indomethacin has been researched along with Brain Disorders in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral hematoma enhances vasoconstriction induced by topical application of the vasoconstrictor agents endothelin-1 (ET-1) and leukotriene C4 (LTC4)." | 7.69 | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. ( Leffler, CW; Shibata, M; Yakubu, MA, 1995) |
| "Cerebral hematoma enhances vasoconstriction induced by topical application of the vasoconstrictor agents endothelin-1 (ET-1) and leukotriene C4 (LTC4)." | 3.69 | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. ( Leffler, CW; Shibata, M; Yakubu, MA, 1995) |
| "The diagnosis of hemicrania continua was made according to the International Headache Society (IHS) criteria." | 1.34 | Hemicrania continua secondary to an ipsilateral brainstem lesion. ( Andrade-Valença, LP; da Silva, WF; Dodick, DW; Valença, MM, 2007) |
| "Indomethacin has been most effective but not free of significant complications." | 1.26 | Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ( Altmiller, DH; Altshuler, G; Krous, HF; Sharpe, GL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Golombek, SG | 1 |
| Sola, A | 1 |
| Baquero, H | 1 |
| Borbonet, D | 1 |
| Cabañas, F | 1 |
| Fajardo, C | 1 |
| Goldsmit, G | 1 |
| Lemus, L | 1 |
| Miura, E | 1 |
| Pellicer, A | 1 |
| Pérez, JM | 1 |
| Rogido, M | 1 |
| Zambosco, G | 1 |
| van Overmeire, B | 1 |
| Schmidt, B | 1 |
| Asztalos, EV | 1 |
| Roberts, RS | 1 |
| Robertson, CM | 1 |
| Sauve, RS | 1 |
| Whitfield, MF | 1 |
| Rushing, S | 1 |
| Ment, LR | 2 |
| Levene, M | 1 |
| Valença, MM | 1 |
| Andrade-Valença, LP | 1 |
| da Silva, WF | 1 |
| Dodick, DW | 1 |
| Ducobu, J | 1 |
| Dupont, P | 1 |
| Baethmann, A | 1 |
| Maier-Hauff, K | 1 |
| Kempski, O | 1 |
| Unterberg, A | 1 |
| Wahl, M | 1 |
| Siesjö, BK | 1 |
| Rehncrona, S | 1 |
| Smith, D | 1 |
| Yakubu, MA | 1 |
| Shibata, M | 1 |
| Leffler, CW | 1 |
| Mendonca, EV | 1 |
| Stone, RC | 1 |
| Rosa, FC | 1 |
| Yirmiya, R | 1 |
| Barak, O | 1 |
| Avitsur, R | 1 |
| Gallily, R | 1 |
| Weidenfeld, J | 1 |
| Vohr, B | 1 |
| Allan, WC | 1 |
| Scott, DT | 1 |
| Katz, KH | 1 |
| Schneider, KC | 1 |
| Makuch, RW | 1 |
| Altshuler, G | 1 |
| Krous, HF | 1 |
| Altmiller, DH | 1 |
| Sharpe, GL | 1 |
| Lagrue, G | 1 |
| Leroux-Robert, C | 1 |
| Nebout, T | 1 |
| Mentz, P | 1 |
| Giessler, C | 1 |
| Chan, GL | 1 |
| Weinstein, SS | 1 |
| Wright, CE | 1 |
| Bowers, VD | 1 |
| Alveranga, DY | 1 |
| Shires, DL | 1 |
| Ackermann, JR | 1 |
| LeFor, WW | 1 |
| Kahana, L | 1 |
| Seidel, G | 1 |
| Back, G | 1 |
| Payk, TR | 1 |
| Vliegen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Best Treatment Strategy: Surgical Versus Pharmacological, to Close the Ductus Arteriosus Persistent in Preterm Infants. A Randomized Controlled Trial[NCT02602054] | Phase 2 | 40 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646] | Phase 3 | 1,202 participants (Actual) | Interventional | 1993-11-30 | Completed | ||
| Lactoferrin Infant Feeding Trial - LIFT_Canada[NCT03367013] | Phase 3 | 453 participants (Actual) | Interventional | 2018-02-16 | Active, not recruiting | ||
| Enteral Supplementation With High-dose Docosahexaenoic Acid on the Risk for Bronchopulmonary Dysplasia in Very Preterm Infants: A Collaborative Study Protocol for an Individual Participant Data Meta-analysis[NCT05915806] | 1,801 participants (Actual) | Interventional | 2023-07-30 | Active, not recruiting | |||
| Clinical Research on the Predictive Effect of Neonatal Morbidities on the Poor Outcomes to Very Low Birth-weight and Extremely Low Birth-weight Infants[NCT03104946] | 834 participants (Actual) | Observational | 2013-09-01 | Completed | |||
| Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage[NCT00665769] | 103 participants (Actual) | Interventional | 2008-06-30 | Terminated (stopped due to Recruitment was proceeding too slowly) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Brain Disorders
| Article | Year |
|---|---|
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
[Nephrology in 1979].
Topics: Bartter Syndrome; Brain Diseases; Humans; Hyperaldosteronism; Hypertension; Indomethacin; Kidney Fai | 1979 |
2 trials available for indomethacin and Brain Disorders
14 other studies available for indomethacin and Brain Disorders
| Article | Year |
|---|---|
[First SIBEN clinical consensus: diagnostic and therapeutic approach to patent ductus arteriosus in premature newborns].
Topics: Age Factors; Brain Diseases; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Diuretics; Ductus Art | 2008 |
Preterm birth: a cost benefit analysis.
Topics: Adrenal Cortex Hormones; Age Factors; Brain Diseases; Cardiovascular Agents; Cost-Benefit Analysis; | 2004 |
Hemicrania continua secondary to an ipsilateral brainstem lesion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Diseases; Brain Stem; Female; Headache; Humans; Indom | 2007 |
[Inhibition of prostaglandins in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)].
Topics: Adult; Aged; Aspirin; Brain Diseases; Ethanol; Female; Humans; Inappropriate ADH Syndrome; Indometha | 1983 |
Therapeutic considerations in blood-brain barrier disturbances.
Topics: Animals; Barbiturates; Blood-Brain Barrier; Brain Diseases; Brain Edema; Brain Injuries; Humans; Ind | 1983 |
Neuronal cell damage in the brain: possible involvement of oxidative mechanisms.
Topics: Animals; Brain Diseases; Brain Ischemia; Cerebrovascular Circulation; Hypoglycemia; Hypoxia; Indomet | 1980 |
Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids.
Topics: Animals; Animals, Newborn; Brain Diseases; Cerebral Arteries; Endothelins; Hematoma; Indomethacin; L | 1995 |
Prevention of intracranial calcifications and brain damage associated with nephrogenic diabetes insipidus.
Topics: Adolescent; Brain Diseases; Calcinosis; Child; Diabetes Insipidus; Humans; Hydrochlorothiazide; Hype | 1994 |
Intracerebral administration of Mycoplasma fermentans produces sickness behavior: role of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Temperature; Body Weight; B | 1997 |
Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem.
Topics: Animals; Brain Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arterio | 1979 |
Biosynthesis of TXB2 and 6-oxo-PGF1 alpha in the heart and other tissues under pathophysiological conditions.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aqueous Humor; Brain Diseases; Child; Gastric Mucosa; Gastrit | 1992 |
Encephalopathy associated with OKT3 administration. Possible interaction with indomethacin.
Topics: Adult; Antibodies, Monoclonal; Brain Diseases; Drug Interactions; Female; Humans; Indomethacin; Kidn | 1991 |
Proceedings: Therapy of the lymphostatic encephalopathy in rats.
Topics: Alkaloids; Animals; Aprotinin; Brain Diseases; Cellulose; Coumarins; Indoles; Indomethacin; Lymphati | 1974 |
[Polyneuritic manifestations in rheumatic diseases].
Topics: Adult; Brain Diseases; Facial Paralysis; Female; Humans; Indomethacin; Male; Middle Aged; Penicillin | 1973 |