indomethacin has been researched along with Abortion, Spontaneous in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Excerpt | Relevance | Reference |
---|---|---|
" We found no dose-response effect." | 1.40 | Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions. ( Bilenko, N; Daniel, S; Koren, G; Levy, A; Lunenfeld, E; Ratzon, R, 2014) |
"Pretreatment with indomethacin significantly decreased the proportion of fetal death from 83% to < 25% in mice injected with 10 micrograms of LPS." | 1.29 | Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ( Branch, DW; Dudley, DJ; Edwin, SS; Mitchell, MD; Silver, RM; Simmons, DL; Trautman, MS, 1995) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (25.00) | 18.7374 |
1990's | 4 (33.33) | 18.2507 |
2000's | 1 (8.33) | 29.6817 |
2010's | 4 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Guo, Q | 1 |
Li, J | 1 |
Zhong, L | 1 |
Cai, H | 1 |
Wang, H | 1 |
Yan, H | 1 |
Xia, G | 1 |
Kang, Y | 1 |
Wang, C | 1 |
Roizen, JD | 1 |
Asada, M | 1 |
Tong, M | 1 |
Tai, HH | 1 |
Muglia, LJ | 1 |
Daniel, S | 2 |
Koren, G | 2 |
Lunenfeld, E | 2 |
Bilenko, N | 1 |
Ratzon, R | 1 |
Levy, A | 2 |
Wouters, KA | 1 |
Gianotten, J | 1 |
Bayram, N | 1 |
Doornbos, JP | 1 |
Silver, RM | 1 |
Edwin, SS | 1 |
Trautman, MS | 1 |
Simmons, DL | 1 |
Branch, DW | 1 |
Dudley, DJ | 1 |
Mitchell, MD | 1 |
Clark, DA | 1 |
Banwatt, D | 1 |
Chaouat, G | 1 |
Poyser, NL | 1 |
Walker, FM | 1 |
Bischof, P | 1 |
Kaiser, H | 1 |
Lala, PK | 1 |
Molnár, M | 1 |
Hertelendy, F | 1 |
Frohberg, H | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 189 |
Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1078 |
Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 78 |
Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 303 |
Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 134 |
Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 141 |
Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 42 |
Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 352 |
Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 264 |
Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 668 |
Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1506 |
Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 214 |
Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 26 |
Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 54 |
Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 9 |
Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 23 |
Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 290 |
Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 8 |
Placebo Arm | 21 |
2 reviews available for indomethacin and Abortion, Spontaneous
Article | Year |
---|---|
Interruption of murine pregnancy by activation of antigen-non-specific killer cells in the endometrium with indomethacin, high dose IL-2 or a combination.
Topics: Abortion, Spontaneous; Animals; Drug Synergism; Endometrium; Female; G(M1) Ganglioside; Glycosphingo | 1990 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo | 1970 |
10 other studies available for indomethacin and Abortion, Spontaneous
Article | Year |
---|---|
Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1β derived from periaortic lymph nodes lead to abortion.
Topics: Abortion, Spontaneous; Animals; C-Reactive Protein; Chorionic Villi; Dinoprostone; Extracellular Mat | 2019 |
Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD
Topics: Abortion, Spontaneous; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dinoprostone; Embryo | 2019 |
Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 | 2014 |
NSAIDs and spontaneous abortions - true effect or an indication bias?
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Femal | 2015 |
Term life birth after late abortion of the first twin.
Topics: Abortion, Spontaneous; Adult; Antibiotic Prophylaxis; Clinical Protocols; Female; Gestational Age; H | 2009 |
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide.
Topics: Abortion, Spontaneous; Animals; Bacterial Infections; Decidua; Dose-Response Relationship, Drug; Enz | 1995 |
Effect of prostaglandin synthesis inhibitors on spontaneous and endotoxin-induced abortion in mice.
Topics: Abortion, Spontaneous; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Female; Indomethac | 1993 |
Antiluteolytic effect of the embryo.
Topics: Abortion, Spontaneous; Animals; Corpus Luteum; Embryo, Mammalian; Estradiol; Female; Guinea Pigs; In | 1978 |
[Problems of rheumatism therapy in pregnant women].
Topics: Abortion, Spontaneous; Chloroquine; Female; Gold; Humans; Hyperbilirubinemia; Indomethacin; Penicill | 1978 |
PGF2 alpha and PGE2 binding to rat myometrium during gestation, parturition, and postpartum.
Topics: Abortion, Spontaneous; Animals; Cell Membrane; Dinoprost; Dinoprostone; Female; Indomethacin; Kineti | 1990 |