indomethacin has been researched along with Abdominal Aortic Aneurysm in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)." | 5.51 | Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019) |
| "The objective of this study was to trigger the formation of rat abdominal aortic aneurysm by applying calcium chloride periarterially and then to detect the degree of prevention of aneurysm occurrence by oral introduction of indomethacin in some of the rats." | 3.73 | Influence of indomethacin in the rat aneurysm model. ( Erdoğan, F; Erkut, B; Karapolat, S; Koçak, H; Unlu, Y, 2006) |
| "Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)." | 1.51 | Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019) |
| "The rat model of abdominal aortic aneurysm (AAA) is associated with inflammation, destruction of extracellular matrix, and production of both inducible nitric oxide synthase (iNOS) and matrix metalloproteinase-9 (MMP-9)." | 1.33 | Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. ( Armstrong, PJ; Carey, DJ; Elmore, JR; Franklin, DP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomida, S | 1 |
| Aizawa, K | 1 |
| Nishida, N | 1 |
| Aoki, H | 1 |
| Imai, Y | 1 |
| Nagai, R | 1 |
| Suzuki, T | 1 |
| Assar, AN | 1 |
| Armstrong, PJ | 1 |
| Franklin, DP | 1 |
| Carey, DJ | 1 |
| Elmore, JR | 1 |
| Karapolat, S | 1 |
| Unlu, Y | 1 |
| Erkut, B | 1 |
| Koçak, H | 1 |
| Erdoğan, F | 1 |
| Holmes, DR | 1 |
| Petrinec, D | 1 |
| Wester, W | 2 |
| Thompson, RW | 1 |
| Reilly, JM | 2 |
| Miralles, M | 1 |
| Sicard, GA | 1 |
| Thompson, R | 1 |
| Franklin, IJ | 2 |
| Walton, LJ | 2 |
| Greenhalgh, RM | 2 |
| Powell, JT | 2 |
| Bayston, T | 1 |
| Brown, LC | 1 |
| Taylor, GW | 1 |
1 review available for indomethacin and Abdominal Aortic Aneurysm
| Article | Year |
|---|---|
Medical treatment of small abdominal aortic aneurysm.
Topics: Aortic Aneurysm, Abdominal; Cardiovascular Agents; Disease Progression; Doxycycline; Humans; Hydroxy | 2012 |
7 other studies available for indomethacin and Abdominal Aortic Aneurysm
| Article | Year |
|---|---|
Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aort | 2019 |
Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors.
Topics: Amidines; Animals; Aortic Aneurysm, Abdominal; Benzylamines; Blotting, Western; Cyclooxygenase Inhib | 2005 |
Influence of indomethacin in the rat aneurysm model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Ane | 2006 |
Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagenases; Gelatinases; Indomethacin; Infl | 1996 |
Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Collagenases; Cyclooxy | 1999 |
The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta.
Topics: Aorta, Abdominal; Aortic Aneurysm, Abdominal; Culture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 | 1999 |
Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.
Topics: Adolescent; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Apoptosis; Ce | 1999 |