indomethacin has been researched along with Biliary or Urinary Stones in 2 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Excerpt | Relevance | Reference |
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" One thousand three hundred and seventy patients with chronic pancreatitis and pancreatic stones (>5 mm in diameter) treated with P-ESWL at Changhai Hospital will be randomly allocated to rectally administered indomethacin or placebo therapy before the procedure." | 9.24 | Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial. ( Chen, H; Du, YQ; Hu, LH; Jiang, X; Jin, ZD; Li, B; Li, ZS; Liao, Z; Liu, F; Qi, YF; Qian, W; Qian, YY; Tang, XY; Wang, D; Wang, LW; Xin, L; Zou, DW; Zou, WB, 2017) |
" One thousand three hundred and seventy patients with chronic pancreatitis and pancreatic stones (>5 mm in diameter) treated with P-ESWL at Changhai Hospital will be randomly allocated to rectally administered indomethacin or placebo therapy before the procedure." | 5.24 | Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial. ( Chen, H; Du, YQ; Hu, LH; Jiang, X; Jin, ZD; Li, B; Li, ZS; Liao, Z; Liu, F; Qi, YF; Qian, W; Qian, YY; Tang, XY; Wang, D; Wang, LW; Xin, L; Zou, DW; Zou, WB, 2017) |
"Pancreatitis is the most common complication of pancreatic extracorporeal shock wave lithotripsy (ESWL)." | 3.11 | Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial. ( Chen, H; Du, YQ; Guo, JY; Hu, LH; Jin, ZD; Li, B; Li, ZS; Liao, Z; Pan, J; Qian, YY; Ru, N; Tang, XY; Wang, D; Wang, LW; Wu, H; Xin, L; Zou, WB, 2022) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 1 (50.00) | 2.80 |
Authors | Studies |
---|---|
Qian, YY | 2 |
Ru, N | 1 |
Chen, H | 2 |
Zou, WB | 2 |
Wu, H | 1 |
Pan, J | 1 |
Li, B | 2 |
Xin, L | 2 |
Guo, JY | 1 |
Tang, XY | 2 |
Hu, LH | 2 |
Jin, ZD | 2 |
Wang, D | 2 |
Du, YQ | 2 |
Wang, LW | 2 |
Li, ZS | 2 |
Liao, Z | 2 |
Jiang, X | 1 |
Qian, W | 1 |
Qi, YF | 1 |
Zou, DW | 1 |
Liu, F | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Rectally Administered Indomethacin to Prevent Post-ESWL-pancreatitis (RIPEP)[NCT02797067] | Phase 4 | 1,370 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis: A Multicenter, Prospective, Randomized Clinical Trial[NCT05772234] | 1,066 participants (Anticipated) | Interventional | 2023-11-17 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Patients were identified as post-ESWL pancreatitis if meeting two out of three criteria: pain consistent with acute pancreatitis; amylase or lipase>3 times normal limit; characteristic findings on imaging, in according to the Revised Atlanta International consensus. (NCT02797067)
Timeframe: up to 1 months
Intervention | Participants (Count of Participants) |
---|---|
Indomethacin | 60 |
Glycerin | 84 |
"Asymptomatic hyperamylasemia was defined as an increase in serum amylase compared with pre-ESWL levels and beyond the upper limit of the normal range but showing no related symptoms. Serum amylase will be measured in all study patients at 3 and 24 hours after the procedure and subsequently at clinical discretion.~Other post-ESWL complications including bleeding, infection, steinstrasse and perforation.~Bleeding is related to clinical evidence,the level of hemoglobin ( measured at 24 hours after the procedure and at clinical discretion) and treatments.~Infection is related to temperature and treatment. Steinstrasse is related to abdominal pain degree and the combination of other complications.~Perforation is related to treatment." (NCT02797067)
Timeframe: up to 1 months
Intervention | Participants (Count of Participants) | ||||||
---|---|---|---|---|---|---|---|
Infection | Steinstrasse | Perforation | Asymptomatic Hyperamylasemia | Hematuria | Hematemesis | Melena | |
Glycerin | 13 | 1 | 1 | 197 | 25 | 14 | 16 |
Indomethacin | 5 | 0 | 0 | 189 | 18 | 9 | 19 |
Post-ESWL complications are also stratified as mild, moderate and severe depending mainly on the length of hospitalization and the need for invasive treatment. (NCT02797067)
Timeframe: up to 1 months
Intervention | Participants (Count of Participants) | ||
---|---|---|---|
Mild | Moderate | Severe | |
Glycerin | 79 | 5 | 0 |
Indomethacin | 59 | 1 | 0 |
2 trials available for indomethacin and Biliary or Urinary Stones
Article | Year |
---|---|
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome | 2022 |
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome | 2022 |
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome | 2022 |
Rectal indometacin to prevent pancreatitis after extracorporeal shock wave lithotripsy (RIPEP): a single-centre, double-blind, randomised, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calculi; Double-Blind Method; Female; Humans; Indome | 2022 |
Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Calculi; China; Clinical Protocols; | 2017 |