indomethacin has been researched along with B16 Melanoma in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "B16 melanoma-bearing mice were treated with anti-interleukin 4 antibody, indomethacin or its combination to evaluate the ability of the primary tumor to induce lung metastasis and the antitumor host response." | 7.69 | Anti-interleukin 4 antibody and indomethacin synergistic effect on B16 melanoma tumor progression. ( Aliño, SF; Blaya, C; Crespo, A; Crespo, J, 1996) |
| " We report that indomethacin, a nonspecific inhibitor of COX, and NS398, a specific inhibitor of COX2, preserved muscle mass and reduced type 1 TNF receptors in muscles of mice bearing the Lewis lung carcinoma, but not in mice bearing the B16 melanoma." | 3.73 | Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. ( Graves, E; McCarthy, DO; Ramsay, E, 2006) |
| "B16 melanoma-bearing mice were treated with anti-interleukin 4 antibody, indomethacin or its combination to evaluate the ability of the primary tumor to induce lung metastasis and the antitumor host response." | 3.69 | Anti-interleukin 4 antibody and indomethacin synergistic effect on B16 melanoma tumor progression. ( Aliño, SF; Blaya, C; Crespo, A; Crespo, J, 1996) |
| " As determined by Toxilight-cytotoxicity assay, the drug was only toxic to the cancer cells at 100 microM." | 1.33 | Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. ( Chiu, LC; Ooi, VE; Tong, KF, 2005) |
| "We have shown that macrophage-derived prostaglandin (PG)E2 inactivates all interleukin 2 (IL-2) dependent killer cell lineages in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 can cure experimental and spontaneous metastases of a variety of murine tumors." | 1.28 | Cure of human melanoma lung metastases in nude mice with chronic indomethacin therapy combined with multiple rounds of IL-2: characteristics of killer cells generated in situ. ( Elkashab, M; Kerbel, RS; Lala, PK; Parhar, RS, 1990) |
| " The present study examined whether a lasting cure of metastasis is obtainable by chronic indomethacin therapy (CIT) combined with single or multiple rounds of IL-2, and if so, what are the morphological, phenotypic, and functional properties of tumoricidal cells generated in situ." | 1.27 | Cure of B16F10 melanoma lung metastasis in mice by chronic indomethacin therapy combined with repeated rounds of interleukin 2: characteristics of killer cells generated in situ. ( Lala, PK; Parhar, RS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 9 (50.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, K | 1 |
| Takei, M | 1 |
| Iyota, R | 1 |
| Muraoka, Y | 1 |
| Nagashima, M | 1 |
| Yoshimura, Y | 1 |
| Chiu, LC | 1 |
| Tong, KF | 1 |
| Ooi, VE | 1 |
| Graves, E | 1 |
| Ramsay, E | 1 |
| McCarthy, DO | 1 |
| Kudriatsev, IA | 1 |
| Taranenko, IP | 1 |
| Kudriavtsev, IA | 1 |
| Miasishcheva, NV | 1 |
| Suzuki, M | 1 |
| Li, J | 1 |
| Asakura, T | 1 |
| Arai, K | 1 |
| Blaya, C | 1 |
| Crespo, J | 1 |
| Crespo, A | 1 |
| Aliño, SF | 2 |
| Chikatsu, N | 1 |
| Takeuchi, Y | 1 |
| Tamura, Y | 1 |
| Fukumoto, S | 1 |
| Yano, K | 1 |
| Tsuda, E | 1 |
| Ogata, E | 1 |
| Fujita, T | 1 |
| Nakaya, K | 1 |
| Mizuno, R | 1 |
| Ohhashi, T | 1 |
| Unda, FJ | 1 |
| Iruarrizaga, A | 1 |
| Alfaro, J | 1 |
| Hilario, E | 1 |
| Pérez-Yarza, G | 1 |
| Bobadilla, M | 1 |
| Lejarreta, M | 1 |
| Koval'chuk, LV | 1 |
| Karimova, EV | 1 |
| Gankovskaia, LV | 1 |
| Karaseva, MV | 1 |
| Aptsiauri, NE | 1 |
| Sokolova, EV | 1 |
| Titovets, RE | 1 |
| Lala, PK | 3 |
| Elkashab, M | 1 |
| Kerbel, RS | 1 |
| Parhar, RS | 3 |
| Ferrario, A | 1 |
| Gomer, CJ | 1 |
| Eisenthal, A | 1 |
| Nakata, K | 1 |
| Kashimoto, S | 1 |
| Yoshida, H | 1 |
| Oku, T | 1 |
| Nakamura, S | 1 |
| Ashley, MP | 1 |
| Kotlarski, I | 1 |
| Vari, F | 1 |
18 other studies available for indomethacin and B16 Melanoma
| Article | Year |
|---|---|
Indomethacin inhibits melanogenesis via down-regulation of Mitf mRNA transcription.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Indomethacin; Intracellular Space; M | 2017 |
Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells.
Topics: Antineoplastic Agents; Aspirin; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cyclooxygen | 2005 |
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Topics: Analysis of Variance; Animals; Cachexia; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Female; I | 2006 |
[Growth of experimental neoplasms in mice with inhibition of endogenous prostaglandin synthesis].
Topics: Animals; Dinoprostone; Humans; Indomethacin; Leukemia, Experimental; Male; Melanoma, Experimental; M | 1994 |
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice].
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Animals; Arachidonic Acid; Carcinoma, Le | 1995 |
Opposing effects of indomethacin and nordihydroguaiaretic acid on macrophage function and tumor growth.
Topics: Animals; Cell Division; Dinoprostone; Ethanol; Indomethacin; Injections, Intraperitoneal; Macrophage | 1994 |
Anti-interleukin 4 antibody and indomethacin synergistic effect on B16 melanoma tumor progression.
Topics: Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; CD4-Positive T-Lymphocytes; C | 1996 |
Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in vitro.
Topics: Animals; Base Sequence; Bone Marrow Cells; Bone Neoplasms; Carrier Proteins; Cell Adhesion; Cocultur | 2000 |
B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels.
Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biological Assay; Culture Media, Conditioned; Cyclooxygen | 2001 |
Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 tumor cells.
Topics: Animals; Carcinoma; Chromatography, High Pressure Liquid; Dinoprostone; Drug Carriers; Indomethacin; | 1992 |
[Cytokine-dependent regulation of the production of TNF alpha and active forms of oxygen by macrophages of intact mice and mice with B16 melanoma].
Topics: Animals; Cytokines; Indomethacin; Kinetics; Luminescent Measurements; Macrophages; Melanoma, Experim | 1991 |
Cure of human melanoma lung metastases in nude mice with chronic indomethacin therapy combined with multiple rounds of IL-2: characteristics of killer cells generated in situ.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Indomethacin; Interleukin-2 | 1990 |
Systemic toxicity in mice induced by localized porphyrin photodynamic therapy.
Topics: Animals; Aspirin; Blood Cell Count; Dihematoporphyrin Ether; Dose-Response Relationship, Radiation; | 1990 |
Indomethacin up-regulates the generation of lymphokine-activated killer-cell activity and antibody-dependent cellular cytotoxicity mediated by interleukin-2.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Dinoprostone; Dose-Response Relationship, Drug; Femal | 1990 |
Cure of B16F10 melanoma lung metastasis in mice by chronic indomethacin therapy combined with repeated rounds of interleukin 2: characteristics of killer cells generated in situ.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Indomethacin; Interleukin-2; Killer Cells, | 1988 |
Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin.
Topics: Adenocarcinoma; Animals; Cell Division; Drug Administration Schedule; Drug Synergism; Indomethacin; | 1988 |
Amelioration of B16F10 melanoma lung metastasis in mice by a combination therapy with indomethacin and interleukin 2.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytotoxicity, Immunologic; Immunotherapy; I | 1987 |
Defects in tumor cell immunogenicity: lymphokine signals in in vitro cytolytic responses to tumor alloantigens.
Topics: Animals; Antigens, Neoplasm; Cytotoxicity, Immunologic; H-2 Antigens; In Vitro Techniques; Indometha | 1987 |