indomethacin has been researched along with Allergy, Drug in 48 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty aspirin-sensitive asthmatic patients underwent incremental, oral aspirin challenge until a "positive reaction" (delta FEV1 greater than or equal to 25%) occurred." | 7.66 | Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1982) |
| "Eleven patients with asthma and aspirin hypersensitivity have been challenged with eight non-steroidal anti-inflammatory drugs." | 7.65 | Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A, 1975) |
| "The term "aspirin intolerance" is defined as acute urticaria-angioedema, bronchospasm, severe rhinitis, or shock occurring within three hours of aspirin ingestion." | 4.76 | Adverse reactions of aspirin and related drugs. ( Settipane, GA, 1981) |
| " Both patients exhibited anaphylactic manifestations, such as general rash and urticaria, along with angina pectoris with electrocardiographic ST-segment elevations after suppository administration of diclofenac sodium or indomethacin, the most commonly used NSAIDs." | 3.69 | Vasospastic angina induced by nonsteroidal anti-inflammatory drugs. ( Eguchi, H; Haramaki, N; Hashino, T; Ichiki, K; Ikeda, H; Imaizumi, T; Kai, H; Katoh, A; Mori, E; Ueno, T; Ueyama, T, 1997) |
| " No statistically significant difference in delayed hypersensitivity response to dinitrochlorobenzene was found between indomethacin-treated, tumor-bearing and control groups." | 3.67 | Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch. ( Gould, AR; Grant, FT; Miller, RL; Perry, DA, 1985) |
| "Thirty aspirin-sensitive asthmatic patients underwent incremental, oral aspirin challenge until a "positive reaction" (delta FEV1 greater than or equal to 25%) occurred." | 3.66 | Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1982) |
| "Eleven patients with asthma and aspirin hypersensitivity have been challenged with eight non-steroidal anti-inflammatory drugs." | 3.65 | Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A, 1975) |
| "Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics." | 3.65 | Response of aspirin-allergic patients to challenge by some analgesics in common use. ( Smith, AP, 1971) |
| "Then indomethacin was tested in ten patients with hypersensitivity to NSAIDs compared with eight persons in control group." | 1.39 | Basophil activation test with indomethacin to assess hypersensitivity to non-steroidal anti-inflammatory drugs: a preliminary study. ( Calamita, Z; da Silveira Antunes, RN; de Aguiar Cavaretto, D; de Almeida Filho, OM; Fukazawa, JT; Júnior, WB; Pelá Calamita, AB, 2013) |
| "He was diagnosed to have eosinophilic pneumonia because of eosinophilia in his peripheral blood and bronchoalveolar lavage fluid (BALF)." | 1.31 | Indomethacin induced bulky lymphadenopathy and eosinophilic pneumonia. ( Hosono, T; Kurabayashi, M; Maeno, T; Maeno, Y; Nagai, R; Oishi, Y; Sando, Y; Sato, M; Suga, T; Tajima, S, 2001) |
| "The effects of different antirheumatic drugs administered according to various dosing regimes on tuberculin hypersensitivity in rats have been assessed quantitating the changes of exudate volume and mononuclear cells immigration at the site of challenge." | 1.26 | Delayed hypersensitivity to tuberculin in rats: effects of antirheumatic drugs. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (79.17) | 18.7374 |
| 1990's | 6 (12.50) | 18.2507 |
| 2000's | 2 (4.17) | 29.6817 |
| 2010's | 2 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calamita, Z | 1 |
| da Silveira Antunes, RN | 1 |
| Pelá Calamita, AB | 1 |
| Júnior, WB | 1 |
| de Aguiar Cavaretto, D | 1 |
| Fukazawa, JT | 1 |
| de Almeida Filho, OM | 1 |
| Akyel, A | 1 |
| Murat, SN | 1 |
| Cay, S | 1 |
| Kurtul, A | 1 |
| Ocek, AH | 1 |
| Cankurt, T | 1 |
| WANKA, J | 1 |
| JONES, LI | 1 |
| WOOD, PH | 1 |
| DIXON, AS | 1 |
| Vanselow, NA | 1 |
| Smith, JR | 1 |
| Hansbrough, J | 1 |
| Peterson, V | 1 |
| Zapata-Sirvent, R | 1 |
| Claman, HN | 1 |
| Furst, DE | 1 |
| Lumry, WR | 1 |
| Curd, JG | 1 |
| Zeiger, RS | 2 |
| Pleskow, WW | 2 |
| Stevenson, DD | 2 |
| Tompson, HM | 1 |
| Settipane, GA | 1 |
| Mathison, DA | 1 |
| Simon, RA | 1 |
| Schatz, M | 1 |
| Bolser, DC | 1 |
| DeGennaro, FC | 1 |
| O'Reilly, S | 1 |
| Hey, JA | 1 |
| Chapman, RW | 1 |
| Mori, E | 1 |
| Ikeda, H | 1 |
| Ueno, T | 1 |
| Kai, H | 1 |
| Haramaki, N | 1 |
| Hashino, T | 1 |
| Ichiki, K | 1 |
| Katoh, A | 1 |
| Eguchi, H | 1 |
| Ueyama, T | 1 |
| Imaizumi, T | 1 |
| Maria, VA | 1 |
| Victorino, RM | 1 |
| Barchasz, E | 1 |
| Naline, E | 1 |
| Molimard, M | 1 |
| Moreau, J | 1 |
| Georges, O | 1 |
| Emonds-Alt, X | 1 |
| Advenier, C | 1 |
| Lissak, A | 1 |
| Fruchter, O | 1 |
| Abramovici, H | 1 |
| Gómez, A | 1 |
| Florido, JF | 1 |
| Quiralte, J | 1 |
| Martín, AE | 1 |
| Sáenz de San Pedro, B | 1 |
| Oishi, Y | 1 |
| Sando, Y | 1 |
| Tajima, S | 2 |
| Maeno, T | 1 |
| Maeno, Y | 1 |
| Sato, M | 1 |
| Hosono, T | 1 |
| Suga, T | 1 |
| Kurabayashi, M | 1 |
| Nagai, R | 1 |
| Bramm, E | 1 |
| Binderup, L | 1 |
| Arrigoni-Martelli, E | 1 |
| Fisherman, EW | 2 |
| Cohen, GN | 2 |
| Jensen, K | 1 |
| Tolot, F | 1 |
| Prost, G | 1 |
| Guignot, B | 1 |
| Pelletier, M | 1 |
| Santiago, SM | 1 |
| Klaustermeyer, WB | 1 |
| Szczeklik, A | 2 |
| Gryglewski, RJ | 2 |
| Czerniawska-Mysik, G | 2 |
| Namihisa, T | 1 |
| Yamaguchi, K | 1 |
| Kitami, N | 1 |
| Takazakura, Y | 1 |
| Yamada, T | 1 |
| Droszcz, W | 1 |
| Pearson, DJ | 1 |
| Suarez-Mendez, VJ | 1 |
| Wallace, DJ | 1 |
| Metzger, AL | 1 |
| Klinenberg, JR | 1 |
| Grzelewska-Rzymowska, I | 2 |
| Rozniecki, J | 3 |
| Szmidt, M | 2 |
| Pastorello, E | 1 |
| Qualizza, RM | 1 |
| Luraghi, MT | 1 |
| Ispano, M | 1 |
| Villa, AM | 1 |
| Ortolani, C | 1 |
| Zanussi, C | 1 |
| Schlegel, SI | 1 |
| Paulus, HE | 1 |
| Nishimura, N | 1 |
| Ito, K | 1 |
| Tominaga, M | 1 |
| Kohno, S | 1 |
| Tanaka, K | 1 |
| Ohata, K | 1 |
| Faist, E | 1 |
| Ertel, W | 1 |
| Salmen, B | 1 |
| Weiler, A | 1 |
| Ressel, C | 1 |
| Bolla, K | 1 |
| Heberer, G | 1 |
| Kowalski, ML | 2 |
| Mizoguchi, Y | 1 |
| Miyajima, K | 1 |
| Kitamura, M | 1 |
| Tsutsui, H | 1 |
| Takeda, H | 1 |
| Shin, T | 1 |
| Sakagami, Y | 1 |
| Seki, S | 1 |
| Kobayashi, K | 1 |
| Yamamoto, S | 1 |
| Gould, AR | 1 |
| Miller, RL | 1 |
| Grant, FT | 1 |
| Perry, DA | 1 |
| Marsh, FP | 1 |
| Almeyda, JR | 1 |
| Levy, IS | 1 |
| Kinsella, TD | 1 |
| MacKenzie, KR | 1 |
| Kim, SO | 1 |
| Johnson, LG | 1 |
| Bach, GL | 1 |
| Vasilenko, VKh | 1 |
| Tsodikov, GV | 1 |
| Minushkin, ON | 1 |
| Opolon, P | 1 |
| Cartron, J | 1 |
| Chicot, D | 1 |
| Caroli, J | 1 |
| Samter, M | 1 |
| Beers, RF | 1 |
| Miescher, PA | 1 |
| Henrard, JC | 1 |
| Smith, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513458] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.) | ||
| Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513471] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2019-08-09 | Withdrawn (stopped due to The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.) | ||
| Challenge Test for Acetylsalicylic Acid Hypersensitivity[NCT01681615] | 50 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indomethacin and Allergy, Drug
| Article | Year |
|---|---|
Adverse reactions of aspirin and related drugs.
Topics: Aspirin; Bronchial Spasm; Drug Hypersensitivity; Humans; Ibuprofen; Indomethacin; Prostaglandins; Ur | 1981 |
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera | 1976 |
[Hypersensitivity to aspirin and other non-steroidal anti- inflammatory agents--the methods of detecting the hypersensitivity and the development of the state of tolerance].
Topics: Aspirin; Asthma; Bronchial Provocation Tests; Drug Hypersensitivity; Drug Tolerance; Humans; Indomet | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
4 trials available for indomethacin and Allergy, Drug
| Article | Year |
|---|---|
Hypersensitivity to five non-steroidal anti-inflammatory agents: ibuprofen, fenoprofen, indomethacin, naproxen and tolmetin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Hypersensitivity; Fenoprofen | 1978 |
NSAID usage patterns by rheumatologists in the treatment of SLE.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Clinical Trials as | 1989 |
The immune-enhancing effect of perioperative thymopentin administration in elderly patients undergoing major surgery.
Topics: Adjuvants, Immunologic; Aged; Cardiopulmonary Bypass; Clinical Trials as Topic; Drug Hypersensitivit | 1988 |
Evaluation of indomethacin by a controlled, cross-over technique in 30 patients with ankylosing spondylitis.
Topics: Alkaline Phosphatase; Anemia, Hypochromic; Aspartate Aminotransferases; Aspirin; Central Nervous Sys | 1967 |
39 other studies available for indomethacin and Allergy, Drug
| Article | Year |
|---|---|
Basophil activation test with indomethacin to assess hypersensitivity to non-steroidal anti-inflammatory drugs: a preliminary study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Cell Survival; Drug Hypersensitivity; Fem | 2013 |
Late drug eluting stent thrombosis due to acemetacine: type III Kounis syndrome: Kounis syndrome due to acemetacine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Coronary Angiography; Coronary Thrombosis; Coronary Vessels | 2012 |
INDOMETHACIN IN RHEUMATIC DISEASES. A CONTROLLED CLINICAL TRIAL.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Biomedical Research; Drug Hypersensitivity; Gastrointesti | 1964 |
Bronchial asthma induced by indomethacin.
Topics: Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; | 1967 |
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity | 1984 |
Use of ibuprofen in unusual circumstances.
Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersens | 1984 |
Aspirin-sensitive rhinosinusitis: the clinical syndrome and effects of aspirin administration.
Topics: Adult; Aged; Aspirin; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Indometha | 1983 |
Allergic reaction?
Topics: Dimethoate; Drug Hypersensitivity; Humans; Indomethacin; Insecticides; Male; Stomatitis | 1981 |
Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Desensitization, Immunologic; Dose-Response Relationship, | 1982 |
Pharmacological studies of allergic cough in the guinea pig.
Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsai | 1995 |
Vasospastic angina induced by nonsteroidal anti-inflammatory drugs.
Topics: Aged; Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Angiography; Coronary Vasos | 1997 |
Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury.
Topics: Adult; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injury, Chronic; Culture Medi | 1997 |
Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Anti-Inflammatory Agents, | 1999 |
Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Anti-Inflammatory Agents, | 1999 |
Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Anti-Inflammatory Agents, | 1999 |
Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Anti-Inflammatory Agents, | 1999 |
Uncommon adverse maternal effects with indomethacin for tocolysis.
Topics: Adult; Drug Hypersensitivity; Dyspnea; Female; Humans; Indomethacin; Liver Function Tests; Pregnancy | 1999 |
Allergic contact dermatitis due to indomethacin and diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cross Reactions; Dermatitis, Allergic Contact; Diagnosis, D | 2000 |
Indomethacin induced bulky lymphadenopathy and eosinophilic pneumonia.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Humans; Indomethacin; Lymphati | 2001 |
Delayed hypersensitivity to tuberculin in rats: effects of antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Hypersensiti | 1979 |
[Asthmatic reaction provoked by non-steroid antirheumatics. With special attention to cross reactions with acetylsalicylic acid].
Topics: Adult; Age Factors; Aged; Aspirin; Denmark; Drug Hypersensitivity; Drug Interactions; Female; Humans | 1978 |
Acute respiratory failure secondary to indomethacin in an aspirin-intolerant asthmatic patient.
Topics: Acute Disease; Aspirin; Asthma; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; Resp | 1976 |
Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.
Topics: Adult; Aged; Analgesics; Aspirin; Asthma; Bronchi; Drug Hypersensitivity; Female; Flufenamic Acid; H | 1975 |
Letter: Aspirin sensitivity: other drugs.
Topics: Adult; Analgesics; Angioedema; Aspirin; Depression, Chemical; Drug Hypersensitivity; Female; Humans; | 1975 |
[A case with acute colitis induced by drug detected through lymphocyte stimulation test (author's transl)].
Topics: Acute Disease; Adult; Ampicillin; Colitis; Drug Hypersensitivity; Humans; Indomethacin; Lymphocyte A | 1975 |
[Advances in pneumonology. Aspirin-induced asthma].
Topics: Adult; Age Factors; Aspirin; Asthma; Depression, Chemical; Drug Hypersensitivity; Humans; Indomethac | 1975 |
Abnormal platelet hydrogen peroxide metabolism in aspirin hypersensitivity.
Topics: Aspirin; Asthma; Blood Platelets; Drug Hypersensitivity; Glutathione Peroxidase; Humans; Hydrogen Pe | 1990 |
[Occurrence of drug reactions].
Topics: Acetaminophen; Adult; Anaphylaxis; Angioedema; Aspirin; Asthma; Drug Hypersensitivity; Emergencies; | 1986 |
Suppression of delayed-type hypersensitivity mediated by macrophage-like cells in mice with experimental liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver I | 1985 |
Studies on toluene diisocyanate (TDI)-induced delayed type hypersensitivity.
Topics: Animals; Capillary Permeability; Cyanates; Dexamethasone; Drug Hypersensitivity; Hypersensitivity, D | 1985 |
Tolerance to acetylsalicylic acid (ASA) induced in ASA-sensitive asthmatics does not depend on initial adverse reaction.
Topics: Adult; Aspirin; Asthma; Desensitization, Immunologic; Drug Hypersensitivity; Drug Tolerance; Female; | 1987 |
[Augmentation of drug-induced lymphocyte transformation by indomethacin in patients with drug-induced allergic hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Guinea Pigs; Humans; Indomet | 1987 |
[Development of aspirin tolerance in hypersensitive persons. I. Methods of development of tolerance, aspirin refraction time and cross tolerance to other drugs].
Topics: Antipyrine; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Tolerance; Humans; Indomet | 1986 |
Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cheek; Cricetinae; Dinitrochlorobenzene; Drug | 1985 |
Non-thrombocytopenic purpura and acute glomerulonephritis after indomethacin therapy.
Topics: Aged; Drug Hypersensitivity; Female; Glomerulonephritis; Humans; Indomethacin; Kidney; Male; Middle | 1971 |
Adverse reactions of antirheumatic drugs.
Topics: Analgesics; Anti-Inflammatory Agents; Chloroquine; Dimethylamines; Drug Hypersensitivity; Gold; Huma | 1973 |
[Application of the lymphoblastic transformation test (LTT) to the diagnosis of drug-induced hepatitis].
Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; | 1969 |
Aspirin and other cross-reacting small chemicals in known aspirin intolerant patients.
Topics: Analgesics; Antioxidants; Aspirin; Asthma; Blood Coagulation; Cross Reactions; Dose-Response Relatio | 1973 |
Concerning the nature of intolerance to aspirin.
Topics: Aminopyrine; Antipyrine; Aspirin; Asthma; Chemoreceptor Cells; Drug Hypersensitivity; Edema; Histami | 1967 |
[Visceral lupus erythematosus].
Topics: Antigen-Antibody Complex; Antigen-Antibody Reactions; Autoantibodies; Autoimmune Diseases; Diagnosis | 1966 |
[Current analgesic anti-inflammatory drugs].
Topics: Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver In | 1970 |
Response of aspirin-allergic patients to challenge by some analgesics in common use.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Female | 1971 |