indomethacin has been researched along with Aging in 163 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model." | 7.81 | Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015) |
| "The effects of in vivo treatment with indomethacin were assessed in aging (22-36 month old) as compared to young (2-3 month old)F1 (C3H/ebJ x C57BL/6J) mice." | 7.67 | Effects of in vivo indomethacin treatment in aging mice. ( Globerson, A; Hayari, Y; Kukulansky, T, 1984) |
| "Treatment with indomethacin significantly decreased COX-1 and COX-2 transcript expression." | 5.40 | Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. ( Boehme, M; Frahm, C; Guenther, M; Jaenisch, N; Liebmann, M; Stahr, A; Witte, OW, 2014) |
| "Indomethacin did not inhibit the relaxations induced by thrombin or bradykinin, whereas bromophenacyl bromide and methylene blue did." | 5.28 | Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. ( Hatake, K; Hishida, S; Kakishita, E; Sakiyama, N; Wakabayashi, I, 1990) |
| " Addition of misoprostol can minimize this renal impairment without affecting pain control." | 5.08 | Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients. ( Dwolatzky, T; Nesher, G; Sonnenblick, M, 1995) |
| "In a controlled double blind study the therapeutic efficacy and tolerability of equimolar doses of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) and indometacin (acemetacin: 180 mg/day, indometacin: 150 mg/day) were studied in 40 patients suffering from rheumatoid arthritis." | 5.05 | [Treatment of chronic polyarthritis with acemetacin and indomethacin]. ( Badia-Flores, J; Muñoz Barradas, F, 1980) |
| " The focus of the present study was on neurobiological and behavioral differences between young and old rats modulated by indomethacin daily treatment starting at four hours after acute cerebral ischemia in animal model." | 3.81 | Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. ( Coman, C; Popa-Wagner, A; Sandu, RE; Uzoni, A, 2015) |
| " In 4-wk-old rabbits treated with l-NAME and Indo, the maximum ACh hypotension was reduced by the potassium channel inhibitors apamin and charybdotoxin to -6." | 3.74 | 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits. ( Aggarwal, NT; Campbell, WB; Gauthier, KM, 2008) |
| " Indomethacin (10 microM), a nonspecific cyclooxygenase inhibitor, and SQ 29,548 (10 microM), a prostaglandin H(2)/thromboxane A(2) receptor blocker, abolished the t-BOOH-induced vasoconstriction, independent of age and hypertension." | 3.70 | Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. ( Baena, AB; Diez-Picazo, LD; Garcia-Cohen, EC; Marin, J; Rodriguez-Martinez, MA; Salaices, M, 2000) |
| " Gastric ulcers were induced in young, adult, and aged rats using serosal or mucosal (kissing ulcers) application of acetic acid." | 3.69 | Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats. ( Andrews, FJ; O'Brien, PE; Penney, AG, 1996) |
| "Roles of histamine and prostaglandins in the induction of ovarian cysts after unilateral ovarian manipulation (MAN) and in the process of ovulation were evaluated in prepubertal gilts treated with pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG)." | 3.67 | Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. ( Dailey, RA; Hall, JA; Lewis, PE; Meisterling, EM, 1989) |
| "We have recently shown that indomethacin and ASA diminish the elevated blood flow, protein exudation, and leukocyte infiltration during acute inflammation induced by killed Escherichia coli, the reversed Arthus reaction, or zymosan-activated plasma (ZAP; C5ades-arg) in rabbit skin." | 3.66 | Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. ( Issekutz, AC, 1983) |
| "Indomethacin has no effect on the renal responsiveness to plasma AVP." | 2.67 | Arginine vasopressin and osmolality in the elderly. ( Crawford, GA; Gyory, AZ; Johnson, AG; Kelly, D; Nguyen, TV, 1994) |
| " 92 patients received piroxicam in a daily dosage of 4 capsules (40 mg) during the first two days, then 20 mg during the following days." | 2.65 | Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity. ( Commandre, F, 1983) |
| "Indomethacin was likely the most potent of these compounds and one of the earliest to enter clinical trials." | 2.53 | The Pharmacology of Indomethacin. ( Lucas, S, 2016) |
| " In conclusion, many human pathological conditions characterized by a decline in endothelial function are associated with a progressive decrease in NO bioavailability and increase in the production of EDCFs." | 2.46 | Human endothelial dysfunction: EDCFs. ( Ghiadoni, L; Taddei, S; Virdis, A, 2010) |
| "Indomethacin treatment enhanced water maze performance." | 1.48 | Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals. ( Foster, TC; Kumar, A; Ormerod, BK; Rani, A; Scheinert, RB, 2018) |
| "Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied." | 1.42 | Vascular endothelial function is improved by oral glycine treatment in aged rats. ( Cruz, M; García-Macedo, R; Gómez-Zamudio, JH; Ibarra-Barajas, M; Kumate, J; Lázaro-Suárez, M, 2015) |
| "Treatment with indomethacin significantly decreased COX-1 and COX-2 transcript expression." | 1.40 | Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. ( Boehme, M; Frahm, C; Guenther, M; Jaenisch, N; Liebmann, M; Stahr, A; Witte, OW, 2014) |
| "Menopause is the permanent cessation of menstruation that results from depletion of ovarian germ cells and follicles." | 1.39 | Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice. ( Cai, KQ; Smedberg, J; Smith, ER; Xu, XX; Yang, WL; Yeasky, T, 2013) |
| " In conclusion, chronic intake of Crataegus prevented aging-related endothelial dysfunction by reducing the prostanoid-mediated contractile responses, most likely by improving the increased oxidative stress and the overexpression of COX-1 and COX-2." | 1.38 | Crataegus special extract WS(®)1442 prevents aging-related endothelial dysfunction. ( Auger, C; Idris-Khodja, N; Koch, E; Schini-Kerth, VB, 2012) |
| "We tested two hypotheses, first that exercise training reverses age-related decrements in endothelium-dependent dilation in soleus muscle feed arteries and second that this improved endothelium-dependent dilation is the result of increased nitric oxide (NO) bioavailability due to increased content and phosphorylation of endothelial NO synthase (eNOS) and/or increased antioxidant enzyme content." | 1.35 | Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries. ( Gunduz, F; Laughlin, MH; Trott, DW; Woodman, CR, 2009) |
| " We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory increase in ovarian cyclooxygenase 1 expression and prostaglandin E(2) synthesis." | 1.34 | A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. ( Cai, KQ; Hamilton, TC; Klein-Szanto, A; Smedberg, JL; Smith, ER; Xu, XX; Yang, WL, 2007) |
| " Acetylcholine dose-response relaxation curves revealed that SAM-R1 vessels were slightly more sensitive than those of SAM-P8." | 1.34 | The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging. ( de Cabo, C; de Mera, RM; Jordán, J; Lloréns, S; Mendizábal, Y; Nava, E; Pascual, A; Prieto-Martín, A, 2007) |
| "The effect of hyperlipemia associated with diabetes on the contractility of resistance arteries to prostaglandin F2alpha (PGF2alpha) was investigated employing 4 weeks simultaneously hyperlipemic-diabetic (HD), hyperlipemic (H), diabetic (D) and normal hamsters (controls, C)." | 1.32 | The contractile response of the mesenteric resistance arteries to prostaglandin F2alpha; effects of simultaneous hyperlipemia-diabetes. ( Georgescu, A; Popov, D, 2003) |
| "Indomethacin was ineffective in both groups." | 1.31 | Endothelin-1-receptor-mediated responses in resistance vessels of young and adult spontaneously hypertensive rats. ( De Salvia, MA; Mitolo-Chieppa, D; Montagnani, M; Nacci, C; Nazzaro, P; Pirrelli, A; Potenza, MA; Rinaldi, R; Siro Brigiani, G; Vulpis, V, 2000) |
| "Pretreatment with indomethacin enhanced the relaxation response to acetylcholine in only SHRs at ages 16-20 and 55-60 weeks, thereby cancelling the difference in the relaxation response between WKY rats and SHRs." | 1.30 | Nitric oxide-dependent vasodilator mechanism is not impaired by hypertension but is diminished with aging in the rat aorta. ( Imaoka, Y; Kamada, T; Mio, Y; Okumura, K; Osanai, T; Satoh, K, 1999) |
| "When indomethacin was administered 2 h following the third LPS injection, a dose-dependent hypothermia was observed." | 1.29 | Alteration of the physiological responses to indomethacin by endotoxin tolerance in the rat: a possible role for central vasopressin. ( Pittman, QJ; Wilkinson, MF, 1994) |
| "1." | 1.28 | Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990) |
| " After dosing to steady state (7 days), the mean plasma elimination half-life for acemetacin was 1." | 1.28 | The comparative pharmacokinetics of acemetacin in young subjects and elderly patients. ( Collins, AJ; Jones, RW; Notarianni, LJ; Sedman, E, 1991) |
| "Indomethacin did not inhibit the relaxations induced by thrombin or bradykinin, whereas bromophenacyl bromide and methylene blue did." | 1.28 | Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. ( Hatake, K; Hishida, S; Kakishita, E; Sakiyama, N; Wakabayashi, I, 1990) |
| " The antigen dose-response relationship for the induction of PFC in cultures of CBMC is represented by a bell-shaped curve comparable to that found for mononuclear cells from adult peripheral blood (adult PBMC)." | 1.27 | Distinct role of neonatal and adult monocytes in the regulation of the in vitro antigen-induced plaque-forming cell response in man. ( Ballieux, RE; Thomas, CM; van Tol, MJ; Zegers, BJ; Zijlstra, J, 1984) |
| "Pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-HT in brain continued to remain high." | 1.27 | Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. ( Dey, PK; Sharma, HS, 1986) |
| "Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity." | 1.27 | Indomethacin sensitive suppressor-cell activity in head and neck cancer patients. The role of the adherent mononuclear cell. ( Cantrell, RW; Johns, ME; Katz, D; Pace, RC; Riley, T; Wanebo, HJ, 1988) |
| "70 micrograms ml-1 h and the plasma elimination half-life was 4." | 1.27 | Pharmacokinetics of a sustained-release product of indomethacin in the elderly. ( Barbeau, G; Bélanger, PM; Bruguerolle, B; Labrecque, G, 1986) |
| "Progressive myelopathy in the German shepherd dog is a degenerative neurologic disease of unknown etiology." | 1.26 | Progressive myelopathy in older German shepherd dogs. II. Presence of circulating suppressor cells. ( Clemmons, RM; Hinrichs, DJ; Waxman, FJ, 1980) |
| "Acemetacin was tolerated better than indometacin in all cases." | 1.26 | [Toxicology of acemetacin]. ( Dell, HD; Jacobi, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (35.58) | 18.7374 |
| 1990's | 52 (31.90) | 18.2507 |
| 2000's | 31 (19.02) | 29.6817 |
| 2010's | 21 (12.88) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| d'Uscio, LV | 1 |
| Katusic, ZS | 1 |
| Kumar, A | 1 |
| Rani, A | 1 |
| Scheinert, RB | 1 |
| Ormerod, BK | 1 |
| Foster, TC | 1 |
| Guslandi, M | 1 |
| Smith, ER | 2 |
| Yang, WL | 2 |
| Yeasky, T | 1 |
| Smedberg, J | 1 |
| Cai, KQ | 2 |
| Xu, XX | 2 |
| Taylor, JL | 1 |
| Hines, CN | 2 |
| Nicholson, WT | 3 |
| Joyner, MJ | 3 |
| Barnes, JN | 3 |
| Boehme, M | 1 |
| Guenther, M | 1 |
| Stahr, A | 1 |
| Liebmann, M | 1 |
| Jaenisch, N | 1 |
| Witte, OW | 1 |
| Frahm, C | 1 |
| Gómez-Zamudio, JH | 1 |
| García-Macedo, R | 1 |
| Lázaro-Suárez, M | 1 |
| Ibarra-Barajas, M | 1 |
| Kumate, J | 1 |
| Cruz, M | 1 |
| Sandu, RE | 1 |
| Uzoni, A | 1 |
| Coman, C | 1 |
| Popa-Wagner, A | 1 |
| Lucas, S | 1 |
| Choi, S | 1 |
| Kim, JA | 1 |
| Li, HY | 1 |
| Shin, KO | 1 |
| Oh, GT | 1 |
| Lee, YM | 1 |
| Oh, S | 1 |
| Pewzner-Jung, Y | 1 |
| Futerman, AH | 1 |
| Suh, SH | 1 |
| Costa, G | 1 |
| Garabito, M | 1 |
| Jiménez-Altayó, F | 1 |
| Onetti, Y | 1 |
| Sabate, M | 1 |
| Vila, E | 2 |
| Dantas, AP | 1 |
| Trott, DW | 1 |
| Gunduz, F | 1 |
| Laughlin, MH | 2 |
| Woodman, CR | 2 |
| Graham, DA | 1 |
| Rush, JW | 1 |
| LeBlanc, AJ | 1 |
| Reyes, R | 1 |
| Kang, LS | 1 |
| Dailey, RA | 2 |
| Stallone, JN | 2 |
| Moningka, NC | 1 |
| Muller-Delp, JM | 4 |
| Jin, X | 1 |
| Satoh-Otonashi, Y | 1 |
| Zamami, Y | 1 |
| Hobara, N | 1 |
| Koyama, T | 1 |
| Sun, P | 1 |
| Li, S | 1 |
| Kitamura, Y | 1 |
| Kawasaki, H | 1 |
| Zelena, D | 1 |
| Filaretova, L | 1 |
| Virdis, A | 1 |
| Ghiadoni, L | 1 |
| Taddei, S | 1 |
| George, O | 1 |
| Vallée, M | 1 |
| Vitiello, S | 1 |
| Le Moal, M | 1 |
| Piazza, PV | 1 |
| Mayo, W | 1 |
| Líšková, S | 1 |
| Silvia, L | 1 |
| Petrová, M | 1 |
| Miriam, P | 1 |
| Karen, P | 1 |
| Petr, K | 1 |
| Kuneš, J | 1 |
| Jaroslav, K | 1 |
| Zicha, J | 1 |
| Josef, Z | 1 |
| Ebenezar, KK | 1 |
| Wong, AK | 1 |
| Smith, FG | 1 |
| Schmidt, JE | 1 |
| Casey, DP | 1 |
| Idris-Khodja, N | 1 |
| Auger, C | 1 |
| Koch, E | 1 |
| Schini-Kerth, VB | 1 |
| Hong, H | 1 |
| Kim, EH | 1 |
| Lee, HJ | 1 |
| Kim, YJ | 1 |
| Lee, JJ | 1 |
| Hahm, KB | 1 |
| Assadian Narenji, S | 1 |
| Naghdi, N | 1 |
| Oryan, S | 1 |
| Azadmanesh, K | 1 |
| Tang, RS | 1 |
| Chan, FK | 1 |
| Bessler, H | 1 |
| Ziyada, S | 1 |
| Bergman, M | 1 |
| Punsky, I | 1 |
| Sirota, L | 1 |
| Mukai, Y | 1 |
| Shimokawa, H | 1 |
| Higashi, M | 1 |
| Morikawa, K | 1 |
| Matoba, T | 1 |
| Hiroki, J | 1 |
| Kunihiro, I | 1 |
| Talukder, HM | 1 |
| Takeshita, A | 1 |
| Spier, SA | 3 |
| Ramsey, MW | 2 |
| Delp, MD | 3 |
| Geary, GG | 1 |
| Buchholz, JN | 1 |
| Pearce, WJ | 2 |
| Pereira, LS | 1 |
| Ferreira-Alves, DL | 1 |
| de Resende, MA | 1 |
| Romualdo, VA | 1 |
| Dos Reis, WG | 1 |
| Lopes, MT | 1 |
| Santoro, MM | 1 |
| Francischi, JN | 1 |
| Armstead, WM | 2 |
| Price, EM | 1 |
| Meininger, CJ | 1 |
| Donato, AJ | 1 |
| Georgescu, A | 1 |
| Popov, D | 1 |
| Brown, DW | 1 |
| Lee, D | 1 |
| Kumaran, VS | 1 |
| Lee, TY | 1 |
| Williams, JM | 1 |
| Hull, AD | 1 |
| Briones, AM | 1 |
| Montoya, N | 1 |
| Giraldo, J | 1 |
| Nevado, J | 1 |
| Vallejo, S | 1 |
| El-Assar, M | 1 |
| Peiró, C | 1 |
| Sánchez-Ferrer, CF | 1 |
| Rodríguez-Mañas, L | 1 |
| Ibarra, M | 1 |
| López-Guerrero, JJ | 1 |
| Mejía-Zepeda, R | 1 |
| Villalobos-Molina, R | 1 |
| Dominguez, JM | 1 |
| Smedberg, JL | 1 |
| Klein-Szanto, A | 1 |
| Hamilton, TC | 1 |
| Kang, KB | 1 |
| Rajanayagam, MA | 1 |
| van der Zypp, A | 1 |
| Majewski, H | 1 |
| Gendron, ME | 1 |
| Thorin, E | 1 |
| Lloréns, S | 1 |
| de Mera, RM | 1 |
| Pascual, A | 1 |
| Prieto-Martín, A | 1 |
| Mendizábal, Y | 1 |
| de Cabo, C | 1 |
| Nava, E | 1 |
| Jordán, J | 2 |
| Aggarwal, NT | 1 |
| Gauthier, KM | 1 |
| Campbell, WB | 1 |
| Boardman, PL | 1 |
| Hart, FD | 1 |
| Twomey, JJ | 1 |
| Kouttab, NM | 1 |
| Issekutz, AC | 1 |
| Hayari, Y | 1 |
| Kukulansky, T | 1 |
| Globerson, A | 1 |
| Commandre, F | 1 |
| Elliott, GR | 1 |
| Adolfs, MJ | 1 |
| van Tol, MJ | 1 |
| Zijlstra, J | 1 |
| Thomas, CM | 1 |
| Zegers, BJ | 1 |
| Ballieux, RE | 1 |
| Hably, C | 1 |
| Banki, K | 1 |
| Bartha, J | 1 |
| Bräunlich, H | 1 |
| Waxman, FJ | 1 |
| Clemmons, RM | 1 |
| Hinrichs, DJ | 1 |
| Berman, W | 1 |
| Friedman, Z | 1 |
| Vidyasagar, D | 1 |
| Delfraissy, JF | 1 |
| Galanaud, P | 1 |
| Wallon, C | 1 |
| Dormont, J | 1 |
| Hornych, A | 1 |
| Krief, C | 1 |
| Bariety, J | 1 |
| Rosenstein, MM | 2 |
| Strausser, HR | 2 |
| Warner, LA | 1 |
| Holt, PG | 1 |
| Mayrhofer, G | 1 |
| Becker, MJ | 1 |
| Drucker, I | 1 |
| Farkas, R | 1 |
| Steiner, Z | 1 |
| Klajman, A | 1 |
| DeBoer, KP | 1 |
| Braun, DP | 1 |
| Harris, JE | 1 |
| Cassin, S | 3 |
| Nagel, JE | 1 |
| Chrest, FJ | 1 |
| Adler, WH | 1 |
| Jacobi, H | 1 |
| Dell, HD | 1 |
| Badia-Flores, J | 1 |
| Muñoz Barradas, F | 1 |
| Tod, M | 1 |
| Philips, J | 1 |
| Frisinger, J | 1 |
| Gibbs, C | 1 |
| Alexander, AM | 1 |
| Barnett, JW | 1 |
| Veitch, GB | 1 |
| Osborn, JL | 1 |
| Hook, JB | 1 |
| Bailie, MD | 1 |
| Brink, C | 1 |
| Duncan, PG | 1 |
| Midzenski, M | 1 |
| Douglas, JS | 1 |
| Nakashima, M | 1 |
| Vanhoutte, PM | 1 |
| Dussault, I | 2 |
| Miller, SC | 2 |
| Canal, J | 1 |
| Domínguez, E | 1 |
| Torres, MD | 1 |
| Campillo, JE | 1 |
| Pérez, C | 1 |
| Nesher, G | 1 |
| Sonnenblick, M | 1 |
| Dwolatzky, T | 1 |
| Wilkinson, MF | 1 |
| Pittman, QJ | 1 |
| Lamb, VL | 1 |
| Schwartz, AJ | 1 |
| Rohn, WR | 1 |
| Kaiser, L | 1 |
| Kohút, A | 1 |
| Mirossay, L | 1 |
| Gerstle, JT | 1 |
| Seaton, J | 1 |
| Kauffman, GL | 1 |
| Colony, PC | 1 |
| Joseph, SA | 1 |
| Walker, DW | 1 |
| Johnson, AG | 1 |
| Crawford, GA | 1 |
| Kelly, D | 1 |
| Nguyen, TV | 1 |
| Gyory, AZ | 1 |
| Jackson, EK | 2 |
| Herzer, WA | 1 |
| Dyess, DL | 1 |
| Peeples, GL | 1 |
| Ardell, JL | 1 |
| Tacchi, EJ | 1 |
| Roberts, WS | 1 |
| Ferrara, JJ | 1 |
| Powell, RW | 1 |
| Gustin, P | 1 |
| Ansay, M | 1 |
| Advenier, C | 1 |
| Fujii, K | 2 |
| Ohmori, S | 1 |
| Tominaga, M | 1 |
| Abe, I | 2 |
| Takata, Y | 1 |
| Ohya, Y | 1 |
| Kobayashi, K | 1 |
| Fujishima, M | 2 |
| Tu, KY | 1 |
| Matthews, R | 1 |
| Matthews, KS | 1 |
| Tabata, M | 1 |
| Tomomasa, T | 1 |
| Itoh, K | 1 |
| Morikawa, A | 1 |
| Rösen, P | 1 |
| Ballhausen, T | 1 |
| Bloch, W | 1 |
| Addicks, K | 1 |
| Zuckerman, SL | 1 |
| Hsu, P | 1 |
| Shibata, M | 1 |
| Leffler, CW | 2 |
| Sharma, HS | 2 |
| Westman, J | 1 |
| Navarro, JC | 1 |
| Dey, PK | 2 |
| Nyberg, F | 1 |
| Penney, AG | 1 |
| Andrews, FJ | 1 |
| O'Brien, PE | 1 |
| Støen, R | 1 |
| Brubakk, AM | 1 |
| Vik, T | 1 |
| Lossius, K | 1 |
| Jynge, P | 1 |
| Karlsson, JO | 1 |
| Tai, H | 1 |
| Miyaura, C | 1 |
| Pilbeam, CC | 1 |
| Tamura, T | 1 |
| Ohsugi, Y | 1 |
| Koishihara, Y | 1 |
| Kubodera, N | 1 |
| Kawaguchi, H | 1 |
| Raisz, LG | 1 |
| Suda, T | 1 |
| Diestelhorst, M | 1 |
| Kwon, KA | 1 |
| Süverkrup, R | 1 |
| Konishi, C | 2 |
| Naito, Y | 2 |
| Ohara, N | 2 |
| Mhanna, MJ | 1 |
| Dreshaj, IA | 1 |
| Haxhiu, MA | 1 |
| Martin, RJ | 1 |
| Rigamonti, AE | 1 |
| Cella, SG | 1 |
| Marazzi, N | 1 |
| Müller, EE | 1 |
| Onaka, U | 1 |
| Fugelseth, D | 1 |
| Lindemann, R | 1 |
| Liestøl, K | 1 |
| Kiserud, T | 1 |
| Langslet, A | 1 |
| Imaoka, Y | 1 |
| Osanai, T | 1 |
| Kamada, T | 1 |
| Mio, Y | 1 |
| Satoh, K | 1 |
| Okumura, K | 1 |
| Vohr, B | 1 |
| Allan, WC | 1 |
| Scott, DT | 1 |
| Katz, KH | 1 |
| Schneider, KC | 1 |
| Makuch, RW | 1 |
| Ment, LR | 1 |
| Goodwin, AT | 1 |
| Amrani, M | 1 |
| Marchbank, AJ | 1 |
| Gray, CC | 1 |
| Jayakumar, J | 1 |
| Yacoub, MH | 1 |
| Koller, A | 1 |
| Huang, A | 1 |
| Chamiot-Clerc, P | 1 |
| Choukri, N | 1 |
| Legrand, M | 1 |
| Droy-Lefaix, MT | 1 |
| Safar, ME | 1 |
| Renaud, JF | 1 |
| Benesová, O | 1 |
| Tejkalová, H | 1 |
| Kristofiková, Z | 1 |
| Panajotova, V | 1 |
| Husek, P | 1 |
| Garcia-Cohen, EC | 1 |
| Marin, J | 1 |
| Diez-Picazo, LD | 1 |
| Baena, AB | 1 |
| Salaices, M | 1 |
| Rodriguez-Martinez, MA | 1 |
| Sijben, JW | 1 |
| Schrama, JW | 1 |
| Nieuwland, MG | 1 |
| Parmentier, HK | 1 |
| Montagnani, M | 1 |
| Vulpis, V | 1 |
| Nazzaro, P | 1 |
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| Ibe, BO | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Controlled and Randomized Clinical Trial for Evaluating the Effect of a Supplement of Glycine as Adjuvant in the Treatment of COVID-19 Pneumonia in Patients Initiating Mechanical Ventilation[NCT04443673] | 59 participants (Actual) | Interventional | 2020-06-15 | Terminated (stopped due to An interim analysis showed no difference in major outcomes (n=35 glycine and n=24 control participants)) | |||
| The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise[NCT03722953] | 18 participants (Actual) | Interventional | 2018-12-01 | Completed | |||
| Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638] | Early Phase 1 | 80 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness[NCT04586049] | 70 participants (Anticipated) | Observational | 2023-05-16 | Recruiting | |||
| The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity[NCT05396287] | 80 participants (Anticipated) | Observational | 2022-07-19 | Enrolling by invitation | |||
| Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851] | 46 participants (Actual) | Observational | 2016-11-30 | Completed | |||
| Cerebrovascular Outcomes in Ischemic Heart Disease Patients Undergoing Cardiac Rehabilitation[NCT02715661] | 140 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428] | 71 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for indomethacin and Aging
| Article | Year |
|---|---|
The Pharmacology of Indomethacin.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Eating; Humans; Ind | 2016 |
Human endothelial dysfunction: EDCFs.
Topics: Aging; Animals; Endothelin-1; Endothelium, Vascular; Estrogens; Forearm; Humans; Hypertension; Indom | 2010 |
Pharmacokinetics of inhibitors of prostaglandin synthesis in the perinatal period.
Topics: Adolescent; Adult; Aging; Animals; Child; Child, Preschool; Cyclooxygenase Inhibitors; Female; Fetus | 1980 |
Role of prostaglandins and thromboxanes in the control of the pulmonary circulation in the fetus and newborn.
Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Epoprostenol; Female; Fetus; Hum | 1980 |
Immunosuppression as a homeostatic mechanism in disease and aging.
Topics: Aging; Animals; B-Lymphocytes; Homeostasis; Immunity; Immunosuppression Therapy; Indomethacin; Macro | 1979 |
Role of interleukin-2 in the age-related impairment of immune function.
Topics: Aging; Animals; Humans; Immunity, Cellular; Indomethacin; Interleukin-2; Lymphokines; Mice; Mice, In | 1985 |
Implications of drug therapy in the elderly.
Topics: Aged; Aging; Anti-Inflammatory Agents; Antihypertensive Agents; Diuretics; Drug Interactions; Humans | 1986 |
5 trials available for indomethacin and Aging
| Article | Year |
|---|---|
Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity.
Topics: Adult; Aging; Anti-Inflammatory Agents; Athletic Injuries; Clinical Trials as Topic; Double-Blind Me | 1983 |
[Treatment of chronic polyarthritis with acemetacin and indomethacin].
Topics: Adult; Aged; Aging; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Double-Blind M | 1980 |
Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.
Topics: Aged; Aging; Drug Therapy, Combination; Female; Hospitalization; Humans; Indomethacin; Kidney Diseas | 1995 |
Arginine vasopressin and osmolality in the elderly.
Topics: Adult; Age Factors; Aged; Aging; Arginine Vasopressin; Cross-Sectional Studies; Double-Blind Method; | 1994 |
Early-onset intraventricular hemorrhage in preterm neonates: incidence of neurodevelopmental handicap.
Topics: Aging; Brain Diseases; Cerebral Hemorrhage; Cerebral Palsy; Humans; Indomethacin; Infant, Newborn; I | 1999 |
151 other studies available for indomethacin and Aging
| Article | Year |
|---|---|
Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging.
Topics: Aging; Amyloid beta-Protein Precursor; Animals; Aorta, Thoracic; Cyclooxygenase 2; Cyclooxygenase In | 2021 |
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dithiothreitol; Excitatory Postsynaptic Pot | 2018 |
Increased vulnerability of the aging stomach to NSAIDs.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; Stomach | 2013 |
Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.
Topics: Aging; Animals; Celecoxib; Crosses, Genetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2013 |
The effect of ageing and indomethacin on forearm reactive hyperaemia in healthy adults.
Topics: Adolescent; Adult; Aged; Aging; Cyclooxygenase Inhibitors; Female; Forearm; Health Status; Humans; H | 2014 |
Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Biomarkers; Cell Count; Cycloox | 2014 |
Vascular endothelial function is improved by oral glycine treatment in aged rats.
Topics: Acetylcholine; Aging; Animals; Aorta; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium, Vascular; Gly | 2015 |
Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antigens, Nuclear; Brain Ischemia; Cell Proliferation; Cer | 2015 |
KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress.
Topics: Aging; Animals; Antioxidants; Aorta; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Ex | 2016 |
Sex differences in angiotensin II responses contribute to a differential regulation of cox-mediated vascular dysfunction during aging.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 2; Endotheli | 2016 |
Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries.
Topics: Acetylcholine; Aging; Animals; Arteries; Catalase; Endothelium, Vascular; Enzyme Inhibitors; Indomet | 2009 |
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Topics: Acetylcholine; Age Factors; Aging; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Hetero | 2009 |
Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats.
Topics: Age Factors; Aging; Animals; Arterioles; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhi | 2009 |
Age-related disappearance of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric vascular beds.
Topics: Acetylcholine; Aging; Animals; Benzoquinones; Biological Factors; Calcimycin; Catalase; Cyclic N-Oxi | 2009 |
Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Blood Glucose; Corticosterone; Female; Gastric Mucosa; | 2010 |
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats.
Topics: Aging; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indomethacin; Male; Memory Disorder | 2010 |
Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery.
Topics: Acetylcholine; Aging; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothel | 2011 |
Haemodynamic responses to angiotensin II in conscious lambs: role of nitric oxide and prostaglandins.
Topics: Aging; Angiotensin II; Animals; Animals, Newborn; Blood Pressure; Cyclooxygenase Inhibitors; Female; | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aorta; Blood Flow Velocity; Blood Pressure; Blood Press | 2012 |
Crataegus special extract WS(®)1442 prevents aging-related endothelial dysfunction.
Topics: Aging; Animals; Biological Factors; Biphenyl Compounds; Crataegus; Cyclooxygenase 1; Cyclooxygenase | 2012 |
Molecular mechanisms elucidating why old stomach is more vulnerable to indomethacin-induced damage than young stomach.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Disease Susceptibility; G | 2013 |
Effect of 3α-anderostanediol and indomethacin on acquisition, consolidation and retrieval stage of spatial memory in adult male rats.
Topics: Aging; Androstanes; Animals; CA1 Region, Hippocampal; Dimethyl Sulfoxide; Indomethacin; Male; Maze L | 2012 |
Mechanisms behind the increased vulnerability of the aging stomach to NSAID-related injury: perhaps not as simple as we may think.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; Stomach | 2013 |
Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults.
Topics: Adult; Aging; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Indomethacin; Infant, Newb | 2002 |
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Bridged Bicyclo Com | 2002 |
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles.
Topics: Acetylcholine; Adenosine; Aging; Animals; Arterioles; Cyclooxygenase Inhibitors; Endothelium, Vascul | 2002 |
Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms.
Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Cerebral Arteries; Cyclooxygenase Inhibitors; Endo | 2003 |
Reduced production of hyperalgesic substances by mononuclear cells from aged rats incubated with carrageenan: role of interleukin 2 and prostaglandins.
Topics: Aging; Animals; Carrageenan; Cell Separation; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme-Lin | 2003 |
Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation.
Topics: Aging; Animals; Animals, Newborn; Arteries; Blood Chemical Analysis; Brain Injuries; Catalase; Cereb | 2003 |
Selected Contribution: Aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries.
Topics: Acetylcholine; Aging; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothel | 2003 |
Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles.
Topics: Acetylcholine; Aging; Animals; Arterioles; Blotting, Western; Body Weight; Citrate (si)-Synthase; Do | 2004 |
The contractile response of the mesenteric resistance arteries to prostaglandin F2alpha; effects of simultaneous hyperlipemia-diabetes.
Topics: Aging; Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Dinoprost; Disease Model | 2003 |
Age-dependent cerebral hemodynamic effects of indomethacin in the newborn piglet.
Topics: Adaptation, Physiological; Aging; Animals; Animals, Newborn; Blood Volume; Brain; Cardiovascular Age | 2004 |
Maturational modulation of endothelium-dependent vasodilatation in ovine cerebral arteries.
Topics: Adenosine Diphosphate; Aging; Animals; Animals, Newborn; Calcimycin; Carotid Arteries; Cerebral Arte | 2005 |
Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries.
Topics: Acetylcholine; Aging; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Int | 2005 |
Changes in the human peritoneal mesothelial cells during aging.
Topics: Adult; Aged; Aging; Cytokines; Epithelial Cells; Female; Humans; Indomethacin; Inflammation; Male; M | 2006 |
Endothelium-dependent inhibition of the contractile response is decreased in aorta from aged and spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta; Disease Models, Animal; Endothelium; Hypertension; Indomethacin; Male; Muscle | 2006 |
Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide.
Topics: Age Factors; Aging; Animals; Arterioles; Blood Flow Velocity; Cyclooxygenase 1; Cyclooxygenase Inhib | 2007 |
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
Topics: Adenoma; Aging; Animals; Blotting, Western; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygena | 2007 |
A role for cyclooxygenase in aging-related changes of beta-adrenoceptor-mediated relaxation in rat aortas.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Aorta, Thoracic; Aspirin; Immunohistochemistry; Indome | 2007 |
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.
Topics: Acetylcholine; Acetylcysteine; Aging; Animals; Antioxidants; Benzofurans; Bridged Bicyclo Compounds, | 2007 |
The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Cyclooxygenase Inhibitors; Dose-Response Relationshi | 2007 |
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Age Factors; Aging; Ani | 2008 |
Side-effects of indomethacin.
Topics: Aging; Arthritis, Rheumatoid; Headache; Humans; Indomethacin; Osteoarthritis; Spondylitis, Ankylosin | 1967 |
Selected phenotypic induction of null lymphocytes from mice with thymic and nonthymic agents.
Topics: Aging; Animals; Antigens, Surface; Cell Differentiation; Chromosomal Proteins, Non-Histone; Cyclic A | 1982 |
Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits.
Topics: Aging; Animals; Arthus Reaction; Escherichia coli Infections; Exudates and Transudates; Glucocortico | 1983 |
Effects of in vivo indomethacin treatment in aging mice.
Topics: Aging; Animals; Blood Cell Count; Cells, Cultured; Immunity, Cellular; Indomethacin; Interleukin-1; | 1984 |
Continuous monitoring of prostacyclin production by the isolated, intact, rat aorta using a bioassay technique.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Aorta; Biological Assay; Body Weight; Epoprostenol; In | 1984 |
Distinct role of neonatal and adult monocytes in the regulation of the in vitro antigen-induced plaque-forming cell response in man.
Topics: Adult; Aging; Antibody-Producing Cells; Antigens; Antigens, Surface; Cell Adhesion; Dinoprostone; Do | 1984 |
Effects of indomethacin and naproxen on renal p-amino-hippurate (PAH) excretion in rats during postnatal development.
Topics: Aging; Aminohippuric Acids; Animals; Diuresis; Female; Glomerular Filtration Rate; Hematocrit; Indom | 1984 |
Progressive myelopathy in older German shepherd dogs. II. Presence of circulating suppressor cells.
Topics: Aging; Animals; Cell Adhesion; Cell Separation; Dog Diseases; Dogs; Female; Immunity, Cellular; Incu | 1980 |
[Immunologic deficiency linked to aging. Role of monocytes].
Topics: Adult; Aged; Aging; Humans; Immunity; Indomethacin; Monocytes; Prostaglandins | 1981 |
Radioimmunoassay measurement of thromboxane B2 in human plasma and urine.
Topics: Adult; Aging; Antibody Specificity; Chromatography; Female; Humans; Indomethacin; Kinetics; Male; Mi | 1982 |
Macrophage-induced T cell mitogen suppression with age.
Topics: Aging; Animals; Concanavalin A; Female; Immune Tolerance; Indomethacin; Lymphocyte Activation; Macro | 1980 |
Alveolar macrophages. VI. Regulation of alveolar macrophage-mediated suppression of lymphocyte proliferation by a putative T cell.
Topics: Aging; Animals; Cell Count; Cell Separation; Cells, Cultured; Cyclophosphamide; Female; Immune Toler | 1981 |
Monocyte-mediated regulation of cellular immunity in humans: loss of suppressor activity with ageing.
Topics: Adult; Aged; Aging; Cell Adhesion; Cell Division; Cytotoxicity, Immunologic; DNA; Humans; Immunity, | 1981 |
Natural cytotoxicity and antibody-dependent cytotoxicity in solid tumor cancer patients: regulation by adherent cells.
Topics: Adult; Aged; Aging; Antibody-Dependent Cell Cytotoxicity; Antigen-Antibody Complex; Binding Sites; C | 1982 |
Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.
Topics: Adult; Aged; Aging; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female; H | 1982 |
[Toxicology of acemetacin].
Topics: Aging; Animals; Anti-Inflammatory Agents; Cats; Dogs; Female; Indoleacetic Acids; Indomethacin; Leth | 1980 |
Effects of prostaglandin D2 on perinatal circulation.
Topics: Aging; Animals; Animals, Newborn; Blood Circulation; Female; Fetus; Goats; Indomethacin; Lung; Pregn | 1981 |
The Hereford Hospital Prescribing Study. Investigation of methods to identify patients with adverse drug reactions.
Topics: Adolescent; Adult; Aged; Aging; Computers; Data Collection; Drug-Related Side Effects and Adverse Re | 1981 |
Effect of saralasin and indomethacin on renal function in developing piglets.
Topics: Aging; Angiotensin II; Animals; Animals, Newborn; Indomethacin; Kidney; Prostaglandins; Regional Blo | 1980 |
Response and sensitivity of female guinea-pig respiratory tissues to agonists during ontogenesis.
Topics: Age Factors; Aging; Albuterol; Animals; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indomet | 1980 |
Age-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery.
Topics: Acetylcholine; Aging; Animals; Arginine; Endothelins; Endothelium, Vascular; In Vitro Techniques; In | 1993 |
Effectiveness of immunotherapy in aged leukemic mice.
Topics: Aging; Animals; Bone Marrow; Cell Count; Combined Modality Therapy; Immunotherapy; Indomethacin; Int | 1995 |
Age-related increased 14C-arachidonic acid uptake by platelets in normal subjects.
Topics: Adolescent; Adult; Aged; Aging; Arachidonic Acid; Blood Glucose; Blood Platelets; Carbon Radioisotop | 1995 |
Decline in natural killer cell-mediated immunosurveillance in aging mice--a consequence of reduced cell production and tumor binding capacity.
Topics: Aging; Animals; Cell Count; Cell Division; Indomethacin; Interleukin-2; Killer Cells, Natural; Male; | 1994 |
Alteration of the physiological responses to indomethacin by endotoxin tolerance in the rat: a possible role for central vasopressin.
Topics: Aging; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Body Temperature Re | 1994 |
Cyclooxygenase inhibitors depress norepinephrine constriction of rat abdominal, but not thoracic, aorta.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Aorta, Abdominal; Aorta, | 1994 |
[The effect of dopamine and PGI2 on indomethacin and alcohol-induced gastric lesions in rats of various ages in relation to gastric vascular permeability and HCl secretion].
Topics: Aging; Animals; Capillary Permeability; Dopamine; Epoprostenol; Ethanol; Gastric Acid; Gastric Mucos | 1993 |
The association between PGE2 activity and mucosal permeability in proximal small bowel.
Topics: Aging; Animals; Cell Membrane Permeability; Chromium Radioisotopes; Dinoprostone; Edetic Acid; Indom | 1994 |
Monoamine concentrations in cerebrospinal fluid of fetal and newborn sheep.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Biogenic Monoamines; Dinoprostone; | 1994 |
Angiotensin II/prostaglandin I2 interactions in spontaneously hypertensive rats.
Topics: Aging; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Captopril; Cardiac Output; Dos | 1993 |
Indomethacin-induced blood flow distribution in premature and full-term piglets.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Blood Circulation; Hemodynamics; Indomethaci | 1993 |
Effects of age and indomethacin on response and sensitivity of pulmonary artery to phenylephrine and to histamine in pigs.
Topics: Aging; Animals; Arachidonic Acid; Dogs; Dose-Response Relationship, Drug; Female; Histamine; Indomet | 1993 |
Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery.
Topics: Acetylcholine; Aging; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electrophy | 1993 |
Human lymphocytes incubated in vitro share multiple characteristics with geriatric-derived lymphocytes: a potential in vitro model for aging?
Topics: Adult; Aged; Aging; Antigens, Surface; Cell Division; Cells, Cultured; Cellular Senescence; Cyclooxy | 1995 |
Effect of 10% ethanol and sofalcone on prostaglandin E2 content, mucus gel thickness, and experimental ulcers in the stomach of developing rats.
Topics: Aging; Animals; Animals, Newborn; Anti-Ulcer Agents; Chalcone; Chalcones; Dinoprostone; Dose-Respons | 1996 |
Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant.
Topics: Aging; Animals; Antioxidants; Catecholamines; Coronary Circulation; Diabetes Mellitus, Experimental; | 1995 |
Age dependence of cerebrovascular response mechanisms in domestic pigs.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Arterioles; Cerebrovascular Circulation; Cyclooxyge | 1996 |
Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Blood-Br | 1995 |
Influence of age on natural and delayed healing of experimentally-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; | 1996 |
Postnatal changes in mechanisms mediating acetylcholine-induced relaxation in piglet femoral arteries.
Topics: Aging; Aminoquinolines; Animals; Animals, Newborn; Endothelium, Vascular; Enzyme Inhibitors; Femoral | 1997 |
Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation.
Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, N | 1997 |
Dose uniformity of ophthalmic suspensions.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Anti-Infla | 1998 |
Changes in the regulation by endothelium of norepinephrine response in isolated, perfused mesenteric vascular bed of rats at different ages.
Topics: Acetylcholine; Aging; Animals; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesen | 1998 |
Mechanism for substance P-induced relaxation of precontracted airway smooth muscle during development.
Topics: Aging; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; Enzyme In | 1999 |
Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs.
Topics: Aging; Animals; Area Under Curve; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Erythrityl Tet | 1999 |
Eicosanoids and membrane properties in arteries of aged spontaneously hypertensive rats.
Topics: Aging; Animals; Atropine; Blood Pressure; Calcium Channels; Cyclooxygenase Inhibitors; Eicosanoids; | 1999 |
Postnatal closure of ductus venosus in preterm infants < or = 32 weeks. An ultrasonographic study.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Gestational Age; Humans; | 1998 |
Nitric oxide-dependent vasodilator mechanism is not impaired by hypertension but is diminished with aging in the rat aorta.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Biological Factors; Blood Pressure; Body Weight; Eic | 1999 |
Age-related changes in adenosine 5'-triphosphate-induced constriction of isolated, perfused mesenteric arteries of rats.
Topics: Adenosine Triphosphate; Aging; Animals; Blood Pressure; Endothelium, Vascular; In Vitro Techniques; | 1999 |
Coronary vasoconstriction to endothelin-1 increases with age before and after ischaemia and reperfusion.
Topics: Aging; Animals; Coronary Vessels; Cyclooxygenase Inhibitors; Endothelin-1; Heart Arrest, Induced; In | 1999 |
Development of nitric oxide and prostaglandin mediation of shear stress-induced arteriolar dilation with aging and hypertension.
Topics: Aging; Animals; Arterioles; Hypertension; Indomethacin; Male; Nitric Oxide; Nitroarginine; Prostagla | 1999 |
Relaxation of vascular smooth muscle by cicletanine in aged wistar aorta under stress conditions: importance of nitric oxide.
Topics: Aging; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoxia; In Vi | 2000 |
Neuro-immuno-teratogenicity of drugs used in neonatal pharmacotherapy in relation to the ontogenic stage at the time of their administration.
Topics: Aging; Animals; Animals, Newborn; Antibody Formation; Brain; Dexamethasone; Female; Humans; Immunity | 1999 |
Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform.
Topics: Aging; Animals; Aorta, Thoracic; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; C | 2000 |
Immunomodulatory effects of indomethacin and prostaglandin E2 on primary and secondary antibody response in growing layer hens.
Topics: Aging; Animals; Antibody Formation; Antigens; Bacterial Proteins; Chickens; Concanavalin A; Cyclooxy | 2000 |
Endothelin-1-receptor-mediated responses in resistance vessels of young and adult spontaneously hypertensive rats.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Endothelin Recepto | 2000 |
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.
Topics: Aging; Aminoquinolines; Animals; Arginine; Atropine; Electric Stimulation; Guanethidine; Histocytoch | 2001 |
Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Chemistry; Cyclooxygenase 2; E | 2002 |
Relaxation of guinea pig trachealis during electrical field stimulation increases with age.
Topics: Aging; Animals; Bronchoconstriction; Cyclooxygenase Inhibitors; Electric Stimulation; Guinea Pigs; I | 2002 |
Age-dependent lipid peroxidation in neonatal rat lung tissue.
Topics: Aging; Animals; Animals, Newborn; Ascorbic Acid; Bromelains; Calcium; Chloroplasts; Female; Glutathi | 1977 |
Responses of pulmonary and systemic circulations of perinatal goats to prostaglandin F2 alpha.
Topics: Aging; Animals; Animals, Newborn; Blood Circulation; Blood Gas Analysis; Female; Fetus; Goats; Hydro | 1979 |
Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.
Topics: Adult; Aged; Aging; Child; Child, Preschool; Female; Fetal Blood; Humans; Indomethacin; Infant, Newb | 1979 |
Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin.
Topics: Adult; Aged; Aging; Concanavalin A; Dose-Response Relationship, Immunologic; Humans; Indomethacin; L | 1979 |
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I | 1979 |
Increase in body temperature during carrageenin-induced paw oedema in the rat. Effect of non-steroid anti-inflammatory substances and essential fatty acid deficiency.
Topics: Acetaminophen; Aging; Animals; Anti-Inflammatory Agents; Brain Chemistry; Carrageenan; Edema; Fatty | 1979 |
[Special problems of anti-rheumatic drug therapy in the aged].
Topics: Aged; Aging; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; | 1978 |
Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.
Topics: Aged; Aging; Anti-Inflammatory Agents; Cartilage, Articular; Depression, Chemical; Flurbiprofen; Gly | 1976 |
Endothelial modulation of DNA synthesis in isolated arteries of the rat.
Topics: Aging; Animals; Bromodeoxyuridine; Carotid Arteries; Dinoprostone; DNA; Endothelium, Vascular; Ilopr | 1992 |
Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats.
Topics: Aging; Animals; Body Weight; Epidermis; Hyperplasia; Indomethacin; Leydig Cell Tumor; Liver Neoplasm | 1992 |
Ontogeny of neonatal pulmonary vascular pressure-flow relationships.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Hypoxia; Indomethacin; Muscl | 1992 |
In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1.
Topics: Aging; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Fatty Acids, | 1992 |
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Effect of indomethacin on selected immune parameters in different age groups of mice.
Topics: Aging; Animals; Antibody Formation; Dose-Response Relationship, Drug; Female; Immune System; Indomet | 1991 |
Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries.
Topics: Aging; Animals; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothe | 1991 |
The comparative pharmacokinetics of acemetacin in young subjects and elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Half-Life; Humans; Indo | 1991 |
Rat Schwann cells produce interleukin-1.
Topics: Aging; Animals; Cells, Cultured; Cytokines; Drug Combinations; Fluorescent Antibody Technique; Indom | 1991 |
Effect of pentoxifylline in rabbit pulmonary circulation: influence of age and vasomotor tone.
Topics: Aging; Animals; Epoprostenol; Indomethacin; Papaverine; Pentoxifylline; Potassium Chloride; Prostagl | 1991 |
Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Aging; Animals; Dinoprostone; Eicosano | 1991 |
Effects of aging on responses of cerebral arterioles.
Topics: Acetylcholine; Adenosine Diphosphate; Aging; Animals; Arterioles; Bradykinin; Cerebrovascular Circul | 1990 |
Intranephron PGE2 production in stroke-prone spontaneously hypertensive rats.
Topics: Aging; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Calcimycin; Cerebrovascul | 1990 |
Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin.
Topics: Adolescent; Adult; Aged; Aging; Basilar Artery; Bradykinin; Calcimycin; Endothelium, Vascular; Femal | 1990 |
Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus.
Topics: Aging; Animals; DNA Probes; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Gonadotropi | 1990 |
The level of spontaneous myogenic tone in isolated human posterior ciliary arteries decreases with age.
Topics: Acetylcholine; Adult; Aged; Aging; Arteries; Ciliary Body; Dose-Response Relationship, Drug; Endothe | 1990 |
Effect of age on the secretory capacity of pig small intestine in vivo and in vitro.
Topics: Aging; Animals; Chlorides; Cholera Toxin; Dinoprostone; Electric Conductivity; Electrophysiology; Il | 1990 |
Further studies on the mechanisms of the tachykinin-induced activation of micturition reflex in rats: evidence for the involvement of the capsaicin-sensitive bladder mechanoreceptors.
Topics: Aging; Animals; Capsaicin; Diphenhydramine; Electric Stimulation; In Vitro Techniques; Indomethacin; | 1987 |
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H | 1989 |
Defective modulation of noradrenergic neurotransmission by endogenous prostaglandins in aging spontaneously hypertensive rats.
Topics: Aging; Angiotensin II; Animals; Blood Pressure; Ibuprofen; Indomethacin; Male; Norepinephrine; Rats; | 1989 |
Development of the receptors to prostaglandin E2 in the rat kidney and neonatal renal functions.
Topics: Acetaminophen; Aging; Animals; Dinoprostone; Female; In Vitro Techniques; Indomethacin; Kidney; p-Am | 1989 |
Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts.
Topics: Aging; Animals; Cimetidine; Female; Follicular Phase; Histamine; Histamine H1 Antagonists; Indometha | 1989 |
Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs.
Topics: Aging; Animals; Animals, Newborn; Hypoxia; Indomethacin; Lung; Sheep; Vascular Resistance; Vasoconst | 1989 |
Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.
Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Cyproheptadine; Diazepam; Fem | 1986 |
Indomethacin sensitive suppressor-cell activity in head and neck cancer patients. The role of the adherent mononuclear cell.
Topics: Adult; Aged; Aging; Female; Head and Neck Neoplasms; Humans; Immunity, Cellular; Indomethacin; Male; | 1988 |
Carbon dioxide reactivity of the cerebral circulation in extremely premature infants: effects of postnatal age and indomethacin.
Topics: Aging; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Cerebral Arteries; C | 1988 |
Impairment of T immunoregulatory activities in the induction of antibody specific response in aged humans.
Topics: Adolescent; Adult; Aged; Aging; Cells, Cultured; Chlorides; Female; Hemolytic Plaque Technique; Huma | 1985 |
Effects exerted by prostaglandins and indomethacin on the immune response during aging.
Topics: Aging; Alprostadil; Animals; Concanavalin A; Dinoprostone; In Vitro Techniques; Indomethacin; Lympho | 1986 |
Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.
Topics: Aging; Animals; Cimetidine; Concanavalin A; Indomethacin; Interleukin-2; Lymphocyte Activation; Lymp | 1986 |
Regulatory effects mediated by OKT8+ subsets on B cell response in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Antigens, Surface; B-Lymphocytes; Dinoprostone; Female; Humans; Indo | 1987 |
Effect of age on calcium release from mouse calvaria in tissue culture.
Topics: Aging; Animals; Bone and Bones; Bone Resorption; Calcium; Culture Techniques; Dexamethasone; Dinopro | 1986 |
Pharmacokinetics of a sustained-release product of indomethacin in the elderly.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Delayed-Action Preparations; Erythrocytes; Hum | 1986 |
Influence of indomethacin on induced heterotopic bone formation in rats. Importance of length of treatment and of age.
Topics: Aging; Animals; Bone Development; Bone Matrix; Indomethacin; Male; Rats; Rats, Inbred Strains; Time | 1986 |
Indomethacin metabolism in liver microsomes during postnatal development in the rat.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Ind | 1986 |
A possible role of gonad and renal prostaglandin E2 on the development of hypertension in spontaneously hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Castration; Dinoprostone; Hydrogen-Ion Concentration; Hypertension; | 1985 |
The effects of indomethacin and PGE2 on vascular reactivity in spontaneously hypertensive rats: possible role of prostaglandins in the pathogenesis of hypertension.
Topics: Aging; Animals; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; M | 1985 |
Human B-lymphocyte colony responses: suboptimal colony responsiveness in aged humans associated with defective function of B cells and monocytes.
Topics: Adult; Aged; Aging; Alprostadil; B-Lymphocytes; Clone Cells; Humans; Immunologic Capping; Indomethac | 1985 |
Influence of age on the production and regulation of interleukin-1 in mice.
Topics: Aging; Animals; Cells, Cultured; Indomethacin; Interleukin-1; Macrophages; Male; Mice; Mice, Inbred | 1985 |
Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4.
Topics: Adult; Aged; Aging; Antibodies, Monoclonal; Dinoprostone; Humans; Indomethacin; Lymphocyte Activatio | 1985 |
Influence of anti-inflammatory agents on the survival of Drosophila.
Topics: Aging; Animals; Anti-Inflammatory Agents; Chlorpromazine; Copper; Dimethyl Sulfoxide; Drosophila mel | 1985 |