indomethacin has been researched along with Acute Lymphoid Leukemia in 3 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells." | 1.51 | Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. ( Bhagwat, S; Blomhoff, HK; Burman, MM; Duthil, E; Ford, A; Gilljam, KM; Naderi, EH; Richartz, N; Ruud, E; Skah, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richartz, N | 1 |
| Duthil, E | 1 |
| Ford, A | 1 |
| Naderi, EH | 1 |
| Bhagwat, S | 1 |
| Gilljam, KM | 1 |
| Burman, MM | 1 |
| Ruud, E | 1 |
| Blomhoff, HK | 1 |
| Skah, S | 1 |
| Maca, RD | 1 |
| Brown, RE | 1 |
| Alade, SL | 1 |
| Wu, MC | 1 |
| Wu, FM | 1 |
| Bowman, WP | 1 |
3 other studies available for indomethacin and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
Topics: Animals; Biomarkers; Bone Marrow; Cell Line, Tumor; Child; Child, Preschool; Cyclooxygenase Inhibito | 2019 |
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, | 1991 |
Lipoperoxidation and T-cell leukemia of childhood. Effects of indomethacin.
Topics: Child; Dinoprostone; Female; Humans; Indomethacin; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; | 1989 |