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indomethacin and Acute Promyelocytic Leukemia

indomethacin has been researched along with Acute Promyelocytic Leukemia in 6 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As(2)O(3)) generates partial differentiation and apoptosis."7.74Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ( Bazarbachi, A; de Thé, H; Habib, A; Hamade, E; Mahfouz, R; Nasrallah, MS, 2008)
"In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As(2)O(3)) generates partial differentiation and apoptosis."3.74Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ( Bazarbachi, A; de Thé, H; Habib, A; Hamade, E; Mahfouz, R; Nasrallah, MS, 2008)
"When indomethacin in methanol was photo-irradiated with an Hg lamp, methyl ester, ethyl ester, and gamma-lactone derivatives of indomethacin were produced."1.33Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells. ( Chao, SH; Chen, FA; Lee, CJ; Wang, CC; Wu, AB, 2005)
" Indomethacin shifted the G-CSF dose-response curve of cells treated with 10 nM RA to lower G-CSF concentrations."1.29Indomethacin potentiates the induction of HL60 differentiation to neutrophils, by retinoic acid and granulocyte colony-stimulating factor, and to monocytes, by vitamin D3. ( Brown, G; Bunce, CM; Durham, J; French, PJ; Michell, RH; Stockley, RA, 1994)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chao, SH1
Wu, AB1
Lee, CJ1
Chen, FA1
Wang, CC1
Habib, A1
Hamade, E1
Mahfouz, R1
Nasrallah, MS1
de Thé, H1
Bazarbachi, A1
Jamshidi, F1
Zhang, J1
Harrison, JS1
Wang, X1
Studzinski, GP1
Bunce, CM1
French, PJ1
Durham, J1
Stockley, RA1
Michell, RH1
Brown, G1
Finstad, HS1
Kolset, SO1
Holme, JA1
Wiger, R1
Farrants, AK1
Blomhoff, R1
Drevon, CA1
Kawase, T1
Oguro, A1
Orikasa, M1
Burns, DM1

Other Studies

6 other studies available for indomethacin and Acute Promyelocytic Leukemia

ArticleYear
Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases

2005
Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia.
    Leukemia, 2008, Volume: 22, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenic

2008
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling.
    Cell cycle (Georgetown, Tex.), 2008, Apr-01, Volume: 7, Issue:7

    Topics: Aspirin; Calcitriol; Cell Differentiation; Cyclooxygenase Inhibitors; G1 Phase; HL-60 Cells; Humans;

2008
Indomethacin potentiates the induction of HL60 differentiation to neutrophils, by retinoic acid and granulocyte colony-stimulating factor, and to monocytes, by vitamin D3.
    Leukemia, 1994, Volume: 8, Issue:4

    Topics: Arachidonic Acid; Cell Differentiation; Cholecalciferol; Dose-Response Relationship, Drug; Drug Syne

1994
Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells.
    Blood, 1994, Dec-01, Volume: 84, Issue:11

    Topics: Apoptosis; Arachidonic Acid; Cell Differentiation; Cell Division; DNA Replication; DNA, Neoplasm; Do

1994
Characteristics of NaF-induced differentiation of HL-60 cells.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1996, Volume: 11, Issue:11

    Topics: Calcitriol; Cell Differentiation; Cell Division; Dinoprostone; HL-60 Cells; Humans; Indicators and R

1996