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indomethacin and Alveolitis, Fibrosing

indomethacin has been researched along with Alveolitis, Fibrosing in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise."9.06The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986)
"The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog."7.66The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981)
"A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin."5.26Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979)
"We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise."5.06The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986)
"The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog."3.66The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981)
"To characterize the role of GM-CSF in pulmonary fibrosis, we have studied bleomycin-induced fibrosis in wild-type mice vs mice with a targeted deletion of the GM-CSF gene (GM-CSF-/- mice)."1.31GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. ( Christensen, P; Coffey, MJ; McDonald, R; Moore, BB; Ngan, R; Paine, R; Peters-Golden, M; Phare, SM; Sitterding, S; Toews, GB; Wilke, CA, 2000)
"However, in patients with pulmonary fibrosis, PGE(2) levels are decreased."1.31Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. ( Booth, H; Foster, ML; Harrison, NK; Hart, SL; Hernandez-Rodriguez, NA; Jenkins, RG; Keerthisingam, CB; Laurent, GJ; McAnulty, RJ, 2001)
"In order to clarify the mechanism of pulmonary fibrosis, we examined the functional changes of lung fibroblasts in bleomycin (BLM)-induced pulmonary fibrosis."1.30Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis. ( Asada, K; Endo, T; Kawano, T; Maniwa, K; Ogushi, F; Sone, S; Tada, H; Tani, K, 1999)
"Histological examination revealed fibrosing alveolitis in the BLM-treated group which was markedly suppressed in the combination group."1.28Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs. ( Burkhardt, A; Mall, G; Otto, HF; Siemens, I; Zimmermann, P, 1991)
"Pulmonary fibrosis is characterized by an alteration in lung collagen synthesis and deposition, as well as by increased fibroblast proliferation."1.27Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts. ( Gauldie, J; Jordana, M; Newhouse, MT, 1987)
"A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin."1.26Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199010 (55.56)18.7374
1990's5 (27.78)18.2507
2000's3 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hakkinen, PJ1
Schmoyer, RL1
Witschi, HP1
Auletta, M1
Usberti, M1
Antoniello, S1
Stanziale, P1
Kehrer, JP1
Witschi, H1
Marrakchi, H1
Fazaa, B1
Gorgi, Y1
Jellouli, A1
Mokhtar, I1
Kamoun, MR1
Ogushi, F1
Endo, T1
Tani, K1
Asada, K1
Kawano, T1
Tada, H1
Maniwa, K1
Sone, S1
Moore, BB1
Coffey, MJ1
Christensen, P1
Sitterding, S1
Ngan, R1
Wilke, CA1
McDonald, R1
Phare, SM1
Peters-Golden, M1
Paine, R1
Toews, GB1
Keerthisingam, CB1
Jenkins, RG1
Harrison, NK1
Hernandez-Rodriguez, NA1
Booth, H1
Laurent, GJ1
Hart, SL1
Foster, ML1
McAnulty, RJ1
Vancheri, C1
Mastruzzo, C1
Tomaselli, V1
Sortino, MA1
D'Amico, L1
BellistrĂ­, G1
Pistorio, MP1
Salinaro, ET1
Palermo, F1
Mistretta, A1
Crimi, N1
Thrall, RS1
McCormick, JR1
Jack, RM1
McReynolds, RA1
Ward, PA1
Meier-Sydow, J1
Mitrou, PS1
Mall, G1
Zimmermann, P1
Siemens, I1
Burkhardt, A1
Otto, HF1
Taganovich, AD1
Ozaki, T1
Moriguchi, H1
Nakamura, Y1
Kamei, T1
Yasuoka, S1
Ogura, T1
Clark, JG1
Greenberg, J1
Fireman, E1
Ben Efraim, S1
Greif, J1
Alguetti, A1
Ayalon, D1
Topilsky, M1
Heppleston, AG1
Jordana, M1
Newhouse, MT1
Gauldie, J1
O'Neill, PA1
Stretton, TB1
Stark, RD1
Ellis, SH1

Reviews

2 reviews available for indomethacin and Alveolitis, Fibrosing

ArticleYear
[Antiphospholipid antibodies and systemic scleroderma. Apropos of a case with review of the literature].
    La Tunisie medicale, 1995, Volume: 73, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Ar

1995
[Treatment of auto-immune diseases with special reference to their pulmonary manifestations (author's transl)].
    Praxis und Klinik der Pneumologie, 1979, Volume: 33 Suppl 1

    Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents; Antine

1979

Trials

1 trial available for indomethacin and Alveolitis, Fibrosing

ArticleYear
The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung.
    British journal of diseases of the chest, 1986, Volume: 80, Issue:1

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dyspnea; Exercise Test; Female; Forced E

1986

Other Studies

15 other studies available for indomethacin and Alveolitis, Fibrosing

ArticleYear
Potentiation of butylated-hydroxytoluene-induced acute lung damage by oxygen. Effects of prednisolone and indomethacin.
    The American review of respiratory disease, 1983, Volume: 128, Issue:4

    Topics: Animals; Butylated Hydroxytoluene; Hydroxyproline; Indomethacin; Lung; Male; Mice; Mice, Inbred BALB

1983
[Membranoproliferative glomerulonephritis as an unusual initial manifestation in a case of plasmacytoma].
    Minerva medica, 1984, Mar-10, Volume: 75, Issue:9-10

    Topics: Bence Jones Protein; Glomerulonephritis; Humans; Indomethacin; Male; Middle Aged; Plasmacytoma; Pulm

1984
The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen.
    Toxicology, 1981, Volume: 20, Issue:4

    Topics: Animals; Butylated Hydroxytoluene; Collagen; Hydroxyproline; Indomethacin; Male; Mice; Mice, Inbred

1981
Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis.
    International journal of experimental pathology, 1999, Volume: 80, Issue:1

    Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Division; Cyclooxygenase 2; Dinoprostone; Fibrobla

1999
GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Oct-01, Volume: 165, Issue:7

    Topics: Animals; Bleomycin; Cell Division; Dinoprostone; Drug Administration Schedule; Granulocyte-Macrophag

2000
Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice.
    The American journal of pathology, 2001, Volume: 158, Issue:4

    Topics: Bleomycin; Cell Division; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors

2001
Normal human lung fibroblasts differently modulate interleukin-10 and interleukin-12 production by monocytes: implications for an altered immune response in pulmonary chronic inflammation.
    American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; CD40 Antigens; Cell Communication; Cells, Cultured;

2001
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.
    The American journal of pathology, 1979, Volume: 95, Issue:1

    Topics: Animals; Bleomycin; Capillary Permeability; Collagen; Cricetinae; Eosinophils; Indomethacin; Leukocy

1979
Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1991, Volume: 419, Issue:4

    Topics: Animals; Bleomycin; Female; Indomethacin; Lung; Pulmonary Fibrosis; Rats

1991
[Surfactant-inducted suppressive action on fibroblasts of pulmonary macrophages from rats with fibrosis after intratracheal administration of bleomycin].
    Problemy tuberkuleza, 1991, Issue:12

    Topics: Animals; Bleomycin; Cell Division; Cells, Cultured; Fibroblasts; Indomethacin; Macrophages, Alveolar

1991
Regulatory effect of prostaglandin E2 on fibronectin release from human alveolar macrophages.
    The American review of respiratory disease, 1990, Volume: 141, Issue:4 Pt 1

    Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Count; Cells, Cultured; Dinoprostone; Female; Fibronectins

1990
Modulation of the effects of alveolar macrophages on lung fibroblast collagen production rate.
    The American review of respiratory disease, 1987, Volume: 135, Issue:1

    Topics: Animals; Bleomycin; Cells, Cultured; Collagen; Cricetinae; Dinoprostone; Fibroblasts; Humans; Hydrox

1987
Suppressive activity of alveolar macrophages and blood monocytes from interstitial lung diseases: role of released soluble factors.
    International journal of immunopharmacology, 1989, Volume: 11, Issue:7

    Topics: Adult; Dinoprostone; Female; Humans; Immune Tolerance; Indomethacin; Interleukins; Lymphocyte Activa

1989
Determinants of pulmonary fibrosis and lipidosis in the silica model.
    British journal of experimental pathology, 1986, Volume: 67, Issue:6

    Topics: Animals; Cell Membrane; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Indomet

1986
Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts.
    Journal of leukocyte biology, 1987, Volume: 42, Issue:1

    Topics: Biological Products; Cell Division; Cell Line; Cytokines; Dinoprostone; Fibroblasts; Humans; Indomet

1987