indole has been researched along with Neoplasms in 20 studies
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α)." | 6.58 | Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer. ( Barreto, FS; Chaves Filho, AJM; de Araújo, MCCR; de Lucena, DF; de Moraes, MEA; de Moraes, MO; Macedo, DS; Maes, M, 2018) |
| "Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly represented by cryptolepine, isocryptolepine, and neocryptolepine." | 5.22 | Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids. ( Bharate, SB; Mudududdla, R; Nuthakki, VK, 2022) |
| "Human cancer cells have been demonstrated to be inhibited by indoles in the development of new anticancer medicines." | 3.01 | Recent Developments in the Synthesis and Anticancer Activity of Indole and Its Derivatives. ( Kaur, B; Kumar, D; Sahu, SK; Sharma, A; Venugopal, S; Verma, A; Wadhwa, P, 2023) |
| "Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α)." | 2.58 | Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer. ( Barreto, FS; Chaves Filho, AJM; de Araújo, MCCR; de Lucena, DF; de Moraes, MEA; de Moraes, MO; Macedo, DS; Maes, M, 2018) |
| "As indole nucleus is a central component of many natural and synthetic molecules with extensive biological activity, this review incorporates a variety of such hybrid compounds with indole moiety as one of the active units, where better therapeutic effect has been successfully achieved, by either simultaneous or sequential action of individual functional pharmacore." | 2.55 | Multi-Target Directed Indole Based Hybrid Molecules in Cancer Therapy : An Up-To-Date Evidence-Based Review. ( Kamath, PR; Sunil, D, 2017) |
| "The indole ring system is an essential part of several tubulin inhibitors identified in the recent years." | 2.53 | Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015). ( Beaman, KD; Patil, R; Patil, SA, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nuthakki, VK | 1 |
| Mudududdla, R | 1 |
| Bharate, SB | 1 |
| Kaur, B | 1 |
| Venugopal, S | 1 |
| Verma, A | 1 |
| Sahu, SK | 1 |
| Wadhwa, P | 1 |
| Kumar, D | 1 |
| Sharma, A | 1 |
| Wan, Y | 1 |
| Li, Y | 1 |
| Yan, C | 1 |
| Yan, M | 1 |
| Tang, Z | 1 |
| D'Amore, C | 1 |
| Moro, E | 1 |
| Borgo, C | 1 |
| Itami, K | 1 |
| Hirota, T | 1 |
| Pinna, LA | 1 |
| Salvi, M | 1 |
| Devi, N | 1 |
| Kaur, K | 1 |
| Biharee, A | 1 |
| Jaitak, V | 1 |
| Barreto, FS | 1 |
| Chaves Filho, AJM | 1 |
| de Araújo, MCCR | 1 |
| de Moraes, MO | 1 |
| de Moraes, MEA | 1 |
| Maes, M | 1 |
| de Lucena, DF | 1 |
| Macedo, DS | 1 |
| Patil, R | 1 |
| Patil, SA | 2 |
| Beaman, KD | 1 |
| Sunil, D | 1 |
| Kamath, PR | 1 |
| Andreani, A | 1 |
| Burnelli, S | 1 |
| Granaiola, M | 1 |
| Leoni, A | 1 |
| Locatelli, A | 1 |
| Morigi, R | 1 |
| Rambaldi, M | 1 |
| Varoli, L | 1 |
| Landi, L | 1 |
| Prata, C | 1 |
| Berridge, MV | 1 |
| Grasso, C | 1 |
| Fiebig, HH | 1 |
| Kelter, G | 1 |
| Burger, AM | 1 |
| Kunkel, MW | 1 |
| Geng, L | 1 |
| Rachakonda, G | 1 |
| Morré, DJ | 1 |
| Morré, DM | 1 |
| Crooks, PA | 1 |
| Sonar, VN | 1 |
| Roti, JL | 1 |
| Rogers, BE | 1 |
| Greco, S | 1 |
| Ye, F | 1 |
| Salleng, KJ | 1 |
| Sasi, S | 1 |
| Freeman, ML | 1 |
| Sekhar, KR | 1 |
| Riechert-Krause, F | 1 |
| Eick, A | 1 |
| Grünert, R | 1 |
| Bednarski, PJ | 1 |
| Weisz, K | 1 |
| Barraja, P | 1 |
| Caracausi, L | 1 |
| Diana, P | 1 |
| Spanò, V | 1 |
| Montalbano, A | 1 |
| Carbone, A | 1 |
| Parrino, B | 1 |
| Cirrincione, G | 1 |
| PARRI, W | 1 |
| MORTON, RA | 1 |
| FAHMY, I | 1 |
| OYASU, R | 1 |
| MILLER, DA | 1 |
| McDONALD, JH | 1 |
| HASS, GM | 1 |
| DE CLERCQM, M | 1 |
| TRUHAUT, R | 1 |
| ZHAROVA, EI | 1 |
| PROTASOVA, TG | 1 |
| KHRUSTALEV, SA | 1 |
| PREOBRAZHENSKAIA, MN | 1 |
| SUVOROV, NN | 1 |
| RAUSHENBAKH, MO | 1 |
| Shinohara, K | 1 |
| Bando, T | 1 |
| Sasaki, S | 1 |
| Sakakibara, Y | 1 |
| Minoshima, M | 1 |
| Sugiyama, H | 1 |
| Singh, P | 1 |
| Kaur, P | 1 |
| Luxami, V | 1 |
| Kaur, S | 1 |
| Kumar, S | 1 |
| James, DA | 1 |
| Koya, K | 1 |
| Li, H | 1 |
| Liang, G | 1 |
| Xia, Z | 1 |
| Ying, W | 1 |
| Wu, Y | 1 |
| Sun, L | 1 |
7 reviews available for indole and Neoplasms
| Article | Year |
|---|---|
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Topics: Alkaloids; Antimalarials; Antineoplastic Agents; Cell Proliferation; Indoles; Malaria; Molecular Str | 2022 |
Recent Developments in the Synthesis and Anticancer Activity of Indole and Its Derivatives.
Topics: Antineoplastic Agents; Heterocyclic Compounds; Humans; Indoles; Neoplasms | 2023 |
Indole: A privileged scaffold for the design of anti-cancer agents.
Topics: Antineoplastic Agents; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Myeloid Cell | 2019 |
Recent Development in Indole Derivatives as Anticancer Agent: A Mechanistic Approach.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Drug Screening Assays, Antitumor; | 2021 |
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.
Topics: Animals; Depression; Depressive Disorder; Humans; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; In | 2018 |
Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015).
Topics: Antineoplastic Agents; Drug Discovery; Humans; Indoles; Molecular Conformation; Neoplasms; Polymeriz | 2016 |
Multi-Target Directed Indole Based Hybrid Molecules in Cancer Therapy : An Up-To-Date Evidence-Based Review.
Topics: Animals; Antineoplastic Agents; Humans; Indoles; Molecular Structure; Neoplasms | 2017 |
13 other studies available for indole and Neoplasms
| Article | Year |
|---|---|
"Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms.
Topics: Casein Kinase II; Cell Death; CRISPR-Cas Systems; Gene Editing; Hep G2 Cells; Humans; Indoles; Neopl | 2020 |
Antitumor activity of bis-indole derivatives.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Indoles; Molecular Structure; | 2008 |
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
Topics: Cell Movement; Cell Shape; Cells, Cultured; Drug Evaluation, Preclinical; Endothelial Cells; Endothe | 2009 |
In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Circular Dichroism; DNA; Drug Screening Assays, Antitumor; | 2011 |
Synthesis and antiproliferative activity of the ring system [1,2]oxazolo[4,5-g]indole.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Human | 2012 |
[Clarifications on a reaction for determining indole pigments in urine].
Topics: Body Fluids; Indoles; Neoplasms | 1957 |
Idole-3-alde-hyde from tissues.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Aldehydes; Humans; Indoles; Neoplasms; Pancreas; Spleen | 1958 |
Neoplasms of rat urinary bladder and liver. Rats fed 2-acety-laminofluorene and indole.
Topics: Animals; Carcinogens; Indoles; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; Rats; Urinary Bl | 1963 |
[RESEARCH ON TRYPTOPHAN METABOLISM IN THE RAT SUBJECTED TO CHRONIC COTININE POISONING. STUDY OF URINARY ELIMINATION AND DETERMINATION OF CERTAIN INDOLE DERIVATIVES IN THE BRAIN AND INTESTINES].
Topics: Brain; Cotinine; Indoleacetic Acids; Indoles; Intestines; Metabolism; Neoplasms; Neoplasms, Experime | 1963 |
[LEUKEMOGENIC (BLASTOMOGENIC) PROPERTIES OF SOME COMPOUNDS OF THE INDOLE SERIES. 2].
Topics: Carcinogens; Humans; Indoles; Leukemia; Neoplasms; Toxicology | 1965 |
Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker.
Topics: Adenine; Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Cy | 2006 |
Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Molecu | 2007 |
Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.
Topics: Amides; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette T | 2008 |