvarez, E | 1 |
| Manzi, R | 1 |
| Piñero, G | 1 |
| Di Napoli, M | 1 |
| Sader, N | 1 |
| Zeiler, FA | 1 |
| Gillman, LM | 1 |
| West, M | 1 |
| Kazina, CJ | 1 |
| Falsetti, P | 1 |
| Acciai, C | 1 |
| Palilla, R | 1 |
| Carpinteri, F | 1 |
| Patrizio, C | 1 |
| Lenzi, L | 1 |
| Chao, PK | 1 |
| Lu, KT | 1 |
| Jhu, JY | 1 |
| Wo, YY | 1 |
| Huang, TC | 1 |
| Ro, LS | 1 |
| Yang, YL | 1 |
| Girgis, H | 1 |
| Palmier, B | 1 |
| Croci, N | 1 |
| Soustrat, M | 1 |
| Plotkine, M | 1 |
| Marchand-Leroux, C | 1 |
| Kulkarni, M | 1 |
| Armstead, WM | 5 |
| Rau, V | 1 |
| Grijalva, CV | 1 |
| Rasmussen, M | 1 |
| Imberti, R | 1 |
| Fuardo, M | 1 |
| Bellinzona, G | 1 |
| Pagani, M | 1 |
| Langer, M | 1 |
| Puppo, C | 1 |
| Lopez, L | 1 |
| Farina, G | 1 |
| Caragna, E | 1 |
| Moraes, L | 1 |
| Iturralde, A | 1 |
| Biestro, A | 1 |
| Wolfe, LS | 3 |
| Pappius, HM | 4 |
| Baethmann, A | 1 |
| Maier-Hauff, K | 1 |
| Kempski, O | 1 |
| Unterberg, A | 1 |
| Wahl, M | 1 |
| Wei, EP | 1 |
| Kontos, HA | 2 |
| Dietrich, WD | 1 |
| Povlishock, JT | 2 |
| Ellis, EF | 1 |
| Biestro, AA | 1 |
| Alberti, RA | 1 |
| Soca, AE | 1 |
| Cancela, M | 1 |
| Puppo, CB | 1 |
| Borovich, B | 1 |
| Regidor, J | 1 |
| Montesdeoca, J | 1 |
| Ramírez-González, JA | 1 |
| Sosa-Pérez, CD | 1 |
| Hernández-Urquía, CM | 1 |
| Feria, M | 1 |
| Divac, I | 1 |
| Hill, SA | 1 |
| Bukoski, RD | 1 |
| Wang, SN | 1 |
| Bian, K | 1 |
| DeWitt, DS | 1 |
| Dahl, BL | 1 |
| Bergholt, B | 1 |
| Cold, GE | 4 |
| Astrup, J | 4 |
| Mosdal, BA | 1 |
| Jensen, KA | 1 |
| Kjaersgaard, JO | 1 |
| Al-Turki, A | 1 |
| Slavik, RS | 1 |
| Rhoney, DH | 1 |
| Fitch, MT | 1 |
| Doller, C | 1 |
| Combs, CK | 1 |
| Landreth, GE | 1 |
| Silver, J | 1 |
| Ippolito, E | 1 |
| Formisano, R | 1 |
| Caterini, R | 1 |
| Farsetti, P | 1 |
| Penta, F | 1 |
| Golding, EM | 1 |
| You, J | 1 |
| Robertson, CS | 1 |
| Bryan, RM | 1 |
| Rosenblum, WI | 2 |
| El-Sabban, F | 2 |
| Jensen, K | 3 |
| Ohrstrøm, J | 2 |
| Citta-Pietrolungo, TJ | 1 |
| Alexander, MA | 1 |
| Steg, NL | 1 |
| Ohrström, J | 1 |
| Webb, LX | 1 |
| Bosse, MJ | 1 |
| Mayo, KA | 1 |
| Lange, RH | 1 |
| Miller, ME | 1 |
| Swiontkowski, MF | 1 |
| Kim, HJ | 1 |
| Levasseur, JE | 1 |
| Patterson, JL | 1 |
| Jackson, GF | 1 |
| Madge, GE | 1 |
| Benedek, G | 1 |
| Tóth-Daru, P | 1 |
| Janáky, J | 1 |
| Hortobágyi, A | 1 |
| Obál, F | 1 |
| Colner-Sasi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN[NCT01874847] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2013-09-30 | Active, not recruiting | ||
| Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches[NCT04685772] | 25 participants (Anticipated) | Observational [Patient Registry] | 2021-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indomethacin and Brain Injuries
| Article | Year |
|---|---|
Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.
Topics: Adrenal Cortex Hormones; Brain Injuries; Cerebral Hemorrhage; Ethamsylate; Female; Humans; Indometha | 2023 |
Indomethacin for control of ICP.
Topics: Brain Injuries; Cardiovascular Agents; Humans; Indomethacin; Intracranial Hypertension | 2015 |
Treatment of elevated intracranial pressure with indomethacin: friend or foe?
Topics: Animals; Brain; Brain Injuries; Cerebrovascular Circulation; Craniotomy; Cyclooxygenase Inhibitors; | 2005 |
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular | 1999 |
Neurochemical approaches to the amelioration of brain injury.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Injuries; Deoxyglucose; Dibenzocycloheptenes; Di | 1990 |
1 trial available for indomethacin and Brain Injuries
| Article | Year |
|---|---|
Indomethacin and cerebral autoregulation in severe head injured patients: a transcranial Doppler study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Blood Pressure; Bra | 2007 |
40 other studies available for indomethacin and Brain Injuries
| Article | Year |
|---|---|
Impact of quality improvement outreach education on the incidence of acute brain injury in transported neonates born premature.
Topics: Brain Injuries; Female; Gestational Age; Humans; Incidence; Indomethacin; Infant, Newborn; Pregnancy | 2022 |
Prevention of severe brain injury in very preterm neonates: A quality improvement initiative.
Topics: Bicarbonates; Brain Injuries; Cerebral Hemorrhage; Humans; Indomethacin; Infant; Infant, Extremely P | 2022 |
Gestational Age-Dependent Variations in Effects of Prophylactic Indomethacin on Brain Injury and Intestinal Injury.
Topics: Brain Injuries; Canada; Female; Gestational Age; Humans; Indomethacin; Infant; Infant, Extremely Pre | 2021 |
Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation.
Topics: Brain Injuries; Canada; Female; Gestational Age; Humans; Indomethacin; Infant; Infant, Newborn; Infa | 2021 |
Neonatal Network Data Based‒Associations Based on Large Numbers that May Be Spurious.
Topics: Brain Injuries; Gestational Age; Humans; Indomethacin; Infant, Newborn | 2021 |
Central Administration of Indomethacin Mitigates the Injury-Induced Upregulation of Aromatase Expression and Estradiol Content in the Zebra Finch Brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aromatase; Brain; Brain Injuries; Dinoprostone; Es | 2017 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
The physiologic effects of indomethacin test on CPP and ICP in severe traumatic brain injury (sTBI).
Topics: Adolescent; Adult; Aged; Brain Injuries; Cardiovascular Agents; Cerebrovascular Circulation; Glasgow | 2014 |
Bedside ultrasound in early diagnosis of neurogenic heterotopic ossification in patients with acquired brain injury.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Brai | 2011 |
Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression.
Topics: Animals; Brain Injuries; Hippocampus; Indomethacin; Interleukin-1beta; Male; Myelin Proteins; Neuron | 2012 |
Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Behavior, Animal; Blotting, Western; Brain; Brain Edema; Brai | 2013 |
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Cyclooxygenase 2; Dynorphins; Enzyme Activation; Female; | 2002 |
Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation.
Topics: Aging; Animals; Animals, Newborn; Arteries; Blood Chemical Analysis; Brain Injuries; Catalase; Cereb | 2003 |
Indomethacin attenuates hyperthermia produced by anterior coronal lateral hypothalamic knife cuts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain Injuries; Fever; Hypothala | 2004 |
The use of indomethacin in the treatment of plateau waves: effects on cerebral perfusion and oxygenation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Volume; Brain; Brain Injuries; Carbon Dioxide; Cerebr | 2005 |
Involvement of arachidonic acid metabolites in functional disturbances following brain injury.
Topics: Animals; Arachidonic Acids; Brain Injuries; Cerebral Cortex; Dexamethasone; Glucose; Ibuprofen; Indo | 1983 |
Functional disturbances in brain following injury: search for underlying mechanisms.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Brain Edema; Brain Injuries; Dexamethasone; Glu | 1983 |
Effects of indomethacin and ibuprofen on cerebral metabolism and blood flow in traumatized brain.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Autoradiography; Brain; Brain Injuries; Cerebrovascula | 1983 |
Therapeutic considerations in blood-brain barrier disturbances.
Topics: Animals; Barbiturates; Blood-Brain Barrier; Brain Diseases; Brain Edema; Brain Injuries; Humans; Ind | 1983 |
Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.
Topics: Animals; Arterioles; Blood Pressure; Brain Injuries; Cats; Free Radicals; Indomethacin; Mannitol; Ni | 1981 |
Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report.
Topics: Adolescent; Adult; Blood Pressure; Body Temperature; Brain Injuries; Carbon Dioxide; Cerebrovascular | 1995 |
Anti-inflammatory drugs suppress injury-induced NADPH-d activity in CA1 pyramidal neurones.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Brain Injuries | 1994 |
Errors in statistical analysis.
Topics: Brain Injuries; Humans; Indomethacin; Intracranial Pressure; Statistics as Topic | 1996 |
Traumatic brain injury does not alter cerebral artery contractility.
Topics: Acetylcholine; Animals; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Dose-Respons | 1997 |
[CO2 and indomethacin vasoreactivity in patients with cranial trauma].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation | 1998 |
Altered release of prostaglandins by opioids contributes to impaired cerebral hemodynamics following brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Cerebrovascular | 1998 |
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Brain Injuries; Cell Movement; Cells, Cultured; Cerebr | 1999 |
Operative treatment of heterotopic hip ossification in patients with coma after brain injury.
Topics: Adolescent; Adult; Ankylosis; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Coma; Female; | 1999 |
Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood; Blood Pressure; Brain Inj | 2000 |
Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Benzimidaz | 2001 |
Potentiated endothelium-derived hyperpolarizing factor-mediated dilations in cerebral arteries following mild head injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Factors; Brain Injuries; Charybdot | 2001 |
Effects of brain trauma on undamaged cerebral microvessels.
Topics: Animals; Aspirin; Brain; Brain Injuries; Indomethacin; Mice; Microcirculation; Platelet Aggregation | 1977 |
Platelet aggregation and vasoconstriction in undamaged microvessels on cerebral surface adjacent to brain traumatized by a penetrating needle.
Topics: Animals; Arterioles; Aspirin; Brain Injuries; Dipyridamole; Indomethacin; Male; Mice; Pia Mater; Pla | 1978 |
Indomethacin (Confortid) in severe head injury and elevated intracranial pressure (ICP).
Topics: Adult; Blood Pressure; Body Temperature Regulation; Brain; Brain Injuries; Drug Administration Sched | 1992 |
Early detection of heterotopic ossification in young patients with traumatic brain injury.
Topics: Adolescent; Adult; Brain Injuries; Child; Female; Humans; Indomethacin; Male; Ossification, Heteroto | 1992 |
The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Body Temperature; Brain; Brain Injuries; Cerebrovascular | 1991 |
[Indomethacin in severe cerebral contusions with intracranial hypertension].
Topics: Adult; Brain Injuries; Cerebrovascular Circulation; Depression, Chemical; Humans; Indomethacin; Intr | 1990 |
Results in patients with craniocerebral trauma and an operatively managed acetabular fracture.
Topics: Acetabulum; Adolescent; Adult; Aged; Brain Injuries; Etidronic Acid; Female; Fracture Fixation, Inte | 1990 |
Effect of indomethacin pretreatment on acute mortality in experimental brain injury.
Topics: Animals; Brain Injuries; Ethanol; Indomethacin; Rats; Rats, Inbred Strains | 1989 |
Indomethacin is effective against neurogenic hyperthermia following cranial trauma or brain surgery.
Topics: Body Temperature; Brain; Brain Injuries; Dipyrone; Drug Resistance; Fever; Humans; Indomethacin; Pos | 1987 |