Page last updated: 2024-10-29

indomethacin and Anxiety

indomethacin has been researched along with Anxiety in 12 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)."9.22Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016)
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."7.69Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
"To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)."5.22Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016)
" Rats received intra-VTA infusions of either PK11195 (400ng/mul, which inhibits de novo 3alpha,5alpha-THP production), indomethacin (10mug/mul, which blocks metabolism of P(4) to 3alpha,5alpha-THP), PK11195 and indomethacin together, or beta-cyclodextrin vehicle and tested on a battery of anxiety (open field and elevated plus maze), social (partner preference and social interaction), and sexual (paced mating) tasks."3.74Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area. ( Frye, CA; Paris, JJ; Rhodes, ME, 2008)
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."3.69Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
"In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg."1.33Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's2 (16.67)18.2507
2000's4 (33.33)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ferrer-Pérez, C1
Martinez, TE1
Montagud-Romero, S1
Ballestín, R1
Reguilón, MD1
Miñarro, J1
Rodríguez-Arias, M1
Thakre, PP1
Tundulwar, MR1
Chopde, CT1
Ugale, RR1
Karaman, E1
Çim, N1
Alkış, İ1
Yıldırım, A1
Yıldızhan, R1
Frye, CA2
Paris, JJ2
Rhodes, ME2
Valenzano, KJ1
Tafesse, L1
Lee, G1
Harrison, JE1
Boulet, JM1
Gottshall, SL1
Mark, L1
Pearson, MS1
Miller, W1
Shan, S1
Rabadi, L1
Rotshteyn, Y1
Chaffer, SM1
Turchin, PI1
Elsemore, DA1
Toth, M1
Koetzner, L1
Whiteside, GT1
Schwartz, JI1
Moura, RJ1
Gallo, MA1
Smith, SS1
Rahman, AF1
Takahashi, M1
Kaneto, H1
Lukács, H1
Friedman, AP1
McBride, WW1
Dodson, WH1
Bennett, JC1

Trials

1 trial available for indomethacin and Anxiety

ArticleYear
Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial.
    The journal of obstetrics and gynaecology research, 2016, Volume: 42, Issue:2

    Topics: Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Depression; Female;

2016

Other Studies

11 other studies available for indomethacin and Anxiety

ArticleYear
Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat.
    PloS one, 2018, Volume: 13, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Brain; Cocaine; Cocaine-Related Disorders

2018
Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice.
    Neuroscience letters, 2013, Apr-29, Volume: 541

    Topics: Animals; Anxiety; Finasteride; Indomethacin; Male; Maze Learning; Mice; Motor Activity; Neurotransmi

2013
Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.
    Behavioural brain research, 2008, Nov-21, Volume: 193, Issue:2

    Topics: Animals; Antineoplastic Agents; Anxiety; Behavior, Animal; Cyclooxygenase Inhibitors; Desoxycorticos

2008
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin;

2009
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani

2005
Severe depersonalization and anxiety associated with indomethacin.
    Southern medical journal, 1983, Volume: 76, Issue:5

    Topics: Anxiety; Depersonalization; Female; Gout; Humans; Indomethacin; Middle Aged

1983
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electrosh

1993
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:4

    Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm

1994
Rat as model for studying behavior effects of hCG.
    Seminars in reproductive medicine, 2001, Volume: 19, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Chorionic Gonadotropin; Electroencephalography; Electromyography

2001
An overview of chronic recurring headache.
    Wisconsin medical journal, 1972, Volume: 71, Issue:3

    Topics: Acute Disease; Analgesics; Antidepressive Agents; Anxiety; Chronic Disease; Cortisone; Diuretics; Er

1972
Management of rheumatoid arthritis.
    Southern medical journal, 1969, Volume: 62, Issue:3

    Topics: Adrenal Cortex Hormones; Amitriptyline; Anxiety; Arthritis, Rheumatoid; Aspirin; Attitude of Health

1969