indomethacin has been researched along with Adenomatous Polyposis Coli, Familial in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load." | 1.31 | Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000) |
| "Indomethacin suppository treatment was effective in controlling rectal remnant polyps in the two patients with familial adenomatous polyposis." | 1.29 | Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases. ( Hirata, K; Itoh, H; Ohsato, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leibowitz, B | 1 |
| Qiu, W | 1 |
| Buchanan, ME | 1 |
| Zou, F | 1 |
| Vernon, P | 1 |
| Moyer, MP | 1 |
| Yin, XM | 1 |
| Schoen, RE | 1 |
| Yu, J | 1 |
| Zhang, L | 1 |
| RodrÃguez-Sanjuan, JC | 1 |
| Hirata, K | 1 |
| Itoh, H | 1 |
| Ohsato, K | 1 |
| Sandler, RS | 1 |
| Hirota, C | 1 |
| Iida, M | 1 |
| Aoyagi, K | 1 |
| Matsumoto, T | 1 |
| Tada, S | 1 |
| Yao, T | 1 |
| Fujishima, M | 1 |
| Akasu, T | 1 |
| Kakizoe, T | 1 |
| Chiu, CH | 1 |
| McEntee, MF | 1 |
| Whelan, J | 1 |
| Klein, WA | 1 |
| Miller, HH | 1 |
| Anderson, M | 1 |
| DeCosse, JJ | 1 |
2 reviews available for indomethacin and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Adult; Animals; Anti-Inflammatory Agents, Non-S | 1996 |
[Effects of nonsteroidal anti-inflammatory drugs (NSAID) on colorectal polyps in patients with familial adenomatous polyposis: a review of clinical studies].
Topics: Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1998 |
1 trial available for indomethacin and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response | 1996 |
5 other studies available for indomethacin and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis R | 2014 |
Do nonsteroidal anti-inflammatory drugs prevent rectal carcinoma in familial adenomatous polyposis?
Topics: Adenomatous Polyposis Coli; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Rectal Ne | 1995 |
Regression of rectal polyps by indomethacin suppository in familial adenomatous polyposis. Report of two cases.
Topics: Adenomatous Polyposis Coli; Administration, Rectal; Adult; Colectomy; Colonoscopy; Combined Modality | 1994 |
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Ste | 2000 |
The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fibroma; | 1987 |