indomethacin has been researched along with Ache in 423 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Included in the study were 124 patients with initial diagnosis of renal colic and randomized to receive indomethacin suppository (100 mg) with either desmopressin intranasal spray (4 puffs, total dose of 40 micrograms) and or placebo intranasal spray." | 9.30 | Desmopressin/indomethacin combination efficacy and safety in renal colic pain management: A randomized placebo controlled trial. ( Baigi, V; Entezari, P; Hedayatshodeh, M; Jalili, M; Mirfazaelian, H; Shirani, F, 2019) |
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 9.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)." | 9.22 | Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016) |
| "To compare the effectiveness and safety of oral prednisolone versus oral indomethacin in patients presenting to emergency departments (EDs) with acute gout." | 9.22 | Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial. ( Cheng, CH; Choi, YF; Graham, CA; Janssens, HJ; Lee, KH; Man, CY; Rainer, TH; Tam, LS; Yau, WH, 2016) |
| "In a randomized double-blinded clinical trial, 150 patients (50 per group) with irreversible pulpitis were given placebo, 600 mg ibuprofen, or 75 mg indomethacin 1 hour before local anesthesia." | 9.14 | The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. ( Abbott, PV; Ashouri, R; Askarifard, S; Nakhaee, N; Pardakhti, A; Parirokh, M; Rekabi, AR, 2010) |
| "To evaluate the efficacy and safety of etoricoxib and indomethacin in the treatment of patients with acute gout." | 9.11 | Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial. ( Antigua, J; Burton, R; Chen, E; Geba, GP; Londoño, J; Lund, M; Najarian, DK; Navarra, S; Ozturk, ZE; Petruschke, RA; Pryhuber, KG; Rubin, BR, 2004) |
| "The preparation and clinical applications of indomethacin (IM) gel were investigated in the treatment of stomatitis resulting from chemotherapy and radiotherapy for cancer." | 9.11 | Preparation and clinical application of indomethacin gel for medical treatment of stomatitis. ( Hashizaki, K; Makimura, M; Momo, K; Ogawa, N; Saito, Y; Shiratsuchi, T; Taguchi, H, 2005) |
| "25% indomethacin (IM) spray as an in-hospital preparation on the pain of stomatitis after hematopoietic stem cell transplantation in 9 patients with various types of leukemia by measuring the change in pain and the decrease in morphine dose." | 9.10 | [The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation]. ( Aoyama, T; Furukawa, T; Hirai, H; Iga, T; Kanda, Y; Miyoshi, A; Nakamura, T; Yamada, Y; Yanagihara, Y, 2003) |
| " A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain." | 9.09 | Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. ( Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W, 1999) |
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 9.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| "Six orthopaedic clinics in Sweden made a comparison of the effects and side effects of Piroxicam (20 mg) and Indomethacin (100 mg) suppositories in 261 patients with painful coxarthrosis on the waiting list for total hip replacement (THR)." | 9.07 | Piroxicam and indomethacin suppositories for painful coxarthrosis. ( Düppe, H; Ersmark, H; Fagerlund, M; Gudmundsson, G; Jacobsson, B; Ordeberg, G; Tjornstrand, B; Wallinder, L, 1992) |
| "The efficacy and tolerability of etodolac and indomethacin were compared in patients with osteoarthritis of the knee." | 9.07 | Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee. ( Karbowski, A, 1991) |
| "A double-blind, crossover study was undertaken in general practice to compare the efficacy and tolerability of a new controlled-release indomethacin with sustained-release diclofenac sodium in patients with osteoarthritis." | 9.06 | Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: a comparative controlled clinical trial in general practice. ( Gostick, N; James, IG; Khong, TK; Miller, AJ; Roy, P; Shepherd, PR, 1990) |
| "The efficacy and tolerability of a new, controlled-release indomethacin (75 mg) tablet was compared to that of a sustained-release diclofenac sodium (100 mg) tablet in 84 patients with rheumatoid arthritis." | 9.06 | Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of rheumatoid arthritis: a comparative controlled clinical trial. ( Crowley, B; Hamill, JJ; Lyndon, S; McKellican, JF; Miller, AJ; Williams, P, 1990) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 9.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 9.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "The sensitivity of the cold-induced pain (CP) model to the non-steroidal anti-inflammatory drug (NSAID) indomethacin was studied in healthy volunteers." | 9.06 | Indomethacin: effects on cold-induced pain and the nervous system in healthy volunteers. ( Holland, RL; Peck, AW; Telekes, A, 1987) |
| "Using a prospective, double blind, double dummy protocol, we compared the efficacy of subacromial injection of 40 mg of triamcinalone acetonide versus oral indomethacin, 100 mg/day, in 40 patients with acute rotator cuff tendinitis." | 9.06 | Rotator cuff tendinitis: comparison of subacromial injection of a long acting corticosteroid versus oral indomethacin therapy. ( Fleming, KW; Paull, DM; White, RH, 1986) |
| "The efficacy and tolerability of 100 mg suppositories of diclofenac sodium (Voltaren) and indomethacin were investigated in relieving symptoms of rheumatoid arthritis." | 9.05 | Comparison of diclofenac and indomethacin suppositories in rheumatoid arthritis. ( Valindas, E; Wafin, F; Wuolijoki, E, 1984) |
| "The comparative effects of tenoxicam and indomethacin are studied in 20 patients with rheumatoid arthritis." | 9.05 | [Double-blind parallel clinical trial with tenoxicam in comparison with indomethacin in the treatment of rheumatoid arthritis]. ( Azanza, JR; Cuena, R; Honorato, J, 1984) |
| "Indomethacin retard and piroxicam were compared in an open, randomized, parallel study in the treatment of osteoarthritis." | 9.05 | Comparative study of piroxicam and indomethacin retard in osteoarthritis. ( Muller-Fassbender, HH; Nagel, E, 1983) |
| "In a double-blind, parallel-group study indoprofen 800 mg daily was compared with indomethacin 100 mg daily in forty patients suffering from acute painful shoulder and other soft-tissue rheumatic complaints." | 9.05 | Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints. ( Bruni, G; Lavezzari, M; Parrinello, L; Soave, G, 1982) |
| "Forty-one patients with periarthritis of the shoulder were entered into a double-blind, parallel comparison of naproxen and indomethacin." | 9.05 | Naproxen and indomethacin in periarthritis of the shoulder. ( Bird, HA; Downie, WW; Engler, C; Rhind, V; Wright, V, 1982) |
| "A study was carried out to investigate the analgesic effect of an injectable salt of indomethacin - methylglucamine indomethacinate - in patients with acute ureteral and biliary pain." | 9.05 | Treatment of ureteral and biliary pain with an injectable salt of indomethacin. ( Marsala, F, 1980) |
| "Indomethacin was recently shown to have a potent analgesic effect on biliary pain." | 9.05 | Indomethacin reduces raised intraluminal gallbladder pressure in acute cholecystitis. ( Jansson, R; Svanvik, J; Thornell, E, 1985) |
| "In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i." | 9.04 | Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979) |
| "Indomethacin, 100 mg orally, was compared with prednisolone, 5 mg, as addititional therapy at night, in a two-week, double-blind, between-patient study in twenty-four in-patients with rheumatoid arthritis." | 9.04 | Indomethacin or prednisolone at night in rheumatoid arthritis? ( Murthy, MH; Rhymer, AR; Wright, V, 1978) |
| "27 patients with ascertained ankylosing spondylitis experiencing constant after-midnight-pain received, following three medication-free days, in a double blind, randomized, cross-over fashion indometacin (100 g/day) and d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) (500 mg/day), as suppositories, for a period of six days each." | 9.04 | [A double blind comparison of naproxen and indomethacin on the after-midnight-pain of patients with morbus bechterew]. ( Peter, E, 1975) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 8.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 7.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 7.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| "Collectively our data suggest that propofol-evoked vascular pain is mainly initiated by prostanoids." | 7.73 | Characteristics of propofol-evoked vascular pain in anaesthetized rats. ( Ando, R; Watanabe, C, 2005) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 7.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| "Indomethacin (50 mg every eight hours) was given to 17 selected patients with pleurisy to control pain." | 7.67 | Effects of indomethacin on pleural pain. ( Klein, RC, 1984) |
| "The relative efficacy and safety of flurbiprofen (Ansaid, Upjohn) and indomethacin were compared in 29 patients with monoarticular gouty arthritis of less than 48 hours' duration." | 7.67 | Flurbiprofen in the treatment of acute gout. A comparison with indomethacin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Sack, RL; Turner, LF; Winblad, MA, 1986) |
| "Within the framework of a long-term study the efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) were tested in 26 female patients suffering from rheumatoid arthritis." | 7.66 | [Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| "A 71-year-old man with non-lipemic, generalized, plane xanthomas developed nodules and tumors within one month of starting indomethacin therapy." | 7.65 | Plasma cell granulomas in non-lipemic xanthomatosis: apparent induction by indomethacin. ( Rawnsley, HM; Shelley, WB, 1975) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 7.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| "Pain was evaluated with Visual Analog Scale, when the cervical canal was passed, while within the cavity and at 10 min after procedure." | 6.82 | The Effect of Intrauterine Lidocaine and Rectal Indomethacin on Pain during Office Vaginoscopic Hysteroscopy: Randomized Double-Blind Controlled Study. ( Babaoğlu, B; Guraslan, H; Polat, M; Senturk, MB; Yaşar, L, 2016) |
| "As the main intent of delivering maximum concentration of drug available from the dosage form, an oral compression coated tablet (CCT) was intended to develop with a predetermined lag time of 6 hrs before immediate release of drug to target circadian rhythms of rheumatoid arthritis." | 6.78 | Chronotherapeutic drug delivery from indomethacin compression coated tablets for early morning pain associated rheumatoid arthritis. ( Murthy, KV; Rao, NS; Srikanth, MV; Sunil, SA, 2013) |
| "Arthritis and hypertension are frequent comorbidities in the elderly hypertensive population." | 6.69 | Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. ( Anderson, A; Bertram, D; Morgan, TO, 2000) |
| "Droxicam was found to be statistically more active than indomethacin in alleviating morning stiffness and improving the functional status." | 6.67 | Comparative double-blind study of droxicam (new NSAID) versus indomethacin in rheumatoid arthritis. ( Diaz-López, C; Geli-Ferrer, C; Rodríguez-de-la-Serna, A; Sánchez-García, J, 1991) |
| "Chronopharmacologic studies of indomethacin have indicated that time of dosing influences tolerance and effectiveness." | 6.66 | Timing optimizes sustained-release indomethacin treatment of osteoarthritis. ( Le Louarn, C; Levi, F; Reinberg, A, 1985) |
| "Indomethacin was quicker acting, probably due to the intravenous route of administration." | 6.65 | A comparative study on the analgesic effects of indomethacin and hydromorphinechloride-atropine in acute, ureteral-stone pain. ( Berger, T; Rentzhog, L; Udén, P, 1983) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| " Indomethacin was superior to celecoxib for pain score at rest at 8-12 h and celecoxib + parecoxib, diclofenac, and ketorolac for pain score on movement at 48 h." | 5.41 | Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis. ( Blake, L; Carvalho, B; Carver, AL; Desai, N; Murdoch, I; O'Carroll, JE; Onwochei, DN; Sultan, P, 2023) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 5.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Gastric ulcer is a source of visceral pain." | 5.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Indomethacin (0." | 5.32 | Evaluation of chronopharmacodynamics of indomethacin by the kaolin-induced pain model in mice. ( Araki, N; Cui, Y; Fujimura, A; Sugimoto, K, 2003) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 5.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Included in the study were 124 patients with initial diagnosis of renal colic and randomized to receive indomethacin suppository (100 mg) with either desmopressin intranasal spray (4 puffs, total dose of 40 micrograms) and or placebo intranasal spray." | 5.30 | Desmopressin/indomethacin combination efficacy and safety in renal colic pain management: A randomized placebo controlled trial. ( Baigi, V; Entezari, P; Hedayatshodeh, M; Jalili, M; Mirfazaelian, H; Shirani, F, 2019) |
| "Inflammation was induced by daily interplantar injection of 100 microl of Freund's complete adjuvant into the left hind paw of the rat." | 5.30 | Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation. ( Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Pravettoni, G; Tiengo, M, 1999) |
| "Acemetacin was tested in an open clinical study with regard to occurrence and duration of its analgesic effect to 20 patients suffering from arthrosis of the hip and knee joint." | 5.27 | [Acemetacin in the treatment of painful arthroses. Results of an open short-term study on the starting point of the analgesic effect and its duration]. ( Bröll, H; Schragl, F; Siegmeth, W, 1984) |
| "Indomethacin is an effective inhibitor of prostaglandin synthetase and has recently been demonstrated to inhibit inflammatory fluid secretion into the gallbladder in experimental cholecystitis." | 5.26 | Indomethacin intravenously--a new way for effective relief of biliary pain: a double-blind study in man. ( Jansson, R; Svanvik, J; Thornell, E, 1981) |
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 5.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)." | 5.22 | Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016) |
| "To compare the effectiveness and safety of oral prednisolone versus oral indomethacin in patients presenting to emergency departments (EDs) with acute gout." | 5.22 | Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial. ( Cheng, CH; Choi, YF; Graham, CA; Janssens, HJ; Lee, KH; Man, CY; Rainer, TH; Tam, LS; Yau, WH, 2016) |
| "In a randomized double-blinded clinical trial, 150 patients (50 per group) with irreversible pulpitis were given placebo, 600 mg ibuprofen, or 75 mg indomethacin 1 hour before local anesthesia." | 5.14 | The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. ( Abbott, PV; Ashouri, R; Askarifard, S; Nakhaee, N; Pardakhti, A; Parirokh, M; Rekabi, AR, 2010) |
| "Norepinephrine did enhance spontaneous pain and mechanical and thermal hyperalgesia in capsaicin treated skin." | 5.12 | Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia. ( Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I, 2007) |
| "To evaluate the efficacy and safety of etoricoxib and indomethacin in the treatment of patients with acute gout." | 5.11 | Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial. ( Antigua, J; Burton, R; Chen, E; Geba, GP; Londoño, J; Lund, M; Najarian, DK; Navarra, S; Ozturk, ZE; Petruschke, RA; Pryhuber, KG; Rubin, BR, 2004) |
| "The preparation and clinical applications of indomethacin (IM) gel were investigated in the treatment of stomatitis resulting from chemotherapy and radiotherapy for cancer." | 5.11 | Preparation and clinical application of indomethacin gel for medical treatment of stomatitis. ( Hashizaki, K; Makimura, M; Momo, K; Ogawa, N; Saito, Y; Shiratsuchi, T; Taguchi, H, 2005) |
| "There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone." | 5.11 | Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005) |
| "25% indomethacin (IM) spray as an in-hospital preparation on the pain of stomatitis after hematopoietic stem cell transplantation in 9 patients with various types of leukemia by measuring the change in pain and the decrease in morphine dose." | 5.10 | [The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation]. ( Aoyama, T; Furukawa, T; Hirai, H; Iga, T; Kanda, Y; Miyoshi, A; Nakamura, T; Yamada, Y; Yanagihara, Y, 2003) |
| " A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain." | 5.09 | Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. ( Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W, 1999) |
| "Our study highlighted the efficacy of indomethacin as a pain reducer for acute corneal pathology and suggested that the medication may act on the corneal nociceptors in a qualitative way." | 5.09 | Evaluation of the analgesic effect of 0.1% indomethacin solution on corneal abrasions. ( Macri, A; Patrone, G; Rolando, M; Sacca, SC, 1999) |
| " Addition of misoprostol can minimize this renal impairment without affecting pain control." | 5.08 | Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients. ( Dwolatzky, T; Nesher, G; Sonnenblick, M, 1995) |
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 5.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| " Ninety-six patients with rheumatoid arthritis took single daily doses of controlled release naproxen (N), diclofenac S." | 5.07 | Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis. ( Huskisson, EC, 1991) |
| "Six orthopaedic clinics in Sweden made a comparison of the effects and side effects of Piroxicam (20 mg) and Indomethacin (100 mg) suppositories in 261 patients with painful coxarthrosis on the waiting list for total hip replacement (THR)." | 5.07 | Piroxicam and indomethacin suppositories for painful coxarthrosis. ( Düppe, H; Ersmark, H; Fagerlund, M; Gudmundsson, G; Jacobsson, B; Ordeberg, G; Tjornstrand, B; Wallinder, L, 1992) |
| "The efficacy and tolerability of etodolac and indomethacin were compared in patients with osteoarthritis of the knee." | 5.07 | Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee. ( Karbowski, A, 1991) |
| "A double-blind, crossover study was undertaken in general practice to compare the efficacy and tolerability of a new controlled-release indomethacin with sustained-release diclofenac sodium in patients with osteoarthritis." | 5.06 | Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: a comparative controlled clinical trial in general practice. ( Gostick, N; James, IG; Khong, TK; Miller, AJ; Roy, P; Shepherd, PR, 1990) |
| "The efficacy and tolerability of a new, controlled-release indomethacin (75 mg) tablet was compared to that of a sustained-release diclofenac sodium (100 mg) tablet in 84 patients with rheumatoid arthritis." | 5.06 | Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of rheumatoid arthritis: a comparative controlled clinical trial. ( Crowley, B; Hamill, JJ; Lyndon, S; McKellican, JF; Miller, AJ; Williams, P, 1990) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 5.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 5.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "The sensitivity of the cold-induced pain (CP) model to the non-steroidal anti-inflammatory drug (NSAID) indomethacin was studied in healthy volunteers." | 5.06 | Indomethacin: effects on cold-induced pain and the nervous system in healthy volunteers. ( Holland, RL; Peck, AW; Telekes, A, 1987) |
| "Using a prospective, double blind, double dummy protocol, we compared the efficacy of subacromial injection of 40 mg of triamcinalone acetonide versus oral indomethacin, 100 mg/day, in 40 patients with acute rotator cuff tendinitis." | 5.06 | Rotator cuff tendinitis: comparison of subacromial injection of a long acting corticosteroid versus oral indomethacin therapy. ( Fleming, KW; Paull, DM; White, RH, 1986) |
| "The efficacy and tolerability of 100 mg suppositories of diclofenac sodium (Voltaren) and indomethacin were investigated in relieving symptoms of rheumatoid arthritis." | 5.05 | Comparison of diclofenac and indomethacin suppositories in rheumatoid arthritis. ( Valindas, E; Wafin, F; Wuolijoki, E, 1984) |
| "The comparative effects of tenoxicam and indomethacin are studied in 20 patients with rheumatoid arthritis." | 5.05 | [Double-blind parallel clinical trial with tenoxicam in comparison with indomethacin in the treatment of rheumatoid arthritis]. ( Azanza, JR; Cuena, R; Honorato, J, 1984) |
| "In a double-blind cross-over trial of azapropazone and indomethacin in 20 patients with osteoarthritis of the hip and knee with four weeks on each drug, three methods of assessing pain and pain relief were used." | 5.05 | A comparison of three ways of measuring pain. ( Frank, AJ; Hort, JF; Moll, JM, 1982) |
| "Indomethacin retard and piroxicam were compared in an open, randomized, parallel study in the treatment of osteoarthritis." | 5.05 | Comparative study of piroxicam and indomethacin retard in osteoarthritis. ( Muller-Fassbender, HH; Nagel, E, 1983) |
| "In a double-blind, parallel-group study indoprofen 800 mg daily was compared with indomethacin 100 mg daily in forty patients suffering from acute painful shoulder and other soft-tissue rheumatic complaints." | 5.05 | Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints. ( Bruni, G; Lavezzari, M; Parrinello, L; Soave, G, 1982) |
| "Fifty-four hospitalized patients with rheumatoid arthritis participated in a dose-range study comparing benoxaprofen with placebo and in a further study comparing benoxaprofen with indomethacin." | 5.05 | Benoxaprofen--dose-range studies using quantitative thermography. ( Bacon, PA; Davies, J; Ring, FJ, 1980) |
| "Forty-one patients with periarthritis of the shoulder were entered into a double-blind, parallel comparison of naproxen and indomethacin." | 5.05 | Naproxen and indomethacin in periarthritis of the shoulder. ( Bird, HA; Downie, WW; Engler, C; Rhind, V; Wright, V, 1982) |
| "In a double blind study [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) was compared with indometacin in 2 x 20 patients suffering from rheumatoid arthritis." | 5.05 | [Controlled double blind comparison of acemetacin to indomethacin in patients with chronic polyarthritis]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| "In a controlled double blind study the therapeutic efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) and tolmetin were compared in 40 patients suffering from acute and subacute painful irritant conditions in the spinal area and joints." | 5.05 | [Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)]. ( Handrich, L, 1980) |
| "A study was carried out to investigate the analgesic effect of an injectable salt of indomethacin - methylglucamine indomethacinate - in patients with acute ureteral and biliary pain." | 5.05 | Treatment of ureteral and biliary pain with an injectable salt of indomethacin. ( Marsala, F, 1980) |
| "Indomethacin was recently shown to have a potent analgesic effect on biliary pain." | 5.05 | Indomethacin reduces raised intraluminal gallbladder pressure in acute cholecystitis. ( Jansson, R; Svanvik, J; Thornell, E, 1985) |
| "The antiarthrosic effectiveness with respect to spontaneous pain upon movement and pressure, of alclofenac (4-allyloxy-3-chlorophenyl-acetic acid) was tested in a homogeneous group of elderly patients and compared with orally administered indomethacin." | 5.04 | [4-allyloxy-3-chlorophenyl-acetic acid (alclofenac) in the treatment of painful arthroses in the aged. Double-blind controlled clinical trial]. ( Lamberti, G; Ziliotto, G, 1975) |
| "In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i." | 5.04 | Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979) |
| "Indomethacin, 100 mg orally, was compared with prednisolone, 5 mg, as addititional therapy at night, in a two-week, double-blind, between-patient study in twenty-four in-patients with rheumatoid arthritis." | 5.04 | Indomethacin or prednisolone at night in rheumatoid arthritis? ( Murthy, MH; Rhymer, AR; Wright, V, 1978) |
| "27 patients with ascertained ankylosing spondylitis experiencing constant after-midnight-pain received, following three medication-free days, in a double blind, randomized, cross-over fashion indometacin (100 g/day) and d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) (500 mg/day), as suppositories, for a period of six days each." | 5.04 | [A double blind comparison of naproxen and indomethacin on the after-midnight-pain of patients with morbus bechterew]. ( Peter, E, 1975) |
| "This review, which summarizes our findings concerning the long-term effects of pre-, peri- and postnatal factors affecting development, nociception and sensorimotor functions, focuses on three areas: 1) perinatal factors influencing nociception in adult rats were examined in rats with hippocampal lesions, after the administration of stress influencing and psychostimulant drugs (dexamethasone, indomethacine and methamphetamine); 2) the effect of pre- and early postnatal methamphetamine administration was shown to impair the development of sensorimotor functions tested in rat pups throughout the preweaning period; 3) the effect of extensive dorsal rhizotomy of the brachial plexus during the early postnatal period was studied with respect to neuropathic pain development and sensorimotor functions." | 4.84 | Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development. ( Franek, M; Hrubá, L; Pometlová, M; Rokyta, R; Schutová, B; Slamberová, R; Vaculín, S; Yamamotová, A, 2008) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 4.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "In the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner." | 3.96 | Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. ( Haddadi, R; Rashtiani, R, 2020) |
| " In this study, we investigated the development of an indomethacin mouth wash(IM-MW)as a novel approach to treat pain due to oral mucositis." | 3.96 | [Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy]. ( Kiyomi, A; Kuroda, S; Momo, K; Ono, K; Sugiura, M; Yasu, T, 2020) |
| "The aim of this study was to evaluate the effect of vitamin E co-administration with celecoxib in thermal and inflammatory pain in two model of pain assessment including thermal tail flick test of acute pain and formalin induced inflammatory model in adult male rats." | 3.91 | Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats. ( Izadi, G; Sepehri, G; Shamsi Meymandi, M; Zamiri, Z, 2019) |
| "This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats." | 3.85 | N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. ( Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH, 2017) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| " Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue." | 3.83 | Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. ( Dong, K; Sun, JY; Xing, JF; You, CY; You, HS, 2016) |
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 3.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Possible mechanisms underlying alterations in NGF-induced pain behaviour were explored using indomethacin pretreatment, histopathological evaluation of synovitis, and rtPCR for NGF receptor (tropomyosin receptor kinase (Trk)-A) expression in dorsal root ganglia (DRG)." | 3.80 | Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis. ( Ashraf, S; Bennett, AJ; Burston, J; Chapman, V; Mapp, PI; Walsh, DA, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 3.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| "The NO donors nitroglycerin and sodium nitroprusside (SNP) induced allodynia (cold plate test) and hyperalgesia (hot plate test)." | 3.79 | St. John's wort relieves pain in an animal model of migraine. ( Galeotti, N; Ghelardini, C, 2013) |
| " The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)." | 3.78 | Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012) |
| " In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
| "7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain." | 3.77 | Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. ( Barbosa Filho, JM; Couto, RD; de Lima, FO; Nonato, FR; Nunes, XP; Ribeiro dos Santos, R; Soares, MB; Villarreal, CF, 2011) |
| " While the analgesic activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods." | 3.77 | Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. ( Duan, JA; Hua, YQ; Qian, DW; Su, S; Tang, YP; Wang, T; Yu, L; Zhou, W, 2011) |
| " The antinociceptive effects of LEJ were assessed using experimental models of pain, including thermal nociception methods, such as the tail immersion test and the hotplate test, and chemical nociception induced by intraperitoneal acetic acid and subplantar formalin in mice." | 3.77 | Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica. ( Cha, DS; Eun, JS; Jeon, H, 2011) |
| "Dexamethasone and indomethacin each reduced pain behavior, synovial inflammation, and synovial angiogenesis 35 days after meniscal transection." | 3.77 | Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. ( Ashraf, S; Mapp, PI; Walsh, DA, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "Salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their complexes [Zn(LASSBio-466)H(2)O](2) (1) and [Zn(HLASSBio-1064)Cl](2) (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation." | 3.77 | Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. ( Alexandre-Moreira, MS; Alves, MA; Barreiro, EJ; Beraldo, H; Castellano, EE; Júnior, WB; Lima, LM; Parrilha, GL; Perez-Rebolledo, A; Piro, OE, 2011) |
| " The anti- oedema effect was compared with indomethacin." | 3.76 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| "Injection of acetic acid (1% and 3%) induced pain behaviors and bladder overactivity proportional to the concentration." | 3.76 | Behavioral and urological evaluation of a testicular pain model. ( Tanahashi, M; Uchida, W; Yoshioka, K, 2010) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of acute gout and inflammation." | 3.76 | Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways. ( Castañeda-Hernández, G; Chávez-Piña, AE; Gil-Flores, M; Ortiz, MI, 2010) |
| ") were assessed using acetic acid-induced vascular permeability, carrageenan-induced paw edema, and croton oil-induced ear edema." | 3.76 | The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. ( Cho, YB; Hur, J; Jung, I; Jung, KC; Kang, JY; Kang, M; Kim, KS; Kim, SH; Lee, JD; Lee, JH; Park, DS; Yoo, MC, 2010) |
| "Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0." | 3.74 | Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008) |
| "Collectively our data suggest that propofol-evoked vascular pain is mainly initiated by prostanoids." | 3.73 | Characteristics of propofol-evoked vascular pain in anaesthetized rats. ( Ando, R; Watanabe, C, 2005) |
| " Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
| " The antinociceptive effect of 1 was evaluated on chemical (acetic acid, formalin and capsaicin) and thermal (hot plate and tail flick) pain models in mice, using classical standard drugs." | 3.72 | Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla. ( Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C, 2003) |
| "We describe a man with chronic paroxysmal hemicrania, who remained free of headaches on indomethacin, 25 mg once or twice daily." | 3.72 | Non-lateralized pain in a case of chronic paroxysmal hemicrania? ( Mulder, LJ; Spierings, EL, 2004) |
| "In this study, amide derivatives of [6-(5-methyl-3-phenyl-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were synthesized and tested for their in vivo analgesic and anti-inflammatory activity by using the p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively." | 3.72 | Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds. ( Akoğlu, C; Banoglu, E; Küpeli, E; Sahin, MF; Unlü, S; Yeşilada, E, 2004) |
| " Thus, we used acetic acid (AA) which produces a delayed inflammatory response and episodes of abdominal writhing, a marker of pain, when injected intraperitoneally (i." | 3.72 | Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats. ( Angel, F; Aunis, D; Crenner, F; Ghia, JE; Metz-Boutigue, MH, 2004) |
| "The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout." | 3.72 | Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. ( Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R, 2004) |
| " Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade." | 3.72 | Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. ( Ballabeni, V; Barocelli, E; Bianchi, A; Bruni, R; Calcina, F; Chiavarini, M; Impicciatore, M, 2004) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "Topical indomethacin is worthy of further trial and investigation in the management of the Albury-Wodonga syndrome, harvester's eye, Christmas eye or seasonal corneal ulcer." | 3.69 | The Albury-Wodonga syndrome. A tale of two cities. ( Howsam, G, 1995) |
| " Both etodolac and bromelain inhibited the inflammatory pain in concanavalin A-treated paws of rats in a dose-dependent manner, but indomethacin did not." | 3.69 | Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation. ( Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 3.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "Intrathecal acetylsalicylic acid and indomethacin are analgesic for painful stimuli, and this has been demonstrated when the noxious stimuli are applied to normal and inflamed tissue." | 3.68 | Intrathecal acetylsalicylic acid and indomethacin are not analgesic for a supramaximal stimulus. ( Antognini, JF, 1993) |
| "Bradykinin is one of several pro-inflammatory, pain-inducing substances produced during inflammation--the body's response to injury." | 3.68 | G-protein mediation in nociceptive signal transduction: an investigation into the excitatory action of bradykinin in a subpopulation of cultured rat sensory neurons. ( Dolphin, AC; McGuirk, SM, 1992) |
| "Systemic capsaicin and an analogue, olvanil (NE-19550, 4-hydroxy-3-methoxyphenyl methyl-9Z-octadecenamide), were tested for antinociceptive activity in a model of persistent pain produced by the subcutaneous injection of formalin into the rodent hind paw." | 3.68 | Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw. ( Dickenson, A; Dray, A, 1991) |
| "Plasma and cerebrospinal fluid (CSF) concentrations of indomethacin have been determined in 52 patients hospitalized for nerve-root compression pain." | 3.68 | Plasma and cerebrospinal fluid concentrations of indomethacin in humans. Relationship to analgesic activity. ( Bannwarth, B; Gaucher, A; Lapicque, F; Netter, P; Péré, P; Thomas, P, 1990) |
| "Indomethacin (50 mg every eight hours) was given to 17 selected patients with pleurisy to control pain." | 3.67 | Effects of indomethacin on pleural pain. ( Klein, RC, 1984) |
| "The relative efficacy and safety of flurbiprofen (Ansaid, Upjohn) and indomethacin were compared in 29 patients with monoarticular gouty arthritis of less than 48 hours' duration." | 3.67 | Flurbiprofen in the treatment of acute gout. A comparison with indomethacin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Sack, RL; Turner, LF; Winblad, MA, 1986) |
| "Intraarterial injection of histamine into the isolated perfused rabbit ear causes a reflex fall in mean arterial blood pressure by stimulation of perivascular pain receptors." | 3.66 | Dependence of histamine-evoked nociception on prostaglandin release. ( Juan, H, 1981) |
| "Within the framework of a long-term study the efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil) were tested in 26 female patients suffering from rheumatoid arthritis." | 3.66 | [Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)]. ( Eberl, R; Heiter, A; Tausch, G, 1980) |
| "A 71-year-old man with non-lipemic, generalized, plane xanthomas developed nodules and tumors within one month of starting indomethacin therapy." | 3.65 | Plasma cell granulomas in non-lipemic xanthomatosis: apparent induction by indomethacin. ( Rawnsley, HM; Shelley, WB, 1975) |
| "Evidence for the effectiveness of ketoprofen in animal models of inflammation and its antipyretic effect is reviewed." | 3.65 | Some pharmacological and toxicological studies on ketoprofen. ( Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J, 1976) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 3.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| "Pain was evaluated with Visual Analog Scale, when the cervical canal was passed, while within the cavity and at 10 min after procedure." | 2.82 | The Effect of Intrauterine Lidocaine and Rectal Indomethacin on Pain during Office Vaginoscopic Hysteroscopy: Randomized Double-Blind Controlled Study. ( Babaoğlu, B; Guraslan, H; Polat, M; Senturk, MB; Yaşar, L, 2016) |
| "As the main intent of delivering maximum concentration of drug available from the dosage form, an oral compression coated tablet (CCT) was intended to develop with a predetermined lag time of 6 hrs before immediate release of drug to target circadian rhythms of rheumatoid arthritis." | 2.78 | Chronotherapeutic drug delivery from indomethacin compression coated tablets for early morning pain associated rheumatoid arthritis. ( Murthy, KV; Rao, NS; Srikanth, MV; Sunil, SA, 2013) |
| "Currently the sine qua non for hemicrania continua is a response to indometacin." | 2.75 | Hemicrania continua: a clinical study of 39 patients with diagnostic implications. ( Cittadini, E; Goadsby, PJ, 2010) |
| "Arthritis and hypertension are frequent comorbidities in the elderly hypertensive population." | 2.69 | Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. ( Anderson, A; Bertram, D; Morgan, TO, 2000) |
| "Forty-two patients with ankylosing spondylitis were entered into a double-blind study to compare treatment with indomethacin and a new non-steroidal anti-inflammatory drug, nabumetone." | 2.67 | A comparative study of nabumetone and indomethacin in ankylosing spondylitis. ( Palferman, TG; Webley, M, 1991) |
| "Droxicam was found to be statistically more active than indomethacin in alleviating morning stiffness and improving the functional status." | 2.67 | Comparative double-blind study of droxicam (new NSAID) versus indomethacin in rheumatoid arthritis. ( Diaz-López, C; Geli-Ferrer, C; Rodríguez-de-la-Serna, A; Sánchez-García, J, 1991) |
| "Ankylosing spondylitis is a systemic rheumatic disorder characterized by inflammation of the spine, sacroiliac, and large peripheral joints." | 2.66 | Efficacy of diclofenac in ankylosing spondylitis. ( Calabro, JJ, 1986) |
| "In a randomized double-dummy study a new dosage form of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol), i." | 2.66 | Double-dummy comparison of suprofen and indometacin sustained release formulations. ( Höbel, W; Michos, N; Schenker, H, 1986) |
| "Chronopharmacologic studies of indomethacin have indicated that time of dosing influences tolerance and effectiveness." | 2.66 | Timing optimizes sustained-release indomethacin treatment of osteoarthritis. ( Le Louarn, C; Levi, F; Reinberg, A, 1985) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| "Flurbiprofen is an excellent treatment for the control of pain and inflammation in patients with ankylosing spondylitis." | 2.66 | Flurbiprofen in the treatment of ankylosing spondylitis. A comparison with indomethacin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
| "Osteoarthritis is a good indication for these medications whose effectiveness is well documented." | 2.65 | [Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis]. ( Gougeon, J, 1983) |
| " 92 patients received piroxicam in a daily dosage of 4 capsules (40 mg) during the first two days, then 20 mg during the following days." | 2.65 | Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity. ( Commandre, F, 1983) |
| "Indomethacin was quicker acting, probably due to the intravenous route of administration." | 2.65 | A comparative study on the analgesic effects of indomethacin and hydromorphinechloride-atropine in acute, ureteral-stone pain. ( Berger, T; Rentzhog, L; Udén, P, 1983) |
| "Acemetacin has shown that its analgesic, anti-inflammatory and antipyretic effects are equal to those of the reference substance, indometacin." | 2.65 | [Clinical trials with acemetacin on children and adolescents (author's transl)]. ( Neugirg, R; Penners, R, 1980) |
| "35 patients (32 male and 3 female) with ankylosing spondylitis and 19 patients (8 male and 11 female) with osteoarthrosis were treated with either of the drugs for 15 days." | 2.64 | [Methods and statistics of multicentral double-blind "cross-over" examination of naproxen compared to indomethacin]. ( Binzus, G, 1975) |
| "Secondary etiologies for stabbing headaches are part of the differential diagnosis of primary stabbing headache; therefore, it is reasonable to perform neuroimaging." | 2.61 | Primary Stabbing Headache. ( Dilli, E; Murray, D, 2019) |
| "The red ear syndrome is a rare syndrome originally described by Lance in 1994." | 2.44 | Red ear syndrome. ( Dodick, DW; Purdy, RA, 2007) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "Inflammation was induced by intraplantar (i." | 1.43 | [Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats]. ( Hong, Y; Huang, J; Wu, J; Yang, HZ, 2016) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use, such as etoposide, teniposide and etopophos." | 1.39 | Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. ( Abad, A; Del Olmo, E; Guerrero, E; López-Pérez, JL; Montenegro, G; San Feliciano, A, 2013) |
| "We diagnosed late onset spondyloarthropathy according to clinic and radiographic findings." | 1.38 | Late onset spondyloarthropathy mimicking polymyalgia rheumatica. ( Altındağ, O; Aydeniz, A; Gürsoy, S; Oğüt, E, 2012) |
| "Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production." | 1.37 | Antinociceptive properties of bergenin. ( Couto, RD; David, JM; David, JP; de Lima, FO; de Oliveira, CM; Nonato, FR; Soares, MB; Villarreal, CF, 2011) |
| "mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine." | 1.36 | Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats. ( Ibidapo, AJ; Negedu, MN; Oguntoye, SO; Olaniran, SO; Onasanwo, SA; Owoyele, BV; Oyeleke, SA; Sanya, JO; Soladoye, AO, 2010) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| " Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10mg/kg." | 1.35 | Imidazopyridines: a novel class of hNav1.7 channel blockers. ( Abbadie, C; Dean, B; Duffy, JL; Felix, JP; Garcia, ML; Hoyt, SB; Jochnowitz, N; Kaczorowski, GJ; Karanam, BV; Li, X; London, C; Lyons, KA; Martin, WJ; McGowan, E; Parsons, WH; Priest, BT; Smith, MM; Tschirret-Guth, R; Warren, VA; Williams, BS, 2008) |
| " Recently, we described a novel series of potent, selective, and orally bioavailable delta opioid receptor agonists." | 1.35 | Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). ( Ajello, CW; Barker, WM; Belanger, S; Brogdon, BL; Cassel, JA; Chu, GH; DeHaven, RN; DeHaven-Hudkins, DL; Derelanko, MJ; Dolle, RE; Feschenko, MS; Graczyk, TM; Gu, M; Koblish, M; Kutz, S; Le Bourdonnec, B; Leister, LK; Little, PJ; Smith, SA; Tuthill, PA; Wiant, DD; Windh, RT; Zhou, QJ, 2009) |
| "Hyperalgesia was detected 2 h after nerve transection and persisted for 64 days." | 1.35 | The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators. ( Amorim, RL; Brigatte, P; Conceição, IM; Cury, Y; Della-Casa, MS; Ferreira, WA; Gutierrez, VP; Nicoletti, JL; Nogueira-Neto, Fde S; Picolo, G; Takahira, RK, 2008) |
| " This pharmacodynamic phenomenon is referred to in the present work as "teleantagonism"." | 1.35 | Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. ( Cunha, FQ; Duarte, DB; Ferrari, LF; Ferreira, SH; Funez, MI; Lorenzetti, BB; Parada, CA; Sachs, D, 2008) |
| "Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro." | 1.35 | Anti-inflammatory properties of cryptolepine. ( Ajayi, AM; Olajide, OA; Wright, CW, 2009) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "The development of hyperalgesia was dose dependently prevented by the NSAID indomethacin (ED50=2." | 1.35 | Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw. ( Chen, JJ; Ding, X; Dong, H; Johnson, EJ; Kumar, GN; Magal, E; Manning, BH; Sun, H, 2008) |
| " The BK dose-response curve was shifted to the right by topical indomethacin." | 1.35 | A novel model of pain sensation using superfused gastrosplenic omentum preparation of anesthetized rats. ( Katori, M; Majima, M; Yang, SJ, 2008) |
| "Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known." | 1.35 | Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. ( Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D, 2008) |
| "An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described." | 1.34 | Walker 256 tumor-bearing rats as a model to study cancer pain. ( Brigatte, P; Curi, R; Cury, Y; Guerra, JL; Gutierrez, VP; Sampaio, SC; Sinhorini, IL, 2007) |
| "The edema was inhibited by previous treatment with promethazine (5 or 10mg/kg) or cyproheptadine (5 or 10mg/kg), but not by indomethacin (2 or 4mg/kg), dexamethasone (1 or 4mg/kg) or cromolyn (40 or 80mg/kg)." | 1.33 | Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. ( Bertollo, CM; Coelho, MM; Costa, KA; Glória, MB; Moraes-Santos, T; Nascimento, EB; Oliveira, AC; Rocha, LT; Souza, AL, 2005) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 1.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test." | 1.33 | Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006) |
| "Gastric ulcer is a source of visceral pain." | 1.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236." | 1.33 | Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan. ( Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC, 2006) |
| "Each center approached implementation of the practices differently." | 1.32 | Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants. ( Boyle, D; Buchanan, DS; Carteaux, P; Check, J; Clark, SE; Cohen, H; George, JA; Klein, SA; McKinley, P; McLendon, D; Michael, L; Moehring, J; Okuno-Jones, S; Secrest, JW; Whitfield, JM, 2003) |
| "Indomethacin (0." | 1.32 | Evaluation of chronopharmacodynamics of indomethacin by the kaolin-induced pain model in mice. ( Araki, N; Cui, Y; Fujimura, A; Sugimoto, K, 2003) |
| "Loratadine pretreatment, but neither guanethidine nor indomethacin, reduced edema." | 1.32 | Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars. ( de Castro Bastos, L; Guimarães, JA; Tonussi, CR; Veiga, AB, 2004) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| " We evaluated the antinociceptive effects of chronic administration of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), anandamide (an endogenous cannabinoid), arachadonic acid, ethanolamine, and methanandamide on several NSAIDs via p." | 1.31 | Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. ( Anikwue, R; Huffman, JW; Martin, ZL; Welch, SP, 2002) |
| "Mianserin was administered to mice 30min before applying the analgesic drugs." | 1.31 | Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice. ( Czarnecka, E; Pakulska, W, 2002) |
| "In conclusion, NO and PGE2 affect the hyperalgesia induced by excitatory amino acids." | 1.31 | The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats. ( Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD, 2000) |
| "iNOS-/- mice exhibited reduced thermal hyperalgesia after zymosan injection." | 1.31 | Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. ( Ates, M; Brune, K; Coste, O; Görig, M; Gühring, H; Pahl, A; Rehse, K; Zeilhofer, HU, 2000) |
| "Decreased pain was correlated with increased motor activity for morphine and amphetamine, and with decreased activity for xylazine and acepromazine; dipyrone and indomethacin did not alter activity levels." | 1.31 | The formalin test in the mouse: a parametric analysis of scoring properties. ( Abbott, FV; Saddi, GM, 2000) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 1.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Visceral pain was scored by counting abdominal contractions." | 1.30 | Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain. ( Angel, F; Chevalier, E; Dahl, SG; Diop, L; Friese, N; Rivière, PJ, 1997) |
| "5." | 1.30 | Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats. ( Fu, LW; Longhurst, JC, 1998) |
| " However, when animals were pre-treated with BCG, the dose-response curves for both B1 agonists were shifted 2 to 8-fold to the left." | 1.30 | Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice. ( Calixto, JB; de Campos, RO; Henriques, MG, 1998) |
| "Inflammation was induced by daily interplantar injection of 100 microl of Freund's complete adjuvant into the left hind paw of the rat." | 1.30 | Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation. ( Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Pravettoni, G; Tiengo, M, 1999) |
| "Pain was induced by intraplantar injection of carrageenan (3 mg) into the hind paw of rats." | 1.29 | Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats. ( Pichler, L; Schramm, W; Schwarz, HP; Ulrich, W; Varadi, K, 1995) |
| "In indomethacin-pretreated animals, no neurons expressing fos-IR were found in nuclei associated with relay of nociception nor in nuclei contributing to inhibition of nociception." | 1.29 | Expression of c-fos-like protein in the rat brain after injection of interleukin-1-beta into the gingiva. ( Hamba, M; Hiraide, T; Muro, M; Ozawa, H, 1994) |
| "Flurbiprofen (50 mg kg-1) was inactive." | 1.28 | Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. ( Babbedge, RC; Gaffen, Z; Hart, SL; Moore, PK; Morgan, CV; Wallace, P, 1992) |
| "We conclude that serotonin produces hyperalgesia by a direct action on the primary afferent neuron via the 5-HT1A subset of serotonin receptors." | 1.28 | Serotonin is a directly-acting hyperalgesic agent in the rat. ( Levine, JD; Taiwo, YO, 1992) |
| "Meclofenamic acid is an analgesic endowed with anti-inflammatory properties." | 1.28 | Clinical experiences in the treatment of pain in rheumatology. ( Pellegrini, P, 1991) |
| "Indomethacin was used as a reference." | 1.28 | Antinociceptive and anti-inflammatory activity of a novel quipazine derivative (AAL-13): a selective inhibitor of 5-hydroxytryptamine reuptake. ( Alhaider, AA; el-Mahdy, SA; Mahgoub, AA, 1990) |
| "The writhing reaction reached a peak at 5-10 min after the injection of kaolin (0." | 1.28 | A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents. I. Kaolin-induced writhing in mice. ( Fujiyoshi, T; Iida, H; Kuwashima, M; Uematsu, T, 1989) |
| "Acemetacin was tested in an open clinical study with regard to occurrence and duration of its analgesic effect to 20 patients suffering from arthrosis of the hip and knee joint." | 1.27 | [Acemetacin in the treatment of painful arthroses. Results of an open short-term study on the starting point of the analgesic effect and its duration]. ( Bröll, H; Schragl, F; Siegmeth, W, 1984) |
| "This hyperalgesia can be inhibited by prior administration of either indomethacin or delta 1-THC-7-oic acid, presumably because of their ability to inhibit eicosanoid synthesis." | 1.27 | Cannabinoids and pain responses: a possible role for prostaglandins. ( Burstein, SH; Hull, K; Hunter, SA; Latham, V, 1988) |
| "Indomethacin treatment elevated levels of peptido-LTs, reduced PGE2 levels and inhibited writhing." | 1.27 | Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2. ( Beaver, TH; Borgeat, P; Doherty, NS; Poubelle, P; Schrader, NL; Westrich, GL, 1985) |
| "Bradykinin was injected retrogradely into a branch of the splenic artery of lightly anesthetized dogs, and the reflex hypertensive response was used as an indicator of the nociception." | 1.27 | Potentiation of bradykinin-induced nociceptive response by arachidonate metabolites in dogs. ( Harada, Y; Hori, Y; Katori, M; Tanaka, K; Uchida, Y, 1986) |
| "A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described." | 1.27 | A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. ( Brown, F; Dubner, R; Flores, C; Hargreaves, K; Joris, J, 1988) |
| "Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics had dramatic or complete pain relief after receiving indomethacin suppositories (100 mg) (P less than 0." | 1.27 | Prostaglandin synthetase inhibition with indomethacin rectal suppositories in the treatment of acute and chronic urinary calculus obstruction. ( Al-Waili, NS, 1986) |
| "Indomethacin was the most common preoperative drug and the proportion of its regular use decreased from 47 to 12% (P less than 0." | 1.27 | The influence of total hip replacement on hip pain and the use of analgesics. ( Honkanen, R; Koskenvuo, M; Visuri, T, 1985) |
| "Indomethacin is an effective inhibitor of prostaglandin synthetase and has recently been demonstrated to inhibit inflammatory fluid secretion into the gallbladder in experimental cholecystitis." | 1.26 | Indomethacin intravenously--a new way for effective relief of biliary pain: a double-blind study in man. ( Jansson, R; Svanvik, J; Thornell, E, 1981) |
| "The syndrome of cluster headache variant is characterized by the occurrence of three combined symptoms: atypical cluster headaches, multiple jabs, and background vascular headaches." | 1.26 | Cluster headache variant. Spectrum of a new headache syndrome. ( Diamond, S; Medina, JL, 1981) |
| " Long-term use of analgesic drugs in chronic pain usually produces negative behavioral complications that are more difficult to manage than the pain it was desired to eliminate." | 1.26 | Analgesic drugs in the management of pain. ( Halpern, LM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 173 (40.90) | 18.7374 |
| 1990's | 61 (14.42) | 18.2507 |
| 2000's | 90 (21.28) | 29.6817 |
| 2010's | 84 (19.86) | 24.3611 |
| 2020's | 15 (3.55) | 2.80 |
| Authors | Studies |
|---|---|
| Hagmann, WK | 1 |
| Dorn, CP | 1 |
| Frankshun, RA | 1 |
| O'Grady, LA | 1 |
| Bailey, PJ | 1 |
| Rackham, A | 1 |
| Dougherty, HW | 1 |
| Martin, LL | 1 |
| Setescak, LL | 1 |
| Spaulding, TC | 1 |
| Helsley, GC | 1 |
| Toja, E | 1 |
| Selva, D | 2 |
| Schiatti, P | 2 |
| London, C | 1 |
| Hoyt, SB | 1 |
| Parsons, WH | 1 |
| Williams, BS | 1 |
| Warren, VA | 1 |
| Tschirret-Guth, R | 1 |
| Smith, MM | 1 |
| Priest, BT | 1 |
| McGowan, E | 1 |
| Martin, WJ | 1 |
| Lyons, KA | 1 |
| Li, X | 2 |
| Karanam, BV | 1 |
| Jochnowitz, N | 1 |
| Garcia, ML | 1 |
| Felix, JP | 1 |
| Dean, B | 1 |
| Abbadie, C | 1 |
| Kaczorowski, GJ | 1 |
| Duffy, JL | 1 |
| Aridoss, G | 1 |
| Parthiban, P | 1 |
| Ramachandran, R | 1 |
| Prakash, M | 1 |
| Kabilan, S | 1 |
| Jeong, YT | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Paulino, N | 1 |
| Rodrigues, NC | 1 |
| Pardi, PC | 1 |
| Suárez, JA | 1 |
| dos Santos, RP | 1 |
| Scremin, A | 1 |
| Vogel, C | 1 |
| Feist, H | 1 |
| Michalik, D | 1 |
| Vardanyan, R | 1 |
| Vijay, G | 1 |
| Nichol, GS | 1 |
| Liu, L | 1 |
| Kumarasinghe, I | 1 |
| Davis, P | 1 |
| Vanderah, T | 1 |
| Porreca, F | 1 |
| Lai, J | 1 |
| Hruby, VJ | 1 |
| Le Bourdonnec, B | 1 |
| Windh, RT | 1 |
| Leister, LK | 1 |
| Zhou, QJ | 1 |
| Ajello, CW | 1 |
| Gu, M | 1 |
| Chu, GH | 1 |
| Tuthill, PA | 1 |
| Barker, WM | 1 |
| Koblish, M | 1 |
| Wiant, DD | 1 |
| Graczyk, TM | 1 |
| Belanger, S | 1 |
| Cassel, JA | 1 |
| Feschenko, MS | 1 |
| Brogdon, BL | 1 |
| Smith, SA | 1 |
| Derelanko, MJ | 1 |
| Kutz, S | 1 |
| Little, PJ | 1 |
| DeHaven, RN | 1 |
| DeHaven-Hudkins, DL | 1 |
| Dolle, RE | 1 |
| Maia, RC | 1 |
| Silva, LL | 1 |
| Mazzeu, EF | 1 |
| Fumian, MM | 1 |
| de Rezende, CM | 1 |
| Doriguetto, AC | 1 |
| Corrêa, RS | 1 |
| Miranda, AL | 2 |
| Barreiro, EJ | 5 |
| Fraga, CA | 1 |
| da Silva, YK | 1 |
| Augusto, CV | 1 |
| de Castro Barbosa, ML | 1 |
| de Albuquerque Melo, GM | 1 |
| de Queiroz, AC | 1 |
| de Lima Matos Freire Dias, T | 1 |
| Júnior, WB | 2 |
| Lima, LM | 3 |
| Alexandre-Moreira, MS | 5 |
| de Lima, FO | 2 |
| Nonato, FR | 2 |
| Couto, RD | 2 |
| Barbosa Filho, JM | 1 |
| Nunes, XP | 1 |
| Ribeiro dos Santos, R | 1 |
| Soares, MB | 2 |
| Villarreal, CF | 4 |
| de Oliveira, CM | 1 |
| David, JP | 1 |
| David, JM | 1 |
| Hernández, P | 1 |
| Cabrera, M | 1 |
| Lavaggi, ML | 1 |
| Celano, L | 1 |
| Tiscornia, I | 1 |
| Rodrigues da Costa, T | 1 |
| Thomson, L | 1 |
| Bollati-Fogolín, M | 1 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Mizokami, SS | 2 |
| Arakawa, NS | 2 |
| Ambrosio, SR | 2 |
| Zarpelon, AC | 3 |
| Casagrande, R | 4 |
| Cunha, TM | 1 |
| Ferreira, SH | 6 |
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| Taber, RI | 1 |
| Tabachnick, II | 1 |
| Thistle, HG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded C[NCT04804761] | 20 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | |||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior[NCT03662360] | 32 participants (Actual) | Interventional | 2018-05-20 | Completed | |||
| A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966] | 93 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Neuropsychiatric Inventory - Nursing Home Version (NPI-NH) test will characterize the neuropsychiatric and psychopathological symptoms of patients affected by dementia.~Events as delirium, anxiety, depression, etc. will be recorded by the frequency (from 0, absence, to 4, high frequency) and the seriousness (from 0, absence, to 3, high). The total score of the NPI-NH is given by the frequency x (multiply) seriousness (total score for each event has a range from 0 to 12). The patient final score will be given by the sum of the score of the 12 events. For each patient will be given a total score from 0 to 144.~NPI NH score has been collected in both control and aromatherapy groups at T1 and T3, in patients who needed and who did not needed Pro Re Nata." (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| T1 NPI score in patients do not need Pro Re Nata | T3 NPI score in patients needed Pro Re Nata | T3 NPI score in patients do not need Pro Re Nata | |
| GROUP A - Control Group | 21.81 | 32.87 | 20.00 |
| GROUP B - Aromatherapy Group | 25.93 | 16.5 | 7.25 |
NPI-NH assess the psychological distress in physicians, nurses and nursing assistants who managed the patients. It has a score from 0 (no discomfort) to score of 5 (extreme discomfort). The psychological distress is measured for each of the 12 events in the NPI-NH scale, for a total score from 0 to 60. (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T1 NPI NH physicians in pts with PRN | T1 NPI NH physicians in pts without PRN | T1 NPI NH nurses in pts with PRN | T1 NPI NH nurses in pts without PRN | T1 NPI NH nursing assistants in pts with PRN | T1 NPI NH nursing assistants in pts without PRN | T3 NPI NH physician in pts with PRN | T3 NPI NH physician in pts without PRN | T3 NPI NH nurses in pts with PRN | T3 NPI NH nurses in pts without PRN | T3 NPI NH nursing assistants in pts with PRN | T3 NPI NH nursing assistants in pts without PRN | |
| GROUP A - Control Group | 4.19 | 1.60 | 9.63 | 6.40 | 11.00 | 7.10 | 6.00 | 3.20 | 12.00 | 9.30 | 13.19 | 9.90 |
| GROUP B - Aromatherapy Group | 5.64 | 4.13 | 11.64 | 10.13 | 12.21 | 10.88 | 2.64 | 0.88 | 5.79 | 4.25 | 5.93 | 4.38 |
We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)
| Intervention | units on a scale (Mean) |
|---|---|
| Lavender Oil | 0.89 |
| Placebo | .74 |
19 reviews available for indomethacin and Ache
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Batatasin III, a Constituent of
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dendrobium; Lipopolysaccharides; Mice; Nitric Oxide; | 2022 |
Paroxysmal hemicrania in children and adolescents: A systematic review.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Headache Disorders; Humans; Indomethacin; Infant | 2022 |
Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cesarean Section; Diclofenac; Female; Humans; In | 2023 |
Primary Stabbing Headache.
Topics: Comorbidity; Diagnosis, Differential; Female; Headache Disorders, Primary; Humans; Indomethacin; Mal | 2019 |
Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Cyclooxygenase 2 Inhibitors; Humans; | 2015 |
[Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Stability; Drug Storage; Humans | 2015 |
Effects of indomethacin suppository and lidocaine pomade for the relief of post-episiotomy pain.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Episiotomy; Female; Humans; Indomethaci | 2002 |
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Age | 2003 |
The immune-suppressive effects of pain.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Cyclooxygenase Inhibitors; Fentanyl; Humans; Immune Tolera | 2003 |
Red ear syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ear; Erythema; Female; Humans; Indomethacin; Middle Aged; P | 2007 |
Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development.
Topics: Animals; Animals, Newborn; Behavior, Addictive; Behavior, Animal; Dexamethasone; Female; Humans; Ind | 2008 |
Use of Rimazolium in locomotor diseases.
Topics: Analgesics; Arthritis; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Drug Therapy, Combinati | 1983 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evalu | 1985 |
Modern management of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Couns | 1985 |
Inhibition of prostaglandin biosynthesis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cats; Cattle; Depression, Chemical; Dogs; Fa | 1974 |
Periarticular calcific deposits mimicking acute arthritis.
Topics: Adult; Aged; Arthritis; Calcinosis; Diagnosis, Differential; Female; Foot; Gout; Humans; Hydroxyapat | 1970 |
104 trials available for indomethacin and Ache
| Article | Year |
|---|---|
Effects of an Indomethacin Oral Spray on Pain Due to Oral Mucositis in Cancer Patients Treated With Radiotherapy and Chemotherapy: A Double-Blind, Randomized, Placebo-Controlled Trial (JORTC-PAL04).
Topics: Adult; Double-Blind Method; Head and Neck Neoplasms; Humans; Indomethacin; Oral Sprays; Pain; Qualit | 2021 |
Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.
Topics: Analgesics; Cross-Sectional Studies; Humans; Indomethacin; Japan; Middle Aged; Neoplasms; Pain; Phar | 2021 |
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
Topics: Adult; Aged; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Female; Head an | 2017 |
Desmopressin/indomethacin combination efficacy and safety in renal colic pain management: A randomized placebo controlled trial.
Topics: Adult; Chi-Square Distribution; Deamino Arginine Vasopressin; Double-Blind Method; Drug Combinations | 2019 |
The Effect of Intrauterine Lidocaine and Rectal Indomethacin on Pain during Office Vaginoscopic Hysteroscopy: Randomized Double-Blind Controlled Study.
Topics: Adult; Ambulatory Surgical Procedures; Anesthetics, Local; Double-Blind Method; Endometrial Neoplasm | 2016 |
Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial.
Topics: Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Depression; Female; | 2016 |
Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Doubl | 2016 |
Controlled indomethacin release from mucoadhesive film: in vitro and clinical evaluations.
Topics: Adhesiveness; Adjuvants, Pharmaceutic; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non | 2008 |
In-vitro and clinical evaluation of an oral mucosal adhesive film containing indomethacin.
Topics: Adhesiveness; Administration, Oral; Analgesics; Cellulose; Chemistry, Pharmaceutical; Dosage Forms; | 2008 |
A comparison of low-molecular-weight heparin and combined therapy of low-molecular-weight heparin with an anti-inflammatory agent in the treatment of superficial vein thrombosis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; | 2009 |
Hemicrania continua: a clinical study of 39 patients with diagnostic implications.
Topics: Adult; Aged; Chronic Disease; Cohort Studies; Female; Headache; Humans; Indomethacin; Male; Middle A | 2010 |
The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis.
Topics: Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents, Non-S | 2010 |
Chronotherapeutic drug delivery from indomethacin compression coated tablets for early morning pain associated rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cross-Over Studies; Delayed-A | 2013 |
Efficacy and tolerability of acemetacin, a non-steroidal anti-inflammatory drug, in Mexican patients: result of the ETAPAM Study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Female; Humans; Indomethaci | 2002 |
[The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation].
Topics: Administration, Buccal; Adult; Female; Hematopoietic Stem Cell Transplantation; Humans; Indomethacin | 2003 |
Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial.
Topics: Administration, Oral; Double-Blind Method; Drug Administration Schedule; Etoricoxib; Female; Gout; G | 2004 |
[Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Data Interpretation | 2004 |
Preparation and clinical application of indomethacin gel for medical treatment of stomatitis.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Chemical P | 2005 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans | 2005 |
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 2007 |
[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].
Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Hip Joint; | 1983 |
Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity.
Topics: Adult; Aging; Anti-Inflammatory Agents; Athletic Injuries; Clinical Trials as Topic; Double-Blind Me | 1983 |
A multicentre comparison of piroxicam and indomethacin in acute soft tissue sports injuries.
Topics: Athletic Injuries; Clinical Trials as Topic; Edema; Female; Humans; Indomethacin; Joints; Male; Pain | 1984 |
Indomethacin in the treatment of patients with biliary pain. A controlled clinical study.
Topics: Adult; Aged; Cholelithiasis; Clinical Trials as Topic; Double-Blind Method; Humans; Indomethacin; In | 1983 |
Comparison of diclofenac and indomethacin suppositories in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Tolerance; Hu | 1984 |
[Double-blind parallel clinical trial with tenoxicam in comparison with indomethacin in the treatment of rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; I | 1984 |
A comparative study on the analgesic effects of indomethacin and hydromorphinechloride-atropine in acute, ureteral-stone pain.
Topics: Adult; Analgesics; Atropine; Dihydromorphine; Humans; Indomethacin; Injections, Intravenous; Injecti | 1983 |
A comparison of three ways of measuring pain.
Topics: Acetaminophen; Aged; Apazone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomet | 1982 |
Mechanisms in the development of acute cholecystitis and biliary pain. A study on the role of prostaglandins and effects of indomethacin.
Topics: Acute Disease; Animals; Biliary Tract; Cats; Cholecystitis; Cholelithiasis; Clinical Trials as Topic | 1982 |
Effects of intravenous indomethacin during acute ureteral obstruction. Experimental studies and studies in patients with pain due to ureteral stone obstruction.
Topics: Acute Disease; Animals; Clinical Trials as Topic; Double-Blind Method; Female; Hemodynamics; Humans; | 1981 |
Activity and tolerance of oxamethacin.
Topics: Anti-Inflammatory Agents; Arthritis; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; | 1982 |
Comparative study of piroxicam and indomethacin retard in osteoarthritis.
Topics: Anti-Inflammatory Agents; Delayed-Action Preparations; Female; Half-Life; Humans; Indomethacin; Male | 1983 |
Indoprofen versus indomethacin in acute painful shoulder and other soft-tissue rheumatic complaints.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Indomethacin; Indoprofen; Male; Middle Aged; Pain; | 1982 |
Benoxaprofen--dose-range studies using quantitative thermography.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzoxazoles; Clinical Trials as Topic; Dose-Respon | 1980 |
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indome | 1980 |
Fluproquazone for osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Midd | 1981 |
Naproxen and indomethacin in periarthritis of the shoulder.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Napr | 1982 |
[Controlled double blind comparison of acemetacin to indomethacin in patients with chronic polyarthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Double-Blind Method; | 1980 |
[Clinical results of a double blind study with the new antirheumatic agent acemetacin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis; Double-Blind Method; Drug Evaluation; Female; Huma | 1980 |
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Ind | 1980 |
[Clinical trials with acemetacin on children and adolescents (author's transl)].
Topics: Adolescent; Anti-Inflammatory Agents; Body Temperature; Child; Child, Preschool; Double-Blind Method | 1980 |
Treatment of ureteral and biliary pain with an injectable salt of indomethacin.
Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Female; Humans; Indomethacin; Injections, Intramusc | 1980 |
Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.
Topics: Aged; Aging; Drug Therapy, Combination; Female; Hospitalization; Humans; Indomethacin; Kidney Diseas | 1995 |
Worldwide experience with etodolac (Lodine) 300 mg b.i.d. in the treatment of osteoarthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diclofenac; Double-Blind Me | 1993 |
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.
Topics: Administration, Rectal; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Central Nervous System | 1993 |
Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.
Topics: Adult; Analgesics, Non-Narcotic; Animals; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Dinopros | 1999 |
Evaluation of the analgesic effect of 0.1% indomethacin solution on corneal abrasions.
Topics: Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Corneal Injuries; Eye Injuries; F | 1999 |
The usefulness of walking for preventing sarcopenia in dieting postmenopausal women complaining of knee pain.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Appetite Depressants; Body Composition; Combined Moda | 2000 |
Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; | 2000 |
Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 Weeks' postconceptional Age.
Topics: Blood Specimen Collection; Cohort Studies; Dexamethasone; Electrocardiography; Facial Expression; Fe | 2001 |
Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis.
Topics: Acute Disease; Adult; Aged; Arthritis, Gouty; Cyclooxygenase Inhibitors; Double-Blind Method; Etoric | 2002 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
[4-allyloxy-3-chlorophenyl-acetic acid (alclofenac) in the treatment of painful arthroses in the aged. Double-blind controlled clinical trial].
Topics: Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Joint Diseases; Middl | 1975 |
[Reduction of the effects of indomethacin by aspirin. Value of measurement of the articular index and sigma ESR].
Topics: Adult; Aspirin; Blood Sedimentation; Clinical Trials as Topic; Drug Therapy, Combination; Female; He | 1977 |
[Diclofenac in the treatment of inflammatory and degenerative diseases of the locomotor system].
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Humans; Indomethacin; Inflammati | 1977 |
Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Gait; Humans; Indomethacin; | 1979 |
[Double-blind study on the anti-inflammatory effect of indomethacin after surgical removal of lower wisdom teeth].
Topics: Adult; Body Temperature; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Indom | 1979 |
Indomethacin in the treatment of primary dysmenorrhoea.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Dysmenorrhea; Fem | 1979 |
Indomethacin or prednisolone at night in rheumatoid arthritis?
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; | 1978 |
Azapropazone compared with indomethacin in the treatment of rheumatoid arthritis.
Topics: Acetaminophen; Adult; Aged; Apazone; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Hand; | 1976 |
[Studies on the analgesic effect of meglumine indomethacinate in neoplasms].
Topics: Analgesics; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Meglumine | 1976 |
A six-month double-blind trial of ibuprofen and indomethacin in osteoarthritis.
Topics: Adult; Central Nervous System; Clinical Trials as Topic; Digestive System; Female; Humans; Ibuprofen | 1975 |
Anti-inflammatory and analgetic effects of indomethacin following removal of impacted mandibular third molars.
Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Female; Humans; Indomethacin; Mal | 1975 |
[Methods and statistics of multicentral double-blind "cross-over" examination of naproxen compared to indomethacin].
Topics: Aged; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Hum | 1975 |
[A double blind comparison of naproxen and indomethacin on the after-midnight-pain of patients with morbus bechterew].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Naphthaleneacetic | 1975 |
[Comparative evaluation of the therapeutic efficiency of flurbiprofene in rheumatoid polyarthritis].
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Biphenyl Compounds; Chemical Phenomena; Chemistry; Cl | 1975 |
A comparative study of nabumetone and indomethacin in ankylosing spondylitis.
Topics: Adult; Aged; Butanones; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Nabume | 1991 |
Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Cross-Over Studies; Delayed-Action Preparations; Diclof | 1991 |
A double-blind randomised controlled trial of droxicam versus indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Fe | 1991 |
Comparative double-blind study of droxicam (new NSAID) versus indomethacin in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; D | 1991 |
Piroxicam and indomethacin suppositories for painful coxarthrosis.
Topics: Aged; Female; Humans; Indomethacin; Male; Osteoarthritis, Hip; Pain; Piroxicam; Suppositories; Swede | 1992 |
Effect of short-term indomethacin treatment on the clinical course of acute obstructive cholecystitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Body Temperature; Cholecystitis; Double-B | 1991 |
Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Female; Humans; | 1991 |
Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: a comparative controlled clinical trial in general practice.
Topics: Adult; Aged; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Female; Humans; Indometha | 1990 |
Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of rheumatoid arthritis: a comparative controlled clinical trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Fe | 1990 |
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; Clinical Trials as Topic; Do | 1988 |
Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Female; H | 1988 |
Rectal v. intravenous administration of indomethacin in the treatment of renal colic.
Topics: Adult; Clinical Trials as Topic; Colic; Double-Blind Method; Female; Humans; Indomethacin; Injection | 1988 |
Piroxicam in acute musculoskeletal disorders and sports injuries.
Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Athl | 1988 |
Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.
Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Codeine; Colic; Double-Blind Method; Drug Comb | 1987 |
Indomethacin: effects on cold-induced pain and the nervous system in healthy volunteers.
Topics: Adult; Affect; Central Nervous System; Clinical Trials as Topic; Cold Temperature; Double-Blind Meth | 1987 |
Efficacy of diclofenac in ankylosing spondylitis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Gastrointestinal Dis | 1986 |
[New etiopathologic and therapeutic perspectives in ureteral colic. Evaluation of clinical experience with diclofenac sodium and indomethacin].
Topics: Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Indomethacin; Narcotics; Pain; Pa | 1986 |
Rotator cuff tendinitis: comparison of subacromial injection of a long acting corticosteroid versus oral indomethacin therapy.
Topics: Administration, Oral; Adult; Aged; Female; Follow-Up Studies; Humans; Indomethacin; Injections; Male | 1986 |
Double-dummy comparison of suprofen and indometacin sustained release formulations.
Topics: Aged; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle A | 1986 |
Timing optimizes sustained-release indomethacin treatment of osteoarthritis.
Topics: Adult; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; | 1985 |
Indomethacin reduces raised intraluminal gallbladder pressure in acute cholecystitis.
Topics: Acute Disease; Adult; Aged; Analgesics; Cholecystitis; Clinical Trials as Topic; Female; Gallbladder | 1985 |
Comparison of a slow-release indomethacin tablet and naproxen in osteoarthrosis.
Topics: Adult; Aged; Central Nervous System Diseases; Clinical Trials as Topic; Delayed-Action Preparations; | 1985 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
Pirprofen in postoperative course following cataract extraction: a controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Clinical Trials as Topic; Double-Blind | 1985 |
Flurbiprofen in the treatment of ankylosing spondylitis. A comparison with indomethacin.
Topics: Adolescent; Adult; Drug Evaluation; Female; Flurbiprofen; Humans; Indomethacin; Male; Middle Aged; P | 1986 |
Diclofenac in the treatment of ankylosing spondylitis: review of worldwide clinical experience and report of a double-blind comparison with indomethacin.
Topics: Adolescent; Adult; Aged; Diclofenac; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle | 1985 |
Letter: Indomethacin and bone pain.
Topics: Bone Diseases; Clinical Trials as Topic; Humans; Indomethacin; Joint Diseases; Pain | 1974 |
Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease.
Topics: Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Evaluation; Female; Follow-Up Studies | 1974 |
The use of indomethacin and aloxiprin at night.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Pain; Polymers; Spondylitis, | 1972 |
Pain relief with indomethacin in external otitis.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Edema; Female; Humans; Indomethacin; Inflammation | 1972 |
Treatment of acute pleuritic pain. Comparison between indomethacin and a placebo.
Topics: Analgesia; Clinical Trials as Topic; Cough; Evaluation Studies as Topic; Humans; Indomethacin; Pain; | 1973 |
Double-blind cross-over comparison of indomethacin, flurbiprofen, and placebo in ankylosing spondylitis.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Biphenyl Compounds; Blood Sedimentation; Clinical Tr | 1974 |
A sequential trial of indomethacin and sodium amylobarbitone at night in rheumatoid arthritis, with comments on the statistical method.
Topics: Amobarbital; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Ind | 1974 |
Indomethacin for soft-tissue injuries. A double-blind study in football players.
Topics: Analgesics; Athletic Injuries; Humans; Indomethacin; Inflammation; Male; Pain; Time Factors | 1973 |
Mefenamic acid compared with indomethacin and placebo in osteoarthritis.
Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Diarrhea; Digestion; Duodenal Ulcer; Female; Fol | 1966 |
[Comparative study: Alclofenac vs Indomethacin in the treatment of coxarthrosis].
Topics: Clinical Trials as Topic; Drug Tolerance; Hip Joint; Humans; Indomethacin; Osteoarthritis; Pain; Phe | 1971 |
[Analgic effect of indomethacin suppositories on postoperative pain].
Topics: Adult; Aged; Blood; Carbon Dioxide; Cholecystectomy; Clinical Trials as Topic; Female; Gastrectomy; | 1971 |
Statistical approach to indices of disease activity in rheumatoid arthritis.
Topics: Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Blood Sedimentation; Clinical Trials as Topic; | 1971 |
300 other studies available for indomethacin and Ache
| Article | Year |
|---|---|
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzoxepins; Edema; Gastrointestinal Hemorrhage; Male | 1986 |
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c] [1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Benzoxepins; Butyrates; Edema; Male | 1984 |
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini | 1984 |
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Topics: Analgesics; Animals; Inflammation; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Pain; P | 2008 |
Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents; Bacteria; Drug Evaluation, Pre | 2009 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Cell Line; Cell Survival; Dinoprostone; Ede | 2009 |
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; Indenes; Indoleacetic Ac | 2009 |
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Topics: Analgesics; Animals; Benzamides; Benzopyrans; CHO Cells; Clinical Trials as Topic; Cricetinae; Crice | 2009 |
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Female; Humans; Hydrazones; Male; Mice; Pain; Platele | 2009 |
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Ear; Edema; Female; Freund's Adjuvant; Hyd | 2010 |
Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.
Topics: Analgesics; Animals; Brazil; Dinoprostone; Edema; Freund's Adjuvant; Mice; Models, Animal; Molecular | 2011 |
Antinociceptive properties of bergenin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Dose-Response Relationshi | 2011 |
Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase Inhibitors; Drug Design; Fe | 2012 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kin | 2012 |
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agen | 2012 |
Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzoquinones; Carrageenan; Cyclooxygenase 1; Cycloox | 2013 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cyto | 2013 |
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromones; Cyclooxygenase 1; Cyclooxyge | 2014 |
Conventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Analgesics; Anti-Inflammatory Agents; Carrageenan; Cyclic GMP; Diterpenes; Edema; Freun | 2014 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivatives.
Topics: Aminoquinolines; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Freund's Adjuvant; Male; | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids.
Topics: Analgesics; Animals; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; | 2017 |
Rationally designed benzopyran fused isoxazolidines and derived β
Topics: Amino Alcohols; Analgesics; Animals; Benzopyrans; Cell Line; Chemistry Techniques, Synthetic; Drug D | 2017 |
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2017 |
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Drug D | 2018 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Depression; Drug Discovery; In | 2020 |
Evaluation of the treatment of fever, pain and inflammation with Indigofera suffruticosa Miller Leaves Aqueous Extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Fever; Indigofera; Indomethacin; Inflam | 2022 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics | 2023 |
Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies.
Topics: 3T3 Cells; Analgesics; Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Compoundin | 2020 |
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Edema | 2020 |
Effect of Indomethacin Mouthwash on Pain Due to Chemotherapy-Induced Oral Mucositis.
Topics: Antineoplastic Agents; Humans; Indomethacin; Mouthwashes; Pain; Stomatitis | 2020 |
Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Collag | 2020 |
[Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy].
Topics: Humans; Indomethacin; Mouthwashes; Neoplasms; Pain; Stomatitis | 2020 |
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase | 2018 |
[Recurrence of carotodynia or TIPIC syndrome].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System Diseases; Carotid Artery Di | 2018 |
Egad!
Topics: Aged; Baclofen; Colchicine; Diagnosis, Differential; Female; Gout; Hallux; Hospitalization; Humans; | 2019 |
Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Formaldehyde; Indomethacin; | 2019 |
Synthesis and evaluation of anti-inflammatory and analgesic activities of new 1,2,4-triazole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Hindlimb; Indomethacin; Injection | 2014 |
Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Dose-Re | 2014 |
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro | 2012 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
NSAID-sparing effect of glucosamine hydrochloride in patients with knee osteoarthritis: an analysis of data from a French database.
Topics: Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Databases, Factual; Female; France; Gluco | 2014 |
Anti-nociceptive and anti-inflammatory activities of Wrightia arborea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Disease Models, Animal; Edema; Female; I | 2013 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
In brief: low-dose indomethacin (Tivorbex) for pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Humans; Indomethacin; Pain | 2014 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
Summaries for Patients. Oral Prednisolone in the Treatment of Acute Gout.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Doubl | 2016 |
A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen | 2016 |
Prednisolone was equivalent to indomethacin for pain reduction in acute gout.
Topics: Acute Disease; Gout; Humans; Indomethacin; Pain; Prednisolone | 2016 |
[Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Carrageenan; Indomethacin; Inflammation; Naloxone; Pain | 2016 |
Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; | 2016 |
Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.
Topics: Analgesia; Animals; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Pr | 2016 |
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; A | 2017 |
Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Coordination Complexes; C | 2017 |
A surgical ankle sprain pain model in the rat: effects of morphine and indomethacin.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Ankle Injuries; Anti-Inflammatory Agents, Non-Ste | 2008 |
The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygen | 2008 |
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug I | 2008 |
Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relatio | 2008 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Fre | 2008 |
Anti-inflammatory properties of cryptolepine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St | 2010 |
Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose- | 2009 |
PGE(2)-induced lasting nociception to heat: evidences for a selective involvement of A-delta fibres in the hyperpathic component of hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dimethyl Sulfoxide; Dinoprostone; Hot T | 2010 |
Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum.
Topics: Acetic Acid; Analgesics; Anaphylaxis; Animals; Behavior, Animal; Chromobacterium; Dose-Response Rela | 2010 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bidens; Carrageenan; Chromatography, High Pressure Li | 2010 |
Behavioral and urological evaluation of a testicular pain model.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Indomethacin; Male; Nerve | 2010 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin | 2010 |
Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dose-Response Relationship, Drug; F | 2010 |
Late onset spondyloarthropathy mimicking polymyalgia rheumatica.
Topics: Age of Onset; Anti-Inflammatory Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Diagnos | 2012 |
Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Indo | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
A sarcoidosis patient with hand involvement and large pulmonary lymph nodes: results of 1-year treatment with methotrexate.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Finger Phalanges; Humans; Immunosuppressive | 2013 |
The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo.
Topics: Analgesics; Anemarrhena; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2010 |
Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response | 2010 |
Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, | 2010 |
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach.
Topics: Acetic Acid; Action Potentials; Analgesics; Animals; Behavior, Animal; Biological Assay; Diazepam; E | 2010 |
Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Commiphora; Dinoprosto | 2011 |
Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Dose- | 2011 |
Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cartilage, Articular; Dexamethas | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes.
Topics: Acetic Acid; Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Coordination Complexes; Cryst | 2011 |
Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Chro | 2011 |
Indomethacin uptake into poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) network: In vitro and in vivo controlled release study.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Synthesis of 5,6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents.
Topics: Acetic Acid; Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Antinociceptive and anti-inflammatory activities of crude methanolic extract of red alga Bryothamnion triquetrum.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dipyrone; Female; Indomethacin; Leukocytes; Male; Met | 2012 |
St. John's wort relieves pain in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blotting, Western; Cold Temperat | 2013 |
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Central Nervous S | 2013 |
Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; | 2013 |
Synthesis, antiinflammatory and analgesic activity of new hexahydropyrimidine derivatives.
Topics: Acetic Acid; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; Animals; Ant | 2002 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Camp | 2002 |
Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dipyrone; Drug Synergism; Drug Therap | 2002 |
Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Ulcer Agents; Asteraceae; Diterpenes; Dose-Response Relations | 2002 |
Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Body Temperature; Brain Ischemia; Cooperative | 2003 |
Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Benzodiazepinones; Carrageenan; Dexamethas | 2003 |
Antinociceptive effects of Teucrium polium L total extract and essential oil in mouse writhing test.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Indomethacin; Male; Mice; Mice, I | 2003 |
Conjunctival ulcers in Behçet's disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, | 2003 |
Antinociceptive effect of Phlomis olivieri Benth., Phlomis anisodonta Boiss. and Phlomis persica Boiss. total extracts.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, | 2003 |
Evaluation of chronopharmacodynamics of indomethacin by the kaolin-induced pain model in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Circadian Rhythm; Humans; Indomethacin; Kaolin; Ma | 2003 |
Antinociceptive potency of intrathecal morphine in the rat tail flick test: a comparative study using acute lumbar catheter in rats with or without a chronic atlanto-occipital catheter.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atlanto-Occipital Joint; Catheterization; Dose-Res | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
TREATMENT OF OSTEO-ARTHRITIS OF THE HIP WITH INDOMETHACIN. A CONTROLLED CLINICAL TRIAL.
Topics: Arthritis; Biomedical Research; Geriatrics; Hip; Indoles; Indomethacin; Movement; Osteoarthritis; Pa | 1964 |
NOCICEPTIVE THRESHOLDS AS AFFECTED BY PARENTERAL ADMINISTRATION OF IRRITANTS AND OF VARIOUS ANTINOCICEPTIVE DRUGS.
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Flufenamic Acid; Indoles; | 1965 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship | 2003 |
Non-lateralized pain in a case of chronic paroxysmal hemicrania?
Topics: Adult; Cardiovascular Agents; Cluster Headache; Diagnosis, Differential; Humans; Indomethacin; Male; | 2004 |
Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds.
Topics: Acetates; Administration, Oral; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2004 |
Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthropod Venoms; Dose-Response Relationship, Drug | 2004 |
Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats.
Topics: Acetic Acid; Animals; Calcitonin Gene-Related Peptide; Cardiovascular Agents; Chromogranin A; Chromo | 2004 |
Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test.
Topics: Analgesics; Animals; Cyclohexane Monoterpenes; Cyclohexenes; Disease Models, Animal; Drug Therapy, C | 2004 |
Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat.
Topics: Administration, Oral; Analysis of Variance; Animals; Anthocyanins; Anti-Inflammatory Agents, Non-Ste | 2004 |
Peripheral P2X receptors and nociception: interactions with biogenic amine systems.
Topics: Adenosine Triphosphate; Adrenergic Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2004 |
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Mod | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Development and pharmacological characterization of a rat model of osteoarthritis pain.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models | 2005 |
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyproheptadine; Dipyrone; Edema; Indomethacin; Inje | 2005 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Edema; Indomethacin; Inflammation; Mal | 2005 |
Characteristics of propofol-evoked vascular pain in anaesthetized rats.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Animals; Capsaicin; Cyclooxygenase | 2005 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2005 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An | 2006 |
Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis--a population-based survey.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; | 2006 |
Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats.
Topics: Acetic Acid; Adrenal Glands; Animals; Anti-Inflammatory Agents, Non-Steroidal; Consciousness; Cortic | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; | 2006 |
A novel mechanism involved in 5-hydroxytryptamine-induced nociception: the indirect activation of primary afferents.
Topics: Adrenergic beta-Antagonists; Afferent Pathways; Analysis of Variance; Animals; Anti-Inflammatory Age | 2006 |
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antidepressive | 2006 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Walker 256 tumor-bearing rats as a model to study cancer pain.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethaci | 2007 |
Pathogenesis of spinally mediated hyperalgesia in diabetes.
Topics: Aldehyde Reductase; Animals; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Disease Models, Anim | 2007 |
Analgesic and anti-inflammatory activities of a fraction rich in gaultherin isolated from Gaultheria yunnanensis (FRANCH.) REHDER.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Croton | 2007 |
The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-alpha and PGE2-dependent mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bothrops; Crotalid Venoms | 2007 |
Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2007 |
Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dos | 2008 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions | 2008 |
A novel model of pain sensation using superfused gastrosplenic omentum preparation of anesthetized rats.
Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressu | 2008 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; | 2008 |
Dependence of histamine-evoked nociception on prostaglandin release.
Topics: Animals; Drug Interactions; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indometha | 1981 |
The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs.
Topics: Aminopyrine; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthri | 1984 |
Carotidynia: report of eight cases and prospective evaluation of therapy.
Topics: Adult; Aged; Carotid Artery Diseases; Dihydroergotamine; Female; Flurbiprofen; Humans; Indomethacin; | 1983 |
Effects of indomethacin on pleural pain.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Pain; Palliative Care | 1984 |
Acne fulminans with prolonged polyarthralgia.
Topics: Acne Vulgaris; Adult; HLA Antigens; Humans; Indomethacin; Joint Diseases; Male; Pain; Prednisone | 1980 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relati | 1984 |
[Acemetacin in the treatment of painful arthroses. Results of an open short-term study on the starting point of the analgesic effect and its duration].
Topics: Analgesia; Arthritis; Female; Humans; Indomethacin; Male; Pain; Physical Exertion; Rest; Time Factor | 1984 |
The significance of fluid restriction in indomethacin treatment of pain from ureteral stone.
Topics: Adult; Aged; Female; Humans; Indomethacin; Male; Middle Aged; Osmolar Concentration; Pain; Ureteral | 1983 |
Studies on experimental cholecystitis.
Topics: Animals; Biological Transport; Cats; Cholecystitis; Gallbladder; Indomethacin; Movement; Pain | 1983 |
Analgetic effects of indomethacin (Confortid) compared to Ketogin in patients with acute cholecystitis.
Topics: Acute Disease; Allylamine; Amines; Analgesics; Cholecystitis; Drug Combinations; Female; Humans; Ind | 1983 |
The influence of paracetamol on the anti-inflammatory, the anti-pyretic and the analgesic activity of indomethacin.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Indo | 1983 |
[Indomethacin in renal and gallstones pain].
Topics: Adult; Aged; Cholelithiasis; Female; Humans; Indomethacin; Kidney Calculi; Male; Middle Aged; Pain | 1984 |
Acute calcific retropharyngeal tendinitis: an unusual cause of neck pain.
Topics: Adult; Calcinosis; Humans; Indomethacin; Male; Neck; Pain; Pharyngeal Diseases; Tendinopathy | 1984 |
Control of pain by nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; ortho-Aminobenzoates; Pain; Propionat | 1982 |
[Indomethacin treatment of biliary pain].
Topics: Biliary Tract Diseases; Cholecystitis; Humans; Indomethacin; Pain; Prostaglandins | 1982 |
Hypertrophic osteoarthropathy associated with endometrial carcinoma.
Topics: Aged; Bone and Bones; Female; Humans; Indomethacin; Lung Neoplasms; Osteoarthropathy, Secondary Hype | 1982 |
A case of pre-chronic paroxysmal hemicrania.
Topics: Adult; Chronic Disease; Female; Humans; Indomethacin; Migraine Disorders; Neck; Pain | 1982 |
[Pain caused by herpes zoster].
Topics: Adrenochrome; Antiviral Agents; Carbamazepine; Electrogalvanism, Intraoral; Fluorescein; Fluorescein | 1982 |
[Therapy of acute attacks of gout using acemetacin (author's transl)].
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents; Female; Gout; Humans; Indoleacetic Acids; Indo | 1980 |
[Results of a long-term study with acemetacin in the therapy of patients suffering from rheumatoid arthritis (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Indol | 1980 |
Indomethacin intravenously--a new way for effective relief of biliary pain: a double-blind study in man.
Topics: Adult; Aged; Blood Pressure; Cholelithiasis; Double-Blind Method; Female; Gallbladder; Humans; Indom | 1981 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
Cluster headache variant. Spectrum of a new headache syndrome.
Topics: Adult; Cluster Headache; Female; Humans; Indomethacin; Male; Middle Aged; Pain; Vascular Headaches | 1981 |
Measurement of locomotor activity in hyperalgesic rats as an objective method for testing the antialgesic activity of drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Female; Indomethacin; M | 1981 |
The diagnosis and management of scleritis.
Topics: Eye Diseases; Humans; Indomethacin; Inflammation; Necrosis; Oxyphenbutazone; Pain; Sclera | 1980 |
Inhibition of erythromycin lactobionate-induced writhing by analgesic drugs.
Topics: Analgesics; Animals; Aspirin; Codeine; Dextropropoxyphene; Erythromycin; Indomethacin; Male; Mice; M | 1980 |
The Albury-Wodonga syndrome. A tale of two cities.
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Presc | 1995 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depressio | 1994 |
Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats.
Topics: Animals; Antibodies, Monoclonal; Basal Metabolism; Carrageenan; Disease Models, Animal; Female; Hype | 1995 |
Conditioned place preference paradigm: a novel approach for analgesic drug assessment against chronic pain.
Topics: Analgesics; Animals; Chronic Disease; Conditioning, Operant; Dizocilpine Maleate; Edema; Hot Tempera | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Topics: Abscess; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Gene Expressio | 1994 |
Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene.
Topics: Analgesics; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-S | 1994 |
Expression of c-fos-like protein in the rat brain after injection of interleukin-1-beta into the gingiva.
Topics: Animals; Brain; Dental Pulp; Electric Stimulation; Female; Gingiva; Immunohistochemistry; Indomethac | 1994 |
Mechanical hyperalgesia in streptozotocin-diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylate Cyclase Toxin; Animals; Diabetes Mellit | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Intrathecal acetylsalicylic acid and indomethacin are not analgesic for a supramaximal stimulus.
Topics: Animals; Aspirin; Indomethacin; Injections, Spinal; Pain; Rabbits | 1993 |
Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carra | 1996 |
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine.
Topics: Animals; Behavior, Animal; Carrageenan; Cocaine; Conditioning, Operant; Formaldehyde; Indomethacin; | 1996 |
Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 1996 |
The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia.
Topics: Animals; Cyclooxygenase Inhibitors; Edema; Foot; Freund's Adjuvant; Hyperalgesia; Indomethacin; Isoe | 1997 |
Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 1997 |
A sequential trial of pain killers in arthritis: issues of multiple comparisons with control and of interval-censored survival data.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Computer Simulation; Humans; Indomet | 1997 |
Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation.
Topics: Acetic Acid; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; | 1997 |
Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin2A receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dinoprostone; Foot; Formaldehyde | 1997 |
Central antinociceptive effects of meloxicam on rat spinal cord in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; E | 1998 |
Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats.
Topics: Adrenergic Fibers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Electrophysiology; Female | 1998 |
Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
Topics: Abdomen; Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 1998 |
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; C | 1998 |
Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension.
Topics: Adult; Antiemetics; Atropine; Dilatation; Electromyography; Female; Gastrointestinal Motility; Grani | 1998 |
[Analgesic and anti-inflammatory activity of saponins of Argania spinoza].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Edema; Indomethacin; Mice; Pa | 1998 |
Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice.
Topics: Animals; Bradykinin; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Edema; Formald | 1998 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation.
Topics: Alpha-Globulins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; beta-Endorphin; Beta-G | 1999 |
Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice.
Topics: 6-Ketoprostaglandin F1 alpha; Acetic Acid; Analgesics, Non-Narcotic; Animals; Ascitic Fluid; Dinopro | 1999 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indo | 2000 |
Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Gyrus Cinguli; Indomethacin; Injections, Spinal; Isoenz | 2000 |
Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regula | 2000 |
The formalin test in the mouse: a parametric analysis of scoring properties.
Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Ani | 2000 |
Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides.
Topics: Acetic Acid; Analgesics; Aspirin; Chromatography, Thin Layer; Formaldehyde; Glutamic Acid; Humans; I | 2000 |
Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Disease Models, Animal; E | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |
The role of cyclooxygenase-1 and -2 in the rat formalin test.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; | 2002 |
Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cyclooxygenase 1; Cycl | 2002 |
Analgesic drugs in the management of pain.
Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnot | 1977 |
Plasma cell granulomas in non-lipemic xanthomatosis: apparent induction by indomethacin.
Topics: Aged; Blood Cell Count; Granuloma; Humans; Indomethacin; Male; Pain; Plasma Cells; Skin; Time Factor | 1975 |
Raised plasma kininogen levels in rheumatoid patients-response to therapy with monsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Alpha-Globulins; Arthritis, Rheumatoid; Aspirin; Blood Proteins; Female; Humans; Indome | 1976 |
Convulsions in a breast-fed infant after maternal indomethacin.
Topics: Adult; Breast Feeding; Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Mal | 1978 |
[Stiff back and stiff chest. Sectional findings in ankylosing spondylitis].
Topics: Adult; Aminopyrine; Cardiomegaly; Humans; Hypertension, Pulmonary; Indomethacin; Male; Pain; Spine; | 1977 |
Effects of prostaglandins on peripheral nociceptors in acute inflammation.
Topics: Acute Disease; Animals; Blood Pressure; Bradykinin; Cats; Dogs; Female; Indomethacin; Inflammation; | 1979 |
The pain enhancing effect of PGI2.
Topics: Acetylcholine; Animals; Arachidonic Acids; Blood Pressure; Epoprostenol; Indomethacin; Pain; Prostag | 1979 |
Indomethacin in pleurisy.
Topics: Humans; Indomethacin; Pain; Pleurisy | 1977 |
Prostaglandin F2alpha reduces the algesic effect of bradykinin by antagonizing the pain enhancing action of endogenously released prostaglandin E.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Drug Interactions; Ear; Female; Indomethacin; Ma | 1977 |
Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effect.
Topics: Acetylcholine; Animals; Bradykinin; Denervation; Ear; Indomethacin; Pain; Prostaglandins; Prostaglan | 1976 |
Some pharmacological and toxicological studies on ketoprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indometha | 1976 |
Editorial: Pain relief in minor musculoskeletal disorders.
Topics: Aspirin; Athletic Injuries; Dimethyl Sulfoxide; Humans; Indomethacin; Pain; Sprains and Strains | 1976 |
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Blood Pres | 1992 |
G-protein mediation in nociceptive signal transduction: an investigation into the excitatory action of bradykinin in a subpopulation of cultured rat sensory neurons.
Topics: Alkaloids; Animals; Animals, Newborn; Bradykinin; Cells, Cultured; Evoked Potentials; Ganglia, Spina | 1992 |
The triradiate incision for acetabular fractures. A prospective study of 23 cases.
Topics: Acetabulum; Adolescent; Adult; Aged; Combined Modality Therapy; Female; Fractures, Bone; Gait; Hospi | 1992 |
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
Topics: Animals; Carrageenan; Indomethacin; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Male; | 1992 |
Serotonin is a directly-acting hyperalgesic agent in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hype | 1992 |
Pharmacological profile of UP 5145-52, an original antiulcer and antisecretory agent.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relations | 1991 |
Delayed activation of nociceptors: correlation with delayed pain sensations induced by sustained stimuli.
Topics: Aminoquinolines; Animals; Calcimycin; Electrophysiology; Humans; Indomethacin; Male; Nerve Fibers; N | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; | 1991 |
Clinical experiences in the treatment of pain in rheumatology.
Topics: Adult; Aged; Diclofenac; Female; Humans; Indomethacin; Male; Meclofenamic Acid; Middle Aged; Oxyphen | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary | 1991 |
Antinociceptive and anti-inflammatory activity of a novel quipazine derivative (AAL-13): a selective inhibitor of 5-hydroxytryptamine reuptake.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Indometha | 1990 |
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results].
Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug | 1990 |
Inhibition of interleukin-1 (IL-1) enhanced pain reflexes in the rabbit by CGP 28238.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Dinoprostone; Indans; Indomethacin; In | 1991 |
Effect of indomethacin on unilateral obstructed renal pelvis and on ureteral peristalsis. Experimental study in awake sheep.
Topics: Abdomen; Animals; Consciousness; Constriction, Pathologic; Indomethacin; Kidney Diseases; Kidney Pel | 1990 |
Plasma and cerebrospinal fluid concentrations of indomethacin in humans. Relationship to analgesic activity.
Topics: Adult; Aged; Female; Humans; Indomethacin; Male; Middle Aged; Nerve Compression Syndromes; Pain; Pai | 1990 |
Endothelin-1 participation in overt and inflammatory pain.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endothelins; Indomethacin; Inflammation; Injections | 1989 |
[Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Dextrans; Edema; Gossy | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dex | 1989 |
Involvement of prostaglandins in kaolin-induced writhing reaction in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Analgesics; Animals; Captopril; Epoprostenol; Indomethacin; Kaolin; Ma | 1989 |
Morphine self-administration in the rat during adjuvant-induced arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Indomethacin; Male; Morphine; Pain; Rats; Rats, Inbred | 1989 |
Mechanism of bradykinin-induced nociceptive response.
Topics: Animals; Blood Pressure; Bradykinin; Heart Rate; Indomethacin; Male; Nociceptors; Pain; Rats; Rats, | 1989 |
A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents. I. Kaolin-induced writhing in mice.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Captopril; Drug Synergism; Glycine | 1989 |
The differentiation of NSAIDs and prostaglandin action using a mechanical visceral pain model in the rat.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Re | 1989 |
Inhibition by neuropeptides of interleukin-1 beta-induced, prostaglandin-independent hyperalgesia.
Topics: Animals; Dose-Response Relationship, Drug; Indomethacin; Interleukin-1; Male; Melanocyte-Stimulating | 1989 |
Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses.
Topics: Animals; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Injections, Spinal; | 1988 |
Cannabinoids and pain responses: a possible role for prostaglandins.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dronabinol; Female; Hot Temperature; Hyperalge | 1988 |
Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2.
Topics: Animals; Arachidonate Lipoxygenases; Cell Aggregation; Dinoprostone; In Vitro Techniques; Indomethac | 1985 |
Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; | 1986 |
Potentiation of bradykinin-induced nociceptive response by arachidonate metabolites in dogs.
Topics: Animals; Bradykinin; Dogs; Drug Synergism; Fatty Acids, Unsaturated; Female; Indomethacin; Injection | 1986 |
Indomethacin blocks central nociceptive effects of PGF2 alpha.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Central Nervous System; Dinoprost; Dinoprostone; Indom | 1986 |
[Effect of prostaglandins on metastatic spread after surgical removal of tumors and pain stress in mice].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Indomethacin; Male; Mice; Mice, Inbred C57BL; Neoplasm | 1987 |
The effect of non-steroidal anti-inflammatory therapy on plasma neuropeptide concentrations in patients with osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents; beta-Endorphin; Delayed-Action Preparations; Endorphins; Enkephalin, | 1985 |
Pharmacological studies of lappaconitine. Analgesic activities.
Topics: Aconitine; Aconitum; Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Hot Temperature | 1988 |
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Topics: Animals; Carrageenan; Hot Temperature; Hyperalgesia; Hyperesthesia; Indomethacin; Male; Morphine; Pa | 1988 |
Discharge characteristics of receptors with fine afferents from normal and inflamed joints: influence of analgesics and prostaglandins.
Topics: Action Potentials; Afferent Pathways; Alprostadil; Animals; Arthritis; Aspirin; Cats; Dinoprostone; | 1986 |
[The analgesic and antipyretic effects of a non-steroidal antiinflammatory agent, EB-382, in experimental animals].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Ibuprofen; Indom | 1986 |
Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Indomethacin; Inflammation; Pain; Piroxicam | 1987 |
[Effect of pranoprofen on sodium urate crystal-induced inflammation].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Colchicine; Dogs; Female; | 1987 |
Clinical evaluation of the treatment of osteoarthritic knees using a newly designed wedged insole.
Topics: Adult; Aged; Combined Modality Therapy; Equipment Design; Female; Follow-Up Studies; Gait; Humans; I | 1987 |
Case report 426: Unilateral, rapidly destructive arthropathy of the hip ("analgesic hip").
Topics: Aged; Aged, 80 and over; Female; Hip Joint; Humans; Indomethacin; Osteoarthritis; Pain; Tomography, | 1987 |
Prostaglandin synthetase inhibition with indomethacin rectal suppositories in the treatment of acute and chronic urinary calculus obstruction.
Topics: Adolescent; Adult; Colic; Female; Humans; Indomethacin; Kidney Calculi; Male; Middle Aged; Pain; Sup | 1986 |
The nature of the pain reaction associated with orthodontic tooth movement.
Topics: Bromelains; Chlorpheniramine; Humans; Indomethacin; Orthodontic Appliances; Pain; Periodontium; Stre | 1985 |
The influence of total hip replacement on hip pain and the use of analgesics.
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1985 |
[Analgesic effect of topically applied pranoprofen-gel].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; C | 1985 |
[The anti-inflammatory effect of auranofin].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Auranofin; Aurothiogluco | 1985 |
Flurbiprofen in the treatment of acute gout. A comparison with indomethacin.
Topics: Acute Disease; Arthritis; Drug Evaluation; Flurbiprofen; Gout; Humans; Indomethacin; Pain; Propionat | 1986 |
Effects of morphine and indomethacin on evoked neuronal responses of ventrobasal thalamic neurones: site of action of analgesic drugs in non-adjuvant arthritic rats.
Topics: Animals; Arthritis; Electric Stimulation; Evoked Potentials; Indomethacin; Male; Morphine; Naloxone; | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; | 1985 |
[Use of meglumine indomethacin in the treatment of pain due to neoplastic diseases].
Topics: Adult; Aged; Amino Sugars; Analgesics; Female; Humans; Indomethacin; Male; Middle Aged; Neoplasm Met | 1972 |
Pain in haemophilia.
Topics: Acetaminophen; Analgesics; Hemophilia A; Humans; Indomethacin; Male; Meperidine; Oxyphenbutazone; Pa | 1973 |
Pain in haemophilia.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemophilia A; Humans; Indomethacin; Male; Pain; Phenylbutazone | 1973 |
[Undesired collateral effects of antirheumatic drugs: indomethacin].
Topics: Arthritis, Rheumatoid; Drug Eruptions; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Pa | 1972 |
Ischiogluteal bursitis. The pain in the arse.
Topics: Acute Disease; Blood Cell Count; Bursitis; Buttocks; Cortisone; Diagnosis, Differential; Femoral Ner | 1974 |
Pain in osteoarthrosis.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Cartilage Diseases; Exercise Therapy; Hip; Humans; Im | 1974 |
Antiinflammatory activity and other pharmacological properties of phthalazino(2,3-b)phthalazine-5,12(7H, 14H)-dione (Diftalone).
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Blood Pressure; Diuresis; Drug Ev | 1974 |
Analgesics and other drugs for relief of pain.
Topics: Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Indomethacin; Met | 1973 |
Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint.
Topics: Animals; Blood Pressure; Bradykinin; Dogs; Drug Synergism; Hindlimb; Indomethacin; Joints; Pain; Pro | 1974 |
Analgetic drugs--the mild analgetics.
Topics: Acetaminophen; Acetanilides; Administration, Oral; Analgesics; Aspirin; Codeine; Dextropropoxyphene; | 1972 |
[Indomethacin in combination with anticoagulants in the treatment thrombophlebitis].
Topics: Aged; Anticoagulants; Drug Combinations; Edema; Female; Fever; Humans; Indomethacin; Male; Pain; Thr | 1972 |
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh | 1972 |
Anti-inflammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen).
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Fe | 1971 |
[Assessment of analgesic actions of narcotic antagonists, with special reference to nociception induced by retrograde injection of bradykinin into the carotid artery of rats].
Topics: Acetates; Aminopyrine; Analgesics; Animals; Aspirin; Bradykinin; Carotid Arteries; Chlorpromazine; C | 1971 |
[Anti-inflammatory action of Polfa methindol in experimental studies].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Dermatitis; Female; Freund's Adjuvant; Guinea Pigs; In | 1971 |
Gastrointestinal hemorrhage caused by indomethacin.
Topics: Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Melena; Middle Aged; Osteoarthropathy, Prim | 1969 |
[Treatment of hemorrhoid with Indacin suppository--including experiences in administration after anal operation].
Topics: Anus Diseases; Edema; Hemorrhage; Hemorrhoids; Humans; Indomethacin; Pain; Postoperative Care; Suppo | 1970 |
[Results of comparative clinical examinations of antirheumatics: clofezone, indomethacin, phenylbutazone].
Topics: Amides; Anti-Inflammatory Agents; Ethylamines; Humans; Indomethacin; Inflammation; Pain; Phenols; Ph | 1971 |
Measurement of arthritic pain and effects of analgesics in the adjuvant-treated rat.
Topics: Adjuvants, Immunologic; Aminopyrine; Analgesics; Animals; Arthritis; Aspirin; Female; Hydrocortisone | 1971 |
Kinins and intracranial hemorrhages.
Topics: Animals; Brain; Capillaries; Cerebral Hemorrhage; Escape Reaction; Humans; Indomethacin; Injections, | 1970 |
[Clinical aspecs of the anti-inflammatory drugs in the surgical and orthopedic fields].
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis; Gout; Humans; Indomethacin; Joint Diseases; Mefenam | 1970 |
Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrans; Carrageenan; Cellulose; Dogs; Indomethacin; | 1970 |
Anti-inflammatory and analgesic properties of clonixin (2-(2' methyl-3' chloro anilino) nicotinic acid).
Topics: Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Flufenamic Aci | 1971 |
Neck and shoulder pain: evaluation and conservative management.
Topics: Aspirin; Braces; Bursitis; Cryosurgery; Diagnosis, Differential; Electromyography; Ethyl Chloride; E | 1969 |
[A "test" for the study of the painful action of bradykinin in animals: the "cry-flight" phenomenon in the rabbit].
Topics: Analgesics; Animals; Bradykinin; Cisterna Magna; Indomethacin; Injections; Pain; Rabbits | 1966 |