indomethacin has been researched along with Arrhythmia in 30 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1." | 7.69 | Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 7.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts." | 7.67 | Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988) |
| " Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied." | 7.67 | Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs. ( Kaushal, R; Tripathi, RM, 1988) |
| "We report data indicating that pulmonary edema develops after coronary artery ligation despite stable microvascular pressure." | 5.26 | Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin. ( Paulshock, C; Richeson, JF; Yun, PN, 1982) |
| "The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole-heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis." | 4.12 | Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model. ( Bäumer, S; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Leitz, PR; Wegner, F; Willy, K; Wolfes, J, 2022) |
| "During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase." | 3.72 | Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart. ( Krylatov, AV; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stakheev, DL, 2003) |
| "The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1." | 3.69 | Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994) |
| " We tested whether pretreatment with the kinin receptor antagonist Hoe 140, the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor indomethacin blocked the effect of ramiprilat on infarct size and reperfusion arrhythmias." | 3.69 | Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. ( Carretero, OA; Liu, YH; Sabbath, HN; Sharov, VG; Sigmon, DH; Yang, XP, 1996) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 3.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts." | 3.67 | Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988) |
| " Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied." | 3.67 | Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs. ( Kaushal, R; Tripathi, RM, 1988) |
| " The administration of intravenous ergonovine did not provoke ST-segment shifts or arrhythmias." | 3.67 | Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits. ( Cook, L; Reeves, WC; Whitesell, L; Wood, MA, 1985) |
| "Arrhythmias were produced by ouabain (2." | 3.67 | Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain. ( Ferrier, GR; Karmazyn, M; Moffat, MP, 1985) |
| "Effects of an intravenous injection of indomethacin, prostaglandins (PGs) E1, E2 and F2 alpha and prostacyclin were examined by the use of a model of two-stage coronary ligation arrhythmias in conscious dogs." | 3.66 | Effects of prostaglandins on late coronary ligation arrhythmias in the dog. ( Hashimoto, K; Imai, S; Shibuya, T, 1983) |
| "Cardiac arrhythmias were defined as the presence of ventricular tachycardia and/or ventricular fibrillation after the ligation of the coronary artery was released." | 1.31 | Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. ( Almeida, AP; Ferreira, AJ; Santos, RA, 2001) |
| "Bradykinin acts as an endogenous cardioprotective substance because it suppresses ventricular dysrhythmias induced by ischemia." | 1.30 | Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins. ( Bolla, BS; de Guzman, FQ; Hussain, Y; Igić, R; Montiague, RR; Rabito, SF; Rajani, V, 1997) |
| "A 67-year-old man with ulcerative colitis of 1 year's duration was hospitalized with myopericarditis." | 1.28 | [Cardiac involvement in inflammatory bowel disease]. ( Birnbaum, Y; Shpirer, Z, 1989) |
| "Pretreatment with promethazine and cimetidine, as H1 and H2 histamine receptor antagonists, markedly prevented the development of phase II, namely the rise in cardiac frequency, LVPs, MAP and TPR, but did not significantly modify phase I and III." | 1.27 | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. ( Alloatti, G; Camussi, G; Emanuelli, G; Mariano, F; Meda, E; Montrucchio, G; Tetta, C, 1987) |
| "We report data indicating that pulmonary edema develops after coronary artery ligation despite stable microvascular pressure." | 1.26 | Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin. ( Paulshock, C; Richeson, JF; Yun, PN, 1982) |
| "Pretreatment by indomethacin reduced the antiarrhythmic effects of linoleic acid from 40 percent to 9 percent on ouabain-induced arrhythmias in cats." | 1.26 | Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs. ( Blass, KE; Forter, W; Mest, HJ, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (66.67) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Wolfes, J | 1 |
| Ellermann, C | 1 |
| Bäumer, S | 1 |
| Fehr, M | 1 |
| Willy, K | 1 |
| Wegner, F | 1 |
| Leitz, PR | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Lishmanov, YB | 1 |
| Maslov, LN | 1 |
| Krylatov, AV | 1 |
| Solenkova, NV | 1 |
| Stakheev, DL | 1 |
| Hashimoto, K | 1 |
| Shibuya, T | 1 |
| Imai, S | 1 |
| Fagbemi, SO | 1 |
| Miyazaki, Y | 1 |
| Kotaka, K | 1 |
| Ogawa, K | 1 |
| Satake, T | 1 |
| Sugiyama, S | 1 |
| Ozawa, T | 1 |
| Richeson, JF | 1 |
| Paulshock, C | 1 |
| Yun, PN | 1 |
| Bhatti, AS | 1 |
| Khan, HH | 1 |
| Liu, YH | 1 |
| Yang, XP | 1 |
| Sharov, VG | 1 |
| Sigmon, DH | 1 |
| Sabbath, HN | 1 |
| Carretero, OA | 1 |
| Rajani, V | 1 |
| Hussain, Y | 1 |
| Bolla, BS | 1 |
| de Guzman, FQ | 1 |
| Montiague, RR | 1 |
| Igić, R | 1 |
| Rabito, SF | 1 |
| Bakheet, DM | 1 |
| El Tahir, KE | 1 |
| Al-Sayed, MI | 1 |
| El-Obeid, HA | 1 |
| Al-Rashood, KA | 1 |
| Wang, L | 1 |
| Ferreira, AJ | 1 |
| Santos, RA | 1 |
| Almeida, AP | 1 |
| Wilkerson, RD | 1 |
| Glenn, TM | 1 |
| Swift, A | 1 |
| Karmazyn, M | 3 |
| Horrobin, DF | 1 |
| Manku, MS | 1 |
| Karmali, RA | 1 |
| Morgan, RO | 1 |
| Ally, AI | 1 |
| Mest, HJ | 2 |
| Blass, KE | 2 |
| Forter, W | 1 |
| Forster, W | 1 |
| Mentz, P | 1 |
| Bernier, M | 1 |
| Alyea, EP | 1 |
| Hearse, DJ | 1 |
| Birnbaum, Y | 1 |
| Shpirer, Z | 1 |
| Linz, W | 1 |
| Lau, HH | 1 |
| Beck, G | 1 |
| Schökens, BA | 1 |
| Booth, DC | 1 |
| Cunningham, MR | 1 |
| Rountree, RM | 1 |
| Elion, J | 1 |
| Nissen, SE | 1 |
| Gillespie, MN | 1 |
| Montrucchio, G | 1 |
| Alloatti, G | 1 |
| Mariano, F | 1 |
| Meda, E | 1 |
| Tetta, C | 1 |
| Emanuelli, G | 1 |
| Camussi, G | 1 |
| Sambelian, VM | 1 |
| Krasnikov, NF | 1 |
| Malakian, MG | 1 |
| Tripathi, RM | 1 |
| Kaushal, R | 1 |
| McLennan, PL | 1 |
| Abeywardena, MY | 1 |
| Charnock, JS | 1 |
| Moffat, MP | 2 |
| Ferrier, GR | 2 |
| Reeves, WC | 1 |
| Cook, L | 1 |
| Wood, MA | 1 |
| Whitesell, L | 1 |
| Block, AJ | 1 |
| Poole, S | 1 |
| Vane, JR | 1 |
| Riedel, R | 1 |
| Schoetensack, W | 1 |
1 review available for indomethacin and Arrhythmia
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
29 other studies available for indomethacin and Arrhythmia
| Article | Year |
|---|---|
Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Cardiac E | 2022 |
Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Glyburide; In | 2003 |
Effects of prostaglandins on late coronary ligation arrhythmias in the dog.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Dogs; Epoprostenol; Female; Heart R | 1983 |
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Coronary Vessels; Disease Models, | 1984 |
Mechanism of reperfusion arrhythmia prostaglandin as a washout metabolite.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Disease; Dinoprost; Dogs; Female; Indo | 1982 |
Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Body Water; Cardiac Output; Coronary Vessels; Dogs; H | 1982 |
Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study.
Topics: Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cardiac Complexes, Premature; Cause of Death | 1994 |
Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine | 1996 |
Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Car | 1997 |
Studies on the cardiovascular depressant effects of N-ethyl- and N-benzyl-1,2-diphenylethanolamines in the rat: elucidation of the mechanisms of action.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium Chloride; Cardiovascular Agents; Cardiovascul | 1999 |
The role of prostaglandins in the antiarrhythmic effect of ischemic preconditioning.
Topics: Animals; Arrhythmias, Cardiac; Cardiovascular Agents; Electrocardiography; Heart Rate; Indomethacin; | 2001 |
Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion.
Topics: Angiotensin I; Angiotensin II; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradykinin; He | 2001 |
Influence of nonsteroidal anti-inflammatory drugs on ouabain toxicity.
Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Cyclooxygenase Inhibitors; Dogs; F | 1977 |
Low prostaglandin concentrations cause cardiac rhythm disturbances. Effect reversed by low levels of copper or chloroquine.
Topics: Animals; Arrhythmias, Cardiac; Chloroquine; Copper; Drug Synergism; Heart Conduction System; Indomet | 1978 |
Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs.
Topics: Animals; Arachidonic Acids; Arrhythmias, Cardiac; Cats; Drug Synergism; Fatty Acids, Unsaturated; Fe | 1977 |
Antiarrhythmic effects of arachidonic, linoleic, linolenic, and oleic acid, and the influence of indomethacin and polyphloretinephosphate.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Barium; Fatty A | 1976 |
Reperfusion-induced arrhythmias are not prevented by ibuprofen in isolated rat heart.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; Coronary Circulation; Cyclooxyge | 1990 |
[Cardiac involvement in inflammatory bowel disease].
Topics: Aged; Arrhythmias, Cardiac; Colitis, Ulcerative; Humans; Indomethacin; Male; Myocarditis; Pericardit | 1989 |
Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Epoprostenol; Heart; Imidazoles; In Vitro Technique | 1988 |
Coronary arteriography in the intact rabbit: demonstration of coronary vasomotor and electrocardiographic effects of ergonovine and indomethacin in rabbits after abrupt cessation of prolonged nitroglycerin treatment.
Topics: Animals; Arrhythmias, Cardiac; Cineangiography; Coronary Angiography; Coronary Vasospasm; Coronary V | 1987 |
The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition.
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Cyclooxygenase Inhibitors; Drug Interactions; Electrocard | 1987 |
[Anti-arrhythmic effect of indomethacin in experimental studies].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Chloride; Cats; Chick Embr | 1988 |
Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Fem | 1988 |
A comparison of the long-term effects of n-3 and n-6 polyunsaturated fatty acid dietary supplements and the action of indomethacin upon the mechanical performance and susceptibility of the rat heart to dysrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Dietary Fats, Unsaturated; Female; In Vitro Techniques; Indo | 1987 |
A possible role for endogenous prostaglandins in the electrophysiological effects of acetylstrophanthidin on isolated canine ventricular tissues.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arrhythmias, Cardiac; Aspirin; Cardiac Pacing, Artificial; Do | 1986 |
Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Ergonovine; Humans; Indometh | 1985 |
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; As | 1985 |
Modification of basal release of prostaglandins from rabbit isolated hearts.
Topics: Animals; Arrhythmias, Cardiac; Carbon Dioxide; Colon; Depression, Chemical; Electric Stimulation; Em | 1974 |
[Pharmacology of butylmalonic acidmono-(1,2-diphenylhydrazide)-calcium (bumadizone-calcium)].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Blood Pr | 1973 |