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indomethacin and Abdominal Aortic Aneurysm

indomethacin has been researched along with Abdominal Aortic Aneurysm in 8 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)."5.51Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019)
"The objective of this study was to trigger the formation of rat abdominal aortic aneurysm by applying calcium chloride periarterially and then to detect the degree of prevention of aneurysm occurrence by oral introduction of indomethacin in some of the rats."3.73Influence of indomethacin in the rat aneurysm model. ( Erdoğan, F; Erkut, B; Karapolat, S; Koçak, H; Unlu, Y, 2006)
"Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)."1.51Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019)
"The rat model of abdominal aortic aneurysm (AAA) is associated with inflammation, destruction of extracellular matrix, and production of both inducible nitric oxide synthase (iNOS) and matrix metalloproteinase-9 (MMP-9)."1.33Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. ( Armstrong, PJ; Carey, DJ; Elmore, JR; Franklin, DP, 2005)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tomida, S1
Aizawa, K1
Nishida, N1
Aoki, H1
Imai, Y1
Nagai, R1
Suzuki, T1
Assar, AN1
Armstrong, PJ1
Franklin, DP1
Carey, DJ1
Elmore, JR1
Karapolat, S1
Unlu, Y1
Erkut, B1
Koçak, H1
Erdoğan, F1
Holmes, DR1
Petrinec, D1
Wester, W2
Thompson, RW1
Reilly, JM2
Miralles, M1
Sicard, GA1
Thompson, R1
Franklin, IJ2
Walton, LJ2
Greenhalgh, RM2
Powell, JT2
Bayston, T1
Brown, LC1
Taylor, GW1

Reviews

1 review available for indomethacin and Abdominal Aortic Aneurysm

ArticleYear
Medical treatment of small abdominal aortic aneurysm.
    The Journal of cardiovascular surgery, 2012, Volume: 53, Issue:4

    Topics: Aortic Aneurysm, Abdominal; Cardiovascular Agents; Disease Progression; Doxycycline; Humans; Hydroxy

2012

Other Studies

7 other studies available for indomethacin and Abdominal Aortic Aneurysm

ArticleYear
Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model.
    Scientific reports, 2019, 07-24, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aort

2019
Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors.
    Annals of vascular surgery, 2005, Volume: 19, Issue:2

    Topics: Amidines; Animals; Aortic Aneurysm, Abdominal; Benzylamines; Blotting, Western; Cyclooxygenase Inhib

2005
Influence of indomethacin in the rat aneurysm model.
    Annals of vascular surgery, 2006, Volume: 20, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Ane

2006
Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat.
    The Journal of surgical research, 1996, Volume: 63, Issue:1

    Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagenases; Gelatinases; Indomethacin; Infl

1996
Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase.
    Journal of vascular surgery, 1999, Volume: 29, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Collagenases; Cyclooxy

1999
The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 1999, Volume: 18, Issue:1

    Topics: Aorta, Abdominal; Aortic Aneurysm, Abdominal; Culture Techniques; Cyclooxygenase 2; Cyclooxygenase 2

1999
Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.
    Circulation, 1999, Jul-06, Volume: 100, Issue:1

    Topics: Adolescent; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Apoptosis; Ce

1999