indomethacin has been researched along with Asthma, Bronchial in 142 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to determine the effect of inhaled indomethacin on asthma control and asthma exacerbations during reduction of inhaled corticosteroids in patients with moderate-to-severe steroid-dependent asthma." | 9.09 | Effect of inhaled indomethacin in asthmatic patients taking high doses of inhaled corticosteroids. ( Aoshiba, K; Kawatani, K; Kondo, M; Nagai, A; Nakata, J; Nishimura, K; Tamaoki, J, 2000) |
| "Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs." | 9.09 | Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses. ( Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1999) |
| "We evaluated the effect of inhaled indomethacin, a nonsteroidal antiinflammatory drug (NSAID), against bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) in children with asthma." | 9.08 | Inhaled indomethacin prevents bronchoconstrictive response to distilled water but not to histamine in children with asthma. ( Kuroume, T; Maeda, S; Mochizuki, H; Morikawa, A; Shigeta, M; Shimizu, T, 1995) |
| "day-1 for 4 days), on cough response to inhaled capsaicin were examined in eight patients with asthma, 10 patients with chronic bronchitis, and 10 normal subjects." | 9.08 | Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. ( Bando, T; Fujimura, M; Hashimoto, T; Kamio, Y; Kasahara, K; Matsuda, T, 1995) |
| "These results suggest an important role of cyclooxygenase pathway products in decreased response to repeated inhalation of acetaldehyde in patients with asthma." | 9.08 | Inhibitory effect of indomethacin on tachyphylaxis in response to acetaldehyde-induced bronchoconstriction in patients with asthma. ( Fujimura, M; Kamio, Y; Matsuda, T; Myou, S, 1997) |
| "The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects." | 9.07 | Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. ( Christie, PE; Hawksworth, R; Lee, TH; Spur, BW, 1992) |
| " To investigate whether prostaglandin production could also modulate the bronchial antireactive activity of this diuretic drug, we investigated the effect of inhaled lysine acetylsalicylate (162 mg) and of furosemide (18 mg), alone and in combination, on the bronchial obstructive response to ultrasonically nebulized water in asthmatic patients." | 9.07 | Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate. ( Berni, F; Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1993) |
| "The present investigation was designed to evaluate the effects of pre-treatment with the cholinergic muscarinic receptor antagonist, atropine sulfate, or with the cyclooxygenase inhibitor, indomethacin, on adenosine-induced bronchoconstriction in human asthmatics." | 9.06 | Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate. ( Diamond, L; Küng, M, 1990) |
| "We have examined the effects of indomethacin (I) on tolerance to the bronchomotor effects of repetitive challenge with exercise (EX) and eucapnic hyperpnea (EH) in 7 asthmatic subjects." | 9.06 | Indomethacin blocks airway tolerance to repetitive exercise but not to eucapnic hyperpnea in asthmatic subjects. ( Bigby, BG; Boushey, HA; Margolskee, DJ, 1988) |
| "Inhalation histamine challenges were performed in groups of normal and asthmatic subjects." | 9.05 | Prostaglandins and the control of airways responses to histamine in normal and asthmatic subjects. ( Walters, EH, 1983) |
| "The effect of specific antigen challenge on the lung function of eight allergic asthmatic patients after placebo and indomethacin pretreatment has been investigated." | 9.05 | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. ( Joubert, JR; Macfarlane, CM; Malan, L; Mouton, W; Shephard, EG, 1985) |
| " The cells were isolated from 3 groups of subjects: nonasthmatic patients (n = 10), patients with aspirin-tolerant asthma (ATA, n = 9), and patients with aspirin-intolerant asthma (AIA, n = 7)." | 7.72 | Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. ( Pierzchalska, M; Sanak, M; Soja, J; Szabó, Z; Szczeklik, A, 2003) |
| "A life-threatening episode of bronchial asthma may follow treatment by ophthalmic indomethacin." | 7.69 | Acute bronchial asthma associated with the administration of ophthalmic indomethacin. ( Polachek, J; Shvartzman, P, 1996) |
| "Histamine release induced by platelet-activating factor (PAF) from leukocytes of aspirin-sensitive subjects with asthma was higher than that from normal control subjects, despite the similarity of anti-IgE-induced histamine release." | 7.68 | Basophil histamine release by platelet-activating factor in aspirin-sensitive subjects with asthma. ( Hattori, H; Kishimoto, S; Miyatake, A; Okuda, Y; Takashima, T; Tsuyuguchi, I; Yamatodani, A, 1990) |
| "The bronchoconstriction induced by repeated histamine inhalation tests was studied in eight mild stable asthmatic subjects to determine whether histamine tachyphylaxis occurs in asthmatics." | 7.67 | Tachyphylaxis to inhaled histamine in asthmatic subjects. ( Jones, GL; Manning, PJ; O'Byrne, PM, 1987) |
| "Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA)." | 7.67 | Aspirin tolerance induced in aspirin-sensitive asthmatics. ( Grzelewska-Rzymowska, I; Kowalski, ML; Rozniecki, J; Szmidt, M, 1984) |
| "Aspirin-sensitive asthma is a common and severe disorder characterized by asthmatic attacks after oral ingestion of cyclooxygenase inhibiting drugs." | 7.67 | [Demonstration of specific platelet function anomaly in asthma induced by aspirin: diagnostic consequences]. ( Ameisen, JC; Capron, A; Fournier, E; Joseph, M; Pancré, V; Tonnel, AB; Vorng, H; Wallaert, B, 1985) |
| "Airway reactivity to histamine was determined in a group of non-asthmatic and asthmatic patients prior to thoracotomy." | 7.67 | Human isolated bronchial muscle preparations from asthmatic patients: effects of indomethacin and contractile agonists. ( Benveniste, J; Brink, C; Cerrina, J; Haye-Legrande, I; Labat, C; Raffestin, B, 1989) |
| "To examine the role of arachidonic acid metabolism in the modulation of immediate-type immunologic airway responses, we compared the effects of indomethacin (50 mg every 6 h for 96 h) and placebo on responses to antigen inhalation challenge in allergic asthmatic subjects and a group of nonasthmatic subjects with allergic rhinitis." | 7.66 | Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma. ( Adkinson, NF; Ankin, MG; Fish, JE; Peterman, VI, 1981) |
| "In an attempt to elucidate the mechanisms involved in analgesic-induced asthma, I performed bronchial and intravenous challenge tests with indomethacin in 5 aspirin-sensitive asthmatics." | 7.66 | Bronchial and intravenous provocation tests with indomethacin in aspirin-sensitive asthmatics. ( Martelli, NA, 1979) |
| "We studied the effect of ascorbic acid in 14 mild asthmatic subjects." | 7.66 | Effect of ascorbic acid on response to methacholine challenge in asthmatic subjects. ( Douglas, JS; Dubois, AB; Mohsenin, V, 1983) |
| "Thirty aspirin-sensitive asthmatic patients underwent incremental, oral aspirin challenge until a "positive reaction" (delta FEV1 greater than or equal to 25%) occurred." | 7.66 | Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1982) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 7.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "Eleven patients with asthma and aspirin hypersensitivity have been challenged with eight non-steroidal anti-inflammatory drugs." | 7.65 | Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A, 1975) |
| "Indomethacin has been used to demonstrate that cyclooxygenase (COX) metabolites of arachidonic acid play a mechanistic role in ozone-induced spirometric decline in normals (Nm)." | 5.31 | Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals. ( Alexis, N; Corey, P; O'Byrne, P; Pengelly, D; Silverman, F; Tarlo, S; Urch, B, 2000) |
| "We sought to determine the effect of inhaled indomethacin on asthma control and asthma exacerbations during reduction of inhaled corticosteroids in patients with moderate-to-severe steroid-dependent asthma." | 5.09 | Effect of inhaled indomethacin in asthmatic patients taking high doses of inhaled corticosteroids. ( Aoshiba, K; Kawatani, K; Kondo, M; Nagai, A; Nakata, J; Nishimura, K; Tamaoki, J, 2000) |
| "Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs." | 5.09 | Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses. ( Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1999) |
| "day-1 for 4 days), on cough response to inhaled capsaicin were examined in eight patients with asthma, 10 patients with chronic bronchitis, and 10 normal subjects." | 5.08 | Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. ( Bando, T; Fujimura, M; Hashimoto, T; Kamio, Y; Kasahara, K; Matsuda, T, 1995) |
| " In study 1, 15 non-aspirin sensitive patients with mild asthma attended on four occasions and inhaled 5 ml of lysine aspirin (L-aspirin) 900 mg, indomethacin 50 mg, sodium salicylate 800 mg, or saline 20 minutes before an inhaled MBS challenge." | 5.08 | Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma. ( Knox, A; Pavord, I; Tattersfield, A; Wang, M; Wisniewski, A, 1996) |
| "We evaluated the effect of inhaled indomethacin, a nonsteroidal antiinflammatory drug (NSAID), against bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) in children with asthma." | 5.08 | Inhaled indomethacin prevents bronchoconstrictive response to distilled water but not to histamine in children with asthma. ( Kuroume, T; Maeda, S; Mochizuki, H; Morikawa, A; Shigeta, M; Shimizu, T, 1995) |
| "These results suggest an important role of cyclooxygenase pathway products in decreased response to repeated inhalation of acetaldehyde in patients with asthma." | 5.08 | Inhibitory effect of indomethacin on tachyphylaxis in response to acetaldehyde-induced bronchoconstriction in patients with asthma. ( Fujimura, M; Kamio, Y; Matsuda, T; Myou, S, 1997) |
| " To investigate whether prostaglandin production could also modulate the bronchial antireactive activity of this diuretic drug, we investigated the effect of inhaled lysine acetylsalicylate (162 mg) and of furosemide (18 mg), alone and in combination, on the bronchial obstructive response to ultrasonically nebulized water in asthmatic patients." | 5.07 | Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate. ( Berni, F; Bianco, S; Pieroni, MG; Refini, RM; Robuschi, M; Sestini, P; Vaghi, A, 1993) |
| "The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects." | 5.07 | Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. ( Christie, PE; Hawksworth, R; Lee, TH; Spur, BW, 1992) |
| "The present investigation was designed to evaluate the effects of pre-treatment with the cholinergic muscarinic receptor antagonist, atropine sulfate, or with the cyclooxygenase inhibitor, indomethacin, on adenosine-induced bronchoconstriction in human asthmatics." | 5.06 | Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate. ( Diamond, L; Küng, M, 1990) |
| "We have examined the effects of indomethacin (I) on tolerance to the bronchomotor effects of repetitive challenge with exercise (EX) and eucapnic hyperpnea (EH) in 7 asthmatic subjects." | 5.06 | Indomethacin blocks airway tolerance to repetitive exercise but not to eucapnic hyperpnea in asthmatic subjects. ( Bigby, BG; Boushey, HA; Margolskee, DJ, 1988) |
| "The effect of specific antigen challenge on the lung function of eight allergic asthmatic patients after placebo and indomethacin pretreatment has been investigated." | 5.05 | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. ( Joubert, JR; Macfarlane, CM; Malan, L; Mouton, W; Shephard, EG, 1985) |
| "Inhalation histamine challenges were performed in groups of normal and asthmatic subjects." | 5.05 | Prostaglandins and the control of airways responses to histamine in normal and asthmatic subjects. ( Walters, EH, 1983) |
| " Indomethacin had no effect on day-to-day asthmatic symptoms, or challenge-induced asthma, suggesting that prostaglandins are not fundamental to the pathogenesis of asthma." | 5.04 | The response of normal and asthmatic subjects to prostaglandins E2 and F2alpha by different routes, and their significance in asthma. ( Cuthbert, MF; Smith, AP, 1976) |
| " To determine the beneficial effects of statins on the airway hyperresponsiveness, a characteristic feature of allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced bronchial smooth muscle hyperresponsiveness was investigated in mice." | 3.74 | Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice. ( Chiba, Y; Misawa, M; Sato, S, 2008) |
| "Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases." | 3.73 | Discovery of potent CRTh2 (DP2) receptor antagonists. ( Arrowsmith, EC; Beech, C; Bell, FM; Birkinshaw, TN; Bonnert, RV; Carrillo, JJ; Dougall, IG; Hill, S; Paine, SW; Patel, A; Phillips, TT; Reakes, S; Salter, S; Sanganee, H; Schmidt, J; Teague, SJ; Weaver, R, 2006) |
| " The cells were isolated from 3 groups of subjects: nonasthmatic patients (n = 10), patients with aspirin-tolerant asthma (ATA, n = 9), and patients with aspirin-intolerant asthma (AIA, n = 7)." | 3.72 | Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. ( Pierzchalska, M; Sanak, M; Soja, J; Szabó, Z; Szczeklik, A, 2003) |
| "A life-threatening episode of bronchial asthma may follow treatment by ophthalmic indomethacin." | 3.69 | Acute bronchial asthma associated with the administration of ophthalmic indomethacin. ( Polachek, J; Shvartzman, P, 1996) |
| "The anti-asthmatic effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a specific thromboxane A2 (TXA2) synthase inhibitor, were investigated in the ovalbumin-sensitized guinea pig asthmatic model." | 3.68 | Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. ( Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T, 1993) |
| "To determine whether the involvement of thromboxane A2 in bronchial hyperresponsiveness (BHR) is specific to asthma, we examined the effects of a selective inhibitor of thromboxane synthetase (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial responsiveness to methacholine in normal subjects and patients with chronic bronchitis, diffuse bronchiectasis, and intrinsic bronchial asthma." | 3.68 | Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. ( Fujimura, M; Matsuda, T; Sakamoto, S, 1990) |
| "Histamine release induced by platelet-activating factor (PAF) from leukocytes of aspirin-sensitive subjects with asthma was higher than that from normal control subjects, despite the similarity of anti-IgE-induced histamine release." | 3.68 | Basophil histamine release by platelet-activating factor in aspirin-sensitive subjects with asthma. ( Hattori, H; Kishimoto, S; Miyatake, A; Okuda, Y; Takashima, T; Tsuyuguchi, I; Yamatodani, A, 1990) |
| "Airway reactivity to histamine was determined in a group of non-asthmatic and asthmatic patients prior to thoracotomy." | 3.67 | Human isolated bronchial muscle preparations from asthmatic patients: effects of indomethacin and contractile agonists. ( Benveniste, J; Brink, C; Cerrina, J; Haye-Legrande, I; Labat, C; Raffestin, B, 1989) |
| "The formation of 5-lipoxygenase products of arachidonic acid, 5-HETE and 5,12-diHETE, was determined in 100,000 X g supernatant of polymorphonuclear leukocytes from 17 healthy subjects, 17 patients with extrinsic asthma and 15 patients with intrinsic asthma." | 3.67 | Increased activity of 5-lipoxygenase in polymorphonuclear leukocytes from asthmatic patients. ( Mita, H; Shida, T; Taniguchi, N; Yasueda, H; Yui, Y, 1985) |
| "Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA)." | 3.67 | Aspirin tolerance induced in aspirin-sensitive asthmatics. ( Grzelewska-Rzymowska, I; Kowalski, ML; Rozniecki, J; Szmidt, M, 1984) |
| "The bronchoconstriction induced by repeated histamine inhalation tests was studied in eight mild stable asthmatic subjects to determine whether histamine tachyphylaxis occurs in asthmatics." | 3.67 | Tachyphylaxis to inhaled histamine in asthmatic subjects. ( Jones, GL; Manning, PJ; O'Byrne, PM, 1987) |
| "Aspirin-sensitive asthma is a common and severe disorder characterized by asthmatic attacks after oral ingestion of cyclooxygenase inhibiting drugs." | 3.67 | [Demonstration of specific platelet function anomaly in asthma induced by aspirin: diagnostic consequences]. ( Ameisen, JC; Capron, A; Fournier, E; Joseph, M; Pancré, V; Tonnel, AB; Vorng, H; Wallaert, B, 1985) |
| " The pharmacologic characteristics of the antigen-induced airway smooth muscle contraction in vitro were similar to those induced by arachidonic acid and the leukotrienes only in some respects but were clearly different from those induced by compound 48/80." | 3.67 | Pharmacological characterization of airway smooth muscle responses to antigen in ascaris-sensitive dogs. ( Davis, C; Kannan, L; Kannan, MS; Ladenius, AR; Sankaranarayanan, A, 1986) |
| "In an attempt to elucidate the mechanisms involved in analgesic-induced asthma, I performed bronchial and intravenous challenge tests with indomethacin in 5 aspirin-sensitive asthmatics." | 3.66 | Bronchial and intravenous provocation tests with indomethacin in aspirin-sensitive asthmatics. ( Martelli, NA, 1979) |
| " A), and the effects of histamine and indomethacin upon these responses, in normal subjects, and patients with extrinsic and intrinsic asthma, and chronic bronchitis." | 3.66 | Intrinsic and extrinsic asthma, a shared lymphocyte abnormality. ( Brostoff, J; Hudspith, BN; Johnson, NM; Swinburn, CR, 1983) |
| "We studied the effect of ascorbic acid in 14 mild asthmatic subjects." | 3.66 | Effect of ascorbic acid on response to methacholine challenge in asthmatic subjects. ( Douglas, JS; Dubois, AB; Mohsenin, V, 1983) |
| "Thirty aspirin-sensitive asthmatic patients underwent incremental, oral aspirin challenge until a "positive reaction" (delta FEV1 greater than or equal to 25%) occurred." | 3.66 | Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1982) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 3.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "To examine the role of arachidonic acid metabolism in the modulation of immediate-type immunologic airway responses, we compared the effects of indomethacin (50 mg every 6 h for 96 h) and placebo on responses to antigen inhalation challenge in allergic asthmatic subjects and a group of nonasthmatic subjects with allergic rhinitis." | 3.66 | Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma. ( Adkinson, NF; Ankin, MG; Fish, JE; Peterman, VI, 1981) |
| " An analogous mechanism may account for aspirin-induced asthma in man." | 3.66 | Evidence for lipoxygenase pathway involvement in allergic tracheal contraction. ( Burka, JF; Paterson, NA, 1980) |
| "The effect of indomethacin is reported in five patients with chronic asthma." | 3.65 | Treatment of chronic airways obstruction with indomethacin. ( Eddey, V; Hume, M, 1977) |
| "Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics." | 3.65 | Response of aspirin-allergic patients to challenge by some analgesics in common use. ( Smith, AP, 1971) |
| "Eleven patients with asthma and aspirin hypersensitivity have been challenged with eight non-steroidal anti-inflammatory drugs." | 3.65 | Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A, 1975) |
| " UNDW responsiveness was assessed with dose-response curves of UNDW volume output versus the percent fall in FEV1." | 2.66 | The effect of indomethacin on the refractory period occurring after the inhalation of ultrasonically nebulized distilled water. ( Ciappi, G; Corbo, GM; Foresi, A; Mattoli, S; Valente, S, 1987) |
| "Bradykinin (BK) is an endogenous mediator that activates C fibers." | 1.33 | Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs. ( Bergren, DR, 2006) |
| "Indomethacin has been used to demonstrate that cyclooxygenase (COX) metabolites of arachidonic acid play a mechanistic role in ozone-induced spirometric decline in normals (Nm)." | 1.31 | Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals. ( Alexis, N; Corey, P; O'Byrne, P; Pengelly, D; Silverman, F; Tarlo, S; Urch, B, 2000) |
| "Indomethacin tended to enhance antigen-induced contractions of the trachea and significantly enhanced contractions of the lung parenchyma." | 1.29 | Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs. ( Hamada, K; Inoue, K; Kimura, K; Shibata, Y; Ueda, F, 1994) |
| "A 23-year-old male with bronchial asthma developed eosinophilia (eosinophils greater than 2,000/mm3) and was observed at our hospital." | 1.28 | [Acute myocardial injury and repeated angina pectoris-like attacks in a young patient with Churg-Strauss syndrome]. ( Arai, Y; Fukushima, N; Isokane, N; Miyamoto, Y; Sano, Y; Suzuki, N, 1991) |
| " Dose-response lines in response to the two agonists, expressed as percent maximal contraction, did not differ among the groups." | 1.28 | Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs. ( Biggs, DF; Yang, ZJ, 1991) |
| "Pretreatment with indomethacin, 30 mg/kg given intraperitoneally, significantly potentiates the decrements in Cdyn and GL elicited by aerosol LTC4 at 1 microgram/ml." | 1.27 | Indomethacin potentiates the pulmonary response to aerosol leukotriene C4 in the guinea pig. ( Austen, KF; Corey, EJ; Drazen, JM; Leitch, AG, 1983) |
| "Indomethacin pretreatment totally or partially inhibited the delayed asthmatic response in 10 of 11 subjects." | 1.27 | Non-steroid anti-inflammatory drugs in asthma: dangerous or useful therapy? ( Joubert, JR; Mouton, W; Shephard, E; Van Zyl, L; Viljoen, I, 1985) |
| " We determined the nebulizer concentration of PAF which reduced specific airway conductance (SGaw) 35% (PC35 SGaw) and the slope of the PAF dose-response curve." | 1.27 | Mechanism of platelet activating factor-induced bronchoconstriction in humans. ( Patterson, R; Rubin, AH; Smith, LJ, 1988) |
| " Salicylamide, an analgesic without effect on the prostaglandin synthesis was in the oral exposition test of 18 patients with proved analgesics-asthma-syndrome in the dosage of 500 mg subjectively and objectively tolerated without reaction." | 1.26 | [Salicylamide-- a potential pain-remedy alternative in the analgesic asthma syndrome]. ( Hummel, S; Jäger, L; Slapke, J, 1979) |
| "Prevention of arterial hypoxemia by oxygen breathing blocked an increase in pulmonary vascular resistance in four pretreated responders." | 1.26 | Failure of hypoxic pulmonary vasoconstriction in the canine asthma model. Effect of prostaglandin inhibitors. ( Baier, H; Cohn, MA; Wanner, A, 1978) |
| "Eight patients with type I allergic bronchial asthma were given specific allergens by inhalation until symptoms and signs of asthma attacks were provoked." | 1.26 | Aspects of prostaglandin action in asthma. ( Gréen, K; Hedqvist, P; Svanborg, N, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (61.27) | 18.7374 |
| 1990's | 37 (26.06) | 18.2507 |
| 2000's | 13 (9.15) | 29.6817 |
| 2010's | 4 (2.82) | 24.3611 |
| 2020's | 1 (0.70) | 2.80 |
| Authors | Studies |
|---|---|
| Pettipher, R | 1 |
| Whittaker, M | 1 |
| Zasłona, Z | 1 |
| Flis, E | 1 |
| Wilk, MM | 1 |
| Carroll, RG | 1 |
| Palsson-McDermott, EM | 1 |
| Hughes, MM | 1 |
| Diskin, C | 1 |
| Banahan, K | 1 |
| Ryan, DG | 1 |
| Hooftman, A | 1 |
| Misiak, A | 1 |
| Kearney, J | 1 |
| Lochnit, G | 1 |
| Bertrams, W | 1 |
| Greulich, T | 1 |
| Schmeck, B | 1 |
| McElvaney, OJ | 1 |
| Mills, KHG | 1 |
| Lavelle, EC | 1 |
| Wygrecka, M | 1 |
| Creagh, EM | 1 |
| O'Neill, LAJ | 1 |
| Riley, JP | 1 |
| Fuchs, B | 1 |
| Sjöberg, L | 1 |
| Nilsson, GP | 1 |
| Karlsson, L | 1 |
| Dahlén, SE | 1 |
| Rao, NL | 1 |
| Adner, M | 1 |
| Zhou, W | 1 |
| Zhang, J | 1 |
| Goleniewska, K | 1 |
| Dulek, DE | 1 |
| Toki, S | 1 |
| Newcomb, DC | 1 |
| Cephus, JY | 1 |
| Collins, RD | 1 |
| Wu, P | 1 |
| Boothby, MR | 1 |
| Peebles, RS | 1 |
| Chiba, Y | 1 |
| Sato, S | 1 |
| Misawa, M | 1 |
| Rievaj, J | 1 |
| Davidson, C | 1 |
| Nadeem, A | 1 |
| Hollenberg, M | 1 |
| Duszyk, M | 1 |
| Vliagoftis, H | 1 |
| Prasad, K | 1 |
| Gupta, JB | 1 |
| Gray, PA | 1 |
| Warner, TD | 1 |
| Vojnovic, I | 1 |
| Del Soldato, P | 1 |
| Parikh, A | 1 |
| Scadding, GK | 1 |
| Mitchell, JA | 1 |
| Kajekar, R | 1 |
| Undem, BJ | 1 |
| Myers, AC | 1 |
| Pierzchalska, M | 1 |
| Szabó, Z | 1 |
| Sanak, M | 1 |
| Soja, J | 1 |
| Szczeklik, A | 3 |
| Fernandez, J | 1 |
| Reyes, R | 1 |
| Ponce, H | 1 |
| Oropeza, M | 1 |
| Vancalsteren, MR | 1 |
| Jankowski, C | 1 |
| Campos, MG | 1 |
| Bergren, DR | 1 |
| Birkinshaw, TN | 1 |
| Teague, SJ | 1 |
| Beech, C | 1 |
| Bonnert, RV | 1 |
| Hill, S | 1 |
| Patel, A | 1 |
| Reakes, S | 1 |
| Sanganee, H | 1 |
| Dougall, IG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Challenge Test for Acetylsalicylic Acid Hypersensitivity[NCT01681615] | 50 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indomethacin and Asthma, Bronchial
| Article | Year |
|---|---|
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
Topics: Acetates; Animals; Asthma; Aza Compounds; Carbazoles; Clinical Trials as Topic; Humans; Indoleacetic | 2012 |
Prostaglandins, slow-reacting substances (leukotrienes) and the lung.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchi; Epoprostenol; Guinea Pigs; H | 1981 |
The mast cell as a primary effector cell in the pathogenesis of asthma.
Topics: Aspirin; Asthma; Bronchi; Bronchial Provocation Tests; Eosinophils; Histamine Release; Humans; Immun | 1986 |
[Hypersensitivity to aspirin and other non-steroidal anti- inflammatory agents--the methods of detecting the hypersensitivity and the development of the state of tolerance].
Topics: Aspirin; Asthma; Bronchial Provocation Tests; Drug Hypersensitivity; Drug Tolerance; Humans; Indomet | 1989 |
The pathogenesis of asthma.
Topics: Acetaminophen; Adult; Affective Symptoms; Air Pollution; Aspirin; Asthma; Autonomic Nervous System; | 1974 |
27 trials available for indomethacin and Asthma, Bronchial
| Article | Year |
|---|---|
Asthma relieved by acetylsalicylic acid and nonsteroid anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Dipyrone; Female; Forced Expiratory Volume; Humans; Indom | 1984 |
Prostaglandins and the control of airways responses to histamine in normal and asthmatic subjects.
Topics: Adult; Airway Resistance; Albuterol; Asthma; Bronchial Provocation Tests; Dose-Response Relationship | 1983 |
Inhaled indomethacin prevents bronchoconstrictive response to distilled water but not to histamine in children with asthma.
Topics: Administration, Inhalation; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Cross-O | 1995 |
Potentiation of the antireactive, antiasthmatic effect of inhaled furosemide by inhaled lysine acetylsalicylate.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1993 |
Refractoriness to inhaled sodium metabisulphite in subjects with mild asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double- | 1994 |
Prostanoids and cough response to capsaicin in asthma and chronic bronchitis.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchitis; Capsaicin; Chronic Disease; Cough; Cro | 1995 |
Evidence for opioid modulation and generation of prostaglandins in sulphur dioxide (SO)2-induced bronchoconstriction.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Cyclooxygenase Inhibitors; Dose-Respo | 1996 |
Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Anti-Inflammatory Agents, Non-Steroidal; | 1996 |
Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Provocation Tests; Dos | 1997 |
Inhibitory effect of indomethacin on tachyphylaxis in response to acetaldehyde-induced bronchoconstriction in patients with asthma.
Topics: Acetaldehyde; Administration, Inhalation; Administration, Oral; Adult; Aged; Asthma; Bronchoconstric | 1997 |
Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; A | 1999 |
Effect of inhaled indomethacin in asthmatic patients taking high doses of inhaled corticosteroids.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Beclomethasone; Double-Blind Met | 2000 |
Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2alpha, E1, and E2.
Topics: Adult; Aerosols; Airway Resistance; Allergens; Asthma; Bronchial Spasm; Bronchitis; Clinical Trials | 1976 |
Asthma improved by nonsteroidal anti-inflammatory drugs.
Topics: Airway Resistance; Anti-Inflammatory Agents; Aspirin; Asthma; Clinical Trials as Topic; Female; Forc | 1978 |
Effect of indomethacin in asthma: evidence against a role for prostaglandins in its pathogenesis.
Topics: Adolescent; Adult; Antigens; Asthma; Capsules; Clinical Trials as Topic; Female; Forced Expiratory V | 1975 |
The response of normal and asthmatic subjects to prostaglandins E2 and F2alpha by different routes, and their significance in asthma.
Topics: Adolescent; Adult; Aerosols; Allergens; Asthma; Bronchi; Clinical Trials as Topic; Dose-Response Rel | 1976 |
Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Hi | 1992 |
Effect of leukotriene antagonist on experimental and clinical bronchial asthma.
Topics: Allergens; Anaphylaxis; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Chromones; Drug Evalu | 1991 |
Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate.
Topics: Adenosine; Administration, Inhalation; Administration, Oral; Adult; Asthma; Atropine; Bronchial Prov | 1990 |
Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin.
Topics: Adult; Allergens; Arachidonate 5-Lipoxygenase; Asthma; Bronchial Provocation Tests; Humans; Indometh | 1990 |
Tachyphylaxis to inhaled methacholine in normal but not asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchodilator Agents; Female; Flurbiprofen; Forced Expir | 1990 |
Effect of indomethacin on allergen-induced asthmatic responses.
Topics: Adult; Allergens; Asthma; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; | 1989 |
Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Asthma; Beta-Globulins; beta-Thromboglobulin; Human | 1985 |
Injection of low-dose antigen attenuates the response to subsequent bronchoprovocative challenge.
Topics: Adult; Antigens; Asthma; Bronchial Provocation Tests; Child; Clinical Trials as Topic; Female; Human | 1988 |
Indomethacin blocks airway tolerance to repetitive exercise but not to eucapnic hyperpnea in asthmatic subjects.
Topics: Adaptation, Physiological; Adult; Airway Resistance; Asthma; Bronchi; Female; Humans; Hyperventilati | 1988 |
The effect of indomethacin on the refractory period occurring after the inhalation of ultrasonically nebulized distilled water.
Topics: Adolescent; Adult; Asthma; Bronchial Diseases; Clinical Trials as Topic; Constriction, Pathologic; E | 1987 |
The effect of indomethacin on exercise-induced bronchoconstriction and refractoriness after exercise.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Female; Forced Expiratory Volume; Humans; Indomethacin; Mal | 1986 |
110 other studies available for indomethacin and Asthma, Bronchial
| Article | Year |
|---|---|
Caspase-11 promotes allergic airway inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Caspases, Initiator; Cells, Cultured; Dino | 2020 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.
Topics: Allergens; Animals; Antihypertensive Agents; Asthma; CD4-Positive T-Lymphocytes; Cell Proliferation; | 2016 |
Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice.
Topics: Acetylcholine; Animals; Antigens; Asthma; Atropine; Bronchial Hyperreactivity; Bronchodilator Agents | 2008 |
Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation.
Topics: Amiloride; Animals; Asthma; Benzoates; Bestrophins; Chloride Channels; Eye Proteins; Hypersensitivit | 2012 |
Relaxant effect of oxygen free radicals on rabbit tracheal smooth muscle.
Topics: Analysis of Variance; Animals; Asthma; Cyclooxygenase Inhibitors; Epithelium; Hydrogen Peroxide; Hyd | 2002 |
Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Benzene Derivatives; Calcimycin; Cyclooxyg | 2002 |
Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons.
Topics: Action Potentials; Animals; Asthma; Bronchi; Bronchoconstriction; Cyclooxygenase Inhibitors; Dinopro | 2003 |
Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma.
Topics: Adult; Aged; Aspirin; Asthma; Bronchi; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinopros | 2003 |
Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Argemone; Asthma; | 2005 |
Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Asthma; Blood Pressure; Bradykinin; Capsaic | 2006 |
Discovery of potent CRTh2 (DP2) receptor antagonists.
Topics: Asthma; Chemistry, Pharmaceutical; Drug Design; Humans; Indomethacin; Inflammation; Inhibitory Conce | 2006 |
Bronchial asthma induced by indomethacin.
Topics: Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; | 1967 |
The evolution and future horizons of research on the metabolism of arachidonic acid by 5-lipoxygenase.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Asthma; Epoprostenol; Huma | 1984 |
Mexican drug therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Amygdalin; Arthritis; Asthma; Diazepam; Female; Histamin | 1980 |
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macr | 1981 |
Interactions between beta-adrenergic activity and prostaglandin synthesis in control of airways bronchoconstrictor responsiveness.
Topics: Adult; Airway Resistance; Albuterol; Asthma; Bronchi; Female; Histamine; Humans; Indomethacin; Male; | 1983 |
Implications of NSAID effects during allergen-induced bronchospasm.
Topics: Allergens; Anti-Inflammatory Agents; Asthma; Bronchi; Humans; Indomethacin; Mites; Propionates | 1983 |
Indomethacin potentiates the pulmonary response to aerosol leukotriene C4 in the guinea pig.
Topics: Aerosols; Animals; Asthma; Bronchi; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; I | 1983 |
Intrinsic and extrinsic asthma, a shared lymphocyte abnormality.
Topics: Adult; Aged; Asthma; Bronchitis; Concanavalin A; Humans; Indomethacin; Lymphocyte Activation; Middle | 1983 |
Aspirin tolerance induced in aspirin-sensitive asthmatics.
Topics: Aspirin; Asthma; Cross Reactions; Dose-Response Relationship, Drug; Dose-Response Relationship, Immu | 1984 |
Aspirin desensitization in aspirin-sensitive asthma: failure to maintain a desensitized state during prolonged therapy.
Topics: Adult; Aspirin; Asthma; Cross Reactions; Desensitization, Immunologic; Female; Humans; Indomethacin; | 1984 |
Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.
Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Constriction, Pathologic; Guinea Pigs; Histamine; Hyper | 1980 |
[Prevention of food hypersensitivities with aspirin].
Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Food Hypersensitivity; Ibuprofen; Indomethacin; Milk; P | 1980 |
An inhibitor of the lipoxygenase and cyclooxygenase pathways of arachidonic acid, 5, 8, 11, 14-eicosatetraynoic acid, inhibits immunoglobulin E mediated antigen induced monkey asthma and skin reactions.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate Lipoxygenases; Asthma; Cyclooxygenase Inhibit | 1980 |
Effect of ascorbic acid on response to methacholine challenge in asthmatic subjects.
Topics: Adult; Airway Resistance; Ascorbic Acid; Asthma; Bronchial Provocation Tests; Dose-Response Relation | 1983 |
The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.
Topics: Adolescent; Adult; Allergens; Arachidonic Acids; Asthma; Bronchial Provocation Tests; Bronchial Spas | 1983 |
Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Dose-Response Relationship, | 1982 |
Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma.
Topics: Animals; Aspirin; Asthma; Atropine; Disease Models, Animal; Dogs; Female; Indomethacin; Male; Muscle | 1981 |
Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma.
Topics: Adult; Airway Resistance; Arachidonic Acids; Asthma; Dose-Response Relationship, Drug; Female; Human | 1981 |
Prostaglandins in exercise-induced asthma.
Topics: Asthma; Asthma, Exercise-Induced; Child; Forced Expiratory Volume; Humans; Indomethacin; Prostagland | 1981 |
Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site.
Topics: Animals; Asthma; Atropine; Bradykinin; Capillary Permeability; Dipeptides; Evans Blue; Guinea Pigs; | 1994 |
Inhibitory effect of DS-4574 on leukotriene- or antigen-induced bronchoconstriction in guinea pigs.
Topics: Animals; Antigens; Asthma; Atropine; Bronchoconstriction; Guinea Pigs; Histamine Release; Immunizati | 1993 |
Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs.
Topics: Animals; Asthma; Benzoquinones; Disease Models, Animal; Etodolac; Guinea Pigs; Immunization, Passive | 1994 |
Potential species dependency for the pulmonary antiallergic effects of aerosolized heparin.
Topics: Administration, Inhalation; Aerosols; Animals; Antigens; Asthma; Bronchoconstriction; Guinea Pigs; H | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyper | 1993 |
[Hypertonic saline induced bronchoconstriction in sensitized rabbits].
Topics: Animals; Asthma; Atropine; Bronchoconstriction; Chlorpheniramine; Cholinergic Antagonists; Cyclooxyg | 1996 |
Acute bronchial asthma associated with the administration of ophthalmic indomethacin.
Topics: Acute Disease; Aged; Asthma; Cataract Extraction; Humans; Indomethacin; Male; Postoperative Period; | 1996 |
Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, N | 2000 |
Eicosanoid and muscarinic receptor blockade abolishes hyperventilation-induced bronchoconstriction.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyc | 2000 |
Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals.
Topics: Adolescent; Adult; Asthma; Dinoprost; Female; Humans; Indomethacin; Lung; Male; Ozone; Prostaglandin | 2000 |
Role of chemical mediators in airway hyperresponsiveness in an asthmatic model.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response | 2001 |
Pharmacology of Schultz-Dale reaction in canine lung strip in vitro: possible model for allergic asthma.
Topics: Anaphylaxis; Animals; Asthma; Autacoids; Disease Models, Animal; Dogs; Female; Histamine H1 Antagoni | 1979 |
Letter: Prostaglandins and asthma.
Topics: Antigens; Asthma; Humans; Indomethacin; Muscle Contraction; Muscles; Physical Exertion; Prostaglandi | 1975 |
Letter: Prostaglandins and asthma.
Topics: Animals; Asthma; Guinea Pigs; Humans; Indomethacin; Muscle Contraction; Prostaglandins; Spirometry; | 1975 |
Bronchial and intravenous provocation tests with indomethacin in aspirin-sensitive asthmatics.
Topics: Adult; Aspirin; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Female; Humans; Indomethacin; | 1979 |
[Salicylamide-- a potential pain-remedy alternative in the analgesic asthma syndrome].
Topics: Analgesics; Animals; Antipyrine; Asthma; Bronchial Spasm; Cyclooxygenase Inhibitors; Female; Guinea | 1979 |
[Experimental investigation on pathogenesis of indomethacin-induced asthma--effect of indomethacin on the action of various bronchodilators (author's transl)].
Topics: Animals; Asthma; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoprotereno | 1979 |
Experimental investigation on the pathogenesis of tartrazine-induced asthma.
Topics: Animals; Asthma; Azo Compounds; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Synerg | 1979 |
Indomethacin-induced asthma in aspirin-sensitive patients.
Topics: Adult; Aspirin; Asthma; Female; Humans; Indomethacin | 1977 |
Treatment of chronic airways obstruction with indomethacin.
Topics: Aged; Asthma; Chronic Disease; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged | 1977 |
[Indomethacin-induced asthma (author's transl)].
Topics: Adult; Aspirin; Asthma; Female; Humans; Indomethacin; Male; Middle Aged | 1977 |
Failure of hypoxic pulmonary vasoconstriction in the canine asthma model. Effect of prostaglandin inhibitors.
Topics: Animals; Ascaris; Aspirin; Asthma; Dogs; Hypersensitivity; Hypoxia; Indomethacin; Lung; Oxygen; Pros | 1978 |
[A case report of indomethacin induced asthma with special reference to prostaglandins metabolism in the lungs (author's transl)].
Topics: Adult; Asthma; Female; Humans; Indomethacin; Lung; Prostaglandins E | 1978 |
Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors.
Topics: Aspirin; Asthma; Fenoprofen; Humans; Indomethacin; Male; Mefenamic Acid; Middle Aged | 1978 |
Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects.
Topics: Adrenal Cortex Hormones; Adult; Aspirin; Asthma; Cromolyn Sodium; Diethylcarbamazine; Flour; Forced | 1976 |
Effect of indomethacin and atropine in experimental asthma in conscious guinea pigs.
Topics: Aerosols; Airway Resistance; Animals; Antigens; Asthma; Atropine; Guinea Pigs; Horseradish Peroxidas | 1976 |
Acute respiratory failure secondary to indomethacin in an aspirin-intolerant asthmatic patient.
Topics: Acute Disease; Aspirin; Asthma; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; Resp | 1976 |
Aspects of prostaglandin action in asthma.
Topics: Adult; Allergens; Asthma; Cortisone; Female; Heparin; Humans; Indomethacin; Male; Physical Exertion; | 1976 |
Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.
Topics: Adult; Aged; Analgesics; Aspirin; Asthma; Bronchi; Drug Hypersensitivity; Female; Flufenamic Acid; H | 1975 |
[Advances in pneumonology. Aspirin-induced asthma].
Topics: Adult; Age Factors; Aspirin; Asthma; Depression, Chemical; Drug Hypersensitivity; Humans; Indomethac | 1975 |
Prostaglandins and asthma.
Topics: Aerosols; Animals; Asthma; Bronchi; Bronchodilator Agents; Humans; Indomethacin; Infusions, Parenter | 1975 |
Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) in guinea pigs.
Topics: Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationshi | 1992 |
Basophil histamine release by platelet-activating factor in aspirin-sensitive subjects with asthma.
Topics: Adult; Aged; Aspirin; Asthma; Basophils; Cytochalasin B; Dexamethasone; Female; Histamine Release; H | 1990 |
The interaction of acetylcholine and histamine on human bronchial smooth muscle contraction.
Topics: Acetylcholine; Asthma; Atropine; Bronchi; Dose-Response Relationship, Drug; Drug Interactions; Epith | 1991 |
[Acute myocardial injury and repeated angina pectoris-like attacks in a young patient with Churg-Strauss syndrome].
Topics: Adult; Age Factors; Angina Pectoris; Aspirin; Asthma; Churg-Strauss Syndrome; Eosinophilia; Humans; | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationshi | 1991 |
Formation of PGD2 after allergen inhalation in atopic asthmatics.
Topics: Allergens; Asthma; Cyclooxygenase Inhibitors; Double-Blind Method; Forced Expiratory Volume; Hyperse | 1991 |
[Effects of phospholipid platelet activation factor on proliferation of B-lymphocytes of the peripheral blood of healthy donors and patients with bronchial asthma].
Topics: Adult; Asthma; B-Lymphocytes; Cell Division; Cells, Cultured; Female; Humans; Immunoglobulin E; Immu | 1991 |
Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs.
Topics: Aerosols; Animals; Asthma; Bethanidine; Electric Stimulation; Female; Gallamine Triethiodide; Guinea | 1991 |
Aspirin-sensitive asthma: significance of the cyclooxygenase-inhibiting and protein-binding properties of analgesic drugs.
Topics: Acetaminophen; Administration, Inhalation; Adult; Aged; Aspirin; Asthma; Dinoprost; Drug Tolerance; | 1991 |
Epithelium-derived inhibitory factor in human bronchus.
Topics: Animals; Asthma; Biological Factors; Bronchi; Carbachol; Histamine; Humans; In Vitro Techniques; Ind | 1990 |
Mechanisms of decrease in cytoplasmic motility of alveolar macrophages during immediate asthmatic response in dogs.
Topics: Aerosols; Alprostadil; Animals; Antigens, Helminth; Ascaris; Asthma; Carbon Dioxide; Cytoplasm; Dicl | 1990 |
[Eicosanoids in bronchial asthma].
Topics: Acrylates; Arachidonic Acids; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Chromones; Cycloo | 1990 |
Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224.
Topics: Albumins; Anaphylaxis; Animals; Asthma; Azepines; Betamethasone; Bronchoalveolar Lavage Fluid; Cell | 1990 |
Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma.
Topics: Acrylates; Asthma; Bronchi; Bronchial Provocation Tests; Bronchiectasis; Bronchitis; Female; Forced | 1990 |
Responses of equine trachealis and lung parenchyma to methacholine, histamine, serotonin, prostanoids, and leukotrienes in vitro.
Topics: Animals; Asthma; Atropine; Disease Models, Animal; Histamine; Horses; In Vitro Techniques; Indometha | 1990 |
Abnormal platelet hydrogen peroxide metabolism in aspirin hypersensitivity.
Topics: Aspirin; Asthma; Blood Platelets; Drug Hypersensitivity; Glutathione Peroxidase; Humans; Hydrogen Pe | 1990 |
Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs.
Topics: Acrylates; Animals; Asthma; Female; Guinea Pigs; Histamine; Histamine Release; Indomethacin; Lung; M | 1987 |
On the mechanism of aspirin asthma.
Topics: Aspirin; Asthma; Humans; In Vitro Techniques; Indomethacin; Leukotrienes; Lung; Lysine | 1989 |
Inhibitability and enhanceability of basophil histamine release in asthmatic and normal subjects.
Topics: Adolescent; Adult; Asthma; Basophils; Bronchial Provocation Tests; Female; Histamine Release; Humans | 1985 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chrom | 1989 |
Acute asthma attack due to ophthalmic indomethacin.
Topics: Aged; Albuterol; Asthma; Combined Modality Therapy; Female; Glucocorticoids; Humans; Indomethacin; O | 1989 |
Human isolated bronchial muscle preparations from asthmatic patients: effects of indomethacin and contractile agonists.
Topics: Acetylcholine; Asthma; Bronchi; Dinoprost; Dinoprostone; Histamine; Humans; In Vitro Techniques; Ind | 1989 |
Effects of antigen on tracheal circulation and smooth muscle in sheep of different ages.
Topics: Age Factors; Animals; Antigens, Helminth; Ascaris; Asthma; Female; Indomethacin; Male; Muscle Contra | 1989 |
Role of arachidonic acid metabolites in beta-adrenergic desensitization in lungs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Guinea Pigs; Indomethacin; Isoproterenol; Lung | 1987 |
[Occurrence of drug reactions].
Topics: Acetaminophen; Adult; Anaphylaxis; Angioedema; Aspirin; Asthma; Drug Hypersensitivity; Emergencies; | 1986 |
Increased activity of 5-lipoxygenase in polymorphonuclear leukocytes from asthmatic patients.
Topics: Adult; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Asthma; Calcium; Chromatogra | 1985 |
[Effect of indomethacin on beta adrenergic receptor function in bronchial asthma].
Topics: Adult; Asthma; Female; Humans; Indomethacin; Male; Receptors, Adrenergic, beta | 1986 |
Pharmacological characterization of airway smooth muscle responses to antigen in ascaris-sensitive dogs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Airway Resistance; Animals; Antigens, Helminth; Arac | 1986 |
[The role of arachidonic acid metabolites on bronchial hyperresponsiveness to acetylcholine in asthmatic patients].
Topics: Acetylcholine; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Bronchial Provocat | 1986 |
Mechanism of platelet activating factor-induced bronchoconstriction in humans.
Topics: Adolescent; Adult; Asthma; Atropine; Bronchi; Bronchial Provocation Tests; Chlorpheniramine; Dose-Re | 1988 |
Regional differences in the mechanical properties of rabbit airway smooth muscle.
Topics: Acetylcholine; Animals; Asthma; Bronchi; Histamine; In Vitro Techniques; Indomethacin; Male; Muscle | 1988 |
Ciliary responsiveness in allergic and nonallergic airways.
Topics: Alprostadil; Animals; Ascaris; Asthma; Cilia; Dinoprostone; Dose-Response Relationship, Drug; Epithe | 1986 |
Tolerance to acetylsalicylic acid (ASA) induced in ASA-sensitive asthmatics does not depend on initial adverse reaction.
Topics: Adult; Aspirin; Asthma; Desensitization, Immunologic; Drug Hypersensitivity; Drug Tolerance; Female; | 1987 |
Effect of macrophage stimulation on parasympathetic airway contraction in dogs.
Topics: Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Dogs; Electric Stimulation; Fatty | 1987 |
Differential effects of epithelium removal on the responsiveness of guinea-pig tracheal smooth muscle to bronchoconstrictors.
Topics: Animals; Asthma; Bronchi; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle C | 1987 |
Tachyphylaxis to inhaled histamine in asthmatic subjects.
Topics: Acetylcholine; Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Provocation Tests; F | 1987 |
[Development of aspirin tolerance in hypersensitive persons. I. Methods of development of tolerance, aspirin refraction time and cross tolerance to other drugs].
Topics: Antipyrine; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Tolerance; Humans; Indomet | 1986 |
[Immunomodulating therapy with indomethacin and levamisole in patients with chronic bronchitis and bronchial asthma].
Topics: Adult; Asthma; Bronchitis; Chronic Disease; Drug Therapy, Combination; Female; Humans; Indomethacin; | 1985 |
[Demonstration of specific platelet function anomaly in asthma induced by aspirin: diagnostic consequences].
Topics: Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Pro | 1985 |
Non-steroid anti-inflammatory drugs in asthma: dangerous or useful therapy?
Topics: Adolescent; Adult; Allergens; Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Cats; Dust; Fema | 1985 |
Leukotrienes (LTC4, LTD4) confer glass non-adherence on leukocytes of asthmatic individuals. Dependency on cyclooxygenase products and calcium ion.
Topics: Asthma; Calcium; Cell Adhesion; Child; Cyclooxygenase Inhibitors; Dinoprostone; Glass; Humans; Indom | 1985 |
[Inhibitory effects of various drugs on histamine or allergen-induced bronchoconstriction].
Topics: Adolescent; Adult; Aged; Animals; Asthma; Diethylcarbamazine; Drug Evaluation; Female; Guinea Pigs; | 1985 |
[Intravenous indomethacin in therapy of rheumatic diseases and other morbid conditions].
Topics: Adult; Aged; Arthritis, Rheumatoid; Asthma; Female; Gout; Humans; Indomethacin; Male; Middle Aged; O | 1972 |
[Bronchial asthma, a side effect of indomethacin which can be avoided].
Topics: Adult; Aspirin; Asthma; Humans; Indomethacin; Male; Nasal Polyps | 1973 |
Aspirin and other cross-reacting small chemicals in known aspirin intolerant patients.
Topics: Analgesics; Antioxidants; Aspirin; Asthma; Blood Coagulation; Cross Reactions; Dose-Response Relatio | 1973 |
Concerning the nature of intolerance to aspirin.
Topics: Aminopyrine; Antipyrine; Aspirin; Asthma; Chemoreceptor Cells; Drug Hypersensitivity; Edema; Histami | 1967 |
[Clinical observations on the treatment of rheumatic diseases and other morbid states with indomethacin].
Topics: Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Asthma; Crohn Disease; Dexamethasone; Hodgkin | 1966 |
Response of aspirin-allergic patients to challenge by some analgesics in common use.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Female | 1971 |