indomethacin has been researched along with Brain Damage, Chronic in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients." | 2.40 | Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999) |
| "Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result." | 1.28 | Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gano, D | 1 |
| Andersen, SK | 1 |
| Partridge, JC | 1 |
| Bonifacio, SL | 1 |
| Xu, D | 1 |
| Glidden, DV | 2 |
| Ferriero, DM | 1 |
| Barkovich, AJ | 2 |
| Glass, HC | 1 |
| Luu, TM | 2 |
| Ment, LR | 5 |
| Schneider, KC | 4 |
| Katz, KH | 4 |
| Allan, WC | 3 |
| Vohr, BR | 2 |
| Tucker, R | 1 |
| Leroux, P | 1 |
| Hennebert, C | 1 |
| Catteau, J | 1 |
| Legros, H | 1 |
| Hennebert, O | 1 |
| Laudenbach, V | 1 |
| Marret, S | 1 |
| Vohr, B | 3 |
| Allan, W | 2 |
| Westerveld, M | 3 |
| Duncan, CC | 2 |
| Makuch, RW | 2 |
| Miller, SP | 1 |
| Mayer, EE | 1 |
| Clyman, RI | 1 |
| Hamrick, SE | 1 |
| Makuch, R | 1 |
| Slavik, RS | 1 |
| Rhoney, DH | 1 |
| Sparrow, SS | 1 |
| Baerts, W | 1 |
| Fetter, WP | 1 |
| Hop, WC | 1 |
| Wallenburg, HC | 1 |
| Spritzer, R | 1 |
| Sauer, PJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917] | Phase 3 | 630 participants (Actual) | Interventional | 1989-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days
| Intervention | IVH (Number) |
|---|---|
| Indomethacin | 25 |
| Placebo | 40 |
"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years
| Intervention | participants with PPVT score < 70 (Number) |
|---|---|
| Indomethacin - no IVH | 12 |
| Indomethacin - IVH | 5 |
| Placebo - no IVH | 24 |
| Placebo - IVH | 7 |
1 review available for indomethacin and Brain Damage, Chronic
| Article | Year |
|---|---|
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular | 1999 |
4 trials available for indomethacin and Brain Damage, Chronic
| Article | Year |
|---|---|
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni | 2009 |
Trajectories of receptive language development from 3 to 12 years of age for very preterm children.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P | 2009 |
Cognitive outcome at 4 1/2 years of very low birth weight infants enrolled in the multicenter indomethacin intraventricular hemorrhage prevention trial.
Topics: Brain Damage, Chronic; Cerebral Hemorrhage; Cerebral Ventricles; Child, Preschool; Cyclooxygenase In | 1998 |
Outcome of children in the indomethacin intraventricular hemorrhage prevention trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Cerebral Ventri | 2000 |
6 other studies available for indomethacin and Brain Damage, Chronic
| Article | Year |
|---|---|
Diminished white matter injury over time in a cohort of premature newborns.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; California; Cohort Studies; Cross-Se | 2015 |
Neuroprotective effects vary across nonsteroidal antiinflammatory drugs in a mouse model of developing excitotoxic brain injury.
Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Ste | 2010 |
Change in cognitive function over time in very low-birth-weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P | 2003 |
Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth.
Topics: Brain; Brain Damage, Chronic; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Gestational Age; | 2006 |
Cerebral lesions in preterm infants after tocolytic indomethacin.
Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi | 1990 |
Prophylactic agents in the prevention of periventricular hemorrhage.
Topics: Brain Damage, Chronic; Cerebral Hemorrhage; Humans; Indomethacin; Infant, Newborn | 1989 |