indomethacin has been researched along with Bone Cancer in 36 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer." | 7.65 | Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976) |
| " Treatment of mice with 100 micrograms of indomethacin, a potent inhibitor of prostaglandin synthesis, prior to the injection of rhuIL-1 alpha, prevented the increase in number of bone metastases." | 3.68 | Effect of IL-1 on experimental bone/bone-marrow metastases. ( Arguello, F; Baggs, RB; Cohen, HJ; Frantz, CN; Graves, BT; Harwell, SE, 1992) |
| "The responses to Concanavalin A (Con A) of peripheral blood mononuclear cells were studied in 22 patients with malignant bone and soft tissue sarcoma." | 3.66 | [Studies on the suppressor cells acting on the mitogen induced blastogenesis in tumor-bearing hosts. II. Suppressor cells in the peripheral blood of patients with malignant bone and soft tissue sarcoma (author's transl)]. ( Takami, M, 1980) |
| " We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer." | 3.65 | Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976) |
| "MCF-7, non-metastatic breast cancer cells, remained dormant when co-cultured with normal human osteoblast and fibroblast growth factor." | 1.42 | Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment. ( Foster, SJ; Grove, CD; Mastro, AM; Norgard, RJ; Sosnoski, DM, 2015) |
| "Indomethacin is a useful therapy for LCH involving the bony skeleton and may have a role as first-line treatment in single-system bone disease." | 1.30 | Use of indomethacin in Langerhans cell histiocytosis. ( Broadbent, V; Munn, SE; Olliver, L; Pritchard, J, 1999) |
| "Leukotriene B4 (LTB4) is an arachidonic acid lipoxygenase metabolite with well-characterized effects on leukocytes." | 1.28 | Effects of leukotrienes on osteoblastic cell proliferation. ( Dziak, R; Ren, W, 1991) |
| "Indomethacin was given to four patients with hypercalcemia with no effect on serum calcium levels in any cases." | 1.27 | Hypercalcemia of cancer in the digestive tract. ( Furuta, S; Monno, S; Nagata, A, 1987) |
| "Indomethacin may suppress the local acceleration of calcium metabolism." | 1.26 | Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow. ( Ito, Y; Muranaka, A; Nagai, K; Otsuka, N; Terashima, H; Yanagimoto, S, 1981) |
| "The specific bone resorption-stimulating activity of the HSDM(1) factor extracted from the tumor is high and approximately equal to that of PGE(2) as measured in a bone tissue culture system in vitro." | 1.25 | Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer. ( Goldhaber, P; Levine, L; Tashjian, AH; Voelkel, EF, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (72.22) | 18.7374 |
| 1990's | 4 (11.11) | 18.2507 |
| 2000's | 2 (5.56) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Mirshahidi, S | 2 |
| de Necochea-Campion, R | 2 |
| Moretta, A | 1 |
| Williams, NL | 2 |
| Reeves, ME | 1 |
| Otoukesh, S | 1 |
| Mirshahidi, HR | 2 |
| Khosrowpour, S | 1 |
| Duerksen-Hughes, P | 1 |
| Zuckerman, LM | 2 |
| Frames, WL | 1 |
| Elsissy, JG | 1 |
| Shields, TG | 1 |
| Sosnoski, DM | 1 |
| Norgard, RJ | 1 |
| Grove, CD | 1 |
| Foster, SJ | 1 |
| Mastro, AM | 1 |
| Díaz-Rodríguez, L | 1 |
| García-Martínez, O | 1 |
| Morales, MA | 1 |
| Rodríguez-Pérez, L | 1 |
| Rubio-Ruiz, B | 1 |
| Ruiz, C | 1 |
| Shoji, M | 1 |
| Tanabe, N | 1 |
| Mitsui, N | 1 |
| Tanaka, H | 1 |
| Suzuki, N | 1 |
| Takeichi, O | 1 |
| Sugaya, A | 1 |
| Maeno, M | 1 |
| Hirata, Y | 1 |
| Uchihashi, M | 1 |
| Nakashima, H | 1 |
| Fujita, T | 2 |
| Matsukura, S | 1 |
| Matsui, K | 1 |
| Otsuka, N | 1 |
| Ito, Y | 1 |
| Nagai, K | 1 |
| Terashima, H | 1 |
| Yanagimoto, S | 1 |
| Muranaka, A | 1 |
| Takami, M | 1 |
| Ritchie, GA | 1 |
| Rodan, SB | 1 |
| Rodan, GA | 1 |
| Simmons, HA | 1 |
| Walenga, RW | 1 |
| Feinstein, MB | 1 |
| Raisz, LG | 1 |
| Panje, WR | 1 |
| Chan, CC | 1 |
| Rodger, IW | 1 |
| Munn, SE | 1 |
| Olliver, L | 1 |
| Broadbent, V | 1 |
| Pritchard, J | 1 |
| Chikatsu, N | 1 |
| Takeuchi, Y | 1 |
| Tamura, Y | 1 |
| Fukumoto, S | 1 |
| Yano, K | 1 |
| Tsuda, E | 1 |
| Ogata, E | 1 |
| Puppo, N | 1 |
| De Thomatis, M | 1 |
| Oddone, G | 1 |
| Goldring, SR | 1 |
| Dayer, JM | 1 |
| Krane, SM | 1 |
| Coombes, RC | 2 |
| Neville, AM | 5 |
| Gazet, JC | 2 |
| Ford, HT | 1 |
| Nash, AG | 1 |
| Baker, JW | 1 |
| Powles, JT | 1 |
| Easty, GC | 3 |
| Dowsett, M | 1 |
| Powles, TJ | 4 |
| Easty, DM | 3 |
| Eilon, G | 1 |
| Mundy, GR | 1 |
| Galasko, CS | 1 |
| Bennett, A | 1 |
| Robertson, RP | 1 |
| Baylink, DJ | 1 |
| Metz, SA | 1 |
| Cummings, KB | 1 |
| Bondy, PK | 1 |
| Strausser, HR | 1 |
| Humes, JL | 1 |
| Arguello, F | 1 |
| Baggs, RB | 1 |
| Graves, BT | 1 |
| Harwell, SE | 1 |
| Cohen, HJ | 1 |
| Frantz, CN | 1 |
| Ren, W | 1 |
| Dziak, R | 1 |
| Monno, S | 1 |
| Nagata, A | 1 |
| Furuta, S | 1 |
| Ritter, MA | 1 |
| Sieber, JM | 1 |
| Uchida, T | 1 |
| Kuwao, S | 1 |
| Ishibashi, A | 1 |
| Koshiba, K | 1 |
| LiVolsi, VA | 1 |
| Tashjian, AH | 1 |
| Voelkel, EF | 1 |
| Levine, L | 1 |
| Goldhaber, P | 1 |
| Delaveirre, PH | 1 |
| Hureau, J | 1 |
| Grivaux, M | 1 |
| Chretien, J | 1 |
| Etienne, JP | 1 |
| Hart, FD | 1 |
| Clark, SA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Atavistic Chemotherapy and Immunotherapy in Advanced, Metastatic, and Otherwise Incurable and Lethal Cancers Under Conventional Treatments[NCT02366884] | Phase 2 | 250 participants (Anticipated) | Interventional | 2011-07-26 | Recruiting | ||
| The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty[NCT05648916] | 200 participants (Anticipated) | Observational | 2022-08-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Bone Cancer
| Article | Year |
|---|---|
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2 | 1997 |
35 other studies available for indomethacin and Bone Cancer
| Article | Year |
|---|---|
Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line
Topics: Apoptosis; beta Catenin; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase | 2020 |
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati | 2019 |
Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment.
Topics: 3T3 Cells; Animals; Bone Neoplasms; Bone Remodeling; Breast Neoplasms; Cell Line, Tumor; Cell Prolif | 2015 |
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line | 2012 |
Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.
Topics: Alkaline Phosphatase; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cycloo | 2006 |
Specific receptors for epidermal growth factor in human bone tumour cells and its effect on synthesis of prostaglandin E2 by cultured osteosarcoma cell line.
Topics: Adult; Alprostadil; Animals; Bone Neoplasms; Bone Resorption; Calcitonin; Cell Line; Child; Cyclic A | 1984 |
Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow.
Topics: Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Calcium; Diphosphonates; Indomethacin; Mitomyc | 1981 |
[Studies on the suppressor cells acting on the mitogen induced blastogenesis in tumor-bearing hosts. II. Suppressor cells in the peripheral blood of patients with malignant bone and soft tissue sarcoma (author's transl)].
Topics: Bone Neoplasms; Cell Adhesion; Concanavalin A; Humans; Indomethacin; Monocytes; Sarcoma; Soft Tissue | 1980 |
[Hypercalcemia in non-parathyroid malignant tumors].
Topics: Adrenal Cortex Hormones; Bone Neoplasms; Diuretics; Humans; Hypercalcemia; Indomethacin; Neoplasms; | 1981 |
The direct inhibition of prostaglandin synthetase of human breast cancer tumor tissue by tamoxifen.
Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cyclooxygenase Inhibitors; Dose-Response Relation | 1980 |
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line; Chromatography, Thin Layer; Culture Media; Dino | 1981 |
Regression of head and neck carcinoma with a prostaglandin-synthesis inhibitor.
Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Head and N | 1981 |
Use of indomethacin in Langerhans cell histiocytosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Child; Child, Preschool; Female | 1999 |
Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in vitro.
Topics: Animals; Base Sequence; Bone Marrow Cells; Bone Neoplasms; Carrier Proteins; Cell Adhesion; Cocultur | 2000 |
[Clinical use of indomethacin administered intravenously in the analgesic treatment of neoplasms with bone metastases].
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Female; Humans; Indomethacin; Infusions, Parenteral; Inject | 1975 |
Anti-inflammatory drugs and tumour growth.
Topics: Animals; Aspirin; Bone Neoplasms; Carcinogens; Drug Evaluation; Humans; Indomethacin; Neoplasm Metas | 1979 |
Regulation of hormone-induced cyclic AMP response to parathyroid hormone and prostaglandin E2 in cells cultured from human giant cell tumors of bone.
Topics: 1-Methyl-3-isobutylxanthine; Bone Neoplasms; Cells, Cultured; Cyclic AMP; Giant Cell Tumors; Humans; | 1979 |
Agents affecting osteolysis in patients with breast cancer.
Topics: Anti-Inflammatory Agents; Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitonin; Fe | 1979 |
In vitro osteolysis by human breast tumours.
Topics: Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Female; Humans; In Vitro Techni | 1977 |
Direct resorption of bone by human breast cancer cells in vitro.
Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Female; Humans; Indomethacin; Neoplasm | 1978 |
Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins.
Topics: Animals; Bone Neoplasms; Bone Resorption; Indomethacin; Lung Neoplasms; Neoplasm Metastasis; Neoplas | 1976 |
Plasma prostaglandin E in patients with cancer with and without hypercalcemia.
Topics: Bone Neoplasms; Female; Humans; Hypercalcemia; Indomethacin; Male; Neoplasm Metastasis; Neoplasms; P | 1976 |
Failure of indomethacin to reduce hypercalcemia in patients with breast cancer.
Topics: Aspirin; Bone Neoplasms; Breast Neoplasms; Calcium; Creatinine; Female; Humans; Hydroxyproline; Hype | 1976 |
Prostaglandin synthesis inhibition: effect on bone changes and sarcoma tumor induction in balb/c mice.
Topics: Animals; Bone Neoplasms; Immunosuppression Therapy; Indomethacin; Male; Mice; Moloney murine leukemi | 1975 |
Effect of IL-1 on experimental bone/bone-marrow metastases.
Topics: Animals; Bone Marrow Diseases; Bone Neoplasms; Granulocyte-Macrophage Colony-Stimulating Factor; Ind | 1992 |
Effects of leukotrienes on osteoblastic cell proliferation.
Topics: Animals; Benzoquinones; Bone Neoplasms; Cell Division; Cells, Cultured; Culture Media, Serum-Free; D | 1991 |
Hypercalcemia of cancer in the digestive tract.
Topics: Aged; Aged, 80 and over; Bone Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Hypercalcemia; | 1987 |
Prophylactic indomethacin for the prevention of heterotopic bone formation following total hip arthroplasty.
Topics: Adult; Aged; Bone and Bones; Bone Neoplasms; Choristoma; Female; Hip Prosthesis; Humans; Indomethaci | 1985 |
Elevated prostaglandin and indomethacin-responsive hypercalcemia in a patient with malignant pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Bone Neoplasms; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle | 1985 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; Carcinoma 256, Walker; Indomethacin; Lysosomes; N | 1973 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; In Vitro Techniques; Indomethacin; Mice; Neoplasm | 1973 |
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Cells, Cultured; Clone Cells; Culture Techniques; | 1972 |
[Iatrogenic gastroduodenal ulcerations. Corticosteroids excluded].
Topics: Aged; Bone Neoplasms; Carcinoma, Squamous Cell; Cyclophosphamide; Duodenal Ulcer; Female; Humans; In | 1973 |
Analgesics and non-steroid anti-inflammatory agents in rheumatic disease.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Bone Neoplasms; Gout; Humans; | 1972 |
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Calciu | 1973 |