indomethacin has been researched along with Akinetic-Rigid Variant of Huntington Disease in 1 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The binding of beta-catenin to the destruction complex is altered in HD, leading to the toxic stabilization of beta-catenin." | 1.36 | Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. ( Godin, JD; Hickey, MA; Humbert, S; Maschat, F; Poizat, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Godin, JD | 1 |
| Poizat, G | 1 |
| Hickey, MA | 1 |
| Maschat, F | 1 |
| Humbert, S | 1 |
1 other study available for indomethacin and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.
Topics: Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Armadillo Domain Proteins | 2010 |