indole has been researched along with Friedreich Ataxia in 2 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iškauskienė, M | 1 |
| Kadlecová, A | 1 |
| Voller, J | 1 |
| Janovská, L | 1 |
| Malinauskienė, V | 1 |
| Žukauskaitė, A | 1 |
| Šačkus, A | 1 |
| FISCHL, J | 1 |
| RABIAH, S | 1 |
2 other studies available for indole and Friedreich Ataxia
| Article | Year |
|---|---|
Synthesis of 5-[(1H-indol-3-yl)methyl]-1,3,4-oxadiazole-2(3H)-thiones and their protective activity against oxidative stress.
Topics: Acetates; Animals; Antioxidants; Caenorhabditis elegans; Cells, Cultured; Friedreich Ataxia; Humans; | 2021 |
DETERMINATION OF FREE AND TOTAL INDOLE-3-ACETIC ACID AND OF THE INDOLE INDEX.
Topics: Friedreich Ataxia; Humans; Indoleacetic Acids; Indoles; Intestines; Kynurenine; Metabolism; Myotonia | 1964 |