indomethacin has been researched along with Acute Respiratory Distress Syndrome in 20 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this investigation was to evaluate the magnitude and duration of changes in lung function and oxygen transport in patients with adult respiratory distress syndrome (ARDS) receiving indomethacin." | 9.06 | Indomethacin treatment of human adult respiratory distress syndrome. ( Bitzer, LG; Flint, LM; Kelley, KA; Rhee, JW; Rodriguez, JL; Steinberg, SM, 1990) |
| "The effects of prophylactic and delayed treatment with indomethacin were evaluated in a porcine model of early adult respiratory distress syndrome (ARDS) induced by endotoxaemia." | 7.67 | Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. ( Borg, T; Gerdin, B; Modig, J, 1986) |
| "The possibility that prostaglandin synthesis inhibition might favorably inhibit the development of animal adult respiratory distress syndrome models was investigated in two groups of dogs; one group was pretreated with indomethacin 3 mg/kg." | 7.66 | Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog. ( Blatnick, RA; Goitz, H; Johansen, RK; Pace, NL, 1980) |
| "The purpose of this investigation was to evaluate the magnitude and duration of changes in lung function and oxygen transport in patients with adult respiratory distress syndrome (ARDS) receiving indomethacin." | 5.06 | Indomethacin treatment of human adult respiratory distress syndrome. ( Bitzer, LG; Flint, LM; Kelley, KA; Rhee, JW; Rodriguez, JL; Steinberg, SM, 1990) |
| "Similarities between oleic acid (OA)-induced pulmonary injury and clinical adult respiratory distress syndrome (ARDS) have resulted in extensive use of this model." | 3.67 | Indomethacin and dexamethasone decrease oleic acid-induced pulmonary protein leak in rabbits. ( Butler, RR; Spicer, KM, 1986) |
| "The effects of prophylactic and delayed treatment with indomethacin were evaluated in a porcine model of early adult respiratory distress syndrome (ARDS) induced by endotoxaemia." | 3.67 | Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. ( Borg, T; Gerdin, B; Modig, J, 1986) |
| "The possibility that prostaglandin synthesis inhibition might favorably inhibit the development of animal adult respiratory distress syndrome models was investigated in two groups of dogs; one group was pretreated with indomethacin 3 mg/kg." | 3.66 | Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog. ( Blatnick, RA; Goitz, H; Johansen, RK; Pace, NL, 1980) |
| "Pretreatment with indomethacin attenuated the increase in Kf after 65% triolein but not after 99% triolein." | 1.30 | Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs. ( Kuwagata, Y; Nakata, Y; Sugimoto, H; Tanaka, H; Yoshioka, T, 1999) |
| "Indomethacin was able to completely block the cytokine-induced decrease in PC synthesis by pneumocytes from the malignant group and to attenuate the inhibitory effect of TNF alpha in those from donors, nordihydroguaiaretic acid having a similar effect." | 1.29 | Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. ( Arias-Díaz, J; Balibrea, JL; García, C; Vara, E, 1994) |
| "Pretreatment with indomethacin ameliorated the decrease in arterial oxygen tension from prebypass to postbypass values (477 +/- 50 mm Hg versus 339 +/- 57 mm Hg, respectively)." | 1.29 | Neutrophil-mediated acute lung injury after extracorporeal perfusion. ( Hurst, T; Johnson, D; Mayers, I; Murphy, F; Prasad, K; Saxena, A; Thomson, D; Wilson, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Revenäs, B | 1 |
| Smedegård, G | 1 |
| Saldeen, T | 1 |
| Cefalo, RC | 1 |
| Lewis, PE | 1 |
| O'Brien, WF | 1 |
| Fletcher, JR | 1 |
| Ramwell, PW | 1 |
| Pace, NL | 1 |
| Goitz, H | 1 |
| Blatnick, RA | 1 |
| Johansen, RK | 1 |
| Kerstein, MD | 2 |
| Crivello, M | 1 |
| Allen, DA | 1 |
| Schertel, ER | 1 |
| Weisbrode, SE | 1 |
| Myerowitz, PD | 1 |
| Arias-Díaz, J | 1 |
| Vara, E | 1 |
| García, C | 1 |
| Balibrea, JL | 1 |
| Yamaguchi, K | 1 |
| Mori, M | 1 |
| Kawai, A | 1 |
| Asano, K | 1 |
| Takasugi, T | 1 |
| Umeda, A | 1 |
| Kawashiro, T | 1 |
| Yokoyama, T | 1 |
| Johnson, D | 1 |
| Thomson, D | 1 |
| Hurst, T | 1 |
| Prasad, K | 1 |
| Wilson, T | 1 |
| Murphy, F | 1 |
| Saxena, A | 1 |
| Mayers, I | 1 |
| Orfanos, SE | 1 |
| Chen, XL | 1 |
| Ryan, JW | 1 |
| Chung, AY | 1 |
| Burch, SE | 1 |
| Catravas, JD | 1 |
| Nakata, Y | 1 |
| Tanaka, H | 1 |
| Kuwagata, Y | 1 |
| Yoshioka, T | 1 |
| Sugimoto, H | 1 |
| Crivello, MS | 1 |
| Smith, GJ | 1 |
| Lonigro, AJ | 1 |
| Stephenson, AH | 1 |
| Sprague, RS | 1 |
| Duggan, CJ | 1 |
| Castle, WD | 1 |
| Berend, N | 1 |
| Steinberg, SM | 1 |
| Rodriguez, JL | 1 |
| Bitzer, LG | 1 |
| Rhee, JW | 1 |
| Kelley, KA | 1 |
| Flint, LM | 1 |
| Stömmer, P | 1 |
| Steinmann, U | 1 |
| Zazzo, JF | 1 |
| Mercat, A | 1 |
| Wolff, M | 1 |
| Letulzo, Y | 1 |
| Regnier, B | 1 |
| Butler, RR | 1 |
| Spicer, KM | 1 |
| Olson, NC | 1 |
| Brown, TT | 1 |
| Anderson, DL | 1 |
| Parellada, PP | 1 |
| Carbonell, L | 1 |
| Borg, T | 1 |
| Gerdin, B | 1 |
| Modig, J | 1 |
1 trial available for indomethacin and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Indomethacin treatment of human adult respiratory distress syndrome.
Topics: Adult; Aged; Female; Humans; Indomethacin; Male; Middle Aged; Oxygen; Respiratory Distress Syndrome | 1990 |
19 other studies available for indomethacin and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
The pulmonary reaction in aggregate anaphylaxis in the monkey.
Topics: Anaphylaxis; Animals; Blood Platelets; Cardiac Output; Indomethacin; Macaca; Male; Pulmonary Circula | 1980 |
The role of prostaglandins in endotoxemia: comparisons in response in the nonpregnant, maternal, and fetal models. I. Prostaglandins and the pulmonary effect of experimental endotoxemia.
Topics: Animals; Castration; Endotoxins; Escherichia coli; Female; Hypertension, Pulmonary; Ibuprofen; Indom | 1980 |
Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog.
Topics: Animals; Disease Models, Animal; Dogs; Indomethacin; Oleic Acids; Prostaglandins; Pulmonary Edema; R | 1980 |
Reversal of histopathologic pulmonary changes with indomethacin.
Topics: Animals; Blood Gas Analysis; Dogs; Female; Hemodynamics; Indomethacin; Leg Injuries; Lung; Male; Mic | 1980 |
Acute lung injury isolated to an in situ lung preparation causes sustained reflex cardiovascular depression in dogs.
Topics: Animals; Atropine; Blood Gas Analysis; Blood Pressure; Denervation; Disease Models, Animal; Dogs; He | 1994 |
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins.
Topics: Adult; Age Factors; Arachidonic Acid; Humans; In Vitro Techniques; Indomethacin; Lung; Male; Middle | 1994 |
Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites--analysis in acute lung injury.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dogs; Embolism, Fat; Epoprostenol; Female; Hypox | 1994 |
Neutrophil-mediated acute lung injury after extracorporeal perfusion.
Topics: Animals; Cardiopulmonary Bypass; Dogs; Filtration; Indomethacin; Lymphocyte Activation; Neutrophils; | 1994 |
Assay of pulmonary microvascular endothelial angiotensin-converting enzyme in vivo: comparison of three probes.
Topics: Animals; Enalapril; Endothelium, Vascular; Hemodynamics; Humans; Indicator Dilution Techniques; Indo | 1994 |
Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Capillary Permeability; Cyclooxygenase Inhibit | 1999 |
Prevention of pulmonary pathologic changes of trauma by indomethacin.
Topics: Animals; Dogs; Female; Indomethacin; Leg Injuries; Lung; Male; Pulmonary Circulation; Respiratory Di | 1977 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; | 1991 |
Effects of continuous positive airway pressure breathing on lung volume and distensibility.
Topics: Adult; Humans; Indomethacin; Lung Compliance; Lung Volume Measurements; Male; Positive-Pressure Resp | 1990 |
Phospholipase A2 induced diffuse alveolar damage--effect of indomethacin and dexamethasone upon morphology and plasma-histamine level.
Topics: Animals; Dexamethasone; Histamine; Indomethacin; Injections, Intravenous; Male; Phospholipases; Phos | 1989 |
ARDS associated with nosocomial legionellosis: dramatic effect of indomethacin.
Topics: Acute Disease; Aged; Cross Infection; Female; Humans; Indomethacin; Legionellosis; Respiratory Distr | 1988 |
Indomethacin and dexamethasone decrease oleic acid-induced pulmonary protein leak in rabbits.
Topics: Animals; Dexamethasone; Drug Therapy, Combination; Indomethacin; Oleic Acid; Oleic Acids; Rabbits; R | 1986 |
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Endotoxins; Escherichia co | 1985 |
The effect of BW775C on respiratory distress in the rat induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ara | 1985 |
Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia.
Topics: Anesthesia, General; Animals; Blood Pressure; Disease Models, Animal; Endotoxins; Female; Hemodynami | 1986 |