indomethacin has been researched along with Adenomatous Polyposis Coli in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load." | 1.31 | Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000) |
| "Indomethacin suppository treatment was effective in controlling rectal remnant polyps in the two patients with familial adenomatous polyposis." | 1.29 | Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases. ( Hirata, K; Itoh, H; Ohsato, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leibowitz, B | 1 |
| Qiu, W | 1 |
| Buchanan, ME | 1 |
| Zou, F | 1 |
| Vernon, P | 1 |
| Moyer, MP | 1 |
| Yin, XM | 1 |
| Schoen, RE | 1 |
| Yu, J | 1 |
| Zhang, L | 1 |
| RodrÃguez-Sanjuan, JC | 1 |
| Hirata, K | 1 |
| Itoh, H | 1 |
| Ohsato, K | 1 |
| Sandler, RS | 1 |
| Hirota, C | 1 |
| Iida, M | 1 |
| Aoyagi, K | 1 |
| Matsumoto, T | 1 |
| Tada, S | 1 |
| Yao, T | 1 |
| Fujishima, M | 1 |
| Akasu, T | 1 |
| Kakizoe, T | 1 |
| Chiu, CH | 1 |
| McEntee, MF | 1 |
| Whelan, J | 1 |
| Klein, WA | 1 |
| Miller, HH | 1 |
| Anderson, M | 1 |
| DeCosse, JJ | 1 |
2 reviews available for indomethacin and Adenomatous Polyposis Coli
| Article | Year |
|---|---|
Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Adult; Animals; Anti-Inflammatory Agents, Non-S | 1996 |
[Effects of nonsteroidal anti-inflammatory drugs (NSAID) on colorectal polyps in patients with familial adenomatous polyposis: a review of clinical studies].
Topics: Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1998 |
1 trial available for indomethacin and Adenomatous Polyposis Coli
| Article | Year |
|---|---|
Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response | 1996 |
5 other studies available for indomethacin and Adenomatous Polyposis Coli
| Article | Year |
|---|---|
BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis R | 2014 |
Do nonsteroidal anti-inflammatory drugs prevent rectal carcinoma in familial adenomatous polyposis?
Topics: Adenomatous Polyposis Coli; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Rectal Ne | 1995 |
Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases.
Topics: Adenomatous Polyposis Coli; Administration, Rectal; Adult; Colectomy; Colonoscopy; Combined Modality | 1994 |
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Ste | 2000 |
The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fibroma; | 1987 |