indomethacin has been researched along with African Sleeping Sickness in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "The indomethacin-treated co-cultures, which manifest a normal IL 2 production but lack the IL 2 receptors, manifest an impaired DNA synthesis and contain a decreased number of T cell blasts." | 1.28 | Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice. ( Darji, A; De Baetselier, P; Hamers, R; Remels, L; Sileghem, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanderson, L | 1 |
| Dogruel, M | 1 |
| Rodgers, J | 1 |
| De Koning, HP | 1 |
| Thomas, SA | 1 |
| Fierer, J | 1 |
| Salmon, JA | 1 |
| Askonas, BA | 1 |
| Wellhausen, SR | 1 |
| Mansfield, JM | 2 |
| Schleifer, KW | 1 |
| Sileghem, M | 1 |
| Darji, A | 1 |
| Remels, L | 1 |
| Hamers, R | 1 |
| De Baetselier, P | 1 |
| Reed, SL | 1 |
| Fierer, AS | 1 |
| Goddard, DR | 1 |
| Colmerauer, ME | 1 |
| Davis, CE | 1 |
6 other studies available for indomethacin and African Sleeping Sickness
| Article | Year |
|---|---|
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
African trypanosomiasis alters prostaglandin production by murine peritoneal macrophages.
Topics: Animals; Cell Adhesion; Dinoprostone; Epoprostenol; Female; Immune Tolerance; Indomethacin; Lipopoly | 1984 |
Characteristics of the splenic suppressor cell--target cell interaction in experimental African trypanosomiasis.
Topics: Animals; Cell Adhesion; Cell Communication; Cell Survival; Cell-Free System; Immunosuppression Thera | 1980 |
Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.
Topics: Animals; Arginine; Female; Immune Tolerance; Indomethacin; Interferon-gamma; Lymphocyte Activation; | 1993 |
Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Ly; Binding, Competitive; Cells, Culture | 1989 |
Effect of theophylline on differentiation of Trypanosoma brucei.
Topics: Aminophylline; Animals; Cell Differentiation; Cyclic AMP; Female; Indomethacin; Prostaglandins; Rats | 1985 |