indomethacin has been researched along with Acute Promyelocytic Leukemia in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As(2)O(3)) generates partial differentiation and apoptosis." | 7.74 | Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ( Bazarbachi, A; de Thé, H; Habib, A; Hamade, E; Mahfouz, R; Nasrallah, MS, 2008) |
| "In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As(2)O(3)) generates partial differentiation and apoptosis." | 3.74 | Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ( Bazarbachi, A; de Thé, H; Habib, A; Hamade, E; Mahfouz, R; Nasrallah, MS, 2008) |
| "When indomethacin in methanol was photo-irradiated with an Hg lamp, methyl ester, ethyl ester, and gamma-lactone derivatives of indomethacin were produced." | 1.33 | Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells. ( Chao, SH; Chen, FA; Lee, CJ; Wang, CC; Wu, AB, 2005) |
| " Indomethacin shifted the G-CSF dose-response curve of cells treated with 10 nM RA to lower G-CSF concentrations." | 1.29 | Indomethacin potentiates the induction of HL60 differentiation to neutrophils, by retinoic acid and granulocyte colony-stimulating factor, and to monocytes, by vitamin D3. ( Brown, G; Bunce, CM; Durham, J; French, PJ; Michell, RH; Stockley, RA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, SH | 1 |
| Wu, AB | 1 |
| Lee, CJ | 1 |
| Chen, FA | 1 |
| Wang, CC | 1 |
| Habib, A | 1 |
| Hamade, E | 1 |
| Mahfouz, R | 1 |
| Nasrallah, MS | 1 |
| de Thé, H | 1 |
| Bazarbachi, A | 1 |
| Jamshidi, F | 1 |
| Zhang, J | 1 |
| Harrison, JS | 1 |
| Wang, X | 1 |
| Studzinski, GP | 1 |
| Bunce, CM | 1 |
| French, PJ | 1 |
| Durham, J | 1 |
| Stockley, RA | 1 |
| Michell, RH | 1 |
| Brown, G | 1 |
| Finstad, HS | 1 |
| Kolset, SO | 1 |
| Holme, JA | 1 |
| Wiger, R | 1 |
| Farrants, AK | 1 |
| Blomhoff, R | 1 |
| Drevon, CA | 1 |
| Kawase, T | 1 |
| Oguro, A | 1 |
| Orikasa, M | 1 |
| Burns, DM | 1 |
6 other studies available for indomethacin and Acute Promyelocytic Leukemia
| Article | Year |
|---|---|
Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases | 2005 |
Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenic | 2008 |
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling.
Topics: Aspirin; Calcitriol; Cell Differentiation; Cyclooxygenase Inhibitors; G1 Phase; HL-60 Cells; Humans; | 2008 |
Indomethacin potentiates the induction of HL60 differentiation to neutrophils, by retinoic acid and granulocyte colony-stimulating factor, and to monocytes, by vitamin D3.
Topics: Arachidonic Acid; Cell Differentiation; Cholecalciferol; Dose-Response Relationship, Drug; Drug Syne | 1994 |
Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells.
Topics: Apoptosis; Arachidonic Acid; Cell Differentiation; Cell Division; DNA Replication; DNA, Neoplasm; Do | 1994 |
Characteristics of NaF-induced differentiation of HL-60 cells.
Topics: Calcitriol; Cell Differentiation; Cell Division; Dinoprostone; HL-60 Cells; Humans; Indicators and R | 1996 |