indomethacin has been researched along with Adverse Drug Event in 29 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 9.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 5.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| " Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a-e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a-e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin." | 3.75 | Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. ( Abdel-Megeed, AM; Abdel-Rahman, HM; Alkaramany, GE; El-Gendy, MA, 2009) |
| "The purpose of this study was to describe the fetal and newborn safety profile of prolonged indomethacin treatment during pregnancy." | 3.74 | The safety of prolonged indomethacin therapy. ( Anderson, BL; Savage, AH; Simhan, HN, 2007) |
| "Ibuprofen has less effect on blood flow velocity to important organs." | 2.66 | Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2020) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs), which are globally prescribed, exhibit mainly anti-inflammatory and analgesic effects but also can cause adverse effects including gastrointestinal erosions, ulceration, bleeding, and perforation." | 1.43 | (1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats. ( Choi, KH; Chung, MW; Lee, HJ; Park, JH; Um, SY, 2016) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (51.72) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Abdel-Megeed, AM | 1 |
| Abdel-Rahman, HM | 1 |
| Alkaramany, GE | 1 |
| El-Gendy, MA | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Ohlsson, A | 1 |
| Shah, SS | 1 |
| Momo, K | 1 |
| Nagaoka, H | 1 |
| Kizawa, Y | 1 |
| Bukawa, H | 1 |
| Chiba, S | 1 |
| Kohda, Y | 1 |
| Homma, M | 1 |
| Ryu, B | 1 |
| Kim, CY | 1 |
| Oh, H | 1 |
| Kim, U | 1 |
| Kim, J | 1 |
| Jung, CR | 1 |
| Lee, BH | 1 |
| Lee, S | 1 |
| Chang, SN | 1 |
| Lee, JM | 1 |
| Chung, HM | 1 |
| Park, JH | 2 |
| Inoue, T | 1 |
| Iijima, H | 1 |
| Arimitsu, J | 1 |
| Hagihara, K | 1 |
| Kawai, S | 1 |
| Shiraishi, E | 1 |
| Hiyama, S | 1 |
| Mukai, A | 1 |
| Shinzaki, S | 1 |
| Nishida, T | 1 |
| Ogata, A | 1 |
| Tsujii, M | 1 |
| Takehara, T | 1 |
| Um, SY | 1 |
| Chung, MW | 1 |
| Choi, KH | 1 |
| Lee, HJ | 1 |
| Malaterre, V | 1 |
| Ogorka, J | 1 |
| Loggia, N | 1 |
| Gurny, R | 1 |
| Savage, AH | 1 |
| Anderson, BL | 1 |
| Simhan, HN | 1 |
| Alexander, AM | 1 |
| Barnett, JW | 1 |
| Veitch, GB | 1 |
| Menguy, R | 1 |
| Uitdehaag, CM | 1 |
| Hekster, YA | 1 |
| van de Putte, LB | 1 |
| Waas, RJ | 1 |
| Bertels, B | 1 |
| Huysse, H | 1 |
| Slijkhuis, C | 1 |
| Smits, HM | 1 |
| Belousova, IM | 1 |
| Cooke, AR | 1 |
| Brown, SM | 1 |
| Schuckman, TM | 1 |
| Berbatis, CG | 1 |
| Hurley, SF | 1 |
| Andersson, S | 1 |
| Lubeck, MJ | 1 |
| Cheli, R | 1 |
| Ciancamerla, G | 1 |
| Bruinsma, W | 1 |
| Käppeli, F | 1 |
| Bornstein, Y | 1 |
| Frohberg, H | 1 |
| Dodson, WH | 1 |
| Holley, HL | 1 |
| Meiring, Pde V | 1 |
| da Cruz, I | 1 |
4 reviews available for indomethacin and Adverse Drug Event
| Article | Year |
|---|---|
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Topics: Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duc | 2020 |
Oral osmotically driven systems: 30 years of development and clinical use.
Topics: Administration, Oral; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Delivery Systems; | 2009 |
Effects of drugs on ocular muscles.
Topics: Analgesics; Anesthetics; Anti-Infective Agents; Anticonvulsants; Antidepressive Agents; Antihyperten | 1971 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo | 1970 |
2 trials available for indomethacin and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
Topics: Adult; Aged; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Female; Head an | 2017 |
Amelioration of small bowel injury by switching from nonselective nonsteroidal anti-inflammatory drugs to celecoxib in rheumatoid arthritis patients: a pilot study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsule Endoscopy; Celecoxib; | 2014 |
23 other studies available for indomethacin and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity.
Topics: Acetates; Acylation; Animals; Anti-Inflammatory Agents; Drug Design; Drug-Related Side Effects and A | 2009 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Topics: Animal Testing Alternatives; Animals; Caco-2 Cells; Diclofenac; Drug-Related Side Effects and Advers | 2018 |
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; D | 2016 |
The safety of prolonged indomethacin therapy.
Topics: Adolescent; Adult; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Ductus Arteriosu | 2007 |
The Hereford Hospital Prescribing Study. Investigation of methods to identify patients with adverse drug reactions.
Topics: Adolescent; Adult; Aged; Aging; Computers; Data Collection; Drug-Related Side Effects and Adverse Re | 1981 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
[Chinese pills, Cushing's syndrome and drug analysis].
Topics: Arthritis, Rheumatoid; Cushing Syndrome; Dexamethasone; Drug-Related Side Effects and Adverse Reacti | 1979 |
[Gastrointestinal hemorrhage caused by side effect of drugs].
Topics: Adult; Aged; Aspirin; Butadienes; Drug-Related Side Effects and Adverse Reactions; Female; Humans; I | 1976 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Drug protocols.
Topics: Cefotaxime; Clinical Protocols; Dexamethasone; Drug Therapy; Drug-Related Side Effects and Adverse R | 1989 |
Drug-bone marrow interactions.
Topics: Anemia, Aplastic; Australia; Bone Marrow Diseases; Diclofenac; Drug-Related Side Effects and Adverse | 1987 |
[Side effects of drugs. 2. Gastrointestinal side effects].
Topics: Adrenocorticotropic Hormone; Caffeine; Drug-Related Side Effects and Adverse Reactions; Gastrointest | 1969 |
[Gastric erosions and ulcerations in gastritis caused by drugs].
Topics: Aminopyrine; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastritis; Gastroscopy; Gluco | 1972 |
Adverse reaction profiles of drug eruptions.
Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er | 1972 |
[Ocular adverse effects of generally used drugs].
Topics: Chloroquine; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Eye Diseases; Humans; Indo | 1973 |
Iatrogenic disease in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chloroquine; Drug-Related Side Effects and Adverse Reactions; Glucocorticoids | 1971 |
To the Editor. Adverse effects from drugs.
Topics: Chlorpropamide; Digoxin; Drug-Related Side Effects and Adverse Reactions; Indomethacin; Penicillins; | 1969 |