indomethacin and Body Weight studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
"A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera."	9.05	Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985)
"We examined the effects of calcium gluconate, an anti-inflammatory calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss."	7.77	Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. ( Cho, HR; Kang, SJ; Ku, SK; Lee, YJ; Sung, YS, 2011)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."	7.72	Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
" The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)."	7.69	Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996)
" We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction."	7.68	Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993)
" The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse."	7.68	Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990)
"The influence of feeding a marine oil (MaxEPA) with a high content of eicosapentaenoic acid (EPA) to rats for 10 weeks on the development of carrageenin oedema was studied."	7.67	Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2. ( Juan, H; Sametz, W, 1985)
"We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat."	7.67	Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988)
"As the nonsteroidal anti-inflammatory drug indomethacin has already been shown to inhibit cigarette smoke (CS)-induced secretory cell hyperplasia in the airway epithelium of the rat, the present study was undertaken to determine the effects of prophylactic interaperitoneal injection of indomethacin (4 mg/kg body weight) compared with each of three steroidal anti-inflammatory drugs given at comparable doses."	7.67	Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone, or hydrocortisone in the rat. ( Jeffery, PK; Rogers, DF, 1986)
"The response to indomethacin of a patient with Bartter's syndrome and proximal tubular sodium wasting is described."	7.66	Analysis of factors influencing the renin-aldosterone system in a patient with Bartter's syndrome. ( Falls, WF; Stacy, WK; Sudan, M, 1979)
"During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected."	7.65	Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976)
"Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR."	6.80	Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015)
"Arthritis and hypertension are frequent comorbidities in the elderly hypertensive population."	6.69	Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. ( Anderson, A; Bertram, D; Morgan, TO, 2000)
" Incidentally, when NSAID use is combined with exercise there is some evidence that this effect may be exacerbated; however, this hypothesis has not been directly tested in a controlled experiment."	5.39	Indomethacin in combination with exercise leads to muscle and brain inflammation in mice. ( Davis, JM; Enos, RT; McClellan, JL; Murphy, EA, 2013)
" Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas."	5.35	Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009)
"Mild gastritis was induced with 0."	5.32	Gastric hypersecretion associated to iodoacetamide-induced mild gastritis in mice. ( Corpa, JM; Martínez, J; Martínez, V; Piqueras, L, 2003)
" Clentiazem dose-response curves for both coronary dilation and negative inotropic effects were determined under control conditions and in the presence of the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine (L-NAME, 30 microM), and the cyclooxygenase inhibitor, indomethacin (10 microM)."	5.30	Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure. ( Blaise, G; Dumont, L; Jasmin, G; Tanguay, M, 1997)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."	5.28	Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
"Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy."	5.27	Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983)
" We studied 13 patients with mild essential hypertension in a randomized, double-blind design to assess the effects of indomethacin on hydrochlorothiazide's ability to lower blood pressure, alter body weight, stimulate plasma renin activity, and modulate vascular prostacyclin biosynthesis as assessed by the urinary excretion of the major enzymatically produced metabolite of prostacyclin, 2,3-dinor-6-keto-prostaglandin F1 alpha (PGF1 alpha), measured by GC/MS."	5.06	The antihypertensive efficacy of hydrochlorothiazide is not prostacyclin dependent. ( Byyny, RL; Gerber, JG; LoVerde, M; Nies, AS, 1990)
"The effects of 100 mg indomethacin daily for three weeks on blood pressure and urinary excretion of prostaglandin F2 alpha were studied in a double-blind, placebo-controlled comparison of two groups of patients with essential hypertension, eight receiving propranolol and seven thiazide diuretics."	5.05	Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin. ( Abbott, EC; Dollery, CT; Hensby, CN; Watkins, J; Webster, J, 1980)
"A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera."	5.05	Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985)
"Indomethacin significantly suppressed body weight at P21, but liver weight significantly decreased only in 25 mg/kg."	3.85	Hepatocellular and developmental influences of early postnatal indomethacin in mice. ( Azadbakht, M; Nowrouzi, F, 2017)
" The gastrointestinal injury was accompanied by signs of chronic stress: long-lasting increase in corticosterone blood level, adrenal hypertrophy, thymus involution, and loss of body weight."	3.80	[Somatic pain sensitivity under indometacin induced gastric and small intestinal injury in rats]. ( Bagaeva, TR; Filaretova, LP; Iarushkina, NI, 2014)
" As cold allodynia is frequently observed in individuals experiencing toothache pain, we tested whether mice with DPI demonstrate an aversion to drinking cold liquids using a cold-sucrose consumption test."	3.79	Paradoxical surrogate markers of dental injury-induced pain in the mouse. ( Basbaum, AI; Gibbs, JL; Urban, R, 2013)
"001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes observed in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia, the impairment of kidney functions, and the risks for cardiovascular disease in arthritic rats."	3.79	Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. ( El-Menshawy, O; Ramadan, G, 2013)
" With the adjuvant arthritis model, the prophylactic efficacy profile of ABC294640 was similar to indomethacin."	3.77	Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. ( Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y, 2011)
"We examined the effects of calcium gluconate, an anti-inflammatory calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss."	3.77	Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. ( Cho, HR; Kang, SJ; Ku, SK; Lee, YJ; Sung, YS, 2011)
" In the present study, we examined the effect of various COX inhibitors on gastric ulcerogenic and acid secretory responses following daily exposure of the stomach to iodoacetamide (IA) and investigated the role for COX isozyme in gastric protection under subchronic mucosal irritation."	3.72	Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach. ( Hayashi, Y; Murakami, M; Takeeda, M; Takeuchi, K; Yamato, M, 2004)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."	3.72	Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"To evaluate whether the elevated blood pressure induced by chronic treatment with N(omega)-nitro-L-arginine methyl ester (L-NAME) contributes to an impairment of endothelium-dependent relaxation (EDR), the effects of chronic treatment of Wistar rats with L-NAME on systolic blood pressure, pulmonary arterial blood pressure and EDR of the pulmonary arteries were studied and compared with those of stroke-prone spontaneously hypertensive rats (SHRSP)."	3.71	Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats. ( Kawata, K; Matsuda, K; Negishi, M; Sekiguchi, F; Shimamur, K; Shinomiya, K; Sunano, S; Yamamoto, K, 2002)
"To investigate the relationship between cytokine IL-6, IL-1, TNF-alpha and experimental cancer cachexia as well as observe the effect of indomethacin on the cachectic mice."	3.71	[Cytokines in experimental cancer cachexia]. ( Li, T; Liu, A; Niu, Q, 2001)
" The gastric ulcerogenic response to indomethacin was markedly worsened in AA rats, depending on the degree of arthritic change."	3.70	Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide. ( Kato, S; Kunikata, T; Nishijima, M; Takeuchi, K; Tanaka, A, 1999)
" Therefore, the purpose of the present study was to determine if administration of ibuprofen (ibu) or indomethacin (indo), which inhibit PG synthesis, would affect the food intake and body weight of tumor-bearing rats."	3.70	Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats. ( McCarthy, DO, 1999)
" The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)."	3.69	Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996)
" We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction."	3.68	Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993)
"We measured daily food intake and body weight in rats before and after the induction of colitis by intrarectal administration of either 2,4,6-trinitrobenzenesulfonic acid in ethyl alcohol (TNBE) or 4% acetic acid (AA)."	3.68	On the suppression of food intake in experimental models of colitis in the rat. ( Collins, SM; Keenan, C; McHugh, KJ; Wallace, JL; Weingarten, HP, 1993)
" We studied the effects of anti-inflammatory drugs, indomethacin (IND) and dexamethasone (DX), on glucoregulation, body weight, and mortality in 10-day-old suckling rats administered Salmonella enteritidis lipopolysaccharide (LPS)."	3.68	Dexamethasone and indomethacin treatment during endotoxicosis in the suckling rat. ( Goto, M; Hurley, RM; Zeller, WP, 1990)
" The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse."	3.68	Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990)
"This study examines the effect of a purified leukocyte-derived endogenous mediator (LEM) on protein metabolism during liver dysfunction and after sham surgery and the role of a nonsteroidal, antiinflammatory drug (indomethacin sodium trihydrate) in modifying this response."	3.67	Leukocyte endogenous mediator fails to alter protein dynamics in a model of liver dysfunction. ( Bistrian, BR; Blackburn, GL; Dinarello, CA; Drabik, M; Flores, EA; Gauldie, J, 1989)
"The influence of feeding a marine oil (MaxEPA) with a high content of eicosapentaenoic acid (EPA) to rats for 10 weeks on the development of carrageenin oedema was studied."	3.67	Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2. ( Juan, H; Sametz, W, 1985)
"We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat."	3.67	Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. ( Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA, 1988)
"As the nonsteroidal anti-inflammatory drug indomethacin has already been shown to inhibit cigarette smoke (CS)-induced secretory cell hyperplasia in the airway epithelium of the rat, the present study was undertaken to determine the effects of prophylactic interaperitoneal injection of indomethacin (4 mg/kg body weight) compared with each of three steroidal anti-inflammatory drugs given at comparable doses."	3.67	Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone, or hydrocortisone in the rat. ( Jeffery, PK; Rogers, DF, 1986)
"The effect of alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), a new anti-inflammatory drug, on established adjuvant arthritis in rats was compared to that of indomethacin."	3.67	Effect of alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), a new anti-inflammatory drug, on the established adjuvant arthritis in rats. ( Hidaka, T; Hosoe, K; Watanabe, K; Yamashita, T, 1986)
"Studies were performed in conscious rats to evaluate the role of renal prostaglandin biosynthesis in demeclocycline-induced polyuria."	3.66	Effect of prostaglandin inhibition on demeclocycline administration in conscious rats. ( Kirschenbaum, MA; Lowe, AG; Serros, ER, 1980)
"The response to indomethacin of a patient with Bartter's syndrome and proximal tubular sodium wasting is described."	3.66	Analysis of factors influencing the renin-aldosterone system in a patient with Bartter's syndrome. ( Falls, WF; Stacy, WK; Sudan, M, 1979)
"During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected."	3.65	Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976)
" Animals were enrolled at 3 ± 1 d of life, and after 21 d of adaptation, they were randomly assigned to 1 of 3 treatments consisting of intramuscular saline or indomethacin injections every 12 h for 48 h: (1) control (CTL), saline injection, (2) low intramuscular indomethacin (INDO-L) dosed at 1."	3.11	Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves. ( Cangiano, LR; DeVries, TJ; Ipharraguerre, IR; McNeil, B; Renaud, J; Steele, MA; Villot, C, 2022)
"Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR."	2.80	Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015)
"Preterm and term newborn infants show wide interindividual variability (IIV) in pharmacokinetic parameters of gentamicin."	2.74	Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study. ( Ewald, U; Friberg, LE; Honoré, PH; Nielsen, EI; Sandström, M, 2009)
"Arthritis and hypertension are frequent comorbidities in the elderly hypertensive population."	2.69	Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. ( Anderson, A; Bertram, D; Morgan, TO, 2000)
" Renal function was assessed in eight patients with chronic renal insufficiency following the administration of flurbiprofen 50 mg as a single dose and after chronic administration of 50 mg four times daily for 8 and 27 days."	2.67	Effects of flurbiprofen on renal function in patients with moderate renal insufficiency. ( Brater, DC; Greene, PK; Hall, SD; Manatunga, AK; Murray, MD, 1992)
"Hydrochlorothiazide kinetics were not influenced."	2.66	Effects of indomethacin and sulindac on hydrochlorothiazide kinetics. ( Gribnau, FW; Kateman, WG; Koopmans, PP; Tan, Y; van Ginneken, CA, 1985)
"Cancer cachexia is a devastating syndrome of advanced malignancy which negatively impacts on patients' morbidity, mortality and quality of life."	2.49	Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review. ( Cantwell, MM; Hughes, CM; Murray, LJ; Parsons, C; Reid, J, 2013)
"These results suggest that Bartter's syndrome results from beta adrenergic and prostaglandin-mediated proximal tubular rejection of sodium leading to increased distal sodium-potassium exchange."	2.35	Role of prostaglandins in the pathogenesis of Bartter's syndrome. ( Fichman, MP; Golub, M; Rude, R; Speckart, P; Telfer, N; Zia, P, 1976)
" Incidentally, when NSAID use is combined with exercise there is some evidence that this effect may be exacerbated; however, this hypothesis has not been directly tested in a controlled experiment."	1.39	Indomethacin in combination with exercise leads to muscle and brain inflammation in mice. ( Davis, JM; Enos, RT; McClellan, JL; Murphy, EA, 2013)
"Metformin treatment improved these alterations."	1.38	Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012)
" Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas."	1.35	Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009)
"As indomethacin was unable to prevent lipid peroxidation, malondialdehyde concentrations increased to ischemia-induced levels."	1.35	The effects of indomethacin on caspases, glutathione level and lipid peroxidation in the newborn rats with hypoxic-ischemic cerebral injury. ( Canacankatan, N; Erdogan, S; Ozcan, K; Satar, M; Taskin, E; Yapicioglu, HY, 2009)
"Endothelial dysfunction has been linked to a decrease in nitric oxide (NO) bioavailability and attenuated endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation."	1.35	Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats. ( Carneiro, FS; Carneiro, ZN; Dorrance, A; Giachini, FR; Lima, VV; Tostes, RC; Webb, RC, 2009)
"In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82."	1.33	Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005)
"Exposure to hypoxemia resulted in significant elevation of plasma IL-6 in both untreated and treated with lipopolysaccharide (LPS) mice."	1.33	Hypoxia-induced sickness behaviour. ( Kozak, W; Walentynowicz, K; Wrotek, S, 2006)
"Mild gastritis was induced with 0."	1.32	Gastric hypersecretion associated to iodoacetamide-induced mild gastritis in mice. ( Corpa, JM; Martínez, J; Martínez, V; Piqueras, L, 2003)
"The body weights were 17% higher ( P<0."	1.32	Combined lack of estrogen receptors alpha and beta affects vascular iNOS protein expression. ( Ekblad, E; Liang, M; Lydrup, ML; Nilsson, BO, 2003)
"Weight-losing untreated cancer patients had elevated resting energy expenditure compared to undernourished non-cancer patients (23."	1.32	Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. ( Bosaeus, I; Daneryd, P; Hyltander, A; Körner, U; Lundholm, K, 2004)
"Late pregnancy is characterized by a significantly diminished systolic blood pressure in conscious rats (-17 mmHg, P < 0."	1.31	Endothelium and aortic contraction to endothelin-1 in the pregnant rat. ( Dièye, AM; Gairard, A, 2000)
"Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load."	1.31	Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000)
"Indomethacin was provided in the drinking water to explore interactions between host and tumor-derived prostaglandins and proinflammatory cytokines for tumor growth."	1.31	Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. ( Axelsson, H; Cahlin, C; Körner, A; Lundholm, K; Svanberg, E; Wang, W, 2000)
"Indomethacin was also ineffective in altering resveratrol activity in arteries from both lean and dietary-obese rats."	1.31	The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. ( Doyle, PJ; Naderali, EK; Smith, SL; Williams, G, 2001)
"Indomethacin treatment reversed all the measured parameters, although the reversal of mechanical allodynia was only partial."	1.31	Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. ( Fuseler, J; Grisham, M; Roerig, SC; Tedesco, LS; Wolf, R, 2002)
"Pregnancy is associated with a substantial increase in uterine artery blood flow, which may in part result from dilation in response to vascular endothelial growth factor (VEGF)."	1.31	Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake. ( Anthony, FW; Brawley, L; Hanson, MA; Itoh, S; Poston, L; Wheeler, T, 2002)
" The dose-response curve for the acetylcholine-induced relaxation was slightly, but significantly attenuated in diabetic mice."	1.31	Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice. ( Kamata, K; Kanie, N, 2000)
"Local inflammation was induced by subcutaneous injection of turpentine (100 microl/mouse)."	1.30	Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation. ( Conn, CA; Kluger, MJ; Kozak, W; Rudolph, K; Soszynski, D, 1997)
" Clentiazem dose-response curves for both coronary dilation and negative inotropic effects were determined under control conditions and in the presence of the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine (L-NAME, 30 microM), and the cyclooxygenase inhibitor, indomethacin (10 microM)."	1.30	Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure. ( Blaise, G; Dumont, L; Jasmin, G; Tanguay, M, 1997)
" The decrease in edema in the footpads of EFAD rats was nearly identical to the decrease in edema in the footpads of Control rats dosed with indomethacin."	1.30	Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats. ( Chinn, KS; Mehta, A; Obukowicz, MG; Raz, A; Salsgiver, WJ; Welsch, DJ, 1997)
" They were found fairly potent in rat tail flick and mouse phenylquinone writhing assays but the dose-response curves were rather shallow as compared to that of morphine."	1.30	Apparent antinociceptive and anti-inflammatory effects of GYKI 52466. ( Kedves, R; Máté, I; Székely, JI; Tarnawa, I; Török, K, 1997)
"The pharmacokinetic parameters of vancomycin in a neonatal population have been characterized to enable development of optimum dosage guidelines for neonatal intensive-care units and to examine the relationship between these pharmacokinetic parameters and various demographic, developmental and clinical factors which might be associated with changes in the kinetic profile of vancomycin."	1.30	The kinetic profile of vancomycin in neonates. ( Almeida, AM; Bispo, MA; Costa, IM; Falcão, AC; Falcão, F; Palminha, JM; Reis, E; Silva, R, 1998)
"Pretreatment with indomethacin enhanced the relaxation response to acetylcholine in only SHRs at ages 16-20 and 55-60 weeks, thereby cancelling the difference in the relaxation response between WKY rats and SHRs."	1.30	Nitric oxide-dependent vasodilator mechanism is not impaired by hypertension but is diminished with aging in the rat aorta. ( Imaoka, Y; Kamada, T; Mio, Y; Okumura, K; Osanai, T; Satoh, K, 1999)
" Indomethacin did not alter the dose-response curves to KCl or Phe in either swimming or control groups."	1.30	Effects of exercise training on responsiveness of the mesenteric arterial bed to phenylephrine and KCl in male rats. ( Hirunpan, P; Jansakul, C, 1999)
"In indomethacin-treated fetuses, in which the prostanoids had decreased and remained at approximately 20% normal, cooling initiated moderate nonshivering thermogenesis, and ventilation and cord occlusion caused no further changes."	1.29	Role of prostaglandin E2 and prostacyclin in nonshivering thermogenesis during simulated birth in utero. ( Power, GG; Takeuchi, M; Yoneyama, Y, 1994)
"Freund's adjuvant arthritis (FAA) in susceptible rats (male, Lewis strain) is a well-established experimental model of rheumatoid arthritis to evaluate inherent drug properties, i."	1.29	Antirheumatic drug profiles evaluated in the adjuvant arthritis of rats by multiparameter analysis. ( Müller-Peddinghaus, R; Theisen-Popp, P, 1994)
" and higher, and indometacin at a dosage of 2 mg/kg/d p."	1.29	Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. ( Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S, 1995)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."	1.28	Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
" All marmosets given 12 mg/kg/day and one marmoset given 6 mg/kg/day died during the dosing period (within 20 days)."	1.28	Evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (Callithrix jacchus). ( Conz, A; Galli, CL; Giachetti, C; Oberto, G, 1990)
"Benzene is a myelotoxin which affects hemopoietic progenitor cells leading to bone-marrow depression as well as a genotoxin which causes chromosomal abnormalities including micronucleus formation."	1.28	The prevention of benzene-induced genotoxicity in mice by indomethacin. ( Kalf, GF; Pirozzi, SJ; Renz, JF, 1989)
"Indomethacin and sulindac were used as tools to study the role of renal and/or systemic prostaglandins in the pharmacological response to atenolol."	1.27	The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients. ( Abdel-Haq, B; Alberici, P; Magagna, A; Pedrinelli, R; Salvetti, A, 1984)
"Indomethacin (5 mg/kg, IP) was found to be without direct effect upon fixed-ratio behavior or rectal temperature, but significantly enhanced the capacity of low doses of d-amphetamine to suppress behavior and lower temperature."	1.27	Indomethacin potentiates the operant behavior suppressant and rectal temperature lowering effects of low doses of d-amphetamine in rats. ( Nielsen, JA; Sparber, SB, 1984)
"Indomethacin was given in drinking water, and rats consumed between 2."	1.27	Influence of dietary fat and indomethacin on the growth of transplantable mammary tumors in rats. ( Do, C; King, MM; Kollmorgen, GM; Kosanke, SD, 1983)
"Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy."	1.27	Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983)
"The treatment with indomethacin substantially 1) inhibited the tumor growth, 2) prolonged the survival time, 3) caused a regression and disappearance of tumor with some cured mice and 4) reduced the levels of PGE2 and ornithine decarboxylase activity, a first rate limiting enzyme of polyamine synthesis in tumor tissue."	1.27	[Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Suzuki, K; Takahashi, M; Yoshioka, H, 1987)
"Nifedipine was more potent in inhibiting the contraction to K+ and serotonin in WKY diabetic arteries as compared with WKY controls."	1.27	Effect of diabetes on vascular smooth muscle function in normotensive and spontaneously hypertensive rat mesenteric artery. ( Agrawal, DK; McNeill, JH, 1987)
"Metabolic acidosis is associated with enhanced renal ammonia-genesis which is regulated, in part, by glucocorticoids."	1.27	Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. ( Kelly, RA; May, RC; Mitch, WE, 1986)
"When caffeine was added at two concentrations, 0."	1.27	Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat. ( Whiting, SJ; Whitney, HL, 1987)
"The edema is spontaneously well reversible."	1.27	Edemagenic activity of aqueous form of muramyl dipeptide (MDP) in rats. ( Masek, K; Zídek, Z, 1985)
"Two patients with Bartter's syndrome were treated with indomethacin (2 mg/kg/day)."	1.26	Treatment of Bartter's syndrome with indomethacin. ( Fennell, RS; Garin, EH; Iravani, A; Richard, GA, 1980)
"A study of 690 osteoarthrosis (OA) patients with corresponding controls, and 475 soft-tissue rheumatism (STR) patients with the same number of controls was made in Finnish health centres."	1.26	Etiological, social and therapeutical aspects of osteoarthrosis and soft-tissue rheumatism in a Finnish health centre material. ( Julkunen, H; Julkunen, I; Kiehelä, J, 1981)
"Indomethacin did not inhibit ordered growth in either length or width."	1.26	Lack of effect of indomethacin on ordered growth of the femur in rats. ( Hald, J; Sudmann, E; Tveita, T, 1982)
" Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents."	1.26	Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. ( Bennett, A; Berstock, DA; Carroll, MA, 1982)
"Indomethacin plasma levels were about 1 microgram/ml in the indomethacin-treated animals."	1.26	Inhibition of fracture healing by indomethacin in rats. ( Bessesen, A; Dregelid, E; Mørland, J; Sudmann, E, 1979)
"Ten children with Bartter's syndrome are described."	1.26	Bartter's syndrome: 10 cases in childhood. Results of long-term indomethacin therapy. ( Dillon, MJ; Mitchell, MD; Shah, V, 1979)
"Six children with Bartter's syndrome aged 6 years 4 months to 13 years 11 months were treated with indomethacin (1."	1.26	[Bartter's syndrome: the long term effects of indomethacin on growth (author's transl)]. ( David, M; Floret, D; Hage, GN; Roux, A; Teyssier, G, 1979)
"The diagnosis of Bartter's syndrome was made in a 9-month-old boy investigated for poor weight and height gain."	1.26	Treatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors. ( Lee, MR; Littlewood, JM; Meadow, SR, 1978)
"Since the mechanism of seizures inducted by exposure to oxygen high pressure (OHP) is not fully elucidated, this study was designed to investigate the effect of exogenous PG s and of indomethacin (a Pg synthesis inhibitor) upon the development and consequences of seizures in rats exposed to OHP (5 ata)."	1.26	Effect of prostaglandin E2 and of indomethacin upon cerebral and pulmonary consequences of exposure to hyperbaric oxygen in rats. ( Dabrowiecki, Z; Herbaczyńska-Cedro, K; Rap, ZM; Ruszczewski, P; Truskolaski, P, 1979)
"Aspirin treatment, 150 mg/kg twice daily, inhibited growth of a transplantable mast-cell ascites tumor (P815) by 39-43% (p less than 0."	1.26	Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouse. ( Beaven, MA; Hial, V; Horakova, Z; Shaff, FE, 1976)
"Indomethacin and aspirin treatment of animals injected with PMSG also reduced the ovarian weight gain."	1.25	The effect of inhibition of prostaglandin synthesis on ovarian hypertrophy in the rat. ( Castracane, VD; Shaikh, AA; Tankenow, LF, 1975)
"5 Indomethacin treatment did not affect monoamine oxidase and catechol O-methyl-transferase activities in the different tissues."	1.25	Indomethacin-induced increase in noradrenaline turnover in some rat organs. ( Fredholm, BB; Hedqvist, P, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	124 (43.82)	18.7374
1990's	72 (25.44)	18.2507
2000's	60 (21.20)	29.6817
2010's	22 (7.77)	24.3611
2020's	5 (1.77)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358]			Phase 1	49 participants (Actual)	Interventional	2019-03-23	Terminated (stopped due to Study terminated because of COVID19 pandemics.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review. Palliative medicine, 2013, Volume: 27, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Celecoxib; Cyclooxygenase 2 I	2013
Role of prostaglandins in the pathogenesis of Bartter's syndrome. The American journal of medicine, 1976, May-31, Volume: 60, Issue:6 Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Bartter Syndrome; Body Composition; Body Weight; Chi	1976

Article	Year
Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves. Journal of dairy science, 2022, Volume: 105, Issue:8 Topics: Animal Feed; Animals; Body Weight; Cattle; Chromium; Diet; Edetic Acid; Indomethacin; Injections, In	2022
Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:2 Topics: Adolescent; Adult; Amiloride; Blood Pressure; Body Weight; Cross-Over Studies; Dose-Response Relatio	2015
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study. Clinical pharmacokinetics, 2009, Volume: 48, Issue:4 Topics: Age Factors; Biomarkers; Body Weight; Cefuroxime; Creatinine; Cystatin C; Drug Interactions; Female;	2009
Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers. Kidney international, 2005, Volume: 68, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Body Weight; Celecoxib; Creatinine; Cross-Over Stu	2005
Non-steroidal anti-inflammatory drugs and blood pressure. Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Blood Pressure; Blood Pressure Determina	1982
The effect of indomethacin on vasopressin-induced antidiuresis in man. Clinical science (London, England : 1979), 1981, Volume: 61, Issue:4 Topics: Adult; Body Weight; Creatinine; Diuresis; Humans; Indomethacin; Male; Osmolar Concentration; Potassi	1981
Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin. British medical journal, 1980, Sep-13, Volume: 281, Issue:6242 Topics: Adult; Aged; Benzothiadiazines; Body Weight; Diuretics; Double-Blind Method; Female; Humans; Hyperte	1980
Effect of indomethacin on blood pressure control during treatment with nitrendipine. Blood pressure, 1995, Volume: 4, Issue:5 Topics: Aged; Aged, 80 and over; Analysis of Variance; Blood Pressure; Body Weight; Double-Blind Method; Fem	1995
Furosemide does not prevent indomethacin-induced renal side effects in preterm infants. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:2 Topics: Body Weight; Cyclooxygenase Inhibitors; Diuretics; Ductus Arteriosus, Patent; Female; Furosemide; Ge	1997
Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. American journal of hypertension, 2000, Volume: 13, Issue:11 Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal;	2000
Evaluation of long-term treatment with indomethacin in hereditary hypokalemic salt-losing tubulopathies. The Journal of pediatrics, 2001, Volume: 139, Issue:3 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Child; Creatinine; Electrolytes; F	2001
Reduction of plasma renin activity by inhibition of the fatty acid cyclooxygenase in human subjects: independence of sodium retention. Circulation research, 1979, Volume: 44, Issue:6 Topics: Adult; Aged; Aldosterone; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Cycloox	1979
Effects of flurbiprofen on renal function in patients with moderate renal insufficiency. British journal of clinical pharmacology, 1992, Volume: 33, Issue:4 Topics: Aged; Blood Pressure; Body Weight; Female; Flurbiprofen; Hemodynamics; Humans; Indomethacin; Kidney;	1992
Interaction of indomethacin and sulindac with labetalol. British journal of clinical pharmacology, 1991, Volume: 31, Issue:3 Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Body Weight; Chlorides; Drug Interactions; Humans	1991
The antihypertensive efficacy of hydrochlorothiazide is not prostacyclin dependent. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:4 Topics: Adult; Aged; Blood Pressure; Body Weight; Double-Blind Method; Epoprostenol; Female; Humans; Hydroch	1990
The effect of prostaglandin inhibition on the clinical course of chronic hemodialysis. Nephron, 1986, Volume: 42, Issue:2 Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Clinical Trials as Topic; Creatinine;	1986
Effects of indomethacin and sulindac on hydrochlorothiazide kinetics. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:6 Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Drug Interactions; Female; Humans; Hyd	1985
Indomethacin and chloroquine fail to inhibit fluid loss in cholera. Gastroenterology, 1985, Volume: 89, Issue:5 Topics: Adult; Body Weight; Chloroquine; Cholera; Clinical Trials as Topic; Diarrhea; Female; Fluid Therapy;	1985

indomethacin and Body Weight

Research Excerpts

Research

Studies (283)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Cangiano, LR	1
Villot, C	1
Renaud, J	1
Ipharraguerre, IR	1
McNeil, B	1
DeVries, TJ	1
Steele, MA	1
Das, R	1
Khurana, N	2
Sharma, N	1
Shivnath, N	1
Siddiqui, S	1
Rawat, V	1
Khan, MS	1
Arshad, M	1
Wei, Y	1
Wang, R	1
Ren, S	1
Liu, X	1
Jing, M	1
Li, R	1
Tong, Y	1
Wen, J	1
Yang, T	1
Wang, J	1
Zhao, Y	1
Gupta, M	1
Gulati, M	1
Kapoor, B	1
Kumar, B	1
Kumar, R	2
Gupta, R	1
Singh, N	1
Morozova, OY	2
Bagaeva, TR	3
Filaretova, LP	3
Enos, RT	2
Davis, JM	2
McClellan, JL	2
Murphy, EA	2
Gibbs, JL	1
Urban, R	1
Basbaum, AI	1
Ramadan, G	1
El-Menshawy, O	1
Hayward, CE	1
Cowley, EJ	1
Mills, TA	1
Sibley, CP	1
Wareing, M	1
Blanchard, A	1
Vargas-Poussou, R	1
Vallet, M	1
Caumont-Prim, A	1
Allard, J	1
Desport, E	1
Dubourg, L	1
Monge, M	1
Bergerot, D	1
Baron, S	1
Essig, M	1
Bridoux, F	1
Tack, I	1
Azizi, M	1
Ho, N	1
Brookshire, BR	1
Clark, JE	1
Lucki, I	1
Kent, AL	2
Koina, ME	2
Gubhaju, L	1
Cullen-McEwen, LA	1
Bertram, JF	2
Lynnhtun, J	1
Shadbolt, B	2
Falk, MC	2
Dahlstrom, JE	2
Iarushkina, NI	1
Byun, SJ	1
Lim, TJ	1
Lim, YJ	1
Seo, JG	1
Chung, MJ	1
Nowrouzi, F	1
Azadbakht, M	1
Blaha, MD	1
Leon, LR	1
Douglas-Denton, R	1
Maxwell, LE	1
Willenborg, D	1
Bernardi, A	1
Braganhol, E	1
Jäger, E	1
Figueiró, F	1
Edelweiss, MI	1
Pohlmann, AR	1
Guterres, SS	1
Battastini, AM	1
Nielsen, EI	1
Sandström, M	1
Honoré, PH	1
Ewald, U	1
Friberg, LE	1
Taskin, E	1
Ozcan, K	1
Canacankatan, N	1
Satar, M	1
Yapicioglu, HY	1
Erdogan, S	1
Giachini, FR	1
Carneiro, FS	1
Lima, VV	1
Carneiro, ZN	1
Dorrance, A	1
Webb, RC	1
Tostes, RC	2
Coruzzi, G	1
Adami, M	1
Pozzoli, C	1
Solenghi, E	1
Grandi, D	1
Jiang, GL	1
Im, WB	1
Donde, Y	1
Wheeler, LA	1
Leo, CH	1
Hart, JL	1
Woodman, OL	2
Fitzpatrick, LR	1
Green, C	1
Frauenhoffer, EE	1
French, KJ	1
Zhuang, Y	1
Maines, LW	1
Upson, JJ	1
Paul, E	1
Donahue, H	1
Mosher, TJ	1
Smith, CD	1
Chen, SZ	1
Qiu, ZG	1
Ku, SK	1
Cho, HR	1
Sung, YS	1
Kang, SJ	1
Lee, YJ	1
Park, BS	1
Jin, SH	1
Park, JJ	1
Park, JW	1
Namgoong, IS	1
Kim, YI	1
Lee, BJ	1
Kim, JG	1
Lobato, NS	1
Filgueira, FP	1
Hagihara, GN	1
Akamine, EH	1
Pariz, JR	1
Carvalho, MH	1
Fortes, ZB	1
Reid, J	1
Hughes, CM	1
Murray, LJ	1
Parsons, C	1
Cantwell, MM	1
Lake, JL	1
Carmichael, MD	1
McAllister, RM	1
Piqueras, L	1
Corpa, JM	1
Martínez, J	1
Martínez, V	1
Sekiguchi, F	3
Yamamoto, K	1
Matsuda, K	1
Kawata, K	2
Negishi, M	1
Shinomiya, K	1
Shimamur, K	1
Sunano, S	3
Liang, M	1
Ekblad, E	1
Lydrup, ML	1
Nilsson, BO	1
Chamundeeswari, D	1
Vasantha, J	1
Gopalakrishnan, S	1
Sukumar, E	1
Shimizu, Y	1
Nagaya, N	1
Teranishi, Y	1
Imazu, M	1
Yamamoto, H	2
Shokawa, T	1
Kangawa, K	1
Kohno, N	1
Yoshizumi, M	1
Gonzales, RJ	2
Krause, DN	3
Duckles, SP	3
dos Santos, L	1
Xavier, FE	1
Vassallo, DV	1
Rossoni, LV	1
Lundholm, K	4
Daneryd, P	1
Körner, U	1
Hyltander, A	1
Bosaeus, I	1
Spier, SA	1
Delp, MD	1
Meininger, CJ	1
Donato, AJ	1
Ramsey, MW	1
Muller-Delp, JM	1
Egan, CG	1
Lockhart, JC	1
Ferrell, WR	1
Takeeda, M	1
Hayashi, Y	1
Yamato, M	1
Murakami, M	1
Takeuchi, K	2
McCarthy, DO	4
Whitney, P	1
Hitt, A	2
Al-Majid, S	1
Wigg, SJ	1
Tare, M	1
Forbes, J	1
Cooper, ME	1
Thomas, MC	1
Coleman, HA	1
Parkington, HC	1
O'Brien, RC	1
Li, X	1
Geary, GG	2
van den Hoff, MJ	1
Deprez, RH	1
Ruijter, JM	1
de Boer, PA	1
Tesink-Taekema, S	1
Buffing, AA	1
Lamers, WH	1
Moorman, AF	1
Chang, CC	1
Chen, SH	1
Lien, GS	1
Lou, HY	1
Hsieh, CR	1
Fang, CL	1
Pan, S	1
Graves, E	1
Roghani, M	1
Baluchnejadmojarad, T	1
Vaez-Mahdavi, MR	1
Roghani-Dehkordi, F	1
Wang, W	2
Andersson, M	1
Lõnnroth, C	1
Svanberg, E	2
Paula, AC	1
Gracioso, JS	1
Toma, W	1
Bezerra, R	1
Saad, MA	1
De Lucca, IM	1
Carneiro, EM	1
Souza Brito, AR	1
Momma, K	1
Toyoshima, K	1
Imamura, S	1
Nakanishi, T	1
Stichtenoth, DO	1
Marhauer, V	1
Tsikas, D	1
Gutzki, FM	1
Frölich, JC	2
Imai, T	1
Onose, J	1
Hasumura, M	1
Takizawa, T	1
Hirose, M	2
Suresh, Y	1
Das, UN	1
Wang, HP	1
Gao, Q	1
Mei, RH	1
Zhao, MH	1
Lu, Y	1
Li, XY	1
Bruce, IC	1
Xia, Q	1
Kozak, W	3
Wrotek, S	1
Walentynowicz, K	1
Nameda, S	2
Miura, NN	2
Adachi, Y	2
Ohno, N	2
Malakul, W	1
Thirawarapan, S	1
Suvitayavat, W	1
Wainwright, PE	1
Leatherdale, ST	1
Dubin, JA	1
Saito, M	1
Olazabal, A	1
Nascimento, L	1
De Maroussem, D	1
Pipy, B	1
Beraud, M	1
Derache, R	1
Oelkers, W	1
Köhler, A	1
Belkien, L	1
Fuchs-Hammoser, R	1
Maiga, M	1
Scherer, B	1
Weber, PC	1
Juncos, LI	1
Marbury, TC	1
Cade, R	1
Elliott, GR	1
Adolfs, MJ	1
Seyberth, HW	2
Rascher, W	1
Wille, L	1
Hackenthal, E	1
Ulmer, HE	1
Salvetti, A	1
Pedrinelli, R	1
Alberici, P	1
Magagna, A	1
Abdel-Haq, B	1
Tsuchimoto, M	1
Komoriya, K	1
Koyama, T	1
Hosoda, K	1
Takeshita, T	1
Naruchi, T	1
Matsuura, E	1
Yamamoto, I	1
Carter, CA	1
Milholland, RJ	1
Shea, W	1
Ip, MM	1
Ezra, D	1
Bayorh, MA	1
Zukowska-Grojec, Z	1
Lazar, JD	1
Kopin, IJ	1
Feuerstein, G	1
Koltai, MZ	1
Hadházy, P	1
Malomvölgyi, B	1
Wagner, M	1
Pogátsa, G	1
Nielsen, JA	1
Sparber, SB	1
Kollmorgen, GM	1
King, MM	1
Kosanke, SD	1
Do, C	1
Lal, J	1
Meydani, SN	1
Meydani, M	1
Dupont, J	1
Pollard, M	2
Luckert, PH	2
Schmidt, MA	1
Keshavarzian, A	1
Isaacs, P	1
McColl, I	1
Sladen, GE	1
Metzger, U	1
Meier, J	1
Uhlschmid, G	1
Weihe, H	1
Mills, EH	1
Whitworth, JA	1
Andrews, J	1
Kincaid-Smith, P	1
Garin, EH	1
Fennell, RS	1
Iravani, A	1
Richard, GA	1
Serros, ER	1
Lowe, AG	1
Kirschenbaum, MA	1
Francis, MD	1
Horn, PA	1
McCreary, LD	1
Miyamoto-Tiaven, MJ	1
Hillyard, LA	1
Abraham, S	1
Winkelstein, A	1
Kelley, VE	1
Julkunen, I	1
Kiehelä, J	1
Julkunen, H	1
Etzioni, A	1
Chaimovitz, C	1
Levi, Y	1
Benderli, A	1
Better, OS	1
Goldiner, WH	1
Valente, WA	1
Hamilton, BP	1
Mersey, JH	1
Sudmann, E	2
Tveita, T	1
Hald, J	1
Bennett, A	1
Berstock, DA	1
Carroll, MA	1
Merritt, TA	1
White, CL	1
Coen, RW	1
Friedman, WF	1
Gluck, L	1
Rosenberg, M	1
Sweet, AY	1
Kato, Y	1
Senzaki, H	1
Ogura, H	1
Levine, AS	1
Morley, JE	1
Peplow, PV	1
Hurst, PR	1
Padfield, PL	1
Grekin, RJ	1
Baum, J	1
Alekseev, LS	1
Brewer, EJ	1
Dolgopolova, AV	1
Mudholkar, GS	1
Patel, K	1
Watkins, J	1
Abbott, EC	1
Hensby, CN	1
Webster, J	1
Dollery, CT	1
Lennie, TA	1
Hirvonen, MD	1
Keesey, RE	1
Holmäng, S	1
Cano, M	1
Grenabo, L	1
Hedelin, H	1
Johansson, SL	1
Bognar, IT	1
Albrecht, SA	1
Farasaty, M	1
Fuder, H	1
Joly, GA	1
Schini, VB	1
Hughes, H	1
Vanhoutte, PM	1
Bertuglia, S	1
Malandrino, S	1
Colantuoni, A	1
Lopez-Valpuesta, FJ	1
Myers, RD	1
Takeuchi, M	2
Yoneyama, Y	2
Power, GG	2
Theisen-Popp, P	1
Müller-Peddinghaus, R	1
Laufer, S	1
Tries, S	1
Augustin, J	1
Elsässer, R	1
Albrecht, W	1
Guserle, R	1
Algate, DR	1
Atterson, PR	1
Munt, PL	1
Sikorski, BW	2
Hodgson, WC	2
King, RG	2
Conn, CA	2
Kluger, MJ	2
Raij, L	1
Nagy, J	1
Coffee, K	1
DeMaster, EG	1
Tanaka, T	1
Kojima, T	1
Okumura, A	1
Sugie, S	1
Mori, H	1
McHugh, KJ	1
Weingarten, HP	1
Keenan, C	1
Wallace, JL	1
Collins, SM	1
Harvey, PJ	1
Wing, LM	2
Beilby, J	1
Ramsay, A	1
Tonkin, AL	1
Goh, SH	1
Russell, AE	1
Bune, AJ	1
Chalmers, JP	1
Stephan, D	1
Billing, A	1
Krieger, JP	1
Grima, M	1
Fabre, M	1
Hofner, M	1
Imbs, JL	1
Barthelmebs, M	1
Ball, KT	1
Veerabagu, MP	1
Opara, EI	1
Meguid, MM	1
Nandi, J	1
Oler, A	1
Holtzapple, PG	1
Levine, RA	1
Williams, MP	1
Jones, CL	1
Johnstone, LM	1
Walker, RG	1
McCredie, DA	1
Powell, HR	1
Casalino-Matsuda, SM	1
Linares, JA	1
Finkelberg, AB	1
Goldraij, A	1
Yirmiya, R	1
Barak, O	1
Avitsur, R	1
Gallily, R	1
Weidenfeld, J	1
Roe, SY	1
Cooper, AL	1
Morris, ID	1
Rothwell, NJ	1
Soszynski, D	1
Rudolph, K	1
Tanguay, M	1
Jasmin, G	1
Blaise, G	1
Dumont, L	1
Uchida, A	2
Yamada, T	2
Hayakawa, T	2
Hoshino, M	2
Kawabe, M	1
Shibata, MA	1
Sano, M	1
Takesada, Y	1
Tamano, S	1
Ito, N	2
Shirai, T	1
Ohhara, H	1
Yamada, H	1
Nakazawa, T	1
Inagaki, T	1
Iida, M	1
Ogasawara, T	1
Hasegawa, C	1
Murasaki, G	1
Miyaji, M	1
Hirata, A	1
Takeuchi, T	1
Romagnoli, C	1
Zecca, E	1
Papacci, P	1
De Carolis, MP	1
Giannini, R	1
Gallini, F	1
Tortorolo, G	1
Chinn, KS	1
Welsch, DJ	1
Salsgiver, WJ	1
Mehta, A	1
Raz, A	1
Obukowicz, MG	1
Denda, A	1
Endoh, T	1
Kitayama, W	1
Tang, Q	1
Noguchi, O	1
Kobayashi, Y	1
Akai, H	1
Okajima, E	1
Tsujiuchi, T	1
Tsutsumi, M	1
Nakae, D	1
Konishi, Y	1
Saino, H	1
Matsuyama, T	1
Takada, J	1
Kaku, T	1
Ishii, S	1
Székely, JI	1
Kedves, R	1
Máté, I	1
Török, K	1
Tarnawa, I	1
McIntyre, M	1
Hamilton, CA	1
Rees, DD	1
Reid, JL	1
Dominiczak, AF	1
Huang, A	1
Sun, D	1
Kaley, G	1
Koller, A	1
Silva, R	1
Reis, E	1
Bispo, MA	1
Almeida, AM	1
Costa, IM	1
Falcão, F	1
Palminha, JM	1
Falcão, AC	1
Chin-Dusting, JP	1
Jovanovska, V	1
Kingwell, BA	1
Du, XJ	1
Dart, AM	1
Bergula, AP	1
Huang, W	1
Frangos, JA	1
Watanabe, H	1
Tanaka, S	1
Shimamura, K	1
Banks, WA	1
Kastin, AJ	1
Brennan, JM	1
Vallance, KL	1
Imaoka, Y	1
Osanai, T	1
Kamada, T	1
Mio, Y	1
Satoh, K	1
Okumura, K	1
Kato, S	1
Tanaka, A	1
Kunikata, T	1
Nishijima, M	1
Fischer, SM	1
Lo, HH	1
Gordon, GB	1
Seibert, K	1
Kelloff, G	1
Lubet, RA	1
Conti, CJ	1
Jansakul, C	1
Hirunpan, P	1
Pieper, GM	1
Lai, CS	1
Criado, M	2
Flores, O	2
Hidalgo, F	1
López-Novoa, JM	1
Sánchez-Rodríguez, A	1
Omogbai, EK	1
Ozolua, RI	1
Idaewor, PE	1
Isah, AO	1
Samuels, A	1
Perry, MJ	1
Tobias, JH	1
Turull, A	1
Queralt, J	1
Dièye, AM	1
Gairard, A	1
Iqbal, MP	1
Saeed, SA	1
Pertani, S	1
Mehboobali, N	1
Chiu, CH	1
McEntee, MF	1
Whelan, J	1
Bezerra, MM	1
de Lima, V	1
Alencar, VB	1
Vieira, IB	1
Brito, GA	1
Ribeiro, RA	1
Rocha, FA	1
Cahlin, C	1
Körner, A	1
Axelsson, H	1
Morgan, TO	1
Anderson, A	1
Bertram, D	1
Naderali, EK	1
Smith, SL	1
Doyle, PJ	1
Williams, G	1
Kagota, S	1
Yamaguchi, Y	2
Nakamura, K	1
Kunitomo, M	2
Hamada, T	1
Arima, N	1
Shindo, M	1
Sugama, K	1
Sasaguri, Y	1
Vázquez, MJ	1
Esteller, A	1
Kouhata, S	1
Kagaya, A	1
Nakae, S	1
Nakata, Y	1
Yamawaki, S	1
Golding, EM	1
Kepler, TE	1
Nakahira, T	1
Reinalter, SC	1
Gröne, HJ	1
Konrad, M	1
Klaus, G	1
Tubaro, E	1
Belogi, L	1
Mezzadri, CM	1
Niu, Q	1
Li, T	1
Liu, A	1
Tedesco, LS	1
Fuseler, J	1
Grisham, M	1
Wolf, R	1
Roerig, SC	1
Itoh, S	1
Brawley, L	1
Wheeler, T	1
Anthony, FW	1
Poston, L	1
Hanson, MA	1
Kanie, N	1
Kamata, K	1
Ito, Y	1
Nomura, S	1
Ueda, H	1
Sakurai, T	1
Kizaki, T	1
Ohno, H	1
Izawa, T	1
Gorny, D	1
Loufrani, L	1
Kubis, N	1
Lévy, BI	1
Henrion, D	1
Freshwater, JD	1
Svensson, CI	1
Malmberg, AB	1
Calcutt, NA	1
Dregelid, E	1
Bessesen, A	1
Mørland, J	1
Dillon, MJ	1
Shah, V	1
Mitchell, MD	1
Floret, D	1
David, M	1
Roux, A	1
Hage, GN	1
Teyssier, G	1
Castracane, VD	1
Tankenow, LF	1
Shaikh, AA	1
Hollifield, JW	1
Michelakis, AM	1
Vesper, BS	1
Wilson, JP	1
Shand, DG	1
Seyberth, HJ	1
Frölich, WH	1
Oates, JA	1
Littlewood, JM	1
Lee, MR	1
Meadow, SR	1
Sudan, M	1
Stacy, WK	1
Falls, WF	1
Ruszczewski, P	1
Truskolaski, P	1
Dabrowiecki, Z	1
Rap, ZM	1
Herbaczyńska-Cedro, K	1
Draznin, B	1
Morris, HG	1
Burstein, PJ	1
Schalch, DS	1
Sasaki, H	1
Volterra, G	1
Del Soldato, P	1
Meli, A	1
Rampini, S	1
Furrer, J	1
Keller, HP	1
Bucher, H	1
Zachmann, M	1
Hwang, DH	1
Kinsella, JE	1
Powell, JG	1
Cochrane, RL	1
Herrera-Acosta, J	1
Guerrero, J	1
Erbessd, ML	1
Paz-Barahona, M	1
Chessal, F	1
Alarcón-Segovia, D	1
Peña, JC	1
Fichman, MP	1
Telfer, N	1
Zia, P	1
Speckart, P	1
Golub, M	1
Rude, R	1
Galvez, OG	1
Bay, WH	1
Roberts, BW	1
Ferris, TF	1
Dequiedt, P	1
Lefebvre, J	1
Raviart, B	1
Vanhille, P	1
Lepoutre, E	1
Lelièvre, G	1
Tacquet, A	1
Shriver, DA	1
Dove, PA	1
White, CB	1
Sandor, A	1
Rosenthale, ME	1
Verberckmoes, R	1
van Damme B, B	1
Clement, J	1
Amery, A	1
Michielsen, P	1
Hial, V	1
Horakova, Z	1
Shaff, FE	1
Beaven, MA	1
Negus, P	1
Tannen, RL	1
Dunn, MJ	1
Watson, M	1
Pugsley, DJ	2
Mullins, R	1
Beilin, LJ	2
Peto, R	1
Fredholm, BB	1
Hedqvist, P	1
Awouters, F	1
Niemegeers, CJ	1
Lenaerts, FM	1
Janssen, PA	1
Mizukami, Y	2
Nonomura, A	1
Noguchi, M	2
Taniya, T	2
Thomas, M	1
Nakamura, S	1
Miyazaki, I	2
Stonier, C	1
Bennett, J	1
Messenger, EA	1
Aber, GM	1
Kiberd, BA	1
Goerttler, K	1
Edler, L	1
Loehrke, H	1
Murray, MD	1
Greene, PK	1
Brater, DC	1
Manatunga, AK	1
Hall, SD	1
Fulton, DJ	1
Takenaka, T	2
Suzuki, H	1
Sakamaki, Y	1
Itaya, Y	1
Saruta, T	1
Koyasaki, N	1
Kumaki, T	1
Isogai, T	1
Taki, F	1
Suzuki, K	2
Takagi, K	1
Satake, T	1
Gelin, J	1
Andersson, C	1
Abate, MA	1
Neely, JL	1
Layne, RD	1
D'Alessandri, R	1
Oberto, G	1
Conz, A	1
Giachetti, C	1
Galli, CL	1
Lauriault, V	1
Grasso, P	1
Powell, CJ	1
Wight, JP	1
Bassett, AH	1
Le Carpentier, JE	1
el Nahas, AM	1
Oberlin, F	1
Maistre, G	1
Alcaix, D	1
Giral, P	1
Bruckert, E	1
Lamaire, L	1
Carayon, A	1
O'Reilly, M	1
Gamelli, RL	1
Gerber, JG	1
LoVerde, M	1
Byyny, RL	1
Nies, AS	1
Goto, M	1
Zeller, WP	1
Hurley, RM	1
Dhawan, V	1
Ganguly, NK	1
Majumdar, S	1
Chakravarti, RN	1
Rump, LC	1
Wilde, K	1
Schollmeyer, P	1
Tochner, Z	1
Barnes, M	1
Mitchell, JB	1
Orr, K	1
Glatstein, E	1
Russo, A	1
Cadranel, J	1
Philippe, C	1
Perez, J	1
Milleron, B	1
Akoun, G	1
Ardaillou, R	1
Baud, L	1
Knoers, N	1
Monnens, LA	1
Flores, EA	1
Drabik, M	1
Gauldie, J	1
Blackburn, GL	1
Dinarello, CA	1
Bistrian, BR	1
Kohashi, N	1
Okabayashi, T	1
Horiuchi, M	1
Nishiyama, H	1
Katori, R	1
Homem-de-Bittencourt Júnior, PI	1
Pontieri, V	1
Curi, R	1
Lopes, OU	1
Wong, O	1
Huntington, J	1
Nishihata, T	1
Rytting, JH	1
Tanaka, Y	1
Yamada, K	1
Bandô, Y	1
Geller, HS	1
Nyhan, DP	1
Goll, HM	1
Clougherty, PW	1
Chen, BB	1
Murray, PA	1
Pirozzi, SJ	1
Renz, JF	1
Kalf, GF	1
Sametz, W	1
Juan, H	1
Alexander, JW	1
Saito, H	1
Trocki, O	1
Ogle, CK	1
Tsuruta, K	1
Mori, N	1
Takahashi, M	1
Narisawa, T	1
Masuda, T	1
Nagasawa, O	1
Yoshioka, H	1
Koyama, H	1
Inoue, T	1
Masuda, A	1
Tsuda, H	1
Miller, PD	1
Ainsworth, D	1
Lam, HF	1
Amdur, MO	1
Furst, S	1
Gyires, K	1
Knoll, J	1
Goran, MI	1
Little, RA	1
Frayn, KN	1
Jones, R	1
Fozzard, G	1
Inauen, W	1
Wyss, PA	1
Kayser, S	1
Baumgartner, A	1
Schürer-Maly, CC	1
Koelz, HR	1
Halter, F	1
Agrawal, DK	1
McNeill, JH	1
Logan, JL	1
Lee, SM	1
Benson, B	1
Michael, UF	1
Stahl, RA	1
Kudelka, S	1
Helmchen, U	1
May, RC	1
Kelly, RA	1
Mitch, WE	1
Borges, HF	1
Kjellstrand, CM	1
Lowell, BB	1
Ruderman, NB	1
Goodman, MN	1
Tsurumi, K	2
Kokuba, S	1
Okada, K	1
Yanagihara, M	1
Fujimura, H	1
Nagasawa, H	1
Naito, T	1
Randall, CL	1
Anton, RF	1
Becker, HC	1
Whiting, SJ	1
Whitney, HL	1
Rogers, DF	1
Jeffery, PK	1
Jensen, PK	1
Steven, K	1
Blaehr, H	1
Christiansen, JS	1
Parving, HH	1
Hidaka, T	1
Hosoe, K	1
Yamashita, T	1
Watanabe, K	1
Koopmans, PP	1
Kateman, WG	1
Tan, Y	1
van Ginneken, CA	1
Gribnau, FW	1
Shimokawa, H	1
Tomoike, H	1
Nabeyama, S	1
Nakamura, M	1
Rabbani, GH	1
Butler, T	1
Eskew, ML	1
Scholz, RW	1
Reddy, CC	1
Todhunter, DA	1
Zarkower, A	1
Weissenborn, U	1
Maedge, S	1
Buettner, D	1
Sewing, KF	1
Zídek, Z	1
Masek, K	1
Wilhelmi, G	1
Menassé-Gdynia, R	1
DiPasquale, G	1
Welaj, P	1
Bonney, WW	1
Feldbush, TL	1
Neufeld, SE	1
Sofia, RD	2
Vassar, HB	1
Nalepa, SD	1
Douglas, JF	1
Platt, DS	1
Cockrill, BL	1
Leary, WP	1
Ledingham, JG	1
Vane, JR	1
Shakhbazian, IE	1
Ulybina, OV	1
El'iashevich, VIa	1
Jacoby, HI	1
Marshall, CH	1
Gupta, N	1
Levy, L	1
Tashjian, AH	1
Voelkel, EF	1
Goldhaber, P	1
Levine, L	1
Van Arman, CG	1
Nuss, GW	1
Risley, EA	1
Hiramatsu, Y	1
Yamaguchi, A	1
Hayashi, M	1
Shibuya, T	1
De Cato, L	1
Brown, JK	1
Malone, MH	1
Ehara, N	1
Nagashima, M	1
Stjärne, L	1
Hamberg, M	1
Samuelsson, B	1
Iizuka, Y	1
Tanaka, K	1
Gaetani, M	1
Debeus, R	1
Vidi, A	1
Coppi, G	1
Kobayakawa, T	1
Walz, DT	1
DiMartino, MJ	1
Misher, A	1
Fukuhara, M	2
Tsurufuji, S	2