indomethacin has been researched along with Alveolitis, Fibrosing in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise." | 9.06 | The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986) |
| "The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog." | 7.66 | The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981) |
| "A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin." | 5.26 | Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979) |
| "We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise." | 5.06 | The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986) |
| "The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog." | 3.66 | The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981) |
| "To characterize the role of GM-CSF in pulmonary fibrosis, we have studied bleomycin-induced fibrosis in wild-type mice vs mice with a targeted deletion of the GM-CSF gene (GM-CSF-/- mice)." | 1.31 | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. ( Christensen, P; Coffey, MJ; McDonald, R; Moore, BB; Ngan, R; Paine, R; Peters-Golden, M; Phare, SM; Sitterding, S; Toews, GB; Wilke, CA, 2000) |
| "However, in patients with pulmonary fibrosis, PGE(2) levels are decreased." | 1.31 | Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. ( Booth, H; Foster, ML; Harrison, NK; Hart, SL; Hernandez-Rodriguez, NA; Jenkins, RG; Keerthisingam, CB; Laurent, GJ; McAnulty, RJ, 2001) |
| "In order to clarify the mechanism of pulmonary fibrosis, we examined the functional changes of lung fibroblasts in bleomycin (BLM)-induced pulmonary fibrosis." | 1.30 | Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis. ( Asada, K; Endo, T; Kawano, T; Maniwa, K; Ogushi, F; Sone, S; Tada, H; Tani, K, 1999) |
| "Histological examination revealed fibrosing alveolitis in the BLM-treated group which was markedly suppressed in the combination group." | 1.28 | Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs. ( Burkhardt, A; Mall, G; Otto, HF; Siemens, I; Zimmermann, P, 1991) |
| "Pulmonary fibrosis is characterized by an alteration in lung collagen synthesis and deposition, as well as by increased fibroblast proliferation." | 1.27 | Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts. ( Gauldie, J; Jordana, M; Newhouse, MT, 1987) |
| "A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin." | 1.26 | Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hakkinen, PJ | 1 |
| Schmoyer, RL | 1 |
| Witschi, HP | 1 |
| Auletta, M | 1 |
| Usberti, M | 1 |
| Antoniello, S | 1 |
| Stanziale, P | 1 |
| Kehrer, JP | 1 |
| Witschi, H | 1 |
| Marrakchi, H | 1 |
| Fazaa, B | 1 |
| Gorgi, Y | 1 |
| Jellouli, A | 1 |
| Mokhtar, I | 1 |
| Kamoun, MR | 1 |
| Ogushi, F | 1 |
| Endo, T | 1 |
| Tani, K | 1 |
| Asada, K | 1 |
| Kawano, T | 1 |
| Tada, H | 1 |
| Maniwa, K | 1 |
| Sone, S | 1 |
| Moore, BB | 1 |
| Coffey, MJ | 1 |
| Christensen, P | 1 |
| Sitterding, S | 1 |
| Ngan, R | 1 |
| Wilke, CA | 1 |
| McDonald, R | 1 |
| Phare, SM | 1 |
| Peters-Golden, M | 1 |
| Paine, R | 1 |
| Toews, GB | 1 |
| Keerthisingam, CB | 1 |
| Jenkins, RG | 1 |
| Harrison, NK | 1 |
| Hernandez-Rodriguez, NA | 1 |
| Booth, H | 1 |
| Laurent, GJ | 1 |
| Hart, SL | 1 |
| Foster, ML | 1 |
| McAnulty, RJ | 1 |
| Vancheri, C | 1 |
| Mastruzzo, C | 1 |
| Tomaselli, V | 1 |
| Sortino, MA | 1 |
| D'Amico, L | 1 |
| Bellistrí, G | 1 |
| Pistorio, MP | 1 |
| Salinaro, ET | 1 |
| Palermo, F | 1 |
| Mistretta, A | 1 |
| Crimi, N | 1 |
| Thrall, RS | 1 |
| McCormick, JR | 1 |
| Jack, RM | 1 |
| McReynolds, RA | 1 |
| Ward, PA | 1 |
| Meier-Sydow, J | 1 |
| Mitrou, PS | 1 |
| Mall, G | 1 |
| Zimmermann, P | 1 |
| Siemens, I | 1 |
| Burkhardt, A | 1 |
| Otto, HF | 1 |
| Taganovich, AD | 1 |
| Ozaki, T | 1 |
| Moriguchi, H | 1 |
| Nakamura, Y | 1 |
| Kamei, T | 1 |
| Yasuoka, S | 1 |
| Ogura, T | 1 |
| Clark, JG | 1 |
| Greenberg, J | 1 |
| Fireman, E | 1 |
| Ben Efraim, S | 1 |
| Greif, J | 1 |
| Alguetti, A | 1 |
| Ayalon, D | 1 |
| Topilsky, M | 1 |
| Heppleston, AG | 1 |
| Jordana, M | 1 |
| Newhouse, MT | 1 |
| Gauldie, J | 1 |
| O'Neill, PA | 1 |
| Stretton, TB | 1 |
| Stark, RD | 1 |
| Ellis, SH | 1 |
2 reviews available for indomethacin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
[Antiphospholipid antibodies and systemic scleroderma. Apropos of a case with review of the literature].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Ar | 1995 |
[Treatment of auto-immune diseases with special reference to their pulmonary manifestations (author's transl)].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents; Antine | 1979 |
1 trial available for indomethacin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dyspnea; Exercise Test; Female; Forced E | 1986 |
15 other studies available for indomethacin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
Potentiation of butylated-hydroxytoluene-induced acute lung damage by oxygen. Effects of prednisolone and indomethacin.
Topics: Animals; Butylated Hydroxytoluene; Hydroxyproline; Indomethacin; Lung; Male; Mice; Mice, Inbred BALB | 1983 |
[Membranoproliferative glomerulonephritis as an unusual initial manifestation in a case of plasmacytoma].
Topics: Bence Jones Protein; Glomerulonephritis; Humans; Indomethacin; Male; Middle Aged; Plasmacytoma; Pulm | 1984 |
The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen.
Topics: Animals; Butylated Hydroxytoluene; Collagen; Hydroxyproline; Indomethacin; Male; Mice; Mice, Inbred | 1981 |
Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis.
Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Division; Cyclooxygenase 2; Dinoprostone; Fibrobla | 1999 |
GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism.
Topics: Animals; Bleomycin; Cell Division; Dinoprostone; Drug Administration Schedule; Granulocyte-Macrophag | 2000 |
Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice.
Topics: Bleomycin; Cell Division; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors | 2001 |
Normal human lung fibroblasts differently modulate interleukin-10 and interleukin-12 production by monocytes: implications for an altered immune response in pulmonary chronic inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; CD40 Antigens; Cell Communication; Cells, Cultured; | 2001 |
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.
Topics: Animals; Bleomycin; Capillary Permeability; Collagen; Cricetinae; Eosinophils; Indomethacin; Leukocy | 1979 |
Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs.
Topics: Animals; Bleomycin; Female; Indomethacin; Lung; Pulmonary Fibrosis; Rats | 1991 |
[Surfactant-inducted suppressive action on fibroblasts of pulmonary macrophages from rats with fibrosis after intratracheal administration of bleomycin].
Topics: Animals; Bleomycin; Cell Division; Cells, Cultured; Fibroblasts; Indomethacin; Macrophages, Alveolar | 1991 |
Regulatory effect of prostaglandin E2 on fibronectin release from human alveolar macrophages.
Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Count; Cells, Cultured; Dinoprostone; Female; Fibronectins | 1990 |
Modulation of the effects of alveolar macrophages on lung fibroblast collagen production rate.
Topics: Animals; Bleomycin; Cells, Cultured; Collagen; Cricetinae; Dinoprostone; Fibroblasts; Humans; Hydrox | 1987 |
Suppressive activity of alveolar macrophages and blood monocytes from interstitial lung diseases: role of released soluble factors.
Topics: Adult; Dinoprostone; Female; Humans; Immune Tolerance; Indomethacin; Interleukins; Lymphocyte Activa | 1989 |
Determinants of pulmonary fibrosis and lipidosis in the silica model.
Topics: Animals; Cell Membrane; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Indomet | 1986 |
Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts.
Topics: Biological Products; Cell Division; Cell Line; Cytokines; Dinoprostone; Fibroblasts; Humans; Indomet | 1987 |