Page last updated: 2024-10-29

indomethacin and Brain Damage, Chronic

indomethacin has been researched along with Brain Damage, Chronic in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients."2.40Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999)
"Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result."1.28Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's3 (27.27)18.2507
2000's5 (45.45)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gano, D1
Andersen, SK1
Partridge, JC1
Bonifacio, SL1
Xu, D1
Glidden, DV2
Ferriero, DM1
Barkovich, AJ2
Glass, HC1
Luu, TM2
Ment, LR5
Schneider, KC4
Katz, KH4
Allan, WC3
Vohr, BR2
Tucker, R1
Leroux, P1
Hennebert, C1
Catteau, J1
Legros, H1
Hennebert, O1
Laudenbach, V1
Marret, S1
Vohr, B3
Allan, W2
Westerveld, M3
Duncan, CC2
Makuch, RW2
Miller, SP1
Mayer, EE1
Clyman, RI1
Hamrick, SE1
Makuch, R1
Slavik, RS1
Rhoney, DH1
Sparrow, SS1
Baerts, W1
Fetter, WP1
Hop, WC1
Wallenburg, HC1
Spritzer, R1
Sauer, PJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917]Phase 3630 participants (Actual)Interventional1989-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

IVH at 5 Postnatal Days

Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days

InterventionIVH (Number)
Indomethacin25
Placebo40

Language Outcome

"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years

Interventionparticipants with PPVT score < 70 (Number)
Indomethacin - no IVH12
Indomethacin - IVH5
Placebo - no IVH24
Placebo - IVH7

Reviews

1 review available for indomethacin and Brain Damage, Chronic

ArticleYear
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
    Neurological research, 1999, Volume: 21, Issue:5

    Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular

1999

Trials

4 trials available for indomethacin and Brain Damage, Chronic

ArticleYear
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
    Pediatrics, 2009, Volume: 123, Issue:3

    Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni

2009
Trajectories of receptive language development from 3 to 12 years of age for very preterm children.
    Pediatrics, 2009, Volume: 124, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P

2009
Cognitive outcome at 4 1/2 years of very low birth weight infants enrolled in the multicenter indomethacin intraventricular hemorrhage prevention trial.
    Pediatrics, 1998, Volume: 102, Issue:1 Pt 1

    Topics: Brain Damage, Chronic; Cerebral Hemorrhage; Cerebral Ventricles; Child, Preschool; Cyclooxygenase In

1998
Outcome of children in the indomethacin intraventricular hemorrhage prevention trial.
    Pediatrics, 2000, Volume: 105, Issue:3 Pt 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Cerebral Ventri

2000

Other Studies

6 other studies available for indomethacin and Brain Damage, Chronic

ArticleYear
Diminished white matter injury over time in a cohort of premature newborns.
    The Journal of pediatrics, 2015, Volume: 166, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; California; Cohort Studies; Cross-Se

2015
Neuroprotective effects vary across nonsteroidal antiinflammatory drugs in a mouse model of developing excitotoxic brain injury.
    Neuroscience, 2010, May-19, Volume: 167, Issue:3

    Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Ste

2010
Change in cognitive function over time in very low-birth-weight infants.
    JAMA, 2003, Feb-12, Volume: 289, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P

2003
Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth.
    Pediatrics, 2006, Volume: 117, Issue:5

    Topics: Brain; Brain Damage, Chronic; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Gestational Age;

2006
Cerebral lesions in preterm infants after tocolytic indomethacin.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:10

    Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi

1990
Prophylactic agents in the prevention of periventricular hemorrhage.
    The Journal of pediatrics, 1989, Volume: 114, Issue:4 Pt 1

    Topics: Brain Damage, Chronic; Cerebral Hemorrhage; Humans; Indomethacin; Infant, Newborn

1989