indomethacin has been researched along with Astrocytoma in 10 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compares the effect of gamma-linolenic acid (GLA) and its precursor linoleic acid (LA) on survival of 36B10 malignant rat astrocytoma cells and 'normal' rat astrocytes." | 7.70 | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. ( Davis, CS; McCaw, R; Robbins, ME; Spector, AA; Vartak, S, 1998) |
| "Substance P (SP) and lipopolysaccharide (LPS) stimulated interleukin-6 (IL-6) gene expression, as well as IL-6 protein secretion in the human astrocytoma cell line U373 MG." | 7.69 | Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation. ( Manzini, S; Palma, C; Urbani, F, 1995) |
| "This study compares the effect of gamma-linolenic acid (GLA) and its precursor linoleic acid (LA) on survival of 36B10 malignant rat astrocytoma cells and 'normal' rat astrocytes." | 3.70 | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. ( Davis, CS; McCaw, R; Robbins, ME; Spector, AA; Vartak, S, 1998) |
| "Substance P (SP) and lipopolysaccharide (LPS) stimulated interleukin-6 (IL-6) gene expression, as well as IL-6 protein secretion in the human astrocytoma cell line U373 MG." | 3.69 | Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation. ( Manzini, S; Palma, C; Urbani, F, 1995) |
| "Levels of indomethacin-sensitive, glass-adherent, preculture-sensitive, and lymphocyte-mediated immunoregulatory activity were measured in peripheral blood mononuclear cells from 12 patients with intracranial astrocytomas." | 3.66 | Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas. ( Braun, DP; Flannery, AM; Harris, JE; Penn, RD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 7 (70.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baqi, Y | 1 |
| Pillaiyar, T | 1 |
| Abdelrahman, A | 1 |
| Kaufmann, O | 1 |
| Alshaibani, S | 1 |
| Rafehi, M | 1 |
| Ghasimi, S | 1 |
| Akkari, R | 1 |
| Ritter, K | 1 |
| Simon, K | 1 |
| Spinrath, A | 1 |
| Kostenis, E | 1 |
| Zhao, Q | 1 |
| Köse, M | 1 |
| Namasivayam, V | 1 |
| Müller, CE | 1 |
| Braun, DP | 1 |
| Penn, RD | 1 |
| Flannery, AM | 1 |
| Harris, JE | 1 |
| Cadman, ED | 1 |
| Witte, DG | 1 |
| Lee, CM | 1 |
| Mollace, V | 3 |
| Colasanti, M | 1 |
| Rodino, P | 1 |
| Lauro, GM | 1 |
| Nistico, G | 2 |
| Palma, C | 1 |
| Urbani, F | 1 |
| Manzini, S | 1 |
| Muscoli, C | 1 |
| Rotiroti, D | 1 |
| Blom, MA | 1 |
| van Twillert, MG | 1 |
| de Vries, SC | 1 |
| Engels, F | 1 |
| Finch, CE | 1 |
| Veerhuis, R | 1 |
| Eikelenboom, P | 1 |
| Vartak, S | 1 |
| McCaw, R | 1 |
| Davis, CS | 1 |
| Robbins, ME | 1 |
| Spector, AA | 1 |
| van Muiswinkel, FL | 1 |
| Riemers, FM | 1 |
| Peters, GJ | 1 |
| LaFleur, MV | 1 |
| Siegel, D | 1 |
| Jongenelen, CA | 1 |
| Drukarch, B | 1 |
| Salvemini, D | 1 |
| Pistelli, A | 1 |
| Anggård, E | 1 |
| Vane, J | 1 |
10 other studies available for indomethacin and Astrocytoma
| Article | Year |
|---|---|
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Calcium; Humans; Indoles; Models, Molecular; Molecular | 2018 |
Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; DNA; Glioblastoma; Humans; Immunity, Cellular; Indomethac | 1982 |
Regulation of the release of interleukin-6 from human astrocytoma cells.
Topics: Adenylyl Cyclases; Alzheimer Disease; Astrocytoma; Calcium; Cycloheximide; Dinoprostone; Enzyme-Link | 1994 |
HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation.
Topics: Amino Acid Oxidoreductases; Arginine; Astrocytoma; Cell Line; Dinoprostone; Dose-Response Relationsh | 1994 |
Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation.
Topics: Alkaloids; Astrocytoma; Bucladesine; Calcimycin; Cholera Toxin; Humans; Indomethacin; Interleukin-6; | 1995 |
Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta.
Topics: Animals; Astrocytes; Astrocytoma; Cell Hypoxia; Cell-Free System; Dinoprostone; Humans; Indomethacin | 1997 |
NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Astrocytoma; Cyclooxy | 1997 |
Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes.
Topics: alpha-Linolenic Acid; Animals; Antineoplastic Agents; Antioxidants; Astrocytes; Astrocytoma; Brain N | 1998 |
L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Astrocytoma; Cells, Cultured; Dicumarol; Gene Expression Regu | 2000 |
Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: effect of E. coli lipopolysaccharide.
Topics: Arginine; Astrocytoma; Cyclic GMP; Escherichia coli; Humans; Indomethacin; Lipopolysaccharides; Nitr | 1992 |