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indomethacin and Adenomatous Polyposis Coli

indomethacin has been researched along with Adenomatous Polyposis Coli in 8 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.

Research Excerpts

ExcerptRelevanceReference
"Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load."1.31Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000)
"Indomethacin suppository treatment was effective in controlling rectal remnant polyps in the two patients with familial adenomatous polyposis."1.29Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases. ( Hirata, K; Itoh, H; Ohsato, K, 1994)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's5 (62.50)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leibowitz, B1
Qiu, W1
Buchanan, ME1
Zou, F1
Vernon, P1
Moyer, MP1
Yin, XM1
Schoen, RE1
Yu, J1
Zhang, L1
Rodríguez-Sanjuan, JC1
Hirata, K1
Itoh, H1
Ohsato, K1
Sandler, RS1
Hirota, C1
Iida, M1
Aoyagi, K1
Matsumoto, T1
Tada, S1
Yao, T1
Fujishima, M1
Akasu, T1
Kakizoe, T1
Chiu, CH1
McEntee, MF1
Whelan, J1
Klein, WA1
Miller, HH1
Anderson, M1
DeCosse, JJ1

Reviews

2 reviews available for indomethacin and Adenomatous Polyposis Coli

ArticleYear
Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer.
    Important advances in oncology, 1996

    Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Adult; Animals; Anti-Inflammatory Agents, Non-S

1996
[Effects of nonsteroidal anti-inflammatory drugs (NSAID) on colorectal polyps in patients with familial adenomatous polyposis: a review of clinical studies].
    Nihon Geka Gakkai zasshi, 1998, Volume: 99, Issue:6

    Topics: Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal;

1998

Trials

1 trial available for indomethacin and Adenomatous Polyposis Coli

ArticleYear
Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
    Cancer, 1996, Oct-15, Volume: 78, Issue:8

    Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response

1996

Other Studies

5 other studies available for indomethacin and Adenomatous Polyposis Coli

ArticleYear
BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Nov-18, Volume: 111, Issue:46

    Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis R

2014
Do nonsteroidal anti-inflammatory drugs prevent rectal carcinoma in familial adenomatous polyposis?
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:6

    Topics: Adenomatous Polyposis Coli; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Rectal Ne

1995
Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases.
    Diseases of the colon and rectum, 1994, Volume: 37, Issue:9

    Topics: Adenomatous Polyposis Coli; Administration, Rectal; Adult; Colectomy; Colonoscopy; Combined Modality

1994
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 2000, Volume: 62, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Ste

2000
The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis.
    Cancer, 1987, Dec-15, Volume: 60, Issue:12

    Topics: Adenomatous Polyposis Coli; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fibroma;

1987