indoleacetic acid has been researched along with Renal Insufficiency, Chronic in 28 studies
indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841
auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").
indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adults with chronic kidney disease (CKD) exhibit alterations in tryptophan metabolism, mainly via the kynurenine pathway, due to higher enzymatic activity induced mainly by inflammation." | 7.83 | Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study. ( Davies, N; Hilder, EF; Jose, MD; Karu, N; McKercher, C; Nichols, DS; Shellie, RA, 2016) |
| "Adults with chronic kidney disease (CKD) exhibit alterations in tryptophan metabolism, mainly via the kynurenine pathway, due to higher enzymatic activity induced mainly by inflammation." | 3.83 | Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study. ( Davies, N; Hilder, EF; Jose, MD; Karu, N; McKercher, C; Nichols, DS; Shellie, RA, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (60.71) | 24.3611 |
| 2020's | 9 (32.14) | 2.80 |
| Authors | Studies |
|---|---|
| Steenbeke, M | 1 |
| Valkenburg, S | 1 |
| Gryp, T | 2 |
| Van Biesen, W | 4 |
| Delanghe, JR | 1 |
| Speeckaert, MM | 1 |
| Glorieux, G | 9 |
| Cernaro, V | 1 |
| Calabrese, V | 1 |
| Loddo, S | 1 |
| Corsaro, R | 1 |
| Macaione, V | 1 |
| Ferlazzo, VT | 1 |
| Cigala, RM | 1 |
| Crea, F | 1 |
| De Stefano, C | 1 |
| Gembillo, G | 1 |
| Romeo, A | 1 |
| Longhitano, E | 1 |
| Santoro, D | 1 |
| Buemi, M | 1 |
| Benvenga, S | 1 |
| Vial, R | 1 |
| Poitevin, S | 4 |
| McKay, N | 3 |
| Burtey, S | 6 |
| Cerini, C | 4 |
| Paats, J | 1 |
| Adoberg, A | 1 |
| Arund, J | 1 |
| Dhondt, A | 3 |
| Fernström, A | 1 |
| Fridolin, I | 1 |
| Leis, L | 1 |
| Luman, M | 1 |
| Gonzalez-Parra, E | 1 |
| Perez-Gomez, VM | 1 |
| Pilt, K | 1 |
| Sanchez-Ospina, D | 1 |
| Segelmark, M | 1 |
| Uhlin, F | 1 |
| Arduan Ortiz, A | 1 |
| Huys, GRB | 1 |
| Joossens, M | 1 |
| Vaneechoutte, M | 1 |
| Liabeuf, S | 3 |
| Laville, SM | 1 |
| Cheddani, L | 1 |
| Brazier, F | 1 |
| Titeca Beauport, D | 1 |
| Valholder, R | 1 |
| Choukroun, G | 2 |
| Massy, ZA | 2 |
| Olivier, V | 1 |
| Dunyach-Remy, C | 1 |
| Corbeau, P | 1 |
| Cristol, JP | 1 |
| Sutra, T | 1 |
| Lavigne, JP | 1 |
| Moranne, O | 1 |
| Liu, JR | 1 |
| Miao, H | 1 |
| Deng, DQ | 1 |
| Vaziri, ND | 1 |
| Li, P | 1 |
| Zhao, YY | 1 |
| Yamamoto, S | 1 |
| Sasahara, K | 1 |
| Domon, M | 1 |
| Yamaguchi, K | 1 |
| Ito, T | 1 |
| Goto, S | 1 |
| Goto, Y | 1 |
| Narita, I | 1 |
| Brito, JS | 1 |
| Borges, NA | 1 |
| Esgalhado, M | 1 |
| Magliano, DC | 1 |
| Soulage, CO | 1 |
| Mafra, D | 2 |
| Deltombe, O | 3 |
| de Loor, H | 1 |
| Meijers, B | 1 |
| Eloot, S | 4 |
| Bataille, S | 1 |
| Pelletier, M | 1 |
| Sallée, M | 3 |
| Berland, Y | 1 |
| Duval, A | 1 |
| Gentile, S | 1 |
| Mouelhi, Y | 1 |
| Brunet, P | 4 |
| Black, AP | 1 |
| Anjos, JS | 1 |
| Cardozo, L | 1 |
| Carmo, FL | 1 |
| Dolenga, CJ | 1 |
| Nakao, LS | 1 |
| de Carvalho Ferreira, D | 1 |
| Rosado, A | 1 |
| Carraro Eduardo, JC | 1 |
| Addi, T | 1 |
| El Mecherfi, KE | 1 |
| Kheroua, O | 1 |
| Jourde-Chiche, N | 3 |
| de Macedo, A | 1 |
| Gondouin, B | 3 |
| Dignat-George, F | 3 |
| Dou, L | 3 |
| Chinnappa, S | 1 |
| Tu, YK | 1 |
| Yeh, YC | 1 |
| Vanholder, R | 3 |
| Mooney, A | 1 |
| Lopes, RCSO | 1 |
| Theodoro, JMV | 1 |
| da Silva, BP | 1 |
| Queiroz, VAV | 1 |
| de Castro Moreira, ME | 1 |
| Mantovani, HC | 1 |
| Hermsdorff, HH | 1 |
| Martino, HSD | 1 |
| Bennis, Y | 1 |
| Cluet, Y | 1 |
| Titeca-Beauport, D | 1 |
| El Esper, N | 1 |
| Ureña, P | 1 |
| Bodeau, S | 1 |
| Combe, C | 1 |
| Dussol, B | 2 |
| Fouque, D | 1 |
| Marzouki, S | 1 |
| Masereeuw, R | 1 |
| Schneditz, D | 1 |
| Duval-Sabatier, A | 1 |
| Pletinck, A | 1 |
| Calaf, R | 2 |
| Lacroix, R | 1 |
| Arnaud, L | 1 |
| Fallague, K | 1 |
| Mallet, B | 1 |
| Massy, Z | 1 |
| Liu, H | 1 |
| Narayanan, R | 1 |
| Hoffmann, M | 1 |
| Surapaneni, S | 1 |
| Ichimura, Y | 1 |
| Takamatsu, H | 1 |
| Ideuchi, H | 1 |
| Oda, M | 1 |
| Takeda, K | 1 |
| Saitoh, H | 1 |
| Villain, C | 1 |
| Karu, N | 1 |
| McKercher, C | 1 |
| Nichols, DS | 1 |
| Davies, N | 1 |
| Shellie, RA | 1 |
| Hilder, EF | 1 |
| Jose, MD | 1 |
| Boelaert, J | 1 |
| Lynen, F | 1 |
| Van Landschoot, M | 1 |
| Waterloos, MA | 1 |
| Sandra, P | 1 |
| AMERIO, A | 2 |
| MICELLI, O | 2 |
3 reviews available for indoleacetic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation.
Topics: Biological Products; Cytochrome P-450 CYP2E1; Gastrointestinal Microbiome; Humans; Indoleacetic Acid | 2021 |
Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins.
Topics: Animals; Cardiovascular Diseases; Glucuronates; Humans; Indican; Indoleacetic Acids; Indoles; Models | 2017 |
Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
Topics: Animals; Cardiovascular Diseases; Cresols; Humans; Indican; Indoleacetic Acids; Proteins; Renal Insu | 2016 |
2 trials available for indoleacetic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.
Topics: Aged; Bifidobacterium longum; Biomarkers; Brazil; Cresols; Female; Gastrointestinal Microbiome; Huma | 2019 |
The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Topics: Adsorption; Aged; Chelating Agents; Cresols; Double-Blind Method; Female; Gastrointestinal Tract; Hu | 2019 |
23 other studies available for indoleacetic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease.
Topics: Butyric Acid; Cohort Studies; Dysbiosis; Feces; Gastrointestinal Microbiome; Humans; Indoleacetic Ac | 2021 |
Indole-3-acetic acid correlates with monocyte-to-high-density lipoprotein (HDL) ratio (MHR) in chronic kidney disease patients.
Topics: Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Female; Humans; Indoleacetic Acids; Lipoprote | 2022 |
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Ve | 2022 |
Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients.
Topics: Adult; Aged; Aged, 80 and over; Female; Hemodiafiltration; Humans; Indican; Indoleacetic Acids; Kidn | 2020 |
Isolation and Quantification of Uremic Toxin Precursor-Generating Gut Bacteria in Chronic Kidney Disease Patients.
Topics: Amino Acids, Aromatic; Bacteria; Cresols; Feces; Gastrointestinal Microbiome; Humans; Indican; Indol | 2020 |
Difference in Profiles of the Gut-Derived Tryptophan Metabolite Indole Acetic Acid between Transplanted and Non-Transplanted Patients with Chronic Kidney Disease.
Topics: Adult; Aged; Biomarkers; Female; Glomerular Filtration Rate; Graft Survival; Humans; Indoleacetic Ac | 2020 |
Factors of microinflammation in non-diabetic chronic kidney disease: a pilot study.
Topics: Bacterial Translocation; Biomarkers; C-Reactive Protein; Female; Gastrointestinal Microbiome; Humans | 2020 |
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.
Topics: Calorimetry; Circular Dichroism; Cresols; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic | 2021 |
Exploring binding characteristics and the related competition of different protein-bound uremic toxins.
Topics: Binding, Competitive; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Hippurate | 2017 |
Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients.
Topics: Aged; Aged, 80 and over; Anemia; Biomarkers; Cross-Sectional Studies; Female; Humans; Indican; Indol | 2017 |
Does Low-Protein Diet Influence the Uremic Toxin Serum Levels From the Gut Microbiota in Nondialysis Chronic Kidney Disease Patients?
Topics: Adult; Aged; Cresols; Diet, Protein-Restricted; Feces; Female; Gastrointestinal Microbiome; Humans; | 2018 |
Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells.
Topics: Adult; Aged; Aged, 80 and over; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Femal | 2019 |
Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease.
Topics: Adult; Arterial Pressure; Cardiac Output; Cresols; Exercise; Glucuronides; Heart Diseases; Heart Rat | 2018 |
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes.
Topics: Biological Transport; Cresols; Erythrocytes; Hippurates; Humans; Indican; Indoleacetic Acids; Protei | 2019 |
Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway.
Topics: Adult; Aged; Aged, 80 and over; Benzoquinones; Case-Control Studies; Cells, Cultured; Dioxins; Endot | 2013 |
The cardiovascular effect of the uremic solute indole-3 acetic acid.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cyclooxygenase 2; Endothelium, Vascular; Fe | 2015 |
Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis.
Topics: Aged; Aged, 80 and over; Cresols; Cross-Sectional Studies; Female; Glucuronides; Hippurates; Humans; | 2015 |
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Topics: Adult; Aged; Cells, Cultured; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Hep | 2016 |
Correlations between Plasma Levels of Anionic Uremic Toxins and Clinical Parameters in Hemodialysis Patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Glomerular Fil | 2016 |
Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study.
Topics: Aged; Aged, 80 and over; Anxiety; Biomarkers; Cognition; Cross-Sectional Studies; Depression; Female | 2016 |
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients.
Topics: Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Female | 2013 |
[The urinary excretion of 5-hydroxyindolacetic acid in normal humans and in patients with chronic kidney diseases. I. Determination by a biochemical method].
Topics: Hydroxyindoleacetic Acid; Indoleacetic Acids; Kidney Diseases; Renal Insufficiency, Chronic | 1958 |
[The urinary excretion of 5-hydroxyindolacetic acid in normal humans and in patients with chronic kidney diseases. II. Chromatographic determination].
Topics: Chromatography; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kidney Diseases; Renal Insufficiency, | 1958 |