indomethacin has been researched along with Allergic Encephalomyelitis in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental allergic encephalomyelitis in Lewis rats was suppressed by treatment with essential fatty acids (EFA) given perorally." | 5.26 | Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin. ( Mertin, J; Stackpoole, A, 1978) |
| "Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS)." | 1.29 | Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. ( Jensen, MA; Reder, AT; Sapugay, AM; Thapar, M, 1994) |
| "Indomethacin was active too when predosed in the rat EAE model." | 1.27 | Immunomodulating activity of Wy-41,770 (5H-dibenzo[A,D]cyclohepten-5-ylidene) acetic acid. ( Carlson, RP; Datko, LJ; Lewis, AJ; O'Neill-Davis, L, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blidner, AG | 1 |
| Salatino, M | 1 |
| Mascanfroni, ID | 1 |
| Diament, MJ | 1 |
| Bal de Kier Joffé, E | 1 |
| Jasnis, MA | 1 |
| Klein, SM | 1 |
| Rabinovich, GA | 1 |
| Stackpoole, A | 2 |
| Mertin, J | 2 |
| Ovadia, H | 1 |
| Paterson, PY | 2 |
| Reder, AT | 1 |
| Thapar, M | 1 |
| Sapugay, AM | 1 |
| Jensen, MA | 1 |
| Sacco, S | 1 |
| Agnello, D | 1 |
| Sottocorno, M | 1 |
| Lozza, G | 1 |
| Monopoli, A | 1 |
| Villa, P | 1 |
| Ghezzi, P | 1 |
| Chung, IY | 1 |
| Norris, JG | 1 |
| Benveniste, EN | 1 |
| Mannie, MD | 1 |
| Pope, L | 1 |
| Carlson, RP | 2 |
| Datko, LJ | 1 |
| O'Neill-Davis, L | 1 |
| Lewis, AJ | 2 |
| Gilman, SC | 1 |
| Millonig, RC | 1 |
| Goldlust, MB | 1 |
| Maguire, WE | 1 |
| Rubin, B | 1 |
| Schulze, E | 1 |
| Wojnar, RJ | 1 |
| Turkheimer, AR | 1 |
| Schreiber, WF | 1 |
| Brittain, RJ | 1 |
11 other studies available for indomethacin and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmunity; Cellular Microenvironment; Disease M | 2015 |
The effect of prostaglandin precursors in in vivo models of cell-mediated immunity.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Essential | 1981 |
Effect of indomethacin treatment upon actively-induced and transferred experimental allergic encephalomyelitis (EAE) in Lewis rats.
Topics: Animals; Concanavalin A; Encephalomyelitis, Autoimmune, Experimental; Immunization; Immunization, Pa | 1982 |
Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis.
Topics: Alprostadil; Animals; Arachidonic Acid; Drug Combinations; Edema; Encephalomyelitis, Autoimmune, Exp | 1994 |
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Brain; Brain Ischemia; En | 1998 |
Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Essential; Female; Indomethacin; | 1978 |
Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.
Topics: Animals; Astrocytes; Base Sequence; Encephalomyelitis, Autoimmune, Experimental; Indomethacin; Inter | 1991 |
Indomethacin augments in vitro proliferative responses of Lewis rat lymphocytes to myelin basic protein. Implications for experimental autoimmune encephalomyelitis.
Topics: Animals; Cell Division; Dinoprostone; Encephalomyelitis, Autoimmune, Experimental; In Vitro Techniqu | 1989 |
Immunomodulating activity of Wy-41,770 (5H-dibenzo[A,D]cyclohepten-5-ylidene) acetic acid.
Topics: Acetates; Animals; Arthritis, Experimental; Dibenzocycloheptenes; Encephalomyelitis, Autoimmune, Exp | 1986 |
Immunomodulatory activity of Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).
Topics: Animals; Benzimidazoles; Encephalomyelitis, Autoimmune, Experimental; Immune System Diseases; Immuno | 1985 |
Antiinflammatory activities of 2-acetyl- and 2-(1-hydroxyethyl)-4-(3-(dimethylamino)propyl)-3,4-dihydro-3-phenyl-2H-1,4-benzothiazine.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthus Reaction; Cell Membrane; DNA; Dogs; Edema; Ence | 1973 |