indomethacin has been researched along with Bile Duct Obstruction in 22 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with no prior history of liver disease developed mild cholestasis, with a moderate elevation of the serum alkaline phosphatase level, several days after instituting indomethacin therapy." | 8.77 | Indomethacin-associated cholestasis. ( Cappell, MS; Competiello, LS; Kozicky, O, 1988) |
| "Hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) infants is routinely treated in many countries with oral ibuprofen." | 8.02 | Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus. ( Guo, H; Huang, Y; Lin, HC; Liu, H; Peng, H; Shen, X; Yao, S; Zhou, M; Zhou, P, 2021) |
| "Indomethacin is a well tolerated non-steroidal inflammatory drug (NSAID) widely used in the treatment of pericarditis but it can provoke acute renal failure." | 5.40 | Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report. ( Bonura, S; Colomba, C; Madonia, S; Rubino, R; Siracusa, L, 2014) |
| "A patient with no prior history of liver disease developed mild cholestasis, with a moderate elevation of the serum alkaline phosphatase level, several days after instituting indomethacin therapy." | 4.77 | Indomethacin-associated cholestasis. ( Cappell, MS; Competiello, LS; Kozicky, O, 1988) |
| "Hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) infants is routinely treated in many countries with oral ibuprofen." | 4.02 | Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus. ( Guo, H; Huang, Y; Lin, HC; Liu, H; Peng, H; Shen, X; Yao, S; Zhou, M; Zhou, P, 2021) |
| " 19, (e) the effect of indomethacin, and (f) the role of increased biliary pressure, in the absence of physiological and biochemical evidence of cholestasis, on [3H]thymidine incorporation by the bile-duct cells." | 3.68 | Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat. ( Liu, MH; Slott, PA; Tavoloni, N, 1990) |
| " This was complicated by prerenal oliguria due to indomethacin therapy and liver dysfunction." | 3.68 | Acute prerenal failure and liver dysfunction in a patient with severe ovarian hyperstimulation syndrome. ( Arroyo, V; Balasch, J; Carmona, F; Jové, I; Llach, J; Vanrell, JA, 1990) |
| "Indomethacin is a well tolerated non-steroidal inflammatory drug (NSAID) widely used in the treatment of pericarditis but it can provoke acute renal failure." | 1.40 | Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report. ( Bonura, S; Colomba, C; Madonia, S; Rubino, R; Siracusa, L, 2014) |
| "Indomethacin was administered orally in a dose-dependent manner at 10, 30, and 45 mg/ kg." | 1.30 | Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats. ( Amanlou, M; Amanpour, S; Bahadori, M; Dehpour, AR; Mani, AR; Nahavandi, A, 1999) |
| "Indomethacin prevented the increase in urinary PG excretion otherwise seen with BDL and resulted in an additional 41% reduction in UNaV (p = 0." | 1.28 | Obstructive jaundice and renal failure in the rat: the role of renal prostaglandins and the renin-angiotensin system. ( Kahng, KU; O'Neill, P; Wait, RB, 1990) |
| " The dose-response curves were significantly depressed in both MRAs and ILAs from BDL animals." | 1.27 | Renal vascular reactivity in jaundice. ( Cioffi, WG; DeMeules, JE; Kahng, KU; Wait, RB, 1986) |
| "Pretreatment with indomethacin 3 mg/kg i." | 1.26 | Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. ( Fletcher, MS; Kakkar, VV; Westwick, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, X | 1 |
| Huang, Y | 1 |
| Guo, H | 1 |
| Peng, H | 1 |
| Yao, S | 2 |
| Zhou, M | 1 |
| Liu, H | 1 |
| Lin, HC | 1 |
| Zhou, P | 1 |
| Kang, X | 1 |
| Zheng, L | 1 |
| Zeng, W | 1 |
| Yang, S | 1 |
| Sun, H | 1 |
| Zhang, R | 1 |
| Wang, X | 1 |
| Wang, B | 1 |
| Tao, Q | 1 |
| Chen, J | 1 |
| Pan, Y | 1 |
| Guo, X | 1 |
| Colomba, C | 1 |
| Siracusa, L | 1 |
| Madonia, S | 1 |
| Bonura, S | 1 |
| Rubino, R | 1 |
| Fletcher, MS | 1 |
| Westwick, J | 1 |
| Kakkar, VV | 1 |
| Thornell, E | 1 |
| Dehpour, AR | 2 |
| Mani, AR | 1 |
| Amanlou, M | 1 |
| Nahavandi, A | 1 |
| Amanpour, S | 1 |
| Bahadori, M | 1 |
| Rastegar, H | 1 |
| Jorjani, M | 1 |
| Roushanzamir, F | 1 |
| Ahmadiani, A | 1 |
| Namiranian, K | 1 |
| Schilling, F | 1 |
| Siegmund, H | 2 |
| Kuroda, T | 1 |
| Kajikawa, S | 1 |
| Hanazaki, K | 1 |
| Horigome, N | 1 |
| Sodeyama, H | 1 |
| Horiuchi, A | 1 |
| Iwatsuki, K | 1 |
| Chiba, S | 1 |
| Homma, T | 1 |
| Iida, F | 1 |
| Slott, PA | 1 |
| Liu, MH | 1 |
| Tavoloni, N | 1 |
| Akerboom, T | 1 |
| Schneider, I | 1 |
| vom Dahl, S | 1 |
| Sies, H | 1 |
| Lichtman, SN | 1 |
| Sartor, RB | 1 |
| Balasch, J | 1 |
| Carmona, F | 1 |
| Llach, J | 1 |
| Arroyo, V | 1 |
| Jové, I | 1 |
| Vanrell, JA | 1 |
| O'Neill, P | 1 |
| Wait, RB | 2 |
| Kahng, KU | 2 |
| Schneider, HT | 1 |
| Nuernberg, B | 1 |
| Dietzel, K | 1 |
| Brune, K | 1 |
| Victorino, RM | 1 |
| Maria, VA | 1 |
| Komoda, T | 1 |
| Koyama, I | 1 |
| Nagata, A | 1 |
| Sakagishi, Y | 1 |
| Kurata, M | 1 |
| Kumegawa, M | 1 |
| Cappell, MS | 1 |
| Kozicky, O | 1 |
| Competiello, LS | 1 |
| Terhaag, B | 1 |
| Hermann, U | 1 |
| Cioffi, WG | 1 |
| DeMeules, JE | 1 |
| Sun, DC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Risk Factors Related to Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-risk Patients Who Underwent ERCP and Received Prophylactic Rectal Indomethacin[NCT02709421] | 790 participants (Actual) | Observational | 2016-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Bile Duct Obstruction
| Article | Year |
|---|---|
Indomethacin-associated cholestasis.
Topics: Cholestasis; Female; Humans; Indomethacin; Middle Aged | 1988 |
21 other studies available for indomethacin and Bile Duct Obstruction
| Article | Year |
|---|---|
Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus.
Topics: Birth Weight; Cholestasis; Ductus Arteriosus, Patent; Emulsions; Humans; Ibuprofen; Indomethacin; In | 2021 |
Risk Factors for Post-ERCP Pancreatitis in High-Risk Patients Receiving Post-procedure Rectal Indomethacin.
Topics: Administration, Rectal; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Chola | 2018 |
Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cholestasis; Endotoxins; Epoprostenol; Escherichia coli; Fibr | 1982 |
Effects of raised intraluminal pressure on gallbladder function and hepatic bile outflow in the cat.
Topics: Animals; Bile; Cats; Cholecystitis; Cholestasis; Disease Models, Animal; Gallbladder; Indomethacin; | 1981 |
Naloxone is protective against indomethacin-induced gastric damage in cholestatic rats.
Topics: Animals; Cholestasis; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Male; Naloxone | 1999 |
Time-dependent reduction of acetylcholine-induced relaxation in aortic rings of cholestatic rats.
Topics: Acetylcholine; Animals; Aorta; Arginine; Cholestasis; Cyclooxygenase Inhibitors; Endothelium, Vascul | 2001 |
[Intrahepatic cholestasis following treatment with penicillamine D and indomethacine].
Topics: Cholestasis; Humans; Indomethacin; Penicillamine; Rheumatic Diseases | 1976 |
[Intrahepatic cholestasis following treatment with D-penicillamine and indomethacin].
Topics: Adult; Arthritis, Rheumatoid; Cholestasis; Drug Therapy, Combination; Female; Humans; Indomethacin; | 1976 |
Enhanced production of endogenous prostaglandin in obstructive jaundiced pancreas in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Amylases; Animals; Cells, Cultured; Cholestasis; Chromatography, High | 1990 |
Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat.
Topics: Animals; Autoradiography; Bile Ducts, Intrahepatic; Cell Division; Cholestasis; Common Bile Duct; Hy | 1990 |
Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver.
Topics: Animals; Bile; Blood Pressure; Chlorpromazine; Cholestasis; Cyclooxygenase Inhibitors; Indomethacin; | 1991 |
Duct proliferation following biliary obstruction in the rat.
Topics: Animals; Bile Ducts; Cholestasis; Hyperplasia; Indomethacin; Kupffer Cells; Rats | 1991 |
Acute prerenal failure and liver dysfunction in a patient with severe ovarian hyperstimulation syndrome.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anuria; Cholestasis; Female; Fertilization in Vitro; | 1990 |
Obstructive jaundice and renal failure in the rat: the role of renal prostaglandins and the renin-angiotensin system.
Topics: Acute Kidney Injury; Animals; Bile Ducts; Cholestasis; Indomethacin; Kidney; Ligation; Male; Prostag | 1990 |
Biliary elimination of non-steroidal anti-inflammatory drugs in patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cholestasis; Common B | 1990 |
Modifications of the lymphocyte transformation test in a case of drug-induced cholestatic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Erythromycin; Erythromycin Ethylsuccinat | 1985 |
A possible mechanism of induction and translocation into blood stream of rat alkaline phosphatase activity by bile duct ligation.
Topics: Alkaline Phosphatase; Animals; Bile Ducts; Bone and Bones; Calmodulin; Chlorpromazine; Cholestasis; | 1986 |
Biliary elimination of indomethacin in man.
Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholestasis; Cholesterol; Humans; Indomethacin; Kinetics; M | 1986 |
Renal vascular reactivity in jaundice.
Topics: Acute Kidney Injury; Animals; Cholestasis; Female; Indomethacin; Kidney; Norepinephrine; Postoperati | 1986 |
Iatrogenic gastrointestinal diseases in the aged.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Cathartics; Chemical and Drug Induced Li | 1972 |