Page last updated: 2024-10-29

indomethacin and Active Hyperemia

indomethacin has been researched along with Active Hyperemia in 76 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"In patients with measles during the first two weeks of infection, ketorolac and indomethacin were more effective than artificial tears in decreasing conjunctival hyperemia, but burning sensations, foreign-body sensations, and photophobia were unaffected."9.12The effects of topical ketorolac and indomethacin on measles conjunctivitis: randomized controlled trial. ( Arici, MK; Arslan, OS; Erdem, H; Erdogan, H; Pahsa, A; Toker, MI; Topalkara, A, 2006)
"We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils."7.72Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003)
"The mechanism of isoflurane-induced cerebral hyperemia is poorly understood."7.69Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs. ( Helfaer, MA; Kirsch, JR; McPherson, RW; Moore, LE; Tobin, JR; Traystman, RJ, 1994)
"The effects of indomethacin and meclofenamate on active hyperemia following sustained, maximal isometric contractions were studied in free-flowing dog gracilis muscles."7.67Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia. ( Klabunde, RE; Rankin, RS, 1985)
"A nonlymphokine mediator of hyperemia has been shown to be secreted by both rabbit peritoneal exudate cells stimulated with 5% glycogen and by concanavalin A treated cells from afferent lymph of sheep."7.66Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit. ( Hay, JB; Vadas, P, 1980)
"Direct, in vivo microcirculatory experiments were undertaken with anesthetized rats to determine whether prostaglandin (PG)-like compounds and histamine may mediate post-occlusion hyperemia in single mesenteric arterioles."7.66Role of prostaglandins and histamine in reactive hyperemia: in-vivo studies on single mesenteric arterioles. ( Altura, BM, 1978)
"The effect of indomethacin (10 mg/kg) on the distribution of cortical blood flow during postocclusive reactive hyperemia was evaluated in denervated kidneys of anesthetized rabbits by the radioactive microsphere technique."7.65Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits. ( Aizawa, C; Honda, N, 1977)
"In patients with measles during the first two weeks of infection, ketorolac and indomethacin were more effective than artificial tears in decreasing conjunctival hyperemia, but burning sensations, foreign-body sensations, and photophobia were unaffected."5.12The effects of topical ketorolac and indomethacin on measles conjunctivitis: randomized controlled trial. ( Arici, MK; Arslan, OS; Erdem, H; Erdogan, H; Pahsa, A; Toker, MI; Topalkara, A, 2006)
" We tested the hypothesis that adenosine, prostaglandins, and NO act in synergy to regulate skeletal muscle hyperemia by determining the following: (1) the effect of adenosine receptor blockade on skeletal muscle exercise hyperemia with and without simultaneous inhibition of prostaglandins (indomethacin; 0."3.75Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. ( Hellsten, Y; Mortensen, SP; Nyberg, M; Saltin, B; Thaning, P, 2009)
" In nondiabetic rats, stimulation of the endothelium by locally administered ACh or bradykinin-induced transient renal hyperemia."3.74In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes. ( Edgley, AJ; Evans, RG; Parkington, HC; Skordilis, C; Tare, M, 2008)
"We investigated antioxidative activity and the effect of indomethacin, an agent that inhibits cyclooxygenase, on extracellular glutamate and cerebral blood flow in cerebral ischemia in gerbils."3.72Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ( Hayashida, Y; Hirakawa, H; Itano, T; Kasai, H; Konishi, R; Miyamoto, O; Tamae, K, 2003)
"The mechanism of isoflurane-induced cerebral hyperemia is poorly understood."3.69Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs. ( Helfaer, MA; Kirsch, JR; McPherson, RW; Moore, LE; Tobin, JR; Traystman, RJ, 1994)
" Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)."3.69Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S, 1997)
" It has also been observed that the cyclooxygenase inhibitor indomethacin attenuates hypoxic hyperemia in piglets."3.69Relationship between opioids and prostaglandins in hypoxia-induced vasodilation of pial arteries in the newborn pig. ( Armstead, WM, 1996)
"The gastric hyperemia induced by intragastric 2 mol/L saline was completely blocked only by indomethacin."3.68Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats. ( Domek, MJ; Endoh, K; Kao, J; Leung, FW, 1993)
"Experiments on anesthesized dogs demonstrated that gastrocnemius muscle vessels working hyperemia substantially decreased after chemical destruction of endothelium by saponin, inhibition of endothelium-derived relaxing factor synthesis by gossypol and inhibition of quanylate cyclase by methylene blue."3.68[The role of the endothelium in the development of functional hyperemia of the skeletal muscles]. ( Kindybaliuk, AM; Sagach, VF, 1991)
"The experiments on anesthetized dogs demonstrated that reaction of the femoral vessels reactive hyperemia essentially decreased after chemical inhibition of endothelium by saponin, inhibition of lipoxygenase by quercetin and guanylate cyclase by methylene blue."3.67[Role of the endothelium in the development of reactive hyperemia]. ( Sagach, VF; Tkachenko, MN, 1989)
"The effects of indomethacin and meclofenamate on active hyperemia following sustained, maximal isometric contractions were studied in free-flowing dog gracilis muscles."3.67Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia. ( Klabunde, RE; Rankin, RS, 1985)
"Following the induction of immunogenic uveitis betamethasone and dexamethasone reduced conjunctiva and iris hyperemia and aqueous flare."3.66Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. ( Bhattacherjee, P; Eakins, KE; Kulkarni, PS; Srinivasan, BD, 1981)
"A nonlymphokine mediator of hyperemia has been shown to be secreted by both rabbit peritoneal exudate cells stimulated with 5% glycogen and by concanavalin A treated cells from afferent lymph of sheep."3.66Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit. ( Hay, JB; Vadas, P, 1980)
"Direct, in vivo microcirculatory experiments were undertaken with anesthetized rats to determine whether prostaglandin (PG)-like compounds and histamine may mediate post-occlusion hyperemia in single mesenteric arterioles."3.66Role of prostaglandins and histamine in reactive hyperemia: in-vivo studies on single mesenteric arterioles. ( Altura, BM, 1978)
" sar1gly8AII, abolished the hypertensive response to acute ureteral obstruction, and pretreatment with 2 mg/kg of either indomethacin (n=6) or meclofenamate (n=3), 15 min before obstruction, prevented the hyperemic response."3.66Prostaglandin-mediated hyperemia and renin-mediated hypertension during acute ureteral obstruction. ( Aisenbrey, G; Burke, TJ; Cadnapaphornchai, P; McDonald, KM; Schrier, RW, 1978)
"The effect of indomethacin (10 mg/kg) on the distribution of cortical blood flow during postocclusive reactive hyperemia was evaluated in denervated kidneys of anesthetized rabbits by the radioactive microsphere technique."3.65Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits. ( Aizawa, C; Honda, N, 1977)
"In two series of experiments we studied the effects of indomethacin on (a) coronary reactive hyperemia and, (b) renal blood flow, autoregulation, and reactive dilation."3.65Effects of indomethacin on local blood flow regulation in canine heart and kidney. ( Ehrhart, IC; Haddy, FJ; Owen, TL; Scott, JB; Weidner, WJ, 1975)
"Ibuprofen was the most efficient agent, inhibiting the total reactive hyperemia by more than 70%, and naproxen was least active, producing about 35% inhibition."2.65Effect of different prostaglandin synthesis inhibitors on post-occlusive blood flow in human forearm. ( Carlsson, I; Wennmalm, A, 1983)
"This hyperemia was significantly (p less than 0."2.65Cigarette smoking, prostaglandins and reactive hyperemia. ( Wennmalm, A, 1979)
"Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po(2) increased."1.33Effect of indomethacin on cerebral blood flow and development of oxygen convulsions. ( Alekseeva, OS; Gutsaeva, DR; Khmel'nitskii, AV; Moskvin, AN; Sharapov, OI, 2006)
"Coronary reactive hyperemia was observed even after the inhibition of nitric oxide synthase by N(omega)-nitro-L-arginine methylester (L-NAME)."1.30Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. ( Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y, 1997)
"Indomethacin treatment or removal of the venular endothelium will attenuate functional arteriolar vasodilation in the hamster cremaster muscle."1.30Influence of venular prostaglandin release on arteriolar diameter during functional hyperemia. ( Boyd, D; Gardner, AL; Hester, RL; McKay, MK, 1998)
"Pretreatment with indomethacin partially blocked the enhancing effect of SP on protein leakage, while it did not block that of NKA."1.30Tachykinins as enhancers of prostaglandin E2-induced intraocular inflammation. ( Hamada, M; Shirasawa, E; Tsuji, F, 1998)
"Gastric hyperemia is mediated by CGRP contained in capsaicin-sensitive afferent fibers, whereas acid secretion is under the inhibitory influence of prostaglandins and CGRP."1.30Mechanisms mediating gastric hyperemic and acid responses to central TRH analog at a cytoprotective dose. ( Guth, PH; Király, A; Sütó, G; Taché, Y, 1997)
"Indomethacin was also found to be effective in suppressing reactive hyperemia."1.29Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. ( Larkin, SW; Williams, TJ, 1993)
"This hyperemia was reduced by L-NMMA but not by 8-PT."1.29Role of adenosine and nitric oxide in the hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats. ( Gislason, H; Svanes, K; Sørbye, H; Varhaug, P; Waldum, HL, 1996)
"Reactive hyperemia was also not affected by 30 microM theophylline (an adenosine antagonist) or suffusion of catalase (160 U/ml) plus superoxide dismutase (240 U/ml)."1.28Similarities in the pharmacological modulation of reactive hyperemia and vasodilation to hydrogen peroxide in rat skeletal muscle arterioles: effects of probes for endothelium-derived mediators. ( Kaley, G; Messina, EJ; Rodenburg, JM; Wolin, MS, 1990)
" Dose-response experiments performed with 2 to 90 per cent (v/v) zymosan-activated plasma showed a direct correlation between the rate of neutrophil influx and the degree of vascular permeability in blood flow."1.26Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration. ( Issekutz, AC, 1981)
"The effects of the inhibitors on reactive hyperemia resulting from 5-, 10-, 15-, and 20-second occlusions and the dilation resulting from 90-second exposure to 8% O2 were also examined."1.26Prostaglandins and the control of blood flow in the canine myocardium. ( Hintze, TH; Kaley, G, 1977)

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-199039 (51.32)18.7374
1990's24 (31.58)18.2507
2000's11 (14.47)29.6817
2010's1 (1.32)24.3611
2020's1 (1.32)2.80

Authors

AuthorsStudies
Šušnjara, P1
Mihaljević, Z1
Stupin, A1
Kolobarić, N1
Matić, A1
Jukić, I1
Kralik, Z1
Kralik, G1
Miloloža, A1
Pavošević, T1
Šerić, V1
Lončarić, Z1
Kerovec, D1
Galović, O1
Drenjančević, I1
Taylor, JL1
Hines, CN1
Nicholson, WT1
Joyner, MJ1
Barnes, JN1
Edgley, AJ1
Tare, M1
Evans, RG1
Skordilis, C1
Parkington, HC1
Mortensen, SP2
Nyberg, M1
Thaning, P1
Saltin, B2
Hellsten, Y2
Miyamoto, O1
Tamae, K1
Kasai, H1
Hirakawa, H1
Hayashida, Y1
Konishi, R1
Itano, T1
Rogers, J1
Sheriff, DD1
Toker, MI1
Erdem, H1
Erdogan, H1
Arici, MK1
Topalkara, A1
Arslan, OS1
Pahsa, A1
González-Alonso, J1
Damsgaard, R1
Moskvin, AN1
Alekseeva, OS1
Gutsaeva, DR1
Khmel'nitskii, AV1
Sharapov, OI1
Yada, T1
Shimokawa, H1
Morikawa, K1
Takaki, A1
Shinozaki, Y1
Mori, H1
Goto, M1
Ogasawara, Y1
Kajiya, F1
Siesjö, BK1
Nilsson, B1
Carlsson, I3
Wennmalm, A6
Lorenzini, P1
Linde, B1
Barnett, AH1
Koullapis, EN1
Nicolaides, K1
Pyke, DA1
Spiliopoulos, AJ1
Issekutz, AC1
Gallavan, RH1
Chou, CC1
Vadas, P2
Hay, JB2
Kulkarni, PS1
Bhattacherjee, P1
Eakins, KE1
Srinivasan, BD1
Koyama, K1
Kaneko, I1
Mori, K1
Moore, LE1
Kirsch, JR1
Helfaer, MA1
Tobin, JR1
McPherson, RW1
Traystman, RJ1
King-Vanvlack, CE1
Curtis, SE1
Mewburn, JD1
Cain, SM1
Chapler, CK1
Gislason, H2
Sørbye, H2
Abdi-Dezfuli, F1
Waldum, HL2
Svanes, K2
Chłopicki, S1
Gryglewski, RJ2
Tasdemiroglu, E1
Christenberry, PD1
Ardell, JL1
Chronister, RB1
Taylor, AE1
Herbert, MK1
Holzer, P2
Lopez-Belmonte, J1
Whittle, BJ1
Endoh, K1
Kao, J1
Domek, MJ1
Leung, FW1
Andersen, PH1
Broichmann, PW1
Maibach, H1
Larkin, SW1
Williams, TJ1
Armstead, WM1
Tanaka, S1
Kaunitz, JD1
Varhaug, P1
Chlopicki, S1
Niezabitowski, P1
Jakubowski, A1
Lomnicka, M1
Király, A1
Sütó, G1
Guth, PH1
Taché, Y1
Shinoda, M1
Toki, Y1
Murase, K1
Mokuno, S1
Okumura, K1
Ito, T1
Viau, S1
Fontaine, E1
Véronneau, M1
Jasmin, G1
Dumont, L1
McKay, MK1
Gardner, AL1
Boyd, D1
Hester, RL1
Tsuji, F1
Hamada, M1
Shirasawa, E1
Naylor, HL1
Shoemaker, JK1
Brock, RW1
Hughson, RL1
Ruh, J2
Vogel, F2
Schmidt, E2
Werner, M1
Klar, E1
Secchi, A1
Gebhard, MM1
Glaser, F1
Herfarth, C1
Shimizu, K1
Bari, F1
Busija, DW2
Altura, BM1
Andersson, RG1
Aberg, G1
Brattsand, R1
Ericsson, E1
Lundholm, L1
Beaty, O1
Donald, DE1
Deutsch, TA1
Hughes, WF1
Cuypers, J1
Cuevas, A1
Duisberg, R1
Cadnapaphornchai, P1
Aisenbrey, G1
McDonald, KM1
Burke, TJ1
Schrier, RW1
Vane, JR2
McGiff, JC1
Alexander, RW1
Kent, KM1
Pisano, JJ1
Keiser, HR1
Cooper, T1
Hintze, TH1
Kaley, G3
Giles, RW1
Wilcken, DE1
Messina, EJ2
Weiner, R1
Aizawa, C1
Honda, N1
Kilbom, A1
Block, AJ1
Feinberg, H1
Herbaczynska-Cedro, K1
Obstbaum, SA1
Podos, SM1
Owen, TL1
Ehrhart, IC1
Weidner, WJ1
Scott, JB1
Haddy, FJ1
Lippe, IT1
Sagach, VF3
Kindybaliuk, AM1
Wolin, MS1
Rodenburg, JM1
Sitzmann, JV1
Bulkley, GB1
Mitchell, MC1
Campbell, K1
Tkachenko, MN2
Dmitrieva, AV1
Phillis, JW1
DeLong, RE1
Towner, JK1
Rankin, RS1
Klabunde, RE1
Kimura, T1
Satoh, S1
Leffler, CW1
Fletcher, AM1
Beasley, DG1
Hessler, JR1
Green, RS1
Bowery, B1
Lewis, GP1
Neufeld, AH1
Chavis, RM1
Sears, ML1
Ryan, MJ1
Clark, KE1
Van Orden, DE1
Farley, D1
Edvinsson, L1
Sjoberg, NO1
Van Orden, LS1
Brody, MJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Treatment of Acute Viral Conjunctivitis[NCT01799863]Phase 2/Phase 350 participants (Actual)Interventional2012-06-30Completed
Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638]Early Phase 180 participants (Actual)Interventional2016-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for indomethacin and Active Hyperemia

ArticleYear
Prostaglandins and the cerebral circulation.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1982, Volume: 10

    Topics: Animals; Brain; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dose-Response Relationship,

1982
Interaction of nicotine and prostaglandins in the cardiovascular system.
    Prostaglandins, 1982, Volume: 23, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cardiov

1982

Trials

7 trials available for indomethacin and Active Hyperemia

ArticleYear
Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.
    Nutrients, 2023, Mar-25, Volume: 15, Issue:7

    Topics: Acetylcholine; Animals; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium; Endothelium, Vasc

2023
The effects of topical ketorolac and indomethacin on measles conjunctivitis: randomized controlled trial.
    American journal of ophthalmology, 2006, Volume: 141, Issue:5

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Conjunctiva; Conjunctivitis

2006
Effect of different prostaglandin synthesis inhibitors on post-occlusive blood flow in human forearm.
    Prostaglandins, 1983, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Female; Forearm; Humans; Hyperemi

1983
[The effect of indomethacin suppository in preventing mesenteric traction syndrome].
    Masui. The Japanese journal of anesthesiology, 1995, Volume: 44, Issue:8

    Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Female; H

1995
A corticosteroid, a non-steroidal anti-inflammatory drug and an antihistamine modulate in vivo vascular reactions before and during post-occlusive hyperaemia.
    The British journal of dermatology, 1993, Volume: 128, Issue:2

    Topics: Adult; Betamethasone Valerate; Blood Flow Velocity; Diphenhydramine; Female; Hemoglobins; Humans; Hy

1993
Prostaglandin inhibition causes an increase in reactive hyperaemia after ischaemic exercise in human forearm.
    Clinical physiology (Oxford, England), 1999, Volume: 19, Issue:3

    Topics: Adult; Cyclooxygenase Inhibitors; Forearm; Humans; Hyperemia; Ibuprofen; Indomethacin; Ischemia; Mal

1999
Cigarette smoking, prostaglandins and reactive hyperemia.
    Prostaglandins and medicine, 1979, Volume: 3, Issue:6

    Topics: Adult; Female; Forearm; Humans; Hyperemia; Indomethacin; Ischemia; Male; Middle Aged; Prostaglandin

1979

Other Studies

67 other studies available for indomethacin and Active Hyperemia

ArticleYear
The effect of ageing and indomethacin on forearm reactive hyperaemia in healthy adults.
    Experimental physiology, 2014, Volume: 99, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Cyclooxygenase Inhibitors; Female; Forearm; Health Status; Humans; H

2014
In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:3

    Topics: Acetylcholine; Anesthesia; Animals; Animals, Outbred Strains; Biological Factors; Blood Pressure; Br

2008
Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:6

    Topics: Adenosine; Adult; Analysis of Variance; Cohort Studies; Exercise; Humans; Hyperemia; Indomethacin; L

2009
Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia.
    European journal of pharmacology, 2003, Jan-17, Volume: 459, Issue:2-3

    Topics: Animals; Brain Ischemia; Cell Count; Cell Death; DNA; DNA Damage; Gerbillinae; Hyperemia; Indomethac

2003
Role of estrogen in nitric oxide- and prostaglandin-dependent modulation of vascular conductance during treadmill locomotion in rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estr

2004
Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg.
    The Journal of physiology, 2007, Jun-01, Volume: 581, Issue:Pt 2

    Topics: Adenosine Triphosphate; Adult; Biological Factors; Blood Flow Velocity; Cardiac Output; Cyclooxygena

2007
Effect of indomethacin on cerebral blood flow and development of oxygen convulsions.
    Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:1

    Topics: Animals; Cyclooxygenase Inhibitors; Hyperbaric Oxygenation; Hyperemia; Indomethacin; Male; Rats; Rat

2006
Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:1

    Topics: Acetylcholine; Animals; Arterioles; Blood Pressure; Carbon Dioxide; Catalase; Cyclic N-Oxides; Cyclo

2008
Test for postischaemic hyperaemia: a means of clinical assessment of microcirculatory reactivity in tissues of patients with liability to seasonal ischaemic noxae.
    International journal of tissue reactions, 1984, Volume: 6, Issue:4

    Topics: Adult; Arthritis; Bronchitis; Female; Humans; Hyperemia; Indomethacin; Iodine; Ischemia; Male; Micro

1984
Arachidonic acid metabolism and regulation of blood flow: effect of indomethacin on cutaneous and subcutaneous reactive hyperaemia in humans.
    Clinical physiology (Oxford, England), 1983, Volume: 3, Issue:4

    Topics: Adipose Tissue; Adult; Arachidonic Acids; Blood Circulation; Female; Fingers; Humans; Hyperemia; Ind

1983
Effect of cigarette smoking on reactive hyperaemia in the human finger.
    Clinical physiology (Oxford, England), 1983, Volume: 3, Issue:5

    Topics: Adult; Blood Pressure; Female; Fingers; Heart Rate; Humans; Hyperemia; Indomethacin; Male; Middle Ag

1983
Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes.
    Clinical endocrinology, 1981, Volume: 15, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Alcoholic Beverages; Chlorpropamide; Diabetes Mellitus; Face; Female;

1981
Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration.
    Laboratory investigation; a journal of technical methods and pathology, 1981, Volume: 45, Issue:5

    Topics: Animals; Aspirin; Capillary Permeability; Cell Movement; Chemotactic Factors; Escherichia coli; Hype

1981
Prostaglandin synthesis inhibition and postprandial intestinal hyperemia.
    The American journal of physiology, 1982, Volume: 242, Issue:2

    Topics: Animals; Dogs; Feeding Behavior; Female; Hyperemia; Indomethacin; Jejunum; Male; Mefenamic Acid; Pro

1982
The appearance and significance of phospholipase A2 in lymph draining tuberculin reactions.
    The American journal of pathology, 1982, Volume: 107, Issue:3

    Topics: Animals; Blood Circulation; Capillary Permeability; Concanavalin A; Female; Hyperemia; Hypersensitiv

1982
Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin.
    Current eye research, 1981, Volume: 1, Issue:1

    Topics: Animals; Aqueous Humor; Betamethasone; Conjunctivitis; Dexamethasone; Disease Models, Animal; Eye; H

1981
Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit.
    International archives of allergy and applied immunology, 1980, Volume: 62, Issue:2

    Topics: Animals; Cells, Cultured; Concanavalin A; Culture Media; Dexamethasone; Female; Glycogen; Guinea Pig

1980
Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs.
    Anesthesiology, 1994, Volume: 80, Issue:6

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Carbon Dioxide; Cerebrovascular Circulation; F

1994
Role of endothelial factors in active hyperemic responses in contracting canine muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:1

    Topics: Animals; Arginine; Dogs; Endothelium, Vascular; Hindlimb; Hyperemia; Indomethacin; Isometric Contrac

1995
Role of prostaglandins and histamine in hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Astemizole; Cats; Dinoprostone; Gastric Acid; Gastric Mucosa;

1995
Nitric oxide is a major mediator in reactive hyperaemia evoked by a brief coronary occlusion in the guinea pig heart.
    European journal of pharmacology, 1993, Sep-07, Volume: 241, Issue:1

    Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Coronary Vessels; Fema

1993
Effects of antioxidants on the blood-brain barrier and postischemic hyperemia.
    Acta neurochirurgica, 1994, Volume: 131, Issue:3-4

    Topics: Animals; Antioxidants; Blood Flow Velocity; Blood-Brain Barrier; Brain; Brain Ischemia; Capillary Pe

1994
Interleukin-1 beta enhances capsaicin-induced neurogenic vasodilatation in the rat skin.
    British journal of pharmacology, 1994, Volume: 111, Issue:3

    Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Drug Synergism; Female; Hyperem

1994
The involvement of endothelial dysfunction, nitric oxide and prostanoids in the rat gastric microcirculatory responses to endothelin-1.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Albumins; Animals; Arginine; Capillary Permeability; Endothelins; Endothelium, Vascular; Gastric Muc

1994
Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats.
    Gastroenterology, 1993, Volume: 104, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Blood Volume; Dose-Response Relationship, D

1993
Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans.
    Circulation research, 1993, Volume: 73, Issue:1

    Topics: Adult; Anesthesia, Local; Calcitonin Gene-Related Peptide; Capsaicin; Constriction; Humans; Hyperemi

1993
Relationship between opioids and prostaglandins in hypoxia-induced vasodilation of pial arteries in the newborn pig.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1996, Volume: 212, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Blood Pressure; Carbon Dioxide;

1996
Indomethacin does not alter the effect of pentagastrin on rat gastric defense mechanisms.
    Peptides, 1996, Volume: 17, Issue:1

    Topics: Animals; Cyclooxygenase Inhibitors; Gastric Mucosa; Homeostasis; Hydrogen-Ion Concentration; Hyperem

1996
Role of adenosine and nitric oxide in the hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats.
    Scandinavian journal of gastroenterology, 1996, Volume: 31, Issue:1

    Topics: Adenosine; Animals; Cats; Diffusion; Disease Models, Animal; Gastric Acidity Determination; Gastric

1996
Ischaemic cardiac hyperaemia: role of nitric oxide and other mediators.
    Physiological research, 1996, Volume: 45, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Coronary Circulation; Cyclic GMP; Cyclooxygenase I

1996
Mechanisms mediating gastric hyperemic and acid responses to central TRH analog at a cytoprotective dose.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Acid; Gastric Mucosa; H

1997
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
    Life sciences, 1997, Volume: 61, Issue:10

    Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vit

1997
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
    Journal of cardiac failure, 1997, Volume: 3, Issue:3

    Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani

1997
Influence of venular prostaglandin release on arteriolar diameter during functional hyperemia.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:1 Pt 2

    Topics: Animals; Arterioles; Cricetinae; Electric Stimulation; Endothelium, Vascular; Hyperemia; Indomethaci

1998
Tachykinins as enhancers of prostaglandin E2-induced intraocular inflammation.
    Ocular immunology and inflammation, 1998, Volume: 6, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Dinoprostone; Dose-Response Relatio

1998
Effects of hydrogen peroxide scavenger Catalase on villous microcirculation in the rat small intestine in a model of inflammatory bowel disease.
    Microvascular research, 2000, Volume: 59, Issue:3

    Topics: Animals; Blood Flow Velocity; Catalase; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Eval

2000
Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat.
    Neuroreport, 2000, Jul-14, Volume: 11, Issue:10

    Topics: Animals; Cerebral Cortex; Charybdotoxin; Cortical Spreading Depression; Glyburide; Hyperemia; Indome

2000
In vivo assessment of villous microcirculation in the rat small intestine in indomethacin-induced inflammation: role of mast-cell stabilizer Ketotifen.
    Acta physiologica Scandinavica, 2000, Volume: 170, Issue:2

    Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Blood Flow Veloc

2000
Role of prostaglandins and histamine in reactive hyperemia: in-vivo studies on single mesenteric arterioles.
    Prostaglandins and medicine, 1978, Volume: 1, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arteries; Arterioles; Cyclooxygenase Inhibitors; Histamine

1978
Studies on the mechanism of flush induced by nicotinic acid.
    Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:1

    Topics: Animals; Aspirin; Cyclic AMP; Cyclooxygenase Inhibitors; Drug Interactions; Ear, External; Female; G

1977
Contribution of prostaglandins to muscle blood flow in anesthetized dogs at rest, during exercise, and following inflow occlusion.
    Circulation research, 1979, Volume: 44, Issue:1

    Topics: Animals; Arachidonic Acids; Depression, Chemical; Dogs; Epoprostenol; Hindlimb; Hyperemia; Indometha

1979
Suppressive effects of indomethacin on thermally induced neovascularization of rabbit corneas.
    American journal of ophthalmology, 1979, Volume: 87, Issue:4

    Topics: Animals; Capillaries; Cornea; Eye Burns; Hyperemia; Indomethacin; Prostaglandin Antagonists; Rabbits

1979
Effect of indomethacin on CO2-induced hyperaemia (CO2-response) in the rabbit brain.
    Neurochirurgia, 1978, Volume: 21, Issue:2

    Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Hyperemia; Indomethacin; Rabbits; Time Factors

1978
Prostaglandin-mediated hyperemia and renin-mediated hypertension during acute ureteral obstruction.
    Prostaglandins, 1978, Volume: 16, Issue:6

    Topics: Acute Disease; Angiotensin II; Animals; Dogs; Female; Hyperemia; Hypertension; Indomethacin; Kidney;

1978
Possible contributions of endogenous prostaglandins to the control of blood pressure.
    Circulation research, 1975, Volume: 36, Issue:6 Suppl 1

    Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Cyclooxygenase Inhibitors; Homeostasis; Hyperem

1975
Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:6

    Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibit

1975
Prostaglandins and the control of blood flow in the canine myocardium.
    Circulation research, 1977, Volume: 40, Issue:3

    Topics: Adenosine; Angiotensin II; Animals; Arachidonic Acids; Blood Pressure; Coronary Circulation; Coronar

1977
Reactive hyperaemia in the dog heart: inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin.
    Cardiovascular research, 1977, Volume: 11, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Aminophylline; Animals; Coronary Circulation; Dogs; Hyperemia; In

1977
Arteriolar reactive hyperemia: modification by inhibitors of prostaglandin synthesis.
    The American journal of physiology, 1977, Volume: 232, Issue:6

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Bradykinin; Hyperemia; Indomethacin; Ischemia; Male; Micro

1977
Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits.
    The American journal of physiology, 1977, Volume: 233, Issue:2

    Topics: Animals; Blood Pressure; Denervation; Hyperemia; Indomethacin; Ischemia; Kidney; Kidney Cortex; Rabb

1977
Endogenous prostaglandins as local regulators of blood flow in man: effect of indomethacin on reactive and functional hyperaemia.
    The Journal of physiology, 1976, Volume: 257, Issue:1

    Topics: Forearm; Hyperemia; Indomethacin; Muscles; Prostaglandins E; Regional Blood Flow

1976
Anoxia-induced release of prostaglandins in rabbit isolated hearts.
    Circulation research, 1975, Volume: 36, Issue:1

    Topics: Animals; Coronary Circulation; Hyperemia; Hypoxia; Indomethacin; Myocardium; Prostaglandin Antagonis

1975
Ocular compression and noncorticosteroidal anti-inflammatory agents.
    American journal of ophthalmology, 1975, Volume: 79, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Conjunctiva; Eye Diseases; Humans; Hyperemia; Indomethac

1975
Effects of indomethacin on local blood flow regulation in canine heart and kidney.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 149, Issue:4

    Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Electrocardiography; Female;

1975
Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion.
    British journal of pharmacology, 1992, Volume: 105, Issue:3

    Topics: Anesthesia; Animals; Arginine; Blood Pressure; Diffusion; Endothelium, Vascular; Epoprostenol; Femal

1992
[The role of the endothelium in the development of functional hyperemia of the skeletal muscles].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:11

    Topics: Animals; Arginine; Dogs; Electric Stimulation; Endothelium, Vascular; Gossypol; Hindlimb; Hyperemia;

1991
Similarities in the pharmacological modulation of reactive hyperemia and vasodilation to hydrogen peroxide in rat skeletal muscle arterioles: effects of probes for endothelium-derived mediators.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2

    Topics: Animals; Arterioles; Drug Interactions; Hydrogen Peroxide; Hyperemia; Indomethacin; Male; Methylene

1990
Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension.
    Annals of surgery, 1989, Volume: 209, Issue:3

    Topics: Animals; Cyclooxygenase Inhibitors; Epoprostenol; Hyperemia; Hypertension, Portal; Indomethacin; Mal

1989
[Role of the endothelium in the development of reactive hyperemia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:10

    Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase;

1989
[The role of endothelium in the coronary vessel reactive hyperemia reaction].
    Doklady Akademii nauk SSSR, 1989, Volume: 307, Issue:3

    Topics: Animals; Blood Circulation; Coronary Vessels; Dogs; Endothelium, Vascular; Hyperemia; Indomethacin;

1989
Indomethacin and ibuprofen enhance anoxia-induced hyperemia in rat brain.
    European journal of pharmacology, 1986, May-13, Volume: 124, Issue:1-2

    Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Diclofenac; Extracorporeal Circulation; Hypere

1986
Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia.
    Life sciences, 1985, Jan-14, Volume: 36, Issue:2

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dogs; Hyperemia; Indomethacin; Male; Meclofenamic Acid

1985
Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1

    Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Catechols; Coronary Circulation; Dogs; Femal

1985
Effects of indomethacin upon cerebral hemodynamics of newborn pigs.
    Pediatric research, 1985, Volume: 19, Issue:11

    Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Cerebrovascular Circulation; Hemodynamics; Hypercapn

1985
Inhibition of prostaglandin synthesis and functional hyperaemia in rabbit adipose tissue.
    British journal of pharmacology, 1972, Volume: 45, Issue:1

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Hyperemia; Indomethacin; Prostaglandins; Rabbi

1972
Degeneration release of norepinephrine causes transient ocular hyperemia mediated by prostaglandins.
    Investigative ophthalmology, 1973, Volume: 12, Issue:3

    Topics: Animals; Conjunctiva; Fluorescein Angiography; Hyperemia; Indomethacin; Intraocular Pressure; Iris;

1973
Role of prostaglandins in estrogen-induced uterine hyperemia.
    Prostaglandins, 1974, Feb-10, Volume: 5, Issue:3

    Topics: Animals; Blood Volume; Chromium Radioisotopes; Estradiol; Female; Hyperemia; Indomethacin; Intestine

1974