indomethacin has been researched along with Apnea, Obstructive Sleep in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with obstructive sleep apnea (OSA) are predisposed to instability in central ventilatory control during sleep." | 1.36 | Exacerbation of obstructive sleep apnea by oral indomethacin. ( Ainslie, P; Burgess, KR; Dawson, A; Fan, JL; Lucas, R; Lucas, S; Peebles, K; Shepherd, K; Swart, M; Thomas, K, 2010) |
| "A hypnic headache was captured in one patient arising out of rapid eye movement sleep at a time of severe oxygen desaturation." | 1.31 | Polysomnography in hypnic headache syndrome. ( Dodick, DW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaudin, AE | 2 |
| Pun, M | 2 |
| Yang, C | 1 |
| Nicholl, DD | 1 |
| Steinback, CD | 1 |
| Slater, DM | 1 |
| Wynne-Edwards, KE | 2 |
| Hanly, PJ | 2 |
| Ahmed, SB | 2 |
| Poulin, MJ | 2 |
| Waltz, X | 1 |
| Anderson, TJ | 1 |
| Ivancev, V | 1 |
| Bakovic, D | 1 |
| Obad, A | 1 |
| Breskovic, T | 1 |
| Palada, I | 1 |
| Joyner, MJ | 1 |
| Dujic, Z | 1 |
| Burgess, KR | 1 |
| Fan, JL | 1 |
| Peebles, K | 1 |
| Thomas, K | 1 |
| Lucas, S | 1 |
| Lucas, R | 1 |
| Dawson, A | 1 |
| Swart, M | 1 |
| Shepherd, K | 1 |
| Ainslie, P | 1 |
| Dodick, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans[NCT01280006] | Phase 1/Phase 2 | 12 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638] | Early Phase 1 | 80 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851] | 46 participants (Actual) | Observational | 2016-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for indomethacin and Apnea, Obstructive Sleep
| Article | Year |
|---|---|
Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.
Topics: Adult; Blood Pressure; Celecoxib; Cerebrovascular Circulation; Cross-Over Studies; Cyclooxygenase 1; | 2014 |
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method; | 2015 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
2 other studies available for indomethacin and Apnea, Obstructive Sleep
| Article | Year |
|---|---|
Exacerbation of obstructive sleep apnea by oral indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebrovascular Circulation; Dose-Response Relationship, Dr | 2010 |
Polysomnography in hypnic headache syndrome.
Topics: Aged; Female; Headache; Humans; Indomethacin; Male; Melatonin; Middle Aged; Polysomnography; Recurre | 2000 |