indomethacin has been researched along with Amnionitis in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral palsy was found in 36 (9." | 6.68 | Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 5.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| " Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models." | 3.83 | Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016) |
| "Our objective was to determine the effect of chorioamnionitis on plasma prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) during the first week in preterm infants." | 3.74 | Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants. ( Aranda, JV; Glibetic, M; Natarajan, G; Thomas, RL, 2008) |
| "Cerebral palsy was found in 36 (9." | 2.68 | Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997) |
| "Chorioamnionitis was positively correlated with the risk, but did not reach statistical significance." | 1.33 | Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. ( Itakura, A; Matsuzawa, K; Mizutani, S; Murata, Y; Okumura, A; Wakai, K, 2005) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 1.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faucett, AM | 1 |
| Metz, TD | 1 |
| DeWitt, PE | 1 |
| Gibbs, RS | 2 |
| Natarajan, G | 1 |
| Glibetic, M | 1 |
| Thomas, RL | 1 |
| Aranda, JV | 1 |
| Grigsby, PL | 1 |
| Novy, MJ | 3 |
| Sadowsky, DW | 3 |
| Morgan, TK | 1 |
| Long, M | 1 |
| Acosta, E | 1 |
| Duffy, LB | 1 |
| Waites, KB | 1 |
| Itabashi, K | 1 |
| Ohno, T | 1 |
| Nishida, H | 1 |
| Murata, Y | 1 |
| Itakura, A | 1 |
| Matsuzawa, K | 1 |
| Okumura, A | 1 |
| Wakai, K | 1 |
| Mizutani, S | 2 |
| Gravett, MG | 2 |
| Adams, KM | 1 |
| Grosvenor, AR | 1 |
| Witkin, SS | 1 |
| Axthelm, MK | 2 |
| Ohno, Y | 1 |
| Kasugai, M | 1 |
| Kurauchi, O | 1 |
| Tomoda, Y | 1 |
| Heddleston, L | 1 |
| McDuffie, RS | 1 |
| Allan, WC | 1 |
| Vohr, B | 1 |
| Makuch, RW | 1 |
| Katz, KH | 1 |
| Ment, LR | 1 |
| Bethea, CL | 1 |
| Haluska, GJ | 1 |
| Axethelm, MK | 1 |
| Bry, K | 1 |
| Hallman, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial[NCT02819570] | Phase 4 | 400 participants (Anticipated) | Interventional | 2015-11-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for indomethacin and Amnionitis
| Article | Year |
|---|---|
Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage.
Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Chorioamnionitis; Female; Gestational Age; | 1997 |
10 other studies available for indomethacin and Amnionitis
| Article | Year |
|---|---|
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage; | 2016 |
Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Bronchopulmonary Dysplasia | 2008 |
Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 2012 |
Indomethacin responsiveness of patent ductus arteriosus and renal abnormalities in preterm infants treated with indomethacin.
Topics: Cardiovascular Agents; Chorioamnionitis; Ductus Arteriosus, Patent; Echocardiography, Doppler; Femal | 2003 |
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
Topics: Apgar Score; Case-Control Studies; Causality; Cerebral Palsy; Chorioamnionitis; Comorbidity; Female; | 2005 |
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model.
Topics: Amnion; Amniotic Fluid; Ampicillin; Animals; Anti-Bacterial Agents; Cesarean Section; Chorioamnionit | 2007 |
Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions.
Topics: Amniotic Fluid; Bacterial Infections; Chorioamnionitis; Culture Techniques; Dinoprostone; Extraembry | 1994 |
A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy.
Topics: Ampicillin; Animals; Chorioamnionitis; Disease Models, Animal; Drug Therapy, Combination; Escherichi | 1993 |
Amniotic fluid prolactin is decreased by experimental intrauterine infection or interleukin-1beta infusion but not via prostaglandins in pregnant rhesus macaques.
Topics: Amnion; Amniotic Fluid; Animals; Chorioamnionitis; Chorion; Decidua; Female; Indomethacin; Interleuk | 1998 |
A product of activated human granulocytes stimulates prostaglandin E2 synthesis in human amnion cells.
Topics: Amnion; Cells, Cultured; Chorioamnionitis; Cytochalasin B; Dinoprostone; Epidermal Growth Factor; Fe | 1991 |