indoleacetic acid has been researched along with Uremia in 34 studies
indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841
auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").
indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Differentiated rhabdomyosarcoma cells were pre-treated with the uremic toxins for seven days, and then the cells were treated with pravastatin or simvastatin." | 3.80 | Uremic toxins enhance statin-induced cytotoxicity in differentiated human rhabdomyosarcoma cells. ( Furukubo, T; Izumi, S; Minegaki, T; Nishiguchi, K; Oda, T; Ogino, H; Shinmoto, T; Tachiki, H; Tsujimoto, M; Uchiyama, H; Yamakawa, T; Yoshida, T, 2014) |
| "Thus, progression of chronic renal failure may be promoted by PAI-1 up-regulation induced by uremic toxins." | 1.32 | Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. ( Hosokawa, A; Motojima, M; Muraki, T; Yamato, H; Yoshioka, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (17.65) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 18 (52.94) | 24.3611 |
| 2020's | 6 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Vial, R | 1 |
| Poitevin, S | 2 |
| McKay, N | 1 |
| Burtey, S | 3 |
| Cerini, C | 3 |
| Nerusu, A | 1 |
| Vaikuntapu, PR | 1 |
| Chinthapalli, DK | 1 |
| Podile, AR | 1 |
| Subramanyam, R | 1 |
| Olivier, V | 1 |
| Dunyach-Remy, C | 1 |
| Corbeau, P | 1 |
| Cristol, JP | 1 |
| Sutra, T | 1 |
| Lavigne, JP | 1 |
| Moranne, O | 1 |
| Salarolli, RT | 1 |
| Alvarenga, L | 1 |
| Cardozo, LFMF | 1 |
| Teixeira, KTR | 1 |
| de S G Moreira, L | 1 |
| Lima, JD | 1 |
| Rodrigues, SD | 1 |
| Nakao, LS | 1 |
| Fouque, D | 2 |
| Mafra, D | 2 |
| Yamamoto, S | 2 |
| Sasahara, K | 1 |
| Domon, M | 1 |
| Yamaguchi, K | 1 |
| Ito, T | 1 |
| Goto, S | 2 |
| Goto, Y | 1 |
| Narita, I | 2 |
| Nishi, K | 1 |
| Sakurama, K | 1 |
| Watanabe, H | 1 |
| Maruyama, T | 1 |
| Yamasaki, K | 1 |
| Otagiri, M | 3 |
| Brito, JS | 1 |
| Borges, NA | 1 |
| Esgalhado, M | 1 |
| Magliano, DC | 1 |
| Soulage, CO | 1 |
| Deltombe, O | 3 |
| de Loor, H | 1 |
| Glorieux, G | 6 |
| Dhondt, A | 3 |
| Van Biesen, W | 3 |
| Meijers, B | 1 |
| Eloot, S | 5 |
| Sato, M | 1 |
| Sato, Y | 1 |
| Wakamatsu, T | 1 |
| Takahashi, Y | 1 |
| Iguchi, A | 1 |
| Omori, K | 1 |
| Suzuki, Y | 1 |
| Ei, I | 1 |
| Kaneko, Y | 1 |
| Kazama, JJ | 1 |
| Gejyo, F | 1 |
| Chinnappa, S | 1 |
| Tu, YK | 1 |
| Yeh, YC | 1 |
| Vanholder, R | 4 |
| Mooney, A | 1 |
| Lopes, RCSO | 1 |
| Theodoro, JMV | 1 |
| da Silva, BP | 1 |
| Queiroz, VAV | 1 |
| de Castro Moreira, ME | 1 |
| Mantovani, HC | 1 |
| Hermsdorff, HH | 1 |
| Martino, HSD | 1 |
| Lin, YT | 1 |
| Wu, PH | 1 |
| Lee, HH | 1 |
| Mubanga, M | 1 |
| Chen, CS | 1 |
| Kuo, MC | 1 |
| Chiu, YW | 1 |
| Kuo, PL | 1 |
| Hwang, SJ | 1 |
| Bennis, Y | 1 |
| Cluet, Y | 1 |
| Titeca-Beauport, D | 1 |
| El Esper, N | 1 |
| Ureña, P | 1 |
| Bodeau, S | 1 |
| Combe, C | 1 |
| Dussol, B | 2 |
| Choukroun, G | 1 |
| Liabeuf, S | 2 |
| Marzouki, S | 1 |
| Masereeuw, R | 1 |
| Schneditz, D | 1 |
| Neirynck, N | 1 |
| Dou, L | 2 |
| Sallée, M | 1 |
| Gondouin, B | 2 |
| Jourde-Chiche, N | 2 |
| Fallague, K | 1 |
| Brunet, P | 2 |
| Calaf, R | 2 |
| Mallet, B | 1 |
| Dignat-George, F | 2 |
| Uchiyama, H | 1 |
| Tsujimoto, M | 1 |
| Shinmoto, T | 1 |
| Ogino, H | 1 |
| Oda, T | 1 |
| Yoshida, T | 1 |
| Furukubo, T | 1 |
| Izumi, S | 1 |
| Yamakawa, T | 1 |
| Tachiki, H | 1 |
| Minegaki, T | 1 |
| Nishiguchi, K | 1 |
| Massy, Z | 1 |
| Gao, C | 1 |
| Ji, S | 1 |
| Dong, W | 1 |
| Qi, Y | 1 |
| Song, W | 1 |
| Cui, D | 1 |
| Shi, J | 1 |
| Liu, H | 1 |
| Narayanan, R | 1 |
| Hoffmann, M | 1 |
| Surapaneni, S | 1 |
| Villain, C | 1 |
| Massy, ZA | 1 |
| Génovésio, C | 1 |
| Verhaeghe, P | 1 |
| Bergé-Lefranc, D | 1 |
| Morange, S | 1 |
| Argilés, A | 1 |
| Rathelot, P | 1 |
| Charpiot, P | 1 |
| Chitalia, VC | 1 |
| Shivanna, S | 1 |
| Martorell, J | 1 |
| Balcells, M | 1 |
| Bosch, I | 1 |
| Kolandaivelu, K | 1 |
| Edelman, ER | 1 |
| Boelaert, J | 1 |
| Lynen, F | 1 |
| Van Landschoot, M | 1 |
| Waterloos, MA | 1 |
| Sandra, P | 1 |
| Motojima, M | 1 |
| Hosokawa, A | 1 |
| Yamato, H | 1 |
| Muraki, T | 1 |
| Yoshioka, T | 1 |
| Deguchi, T | 1 |
| Isozaki, K | 1 |
| Yousuke, K | 1 |
| Terasaki, T | 1 |
| Davilas, A | 1 |
| Koupparis, M | 1 |
| Macheras, P | 1 |
| Valsami, G | 1 |
| Sakai, T | 1 |
| Takadate, A | 1 |
| Mabuchi, H | 4 |
| Nakahashi, H | 4 |
| Schoots, AC | 1 |
| Dijkstra, JB | 1 |
| Ringoir, SM | 1 |
| Cramers, CA | 1 |
| Barnett, AL | 1 |
| Veening, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of Medium Cut-off Dialyzer Membrane and Diet Modification to Alleviate Residual Uremic Syndrome of Dialysis Patients[NCT04247867] | 50 participants (Anticipated) | Interventional | 2020-08-31 | Recruiting | |||
| The Effect of Combining Medium Cut Off Polyarylethersulfone-polyvinylpyrrolidone Dialysis Membrane and Diet Modification on Reducing of Inflammation Response[NCT04260412] | 50 participants (Anticipated) | Interventional | 2020-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indoleacetic acid and Uremia
| Article | Year |
|---|---|
Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins.
Topics: Animals; Cardiovascular Diseases; Glucuronates; Humans; Indican; Indoleacetic Acids; Indoles; Models | 2017 |
Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
Topics: Animals; Cardiovascular Diseases; Cresols; Humans; Indican; Indoleacetic Acids; Proteins; Renal Insu | 2016 |
4 trials available for indoleacetic acid and Uremia
| Article | Year |
|---|---|
Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study.
Topics: Adult; Aged; Cresols; Curcumin; Dietary Supplements; Double-Blind Method; Female; Gastrointestinal M | 2021 |
Adsorption of Protein-Bound Uremic Toxins Through Direct Hemoperfusion With Hexadecyl-Immobilized Cellulose Beads in Patients Undergoing Hemodialysis.
Topics: Adsorption; Aged; Blood Proteins; Cellulose; Cresols; Feasibility Studies; Female; Hemoperfusion; Hu | 2018 |
Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.
Topics: Aged; Bifidobacterium longum; Biomarkers; Brazil; Cresols; Female; Gastrointestinal Microbiome; Huma | 2019 |
The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Topics: Adsorption; Aged; Chelating Agents; Cresols; Double-Blind Method; Female; Gastrointestinal Tract; Hu | 2019 |
28 other studies available for indoleacetic acid and Uremia
| Article | Year |
|---|---|
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Ve | 2022 |
Truncated domains of human serum albumin improves the binding efficiency of uremic toxins: A surface plasmon resonance and computational approach.
Topics: Dialysis Solutions; Hippurates; Humans; Indoleacetic Acids; Melatonin; Molecular Docking Simulation; | 2020 |
Factors of microinflammation in non-diabetic chronic kidney disease: a pilot study.
Topics: Bacterial Translocation; Biomarkers; C-Reactive Protein; Female; Gastrointestinal Microbiome; Humans | 2020 |
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.
Topics: Calorimetry; Circular Dichroism; Cresols; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic | 2021 |
Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin.
Topics: Antipsychotic Agents; Aripiprazole; Binding Sites; Cresols; Humans; Indican; Indoleacetic Acids; Ole | 2021 |
Exploring binding characteristics and the related competition of different protein-bound uremic toxins.
Topics: Binding, Competitive; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Hippurate | 2017 |
Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease.
Topics: Adult; Arterial Pressure; Cardiac Output; Cresols; Exercise; Glucuronides; Heart Diseases; Heart Rat | 2018 |
Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis.
Topics: Aged; Biomarkers; Blood-Brain Barrier; Brain; Capillary Permeability; Cognition; Cognitive Dysfuncti | 2019 |
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes.
Topics: Biological Transport; Cresols; Erythrocytes; Hippurates; Humans; Indican; Indoleacetic Acids; Protei | 2019 |
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; F | 2013 |
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; F | 2013 |
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; F | 2013 |
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; F | 2013 |
The cardiovascular effect of the uremic solute indole-3 acetic acid.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cyclooxygenase 2; Endothelium, Vascular; Fe | 2015 |
Uremic toxins enhance statin-induced cytotoxicity in differentiated human rhabdomyosarcoma cells.
Topics: Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Survival; Drug Synergism; Furans; Hippurates | 2014 |
Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis.
Topics: Aged; Aged, 80 and over; Cresols; Cross-Sectional Studies; Female; Glucuronides; Hippurates; Humans; | 2015 |
Indolic uremic solutes enhance procoagulant activity of red blood cells through phosphatidylserine exposure and microparticle release.
Topics: Anticoagulants; Blood Coagulation; Calcium; Cell-Derived Microparticles; Cytosol; Erythrocytes; Fact | 2015 |
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Topics: Adult; Aged; Cells, Cultured; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Hep | 2016 |
Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay.
Topics: Aged; Chromatography, High Pressure Liquid; Cresols; Female; Humans; Indican; Indoleacetic Acids; Ki | 2011 |
Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor.
Topics: Adult; Aged; Cell Line; Coronary Vessels; Endothelium, Vascular; Female; Humans; In Vitro Techniques | 2013 |
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients.
Topics: Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Female | 2013 |
Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.
Topics: Anions; Cells, Cultured; Free Radicals; Gene Expression; Humans; Indican; Indoleacetic Acids; Kidney | 2003 |
Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Female; Furans; Hippurates; Indoleacetic | 2006 |
In-vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion-probe technique.
Topics: Algorithms; Animals; Binding, Competitive; Blood Proteins; Calibration; Diflunisal; Hippurates; Huma | 2006 |
Characterization of binding site of uremic toxins on human serum albumin.
Topics: Binding Sites; Dansyl Compounds; Furans; Hippurates; Humans; Indoleacetic Acids; Indoles; Propionate | 1995 |
Profiling of endogenous ligand solutes that bind to serum proteins in sera of patients with uremia.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Hippurates; Hot Temperature; Humans; Indican; | 1986 |
Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.
Topics: Animals; Cattle; Dinitrochlorobenzene; Furans; Glutathione Transferase; Humans; Indican; Indoleaceti | 1988 |
Displacement by anionic drugs of endogenous ligands bound to albumin in uremic serum.
Topics: Binding Sites; Furans; Hippurates; Humans; Indican; Indoleacetic Acids; Propionates; Protein Binding | 1988 |
Are the classical markers sufficient to describe uremic solute accumulation in dialyzed patients? Hippurates reconsidered.
Topics: Chromatography, High Pressure Liquid; Creatinine; Hippurates; Humans; Hypoxanthine; Hypoxanthines; I | 1988 |
Determination of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, a major endogenous ligand substance in uremic serum, by high-performance liquid chromatography with ultraviolet detection.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Furans; Humans; Indoleacetic Acids; Male; | 1987 |
Liquid-chromatographic study of fluorescent compounds in hemodialysate solutions.
Topics: Chromatography, High Pressure Liquid; Humans; Indican; Indoleacetic Acids; Renal Dialysis; Solutions | 1985 |