Page last updated: 2024-10-29

indomethacin and Arrhythmia

indomethacin has been researched along with Arrhythmia in 30 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1."7.69Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994)
"The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats."7.67The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984)
"We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts."7.67Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988)
" Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied."7.67Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs. ( Kaushal, R; Tripathi, RM, 1988)
"We report data indicating that pulmonary edema develops after coronary artery ligation despite stable microvascular pressure."5.26Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin. ( Paulshock, C; Richeson, JF; Yun, PN, 1982)
"The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole-heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis."4.12Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model. ( Bäumer, S; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Leitz, PR; Wegner, F; Willy, K; Wolfes, J, 2022)
"During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase."3.72Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart. ( Krylatov, AV; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stakheev, DL, 2003)
"The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1."3.69Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994)
" We tested whether pretreatment with the kinin receptor antagonist Hoe 140, the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor indomethacin blocked the effect of ramiprilat on infarct size and reperfusion arrhythmias."3.69Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. ( Carretero, OA; Liu, YH; Sabbath, HN; Sharov, VG; Sigmon, DH; Yang, XP, 1996)
"The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats."3.67The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984)
"We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts."3.67Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988)
" Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied."3.67Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs. ( Kaushal, R; Tripathi, RM, 1988)
" The administration of intravenous ergonovine did not provoke ST-segment shifts or arrhythmias."3.67Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits. ( Cook, L; Reeves, WC; Whitesell, L; Wood, MA, 1985)
"Arrhythmias were produced by ouabain (2."3.67Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain. ( Ferrier, GR; Karmazyn, M; Moffat, MP, 1985)
"Effects of an intravenous injection of indomethacin, prostaglandins (PGs) E1, E2 and F2 alpha and prostacyclin were examined by the use of a model of two-stage coronary ligation arrhythmias in conscious dogs."3.66Effects of prostaglandins on late coronary ligation arrhythmias in the dog. ( Hashimoto, K; Imai, S; Shibuya, T, 1983)
"Cardiac arrhythmias were defined as the presence of ventricular tachycardia and/or ventricular fibrillation after the ligation of the coronary artery was released."1.31Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. ( Almeida, AP; Ferreira, AJ; Santos, RA, 2001)
"Bradykinin acts as an endogenous cardioprotective substance because it suppresses ventricular dysrhythmias induced by ischemia."1.30Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins. ( Bolla, BS; de Guzman, FQ; Hussain, Y; Igić, R; Montiague, RR; Rabito, SF; Rajani, V, 1997)
"A 67-year-old man with ulcerative colitis of 1 year's duration was hospitalized with myopericarditis."1.28[Cardiac involvement in inflammatory bowel disease]. ( Birnbaum, Y; Shpirer, Z, 1989)
"Pretreatment with promethazine and cimetidine, as H1 and H2 histamine receptor antagonists, markedly prevented the development of phase II, namely the rise in cardiac frequency, LVPs, MAP and TPR, but did not significantly modify phase I and III."1.27The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. ( Alloatti, G; Camussi, G; Emanuelli, G; Mariano, F; Meda, E; Montrucchio, G; Tetta, C, 1987)
"We report data indicating that pulmonary edema develops after coronary artery ligation despite stable microvascular pressure."1.26Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin. ( Paulshock, C; Richeson, JF; Yun, PN, 1982)
"Pretreatment by indomethacin reduced the antiarrhythmic effects of linoleic acid from 40 percent to 9 percent on ouabain-induced arrhythmias in cats."1.26Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs. ( Blass, KE; Forter, W; Mest, HJ, 1977)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199020 (66.67)18.7374
1990's5 (16.67)18.2507
2000's3 (10.00)29.6817
2010's1 (3.33)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Vivier, D1
Bennis, K1
Lesage, F1
Ducki, S1
Wolfes, J1
Ellermann, C1
Bäumer, S1
Fehr, M1
Willy, K1
Wegner, F1
Leitz, PR1
Eckardt, L1
Frommeyer, G1
Lishmanov, YB1
Maslov, LN1
Krylatov, AV1
Solenkova, NV1
Stakheev, DL1
Hashimoto, K1
Shibuya, T1
Imai, S1
Fagbemi, SO1
Miyazaki, Y1
Kotaka, K1
Ogawa, K1
Satake, T1
Sugiyama, S1
Ozawa, T1
Richeson, JF1
Paulshock, C1
Yun, PN1
Bhatti, AS1
Khan, HH1
Liu, YH1
Yang, XP1
Sharov, VG1
Sigmon, DH1
Sabbath, HN1
Carretero, OA1
Rajani, V1
Hussain, Y1
Bolla, BS1
de Guzman, FQ1
Montiague, RR1
Igić, R1
Rabito, SF1
Bakheet, DM1
El Tahir, KE1
Al-Sayed, MI1
El-Obeid, HA1
Al-Rashood, KA1
Wang, L1
Ferreira, AJ1
Santos, RA1
Almeida, AP1
Wilkerson, RD1
Glenn, TM1
Swift, A1
Karmazyn, M3
Horrobin, DF1
Manku, MS1
Karmali, RA1
Morgan, RO1
Ally, AI1
Mest, HJ2
Blass, KE2
Forter, W1
Forster, W1
Mentz, P1
Bernier, M1
Alyea, EP1
Hearse, DJ1
Birnbaum, Y1
Shpirer, Z1
Linz, W1
Lau, HH1
Beck, G1
Schökens, BA1
Booth, DC1
Cunningham, MR1
Rountree, RM1
Elion, J1
Nissen, SE1
Gillespie, MN1
Montrucchio, G1
Alloatti, G1
Mariano, F1
Meda, E1
Tetta, C1
Emanuelli, G1
Camussi, G1
Sambelian, VM1
Krasnikov, NF1
Malakian, MG1
Tripathi, RM1
Kaushal, R1
McLennan, PL1
Abeywardena, MY1
Charnock, JS1
Moffat, MP2
Ferrier, GR2
Reeves, WC1
Cook, L1
Wood, MA1
Whitesell, L1
Block, AJ1
Poole, S1
Vane, JR1
Riedel, R1
Schoetensack, W1

Reviews

1 review available for indomethacin and Arrhythmia

ArticleYear
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc

2016

Other Studies

29 other studies available for indomethacin and Arrhythmia

ArticleYear
Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.
    Basic & clinical pharmacology & toxicology, 2022, Volume: 130, Issue:1

    Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Cardiac E

2022
Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.
    Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:1

    Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Glyburide; In

2003
Effects of prostaglandins on late coronary ligation arrhythmias in the dog.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Dogs; Epoprostenol; Female; Heart R

1983
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
    European journal of pharmacology, 1984, Jan-27, Volume: 97, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Coronary Vessels; Disease Models,

1984
Mechanism of reperfusion arrhythmia prostaglandin as a washout metabolite.
    Journal of electrocardiology, 1982, Volume: 15, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Disease; Dinoprost; Dogs; Female; Indo

1982
Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.
    Circulation research, 1982, Volume: 50, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Body Water; Cardiac Output; Coronary Vessels; Dogs; H

1982
Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study.
    JPMA. The Journal of the Pakistan Medical Association, 1994, Volume: 44, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cardiac Complexes, Premature; Cause of Death

1994
Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats.
    Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine

1996
Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins.
    The American journal of cardiology, 1997, Aug-04, Volume: 80, Issue:3A

    Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Car

1997
Studies on the cardiovascular depressant effects of N-ethyl- and N-benzyl-1,2-diphenylethanolamines in the rat: elucidation of the mechanisms of action.
    General pharmacology, 1999, Volume: 33, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium Chloride; Cardiovascular Agents; Cardiovascul

1999
The role of prostaglandins in the antiarrhythmic effect of ischemic preconditioning.
    Journal of biomedical science, 2001, Volume: 8, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Cardiovascular Agents; Electrocardiography; Heart Rate; Indomethacin;

2001
Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:3 Pt 2

    Topics: Angiotensin I; Angiotensin II; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradykinin; He

2001
Influence of nonsteroidal anti-inflammatory drugs on ouabain toxicity.
    American heart journal, 1977, Volume: 94, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Cyclooxygenase Inhibitors; Dogs; F

1977
Low prostaglandin concentrations cause cardiac rhythm disturbances. Effect reversed by low levels of copper or chloroquine.
    Prostaglandins, 1978, Volume: 15, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Chloroquine; Copper; Drug Synergism; Heart Conduction System; Indomet

1978
Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs.
    Prostaglandins, 1977, Volume: 14, Issue:1

    Topics: Animals; Arachidonic Acids; Arrhythmias, Cardiac; Cats; Drug Synergism; Fatty Acids, Unsaturated; Fe

1977
Antiarrhythmic effects of arachidonic, linoleic, linolenic, and oleic acid, and the influence of indomethacin and polyphloretinephosphate.
    Advances in prostaglandin and thromboxane research, 1976, Volume: 1

    Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Barium; Fatty A

1976
Reperfusion-induced arrhythmias are not prevented by ibuprofen in isolated rat heart.
    Free radical biology & medicine, 1990, Volume: 8, Issue:6

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; Coronary Circulation; Cyclooxyge

1990
[Cardiac involvement in inflammatory bowel disease].
    Harefuah, 1989, Nov-01, Volume: 117, Issue:9

    Topics: Aged; Arrhythmias, Cardiac; Colitis, Ulcerative; Humans; Indomethacin; Male; Myocarditis; Pericardit

1989
Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts.
    Biomedica biochimica acta, 1988, Volume: 47, Issue:10-11

    Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Epoprostenol; Heart; Imidazoles; In Vitro Technique

1988
Coronary arteriography in the intact rabbit: demonstration of coronary vasomotor and electrocardiographic effects of ergonovine and indomethacin in rabbits after abrupt cessation of prolonged nitroglycerin treatment.
    American heart journal, 1987, Volume: 114, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Cineangiography; Coronary Angiography; Coronary Vasospasm; Coronary V

1987
The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition.
    Agents and actions, 1987, Volume: 21, Issue:1-2

    Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Cyclooxygenase Inhibitors; Drug Interactions; Electrocard

1987
[Anti-arrhythmic effect of indomethacin in experimental studies].
    Kardiologiia, 1988, Volume: 28, Issue:2

    Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Chloride; Cats; Chick Embr

1988
Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.
    British journal of pharmacology, 1988, Volume: 93, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Fem

1988
A comparison of the long-term effects of n-3 and n-6 polyunsaturated fatty acid dietary supplements and the action of indomethacin upon the mechanical performance and susceptibility of the rat heart to dysrhythmia.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 27, Issue:2-3

    Topics: Animals; Arrhythmias, Cardiac; Calcium; Dietary Fats, Unsaturated; Female; In Vitro Techniques; Indo

1987
A possible role for endogenous prostaglandins in the electrophysiological effects of acetylstrophanthidin on isolated canine ventricular tissues.
    Circulation research, 1986, Volume: 58, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arrhythmias, Cardiac; Aspirin; Cardiac Pacing, Artificial; Do

1986
Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits.
    The American journal of cardiology, 1985, Apr-01, Volume: 55, Issue:8

    Topics: Animals; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Ergonovine; Humans; Indometh

1985
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain.
    The American journal of physiology, 1985, Volume: 249, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; As

1985
Modification of basal release of prostaglandins from rabbit isolated hearts.
    Prostaglandins, 1974, Sep-25, Volume: 7, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Carbon Dioxide; Colon; Depression, Chemical; Electric Stimulation; Em

1974
[Pharmacology of butylmalonic acidmono-(1,2-diphenylhydrazide)-calcium (bumadizone-calcium)].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Blood Pr

1973