Page last updated: 2024-10-29

indomethacin and Abortion, Spontaneous

indomethacin has been researched along with Abortion, Spontaneous in 12 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.

Research Excerpts

Excerpt	Relevance	Reference
" We found no dose-response effect."	1.40	Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions. ( Bilenko, N; Daniel, S; Koren, G; Levy, A; Lunenfeld, E; Ratzon, R, 2014)
"Pretreatment with indomethacin significantly decreased the proportion of fetal death from 83% to < 25% in mice injected with 10 micrograms of LPS."	1.29	Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ( Branch, DW; Dudley, DJ; Edwin, SS; Mitchell, MD; Silver, RM; Simmons, DL; Trautman, MS, 1995)

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (25.00)	18.7374
1990's	4 (33.33)	18.2507
2000's	1 (8.33)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Guo, Q	1
Li, J	1
Zhong, L	1
Cai, H	1
Wang, H	1
Yan, H	1
Xia, G	1
Kang, Y	1
Wang, C	1
Roizen, JD	1
Asada, M	1
Tong, M	1
Tai, HH	1
Muglia, LJ	1
Daniel, S	2
Koren, G	2
Lunenfeld, E	2
Bilenko, N	1
Ratzon, R	1
Levy, A	2
Wouters, KA	1
Gianotten, J	1
Bayram, N	1
Doornbos, JP	1
Silver, RM	1
Edwin, SS	1
Trautman, MS	1
Simmons, DL	1
Branch, DW	1
Dudley, DJ	1
Mitchell, MD	1
Clark, DA	1
Banwatt, D	1
Chaouat, G	1
Poyser, NL	1
Walker, FM	1
Bischof, P	1
Kaiser, H	1
Lala, PK	1
Molnár, M	1
Hertelendy, F	1
Frohberg, H	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]				11,976 participants (Actual)	Interventional	2016-03-23	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	189
Placebo Arm	230

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

- Birth weight <2500g (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	1078
Placebo Arm	1153

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

- Birth weight <1500g (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	78
Placebo Arm	101

Fetal Outcome 4 - Incidence of Fetal Loss

- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	303
Placebo Arm	353

Fetal Outcome 5 - Incidence of Spontaneous Abortion

- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	134
Placebo Arm	152

Fetal Outcome 6 - Incidence of All Stillbirth

- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	141
Placebo Arm	166

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	42
Placebo Arm	30

Incidence of Hypertensive Disorders of Pregnancy

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

Intervention	Participants (Count of Participants)
Intervention Arm	352
Placebo Arm	325

Incidence of Perinatal Mortality

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	264
Placebo Arm	309

Incidence of Preterm Birth

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

Intervention	Participants (Count of Participants)
Intervention Arm	668
Placebo Arm	754

Incidence of Small for Gestational Age (SGA)

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	1506
Placebo Arm	1564

Maternal Outcome 1 - Incidence of Vaginal Bleeding

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	214
Placebo Arm	246

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	26
Placebo Arm	25

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	54
Placebo Arm	43

Maternal Outcome 4 - Incidence of Maternal Mortality

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	9
Placebo Arm	12

Maternal Outcome 5 - Incidence of Late Abortion

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	23
Placebo Arm	30

Maternal Outcome 6 - Change in Maternal Hemoglobin

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

Intervention	Participants (Count of Participants)
Intervention Arm	290
Placebo Arm	333

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Intervention	Participants (Count of Participants)
Intervention Arm	8
Placebo Arm	21

Reviews

2 reviews available for indomethacin and Abortion, Spontaneous

Article	Year
Interruption of murine pregnancy by activation of antigen-non-specific killer cells in the endometrium with indomethacin, high dose IL-2 or a combination. Research in immunology, 1990, Volume: 141, Issue:2 Topics: Abortion, Spontaneous; Animals; Drug Synergism; Endometrium; Female; G(M1) Ganglioside; Glycosphingo	1990
[Present position of the toxicology of drugs]. Munchener medizinische Wochenschrift (1950), 1970, Aug-28, Volume: 112, Issue:35 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo	1970

Other Studies

10 other studies available for indomethacin and Abortion, Spontaneous

Article	Year
Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1β derived from periaortic lymph nodes lead to abortion. Molecular human reproduction, 2019, 12-01, Volume: 25, Issue:12 Topics: Abortion, Spontaneous; Animals; C-Reactive Protein; Chorionic Villi; Dinoprostone; Extracellular Mat	2019
Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD Scientific reports, 2019, 11-26, Volume: 9, Issue:1 Topics: Abortion, Spontaneous; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dinoprostone; Embryo	2019
Fetal exposure to nonsteroidal anti-inflammatory drugs and spontaneous abortions. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Mar-18, Volume: 186, Issue:5 Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2	2014
NSAIDs and spontaneous abortions - true effect or an indication bias? British journal of clinical pharmacology, 2015, Volume: 80, Issue:4 Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Femal	2015
Term life birth after late abortion of the first twin. Acta obstetricia et gynecologica Scandinavica, 2009, Volume: 88, Issue:10 Topics: Abortion, Spontaneous; Adult; Antibiotic Prophylaxis; Clinical Protocols; Female; Gestational Age; H	2009
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: Abortion, Spontaneous; Animals; Bacterial Infections; Decidua; Dose-Response Relationship, Drug; Enz	1995
Effect of prostaglandin synthesis inhibitors on spontaneous and endotoxin-induced abortion in mice. Journal of reproductive immunology, 1993, Volume: 24, Issue:1 Topics: Abortion, Spontaneous; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Female; Indomethac	1993
Antiluteolytic effect of the embryo. Ciba Foundation symposium, 1978, Issue:64 Topics: Abortion, Spontaneous; Animals; Corpus Luteum; Embryo, Mammalian; Estradiol; Female; Guinea Pigs; In	1978
[Problems of rheumatism therapy in pregnant women]. Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1978, Volume: 5 Topics: Abortion, Spontaneous; Chloroquine; Female; Gold; Humans; Hyperbilirubinemia; Indomethacin; Penicill	1978
PGF2 alpha and PGE2 binding to rat myometrium during gestation, parturition, and postpartum. The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1 Topics: Abortion, Spontaneous; Animals; Cell Membrane; Dinoprost; Dinoprostone; Female; Indomethacin; Kineti	1990