indomethacin has been researched along with Atherogenesis in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis." | 3.85 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. ( Katselou, MG; Kourounakis, AP; Matralis, AN, 2017) |
| "001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes observed in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia, the impairment of kidney functions, and the risks for cardiovascular disease in arthritic rats." | 3.79 | Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. ( El-Menshawy, O; Ramadan, G, 2013) |
| "Inflammation is the main driver of the aggravation of arteriosclerosis, and the complex inflammatory response in plaque is usually the result of the interaction of various cells and cytokines." | 1.72 | Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy. ( Duan, Y; Gong, K; Guo, Q; Jing, H; Li, Z; Lin, J; Tian, Y; Wang, L; Wang, Q; Wu, Z; Yang, X, 2022) |
| "Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design." | 1.40 | Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. ( Kourounakis, AP; Matralis, AN, 2014) |
| "Although long-term use of cyclooxygenase (COX)-2 inhibitors may be associated with increased cardiovascular risk, their effects on vascular reactivity in atherosclerosis has remained largely unexplored." | 1.35 | Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. ( Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M, 2009) |
| "Atherosclerosis is the most important single factor contributing to this disease burden." | 1.33 | Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease. ( Henderson, KK; Laughlin, MH; Turk, JR; Vanvickle, GD; Watkins, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Matralis, AN | 2 |
| Kourounakis, AP | 2 |
| Katselou, MG | 1 |
| Wang, Q | 1 |
| Jing, H | 1 |
| Lin, J | 1 |
| Wu, Z | 1 |
| Tian, Y | 1 |
| Gong, K | 1 |
| Guo, Q | 1 |
| Yang, X | 1 |
| Wang, L | 1 |
| Li, Z | 1 |
| Duan, Y | 1 |
| Ramadan, G | 1 |
| El-Menshawy, O | 1 |
| Marzoll, A | 1 |
| Nagy, N | 1 |
| Wördehoff, L | 1 |
| Dai, G | 1 |
| Fries, S | 1 |
| Lindner, V | 1 |
| Grosser, T | 1 |
| Fischer, JW | 1 |
| Foudi, N | 1 |
| Norel, X | 1 |
| Rienzo, M | 1 |
| Louedec, L | 1 |
| Brink, C | 1 |
| Michel, JB | 1 |
| Bäck, M | 1 |
| Bai, N | 1 |
| Tranfield, EM | 1 |
| Kavanagh, TJ | 1 |
| Kaufman, JD | 1 |
| Rosenfeld, ME | 1 |
| van Eeden, SF | 1 |
| Turk, JR | 1 |
| Henderson, KK | 1 |
| Vanvickle, GD | 1 |
| Watkins, J | 1 |
| Laughlin, MH | 1 |
8 other studies available for indomethacin and Atherogenesis
| Article | Year |
|---|---|
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; | 2014 |
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Mod | 2017 |
Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy.
Topics: Animals; Atherosclerosis; Endothelial Cells; Feedback; Heparin, Low-Molecular-Weight; Indomethacin; | 2022 |
Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Atherosclerosis; | 2013 |
Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Carotid Arteries; Cyclooxygenase Inhibitors; Disease Mo | 2009 |
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholester | 2009 |
Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout mice.
Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2012 |
Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Atherosclerosis; Bradykinin; Carotid Artery, Common; Chole | 2005 |