indomethacin has been researched along with Alcoholic Cirrhosis in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nonsteroidal antiinflammatory drugs (NSAID), such as indomethacin, reduce production of renal prostaglandins and markedly impair renal function in patients with cirrhosis and ascites." | 9.06 | Effects of oral prostaglandins on indomethacin-induced renal failure in patients with cirrhosis and ascites. ( Antillon, M; Cominelli, F; Lo, S; Moran, M; Reynolds, T; Somberg, K; Zipser, RD, 1990) |
| "Nonsteroidal antiinflammatory drugs (NSAID), such as indomethacin, reduce production of renal prostaglandins and markedly impair renal function in patients with cirrhosis and ascites." | 5.06 | Effects of oral prostaglandins on indomethacin-induced renal failure in patients with cirrhosis and ascites. ( Antillon, M; Cominelli, F; Lo, S; Moran, M; Reynolds, T; Somberg, K; Zipser, RD, 1990) |
| "Indomethacin has been shown to have adverse effects on renal function in patients with well-compensated alcoholic cirrhosis." | 3.69 | The effect of misoprostol on indomethacin-induced renal dysfunction in well-compensated cirrhosis. ( Dudley, F; Hsu, P; Massie, D; Wong, F, 1995) |
| " However, the baseline control collections after chronic dosing did not differ from the no-drug control periods." | 1.27 | Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics. ( Anderson, SA; Brater, DC; Brown-Cartwright, D; Toto, RD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerber, JG | 1 |
| Anderson, RJ | 1 |
| Schrier, RW | 1 |
| Nies, AS | 1 |
| Kawasaki, H | 1 |
| Murawaki, Y | 1 |
| Ohtake, H | 1 |
| Hirayama, C | 1 |
| Holdstock, G | 1 |
| Chastenay, BF | 1 |
| Krawitt, EL | 1 |
| Wong, F | 2 |
| Massie, D | 2 |
| Hsu, P | 2 |
| Dudley, F | 2 |
| Enomoto, N | 1 |
| Ikejima, K | 1 |
| Yamashina, S | 1 |
| Enomoto, A | 1 |
| Nishiura, T | 1 |
| Nishimura, T | 1 |
| Brenner, DA | 1 |
| Schemmer, P | 1 |
| Bradford, BU | 1 |
| Rivera, CA | 1 |
| Zhong, Z | 1 |
| Thurman, RG | 1 |
| Stokes, JB | 1 |
| Zipser, RD | 3 |
| Hoefs, JC | 1 |
| Speckart, PF | 1 |
| Zia, PK | 1 |
| Horton, R | 1 |
| Antillon, M | 2 |
| Cominelli, F | 2 |
| Lo, S | 1 |
| Moran, M | 1 |
| Somberg, K | 1 |
| Reynolds, T | 1 |
| Holman, RT | 1 |
| Reynolds, TB | 1 |
| Brater, DC | 1 |
| Anderson, SA | 1 |
| Brown-Cartwright, D | 1 |
| Toto, RD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174] | 50 participants (Actual) | Observational | 2016-06-01 | Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols) | |||
| Effect of High Omega-3 Fish Intake on Lipid Peroxidation[NCT01183520] | 30 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Alcoholic Cirrhosis
| Article | Year |
|---|---|
Prostaglandins and the regulation of renal circulation and function.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Body Water; Glomerular Filtration Rate | 1982 |
Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Dis | 1986 |
2 trials available for indomethacin and Alcoholic Cirrhosis
| Article | Year |
|---|---|
The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.
Topics: Diuresis; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Humans; Indomethacin | 1995 |
Effects of oral prostaglandins on indomethacin-induced renal failure in patients with cirrhosis and ascites.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Ascites; Double-Blind Method; Humans; Indom | 1990 |
8 other studies available for indomethacin and Alcoholic Cirrhosis
| Article | Year |
|---|---|
Effect of prostaglandin inhibition by indomethacin on renal function in alcoholic versus non-alcoholic cirrhotic patients.
Topics: Cyclooxygenase Inhibitors; Female; Glomerular Filtration Rate; Humans; Indocyanine Green; Indomethac | 1983 |
Studies on lymphocyte hyporesponsiveness in cirrhosis: the role of increased monocyte suppressor cell activity.
Topics: Adult; Aged; Hepatitis; Humans; Indomethacin; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Cir | 1982 |
The effect of misoprostol on indomethacin-induced renal dysfunction in well-compensated cirrhosis.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug Therapy | 1995 |
Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Anti-Bacterial Agents; Bucladesine; Calcium Channel | 2000 |
Liver disease and the renal prostaglandin system.
Topics: Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Liver Cirrhosis; Liver Cirrhosis, Alcoholi | 1979 |
Prostaglandins: modulators of renal function and pressor resistance in chronic liver disease.
Topics: Adult; Aldosterone; Ascites; Chronic Disease; Creatinine; Female; Humans; Ibuprofen; Indomethacin; K | 1979 |
Comparative acute effects of diflunisal and indomethacin on renal function in patients with cirrhosis and ascites.
Topics: Diflunisal; Dinoprostone; Diuresis; Drug Interactions; Furosemide; Humans; Indomethacin; Inulin; Kid | 1989 |
Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Dinoprostone; Etodolac; Humans; Indom | 1986 |