Page last updated: 2024-10-29

indomethacin and Biliary or Urinary Stones

indomethacin has been researched along with Biliary or Urinary Stones in 2 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
" One thousand three hundred and seventy patients with chronic pancreatitis and pancreatic stones (>5 mm in diameter) treated with P-ESWL at Changhai Hospital will be randomly allocated to rectally administered indomethacin or placebo therapy before the procedure."9.24Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial. ( Chen, H; Du, YQ; Hu, LH; Jiang, X; Jin, ZD; Li, B; Li, ZS; Liao, Z; Liu, F; Qi, YF; Qian, W; Qian, YY; Tang, XY; Wang, D; Wang, LW; Xin, L; Zou, DW; Zou, WB, 2017)
" One thousand three hundred and seventy patients with chronic pancreatitis and pancreatic stones (>5 mm in diameter) treated with P-ESWL at Changhai Hospital will be randomly allocated to rectally administered indomethacin or placebo therapy before the procedure."5.24Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial. ( Chen, H; Du, YQ; Hu, LH; Jiang, X; Jin, ZD; Li, B; Li, ZS; Liao, Z; Liu, F; Qi, YF; Qian, W; Qian, YY; Tang, XY; Wang, D; Wang, LW; Xin, L; Zou, DW; Zou, WB, 2017)
"Pancreatitis is the most common complication of pancreatic extracorporeal shock wave lithotripsy (ESWL)."3.11Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial. ( Chen, H; Du, YQ; Guo, JY; Hu, LH; Jin, ZD; Li, B; Li, ZS; Liao, Z; Pan, J; Qian, YY; Ru, N; Tang, XY; Wang, D; Wang, LW; Wu, H; Xin, L; Zou, WB, 2022)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Qian, YY2
Ru, N1
Chen, H2
Zou, WB2
Wu, H1
Pan, J1
Li, B2
Xin, L2
Guo, JY1
Tang, XY2
Hu, LH2
Jin, ZD2
Wang, D2
Du, YQ2
Wang, LW2
Li, ZS2
Liao, Z2
Jiang, X1
Qian, W1
Qi, YF1
Zou, DW1
Liu, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Rectally Administered Indomethacin to Prevent Post-ESWL-pancreatitis (RIPEP)[NCT02797067]Phase 41,370 participants (Actual)Interventional2016-05-31Completed
Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis: A Multicenter, Prospective, Randomized Clinical Trial[NCT05772234]1,066 participants (Anticipated)Interventional2023-11-17Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

the Incidence of Post-ESWL Pancreatitis

Patients were identified as post-ESWL pancreatitis if meeting two out of three criteria: pain consistent with acute pancreatitis; amylase or lipase>3 times normal limit; characteristic findings on imaging, in according to the Revised Atlanta International consensus. (NCT02797067)
Timeframe: up to 1 months

InterventionParticipants (Count of Participants)
Indomethacin60
Glycerin84

the Incidence and Severity of Asymptomatic Hyperamylasemia and Other Post-ESWL Complications

"Asymptomatic hyperamylasemia was defined as an increase in serum amylase compared with pre-ESWL levels and beyond the upper limit of the normal range but showing no related symptoms. Serum amylase will be measured in all study patients at 3 and 24 hours after the procedure and subsequently at clinical discretion.~Other post-ESWL complications including bleeding, infection, steinstrasse and perforation.~Bleeding is related to clinical evidence,the level of hemoglobin ( measured at 24 hours after the procedure and at clinical discretion) and treatments.~Infection is related to temperature and treatment. Steinstrasse is related to abdominal pain degree and the combination of other complications.~Perforation is related to treatment." (NCT02797067)
Timeframe: up to 1 months

,
InterventionParticipants (Count of Participants)
InfectionSteinstrassePerforationAsymptomatic HyperamylasemiaHematuriaHematemesisMelena
Glycerin1311197251416
Indomethacin50018918919

the Severity of Post-ESWL Pancreatitis Measured as Consensus Definitions for the Major Complications of ERCP(Endoscopic Retrograde Cholangiopancreatography )

Post-ESWL complications are also stratified as mild, moderate and severe depending mainly on the length of hospitalization and the need for invasive treatment. (NCT02797067)
Timeframe: up to 1 months

,
InterventionParticipants (Count of Participants)
MildModerateSevere
Glycerin7950
Indomethacin5910

Trials

2 trials available for indomethacin and Biliary or Urinary Stones

ArticleYear
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome

2022
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome

2022
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome

2022
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome

2022
Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial.
    Trials, 2017, Nov-02, Volume: 18, Issue:1

    Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Calculi; China; Clinical Protocols;

2017