indomethacin has been researched along with Astrocytoma, Grade IV in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma." | 9.14 | Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide. ( Bähr, O; Bamberg, M; Gorlia, T; Hartmann, C; Herrlinger, U; Meyermann, R; Tatagiba, M; von Deimling, A; Weiler, M; Weller, M; Wick, W; Wiewrodt, D, 2010) |
| "The in vitro antiproliferative and apoptosis inducing properties of the nonsteroidal anti-inflammatory drugs (NSAIDs) like acetyl salicylic acid (aspirin) and indomethacin were investigated in T98G human glioblastoma cells to explore their potential role in the chemoprevention of human glioma." | 7.72 | Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells. ( Amin, R; Eling, TE; Ishibashi, M; Islam, A; Kamitani, H; Sho, A; Sultana, H; Taniura, S; Watanabe, T, 2003) |
| "Thus, pretreatment of glioblastoma with an anti-inflammatory agent, either steroidal or non-steroidal, may compromise the action of a chemotherapeutic agent that mediates therapeutic action via oxidative stress." | 5.34 | Methylprednisolone and indomethacin inhibit oxidative stress mediated apoptosis in rat C6 glioblastoma cells. ( Banik, NL; Das, A; Ray, SK, 2007) |
| "To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma." | 5.14 | Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide. ( Bähr, O; Bamberg, M; Gorlia, T; Hartmann, C; Herrlinger, U; Meyermann, R; Tatagiba, M; von Deimling, A; Weiler, M; Weller, M; Wick, W; Wiewrodt, D, 2010) |
| " Flurbiprofen, indomethacin and other NSAIDs stimulated 15-PGDH activity in colon cancer HT29 cells as well as in lung cancer A549 cells and glioblastoma T98G cells." | 4.87 | Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). ( Chi, X; Tai, HH; Tong, M, 2011) |
| "In this study we investigated the expression of COX-1, COX-2 and COX-3 mRNA in C6 glioblastoma and normal brain tissues and the effects of acetaminophen, indomethacin or metamizole treatments on the development of C6 glioblastoma in relation with COX inhibition." | 3.83 | Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma. ( Atalar, F; Bilir, A; Oksuz, E; Shahzadi, A; Tanırverdi, G; Yazici, Z, 2016) |
| "The in vitro antiproliferative and apoptosis inducing properties of the nonsteroidal anti-inflammatory drugs (NSAIDs) like acetyl salicylic acid (aspirin) and indomethacin were investigated in T98G human glioblastoma cells to explore their potential role in the chemoprevention of human glioma." | 3.72 | Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells. ( Amin, R; Eling, TE; Ishibashi, M; Islam, A; Kamitani, H; Sho, A; Sultana, H; Taniura, S; Watanabe, T, 2003) |
| "Levels of indomethacin-sensitive, glass-adherent, preculture-sensitive, and lymphocyte-mediated immunoregulatory activity were measured in peripheral blood mononuclear cells from 12 patients with intracranial astrocytomas." | 3.66 | Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas. ( Braun, DP; Flannery, AM; Harris, JE; Penn, RD, 1982) |
| "Thus, pretreatment of glioblastoma with an anti-inflammatory agent, either steroidal or non-steroidal, may compromise the action of a chemotherapeutic agent that mediates therapeutic action via oxidative stress." | 1.34 | Methylprednisolone and indomethacin inhibit oxidative stress mediated apoptosis in rat C6 glioblastoma cells. ( Banik, NL; Das, A; Ray, SK, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zmuda, F | 1 |
| Malviya, G | 1 |
| Blair, A | 1 |
| Boyd, M | 1 |
| Chalmers, AJ | 1 |
| Sutherland, A | 1 |
| Pimlott, SL | 1 |
| Bernardi, A | 1 |
| Frozza, RL | 1 |
| Hoppe, JB | 1 |
| Salbego, C | 1 |
| Pohlmann, AR | 2 |
| Battastini, AM | 1 |
| Guterres, SS | 2 |
| Oksuz, E | 1 |
| Atalar, F | 1 |
| Tanırverdi, G | 1 |
| Bilir, A | 1 |
| Shahzadi, A | 1 |
| Yazici, Z | 1 |
| Rodrigues, SF | 1 |
| Fiel, LA | 1 |
| Shimada, AL | 1 |
| Pereira, NR | 1 |
| Farsky, SH | 1 |
| Pantovic, A | 1 |
| Bosnjak, M | 1 |
| Arsikin, K | 1 |
| Kosic, M | 1 |
| Mandic, M | 1 |
| Ristic, B | 1 |
| Tosic, J | 1 |
| Grujicic, D | 1 |
| Isakovic, A | 1 |
| Micic, N | 1 |
| Trajkovic, V | 1 |
| Harhaji-Trajkovic, L | 1 |
| Weiler, M | 1 |
| Hartmann, C | 1 |
| Wiewrodt, D | 1 |
| Herrlinger, U | 1 |
| Gorlia, T | 1 |
| Bähr, O | 1 |
| Meyermann, R | 1 |
| Bamberg, M | 1 |
| Tatagiba, M | 1 |
| von Deimling, A | 1 |
| Weller, M | 1 |
| Wick, W | 1 |
| Tai, HH | 1 |
| Chi, X | 1 |
| Tong, M | 1 |
| Amin, R | 1 |
| Kamitani, H | 2 |
| Sultana, H | 1 |
| Taniura, S | 2 |
| Islam, A | 1 |
| Sho, A | 1 |
| Ishibashi, M | 2 |
| Eling, TE | 2 |
| Watanabe, T | 2 |
| Kardosh, A | 1 |
| Blumenthal, M | 1 |
| Wang, WJ | 1 |
| Chen, TC | 1 |
| Schönthal, AH | 1 |
| Bottone, FG | 1 |
| Das, A | 1 |
| Banik, NL | 1 |
| Ray, SK | 1 |
| Braun, DP | 1 |
| Penn, RD | 1 |
| Flannery, AM | 1 |
| Harris, JE | 1 |
| Kinouchi, T | 1 |
| Ono, Y | 1 |
| Sorimachi, H | 1 |
| Ishiura, S | 1 |
| Suzuki, K | 1 |
1 review available for indomethacin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, | 2011 |
1 trial available for indomethacin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Brain Neopl | 2010 |
11 other studies available for indomethacin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Glioblastoma; Humans; Iodine Radioisotopes; Mice; Mice | 2015 |
The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways.
Topics: Analysis of Variance; Animals; beta Catenin; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Glioblas | 2013 |
Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma.
Topics: Acetaminophen; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cyclooxygenase 1; | 2016 |
Lipid-Core Nanocapsules Act as a Drug Shuttle Through the Blood Brain Barrier and Reduce Glioblastoma After Intravenous or Oral Administration.
Topics: Administration, Oral; Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Diseas | 2016 |
In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Calcium; | 2017 |
Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Division; Cyclooxygenase 1; Cycloo | 2003 |
Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Cycle; Cell Division; Cell Line, Tumor; Cyc | 2004 |
The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; B | 2005 |
Methylprednisolone and indomethacin inhibit oxidative stress mediated apoptosis in rat C6 glioblastoma cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Caspase 3; Glioblastoma; Indomethacin; Meth | 2007 |
Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; DNA; Glioblastoma; Humans; Immunity, Cellular; Indomethac | 1982 |
Arachidonate metabolites affect the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Arachidonic Acids; Cell Line; Culture Media; | 1995 |