indomethacin has been researched along with Arteriosclerosis in 44 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 7.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 3.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "Late-onset sporadic Alzheimer's disease is a heterogeneous disorder." | 2.42 | Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. ( Casserly, I; Topol, E, 2004) |
| "The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis." | 1.36 | Antenatal Bartter syndrome: analysis of two cases with placental findings. ( Aksoy, F; Cetin, A; Dane, B; Dane, C; Yayla, M, 2010) |
| "Rofecoxib treatment did not inhibit platelet thromboxane production, a COX-1-mediated process, but it significantly reduced the urinary prostacyclin metabolite 2,3-dinor-6-keto-PGF1alpha." | 1.31 | Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. ( Babaev, VR; Burleigh, ME; Fazio, S; Gautam, S; Harris, RC; Linton, MF; Marnett, LJ; Morrow, JD; Oates, JA; Riendeau, D, 2002) |
| " Arteries from the late stress group had impaired dilation (shift of the dose-response curve down and to the right) to acetylcholine and the calcium ionophore A23187 (for both, P < 0." | 1.29 | Effects of psychosocial stress on endothelium-mediated dilation of atherosclerotic arteries in cynomolgus monkeys. ( Kaplan, JR; Manuck, SB; Williams, JK, 1993) |
| " The leukotriene receptor antagonist ICI-198,615 (3 x 10(-8)M) produced an approximate 50-fold rightward shift of the leukotriene C4 dose-response curve (n = 5)." | 1.29 | Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4. ( Allen, SP; Chester, AH; Collins, M; Dashwood, MR; Piper, PJ; Tadjkarimi, S; Yacoub, MH, 1993) |
| "During oxygen deficiency, control preparations showed a maximal hyperpolarization of delta V = 10." | 1.28 | Role of prostacyclin in normal and arteriosclerotic human coronary arteries during hypoxia. ( Hetzer, R; Müller, J; Rückborn, K; Schnalke, F; Siegel, G, 1992) |
| "Indomethacin did not inhibit sheep platelet aggregation in the concentration range 0." | 1.26 | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. ( Leach, CM; Thorburn, GD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (40.91) | 18.7374 |
| 1990's | 16 (36.36) | 18.2507 |
| 2000's | 9 (20.45) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dane, B | 1 |
| Dane, C | 1 |
| Aksoy, F | 1 |
| Cetin, A | 1 |
| Yayla, M | 1 |
| Rabelo, LA | 1 |
| Cortes, SF | 1 |
| Alvarez-Leite, JI | 1 |
| Lemos, VS | 1 |
| Shimizu, Y | 1 |
| Nagaya, N | 1 |
| Teranishi, Y | 1 |
| Imazu, M | 1 |
| Yamamoto, H | 3 |
| Shokawa, T | 1 |
| Kangawa, K | 1 |
| Kohno, N | 1 |
| Yoshizumi, M | 1 |
| Casserly, I | 1 |
| Topol, E | 1 |
| Békési, G | 1 |
| Heinle, H | 1 |
| Kakucs, R | 1 |
| Pázmány, T | 1 |
| Szombath, D | 1 |
| Dinya, M | 1 |
| Tulassay, Z | 1 |
| Fehér, J | 1 |
| Rácz, K | 1 |
| Székács, B | 1 |
| Riss, E | 1 |
| Farkas, A | 1 |
| Gódor, F | 1 |
| Illyés, G | 1 |
| Burleigh, ME | 3 |
| Babaev, VR | 3 |
| Patel, MB | 1 |
| Crews, BC | 1 |
| Remmel, RP | 1 |
| Morrow, JD | 3 |
| Oates, JA | 3 |
| Marnett, LJ | 2 |
| Fazio, S | 3 |
| Linton, MF | 3 |
| Yancey, PG | 1 |
| Major, AS | 1 |
| McCaleb, JL | 1 |
| Packham, MA | 1 |
| Mustard, JF | 1 |
| Blackshear, JL | 1 |
| Davidman, M | 1 |
| Stillman, MT | 1 |
| Jouve, R | 1 |
| Juhan-Vague, I | 1 |
| Aillaud, M | 1 |
| Serment-Jouve, M | 1 |
| Payan, H | 1 |
| Leach, CM | 1 |
| Thorburn, GD | 1 |
| Hohlfeld, T | 1 |
| Scharnowski, F | 1 |
| Braun, M | 1 |
| Schrör, K | 1 |
| Ikeda, U | 1 |
| Okada, K | 1 |
| Ishikawa, S | 1 |
| Saito, T | 1 |
| Kasahara, T | 1 |
| Shimada, K | 1 |
| Williams, JK | 1 |
| Kaplan, JR | 1 |
| Manuck, SB | 1 |
| Stoller, DK | 1 |
| Grorud, CB | 1 |
| Michalek, V | 1 |
| Buchwald, H | 1 |
| Allen, SP | 1 |
| Dashwood, MR | 1 |
| Chester, AH | 1 |
| Tadjkarimi, S | 1 |
| Collins, M | 1 |
| Piper, PJ | 1 |
| Yacoub, MH | 1 |
| Akishita, M | 1 |
| Ouchi, Y | 1 |
| Miyoshi, H | 1 |
| Kozaki, K | 1 |
| Inoue, S | 1 |
| Ishikawa, M | 1 |
| Eto, M | 1 |
| Toba, K | 1 |
| Orimo, H | 1 |
| Hangaishi, M | 1 |
| Taguchi, J | 1 |
| Miyata, T | 1 |
| Ikari, Y | 1 |
| Togo, M | 1 |
| Hashimoto, Y | 1 |
| Watanabe, T | 1 |
| Kimura, S | 1 |
| Kurokawa, K | 1 |
| Ohno, M | 1 |
| Azadzoi, KM | 1 |
| Krane, RJ | 1 |
| Saenz de Tejada, I | 1 |
| Goldstein, I | 1 |
| Siroky, MB | 1 |
| Jiang, J | 1 |
| Thorén, P | 1 |
| Caligiuri, G | 1 |
| Hansson, GK | 1 |
| Pernow, J | 1 |
| Stanford, SJ | 1 |
| Pepper, JR | 1 |
| Mitchell, JA | 1 |
| Cyrus, T | 1 |
| Tang, LX | 1 |
| Rokach, J | 1 |
| FitzGerald, GA | 1 |
| Praticò, D | 1 |
| Harris, RC | 1 |
| Gautam, S | 1 |
| Riendeau, D | 1 |
| Jobin, F | 1 |
| Moncada, S | 1 |
| Higgs, EA | 1 |
| Vane, JR | 1 |
| Virág, S | 1 |
| Vértesi, C | 1 |
| Welner, I | 1 |
| Strano, A | 1 |
| Novo, S | 1 |
| Ciammaichella, A | 1 |
| König, HJ | 1 |
| Kogut, MD | 1 |
| Radzivil, VF | 1 |
| Patrignani, P | 1 |
| Daffonchio, L | 1 |
| Hernandez, A | 1 |
| De Caterina, R | 1 |
| Pelosi, G | 1 |
| Patrono, C | 1 |
| Dhawan, V | 1 |
| Ganguly, NK | 1 |
| Majumdar, S | 1 |
| Chakravarti, RN | 1 |
| Siegel, G | 1 |
| Schnalke, F | 1 |
| Rückborn, K | 1 |
| Müller, J | 1 |
| Hetzer, R | 1 |
| Hagihara, H | 1 |
| Nomoto, A | 1 |
| Mutoh, S | 1 |
| Yamaguchi, I | 1 |
| Ono, T | 1 |
| Mügge, A | 1 |
| Heistad, DD | 1 |
| Padgett, RC | 1 |
| Waack, BJ | 1 |
| Densen, P | 1 |
| Lopez, JA | 1 |
| Korbut, R | 1 |
| Ocetkiewicz, A | 1 |
| Dabros, W | 1 |
| Gryglewski, RJ | 1 |
| Sellke, FW | 1 |
| Armstrong, ML | 2 |
| Harrison, DG | 1 |
| Visser, MR | 1 |
| Tracy, PB | 1 |
| Vercellotti, GM | 1 |
| Goodman, JL | 1 |
| White, JG | 1 |
| Jacob, HS | 1 |
| Nakamura, M | 2 |
| Tomoike, H | 2 |
| Shimokawa, H | 2 |
| Mehta, JL | 1 |
| Lawson, D | 1 |
| Mehta, P | 1 |
| Saldeen, T | 1 |
| Bossaller, C | 1 |
| Cartwright, J | 1 |
| Henry, PD | 1 |
| Jayakody, L | 1 |
| Senaratne, M | 1 |
| Thomson, A | 1 |
| Kappagoda, T | 1 |
| Nabeyama, S | 1 |
| Mathur, SN | 1 |
| Field, FJ | 1 |
| Spector, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Retinal Artery Lesions to Predict Long-term Outcomes in Patients With Acute Coronary Syndrome After Drug-Eluting Stent Implantation[NCT02415452] | 660 participants (Actual) | Observational | 2006-07-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for indomethacin and Arteriosclerosis
| Article | Year |
|---|---|
Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cholest | 2004 |
Pharmacology of platelet-affecting drugs.
Topics: Animals; Arachidonic Acids; Arteriosclerosis; Aspirin; Blood Platelets; Cyclic AMP; Dose-Response Re | 1980 |
[Blood platelets and cardiovascular diseases. IV. Platelet-inhibiting drugs and antithrombotic agents].
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Analgesics; Anti-Inflammatory Agents; Arterioscl | 1976 |
[Prospects of antiaggregant therapy in prevention of atherosclerosis].
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Arteriosclerosis; Aspirin; Blood Coagulation Diso | 1979 |
1 trial available for indomethacin and Arteriosclerosis
| Article | Year |
|---|---|
Combined vessel injuring action of adjuvant arthritis and cholesterol diet. (III. Action of Chinoin-123 on a new model of experimental atherosclerosis of rat).
Topics: Animals; Arteriosclerosis; Arthritis; Arthritis, Experimental; Cholesterol, Dietary; Clinical Trials | 1978 |
39 other studies available for indomethacin and Arteriosclerosis
| Article | Year |
|---|---|
Antenatal Bartter syndrome: analysis of two cases with placental findings.
Topics: Adult; Amniocentesis; Amniotic Fluid; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Bar | 2010 |
Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.
Topics: Acetylcholine; Amitrole; Animals; Aorta, Thoracic; Arteriosclerosis; Catalase; Endothelium; Endothel | 2003 |
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Blotting, Western; Body W | 2003 |
Effect of inhibitors of myeloperoxidase on the development of aortic atherosclerosis in an animal model.
Topics: Aniline Compounds; Animals; Aortic Diseases; Arteriosclerosis; Cholesterol, Dietary; Histocytochemis | 2005 |
Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox | 2005 |
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Chemokine CCL2; Cyclooxygenase | 2005 |
Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Adult; Age Factors; Aged; Anti-Inflammatory Agents; Arteriosclerosis; Blood Ure | 1983 |
Comparison of the effects of aspirin and indomethacin on aortic atherogenesis induced in rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Aspirin; Blood Coagulation; Cholesterol; Diet, Atherogenic; Indome | 1982 |
A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteriosclerosis; Blood | 1982 |
Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia.
Topics: Adenosine Diphosphate; Animals; Aortic Diseases; Arteriosclerosis; Biotransformation; Cholesterol, D | 1994 |
Monocyte chemoattractant protein 1 inhibits growth of rat vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arginine; Arteriosclerosis; Cell Division; Cells, Cultured; C | 1995 |
Effects of psychosocial stress on endothelium-mediated dilation of atherosclerotic arteries in cynomolgus monkeys.
Topics: Acetylcholine; Animals; Arginine; Arteriosclerosis; Calcimycin; Diet, Atherogenic; Dose-Response Rel | 1993 |
Reduction of atherosclerosis with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Arachidonic Acid; Arteriosclerosi | 1993 |
Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4.
Topics: Adolescent; Adult; Arteriosclerosis; Child; Child, Preschool; Coronary Vessels; Endothelium, Vascula | 1993 |
Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells.
Topics: Animals; Arteriosclerosis; Blood Pressure; Cell Division; Cell Movement; Cells, Cultured; Deoxygluco | 1997 |
Increased aggregation of human platelets produced by advanced glycation end products in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arginine; | 1998 |
Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle.
Topics: Animals; Arginine; Arteriosclerosis; Electric Stimulation; Enzyme Inhibitors; Hypercholesterolemia; | 1999 |
Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta; Arteriosclerosis; Calcium; Cholera Toxin; Enzyme Inh | 1999 |
Cyclooxygenase-2 regulates granulocyte-macrophage colony-stimulating factor, but not interleukin-8, production by human vascular cells: role of cAMP.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arteriosclerosis; Aspirin; Bucladesi | 2000 |
Lipid peroxidation and platelet activation in murine atherosclerosis.
Topics: Animals; Antioxidants; Aorta; Arteriosclerosis; Cyclooxygenase Inhibitors; Diet, Atherogenic; Dietar | 2001 |
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
Topics: Animals; Arteriosclerosis; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxyg | 2002 |
Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.
Topics: Anticoagulants; Arachidonic Acids; Arteries; Arteriosclerosis; Hot Temperature; Humans; Indomethacin | 1977 |
[Current status of vascular diseases and their treatment].
Topics: Arteriosclerosis; Aspirin; Clofibrate; Humans; Indomethacin; Sulfinpyrazone; Vasodilator Agents | 1979 |
[Therapy of gout].
Topics: Allopurinol; Arteriosclerosis; Benzbromarone; Colchicine; Gout; Humans; Immobilization; Indomethacin | 1979 |
[Effect of acetylsalicylic acid and indomethacin on lipid metabolism].
Topics: Adolescent; Adult; Aged; Arteriosclerosis; Arthritis, Rheumatoid; Aspirin; Female; Humans; Indometha | 1978 |
Release of contracting autacoids by aortae of normal and atherosclerotic rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Calcimycin; Cholesterol, Dietary; Endothelins; Indoles; Indomethac | 1992 |
Effect of indomethacin on serum lipids, lipoproteins, prostaglandins and the extent and severity of atherosclerosis in rhesus monkeys.
Topics: Animals; Apoproteins; Arteriosclerosis; Coronary Artery Disease; Diet, Atherogenic; Hyperlipidemias; | 1992 |
Role of prostacyclin in normal and arteriosclerotic human coronary arteries during hypoxia.
Topics: Arteriosclerosis; Coronary Vessels; Epoprostenol; Humans; Hypoxia; In Vitro Techniques; Indomethacin | 1992 |
Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery.
Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cell Adhesion; Cell Movement; | 1991 |
Mechanisms of contraction induced by human leukocytes in normal and atherosclerotic arteries.
Topics: Animals; Arteriosclerosis; Complement C5a; Femoral Artery; Free Radicals; Humans; In Vitro Technique | 1991 |
A biological method for studying the interaction between platelets and vascular endothelium.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Aspirin; Blood Platelets; Endothelium, Vascular; Epopros | 1990 |
Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arterios | 1990 |
Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium.
Topics: Arteriosclerosis; Blood Platelets; Cell Adhesion; Cell Aggregation; Endothelium; Herpes Simplex; Hum | 1988 |
Effects of prostacyclin, indomethacin, and thiothromboxane A2 on histamine-induced coronary spasm in atherosclerotic miniature swine.
Topics: Animals; Arteriosclerosis; Coronary Vasospasm; Disease Models, Animal; Epoprostenol; Histamine; Indo | 1985 |
Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis.
Topics: Animals; Aorta, Abdominal; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis; Diet, Atherogenic; | 1988 |
Videomicroscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit.
Topics: Acetylcholine; Animals; Arterioles; Arteriosclerosis; Atropine; Blood Pressure; Dose-Response Relati | 1988 |
Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Atropine; Diet, Atherogenic; Endothelium; | 1987 |
Histamine-induced spasm not significantly modulated by prostanoids in a swine model of coronary artery spasm.
Topics: Animals; Arteriosclerosis; Body Weight; Cholesterol; Coronary Vasospasm; Disease Models, Animal; Epo | 1985 |
Increased production of lipoxygenase products by cholesterol-rich mouse macrophages.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Arteriosclerosis; Cells, Cul | 1985 |