indole has been researched along with Disease Models, Animal in 17 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azaindole-1 treatment resulted in a decreased immunoreactivity for phospho-myosin phosphatase target subunit 1 and proliferating cell nuclear antigen in pulmonary vessels of MCT-injected rats, suggesting an impaired ROCK activity and reduced proliferating cells." | 5.36 | Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. ( Dahal, BK; Ghofrani, HA; Grimminger, F; Kast, R; Kosanovic, D; Lai, YJ; Pamarthi, PK; Schermuly, RT; Schirok, H; Seeger, W; Stasch, JP; Sydykov, A; Weissmann, N, 2010) |
| "Formation of amyloid plaques has been induced in a rat model of AD, after what the two compounds were given to experimental groups." | 2.78 | Indole and trans-chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds. ( Dezfulian, M; Ebrahim-Habibi, A; Haeri-Rohani, A; Kheirbakhsh, R; Larijani, B; Yaghmaei, P, 2013) |
| "Azaindole-1 treatment resulted in a decreased immunoreactivity for phospho-myosin phosphatase target subunit 1 and proliferating cell nuclear antigen in pulmonary vessels of MCT-injected rats, suggesting an impaired ROCK activity and reduced proliferating cells." | 1.36 | Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. ( Dahal, BK; Ghofrani, HA; Grimminger, F; Kast, R; Kosanovic, D; Lai, YJ; Pamarthi, PK; Schermuly, RT; Schirok, H; Seeger, W; Stasch, JP; Sydykov, A; Weissmann, N, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lei, H | 2 |
| Cao, Z | 2 |
| Wu, H | 1 |
| Li, T | 1 |
| Wang, X | 1 |
| Chen, Y | 1 |
| Ma, E | 1 |
| Sun, L | 1 |
| Zhai, X | 1 |
| Yang, CY | 1 |
| Chen, TW | 1 |
| Lu, WL | 1 |
| Liang, SS | 1 |
| Huang, HD | 1 |
| Tseng, CP | 1 |
| Tarng, DC | 1 |
| Chen, G | 1 |
| Shi, Z | 1 |
| Chen, C | 1 |
| Yuan, P | 1 |
| Wu, F | 1 |
| Liu, C | 1 |
| Dong, M | 1 |
| Song, Y | 1 |
| Zhou, J | 1 |
| Lu, Y | 1 |
| Zhang, L | 1 |
| Puccetti, M | 1 |
| Pariano, M | 1 |
| Renga, G | 1 |
| Santarelli, I | 1 |
| D'Onofrio, F | 1 |
| Bellet, MM | 1 |
| Stincardini, C | 1 |
| Bartoli, A | 1 |
| Costantini, C | 1 |
| Romani, L | 1 |
| Ricci, M | 1 |
| Giovagnoli, S | 1 |
| Farahat, AA | 1 |
| Ismail, MA | 1 |
| Kumar, A | 1 |
| Wenzler, T | 1 |
| Brun, R | 1 |
| Paul, A | 1 |
| Wilson, WD | 1 |
| Boykin, DW | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Yu, J | 1 |
| Wang, Y | 1 |
| Lu, J | 1 |
| Shang, EX | 1 |
| Zhu, Z | 1 |
| Guo, J | 1 |
| Duan, J | 1 |
| Yaghmaei, P | 1 |
| Kheirbakhsh, R | 1 |
| Dezfulian, M | 1 |
| Haeri-Rohani, A | 1 |
| Larijani, B | 1 |
| Ebrahim-Habibi, A | 1 |
| Özdemir, A | 1 |
| Altintop, MD | 1 |
| Turan-Zitouni, G | 1 |
| Çiftçi, GA | 1 |
| Ertorun, İ | 1 |
| Alataş, Ö | 1 |
| Kaplancikli, ZA | 1 |
| Anraku, M | 1 |
| Iohara, D | 1 |
| Wada, K | 1 |
| Taguchi, K | 1 |
| Maruyama, T | 1 |
| Otagiri, M | 1 |
| Uekama, K | 1 |
| Hirayama, F | 1 |
| Whitfield-Cargile, CM | 1 |
| Cohen, ND | 1 |
| Chapkin, RS | 1 |
| Weeks, BR | 1 |
| Davidson, LA | 1 |
| Goldsby, JS | 1 |
| Hunt, CL | 1 |
| Steinmeyer, SH | 1 |
| Menon, R | 1 |
| Suchodolski, JS | 1 |
| Jayaraman, A | 1 |
| Alaniz, RC | 1 |
| Li, H | 1 |
| Fan, S | 1 |
| Cheng, J | 1 |
| Zhang, P | 1 |
| Zhong, B | 1 |
| Shi, W | 1 |
| Devlin, AS | 1 |
| Marcobal, A | 1 |
| Dodd, D | 1 |
| Nayfach, S | 1 |
| Plummer, N | 1 |
| Meyer, T | 1 |
| Pollard, KS | 1 |
| Sonnenburg, JL | 1 |
| Fischbach, MA | 1 |
| Palm, F | 1 |
| Nangaku, M | 1 |
| Fasching, A | 1 |
| Tanaka, T | 1 |
| Nordquist, L | 1 |
| Hansell, P | 1 |
| Kawakami, T | 1 |
| Nishijima, F | 1 |
| Fujita, T | 1 |
| Dahal, BK | 1 |
| Kosanovic, D | 1 |
| Pamarthi, PK | 1 |
| Sydykov, A | 1 |
| Lai, YJ | 1 |
| Kast, R | 1 |
| Schirok, H | 1 |
| Stasch, JP | 1 |
| Ghofrani, HA | 1 |
| Weissmann, N | 1 |
| Grimminger, F | 1 |
| Seeger, W | 1 |
| Schermuly, RT | 1 |
| Manning, DD | 1 |
| Cioffi, CL | 1 |
| Usyatinsky, A | 1 |
| Fitzpatrick, K | 1 |
| Masih, L | 1 |
| Guo, C | 1 |
| Zhang, Z | 1 |
| Choo, SH | 1 |
| Sikkander, MI | 1 |
| Ryan, KN | 1 |
| Naginskaya, J | 1 |
| Hassler, C | 1 |
| Dobritsa, S | 1 |
| Wierschke, JD | 1 |
| Earley, WG | 1 |
| Butler, AS | 1 |
| Brady, CA | 1 |
| Barnes, NM | 1 |
| Cohen, ML | 1 |
| Guzzo, PR | 1 |
| Valladares, R | 1 |
| Bojilova, L | 1 |
| Potts, AH | 1 |
| Cameron, E | 1 |
| Gardner, C | 1 |
| Lorca, G | 1 |
| Gonzalez, CF | 1 |
1 trial available for indole and Disease Models, Animal
| Article | Year |
|---|---|
Indole and trans-chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds.
Topics: Amyloid beta-Peptides; Animals; Antipsychotic Agents; Avoidance Learning; CA1 Region, Hippocampal; C | 2013 |
16 other studies available for indole and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Indoles; Mice; Mice, Inbr | 2022 |
Synbiotics Alleviate the Gut Indole Load and Dysbiosis in Chronic Kidney Disease.
Topics: Adenine; Aged; Animals; Bacteria; Biodiversity; Body Weight; Diet; Disease Models, Animal; Dysbiosis | 2021 |
Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model.
Topics: Animals; Antineoplastic Agents; Cecum; Cell Line, Tumor; Disease Models, Animal; Fatty Acids, Volati | 2021 |
Targeted Drug Delivery Technologies Potentiate the Overall Therapeutic Efficacy of an Indole Derivative in a Mouse Cystic Fibrosis Setting.
Topics: Administration, Inhalation; Aerosols; Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conduc | 2021 |
Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity.
Topics: Animals; Benzimidazoles; Cell Survival; Disease Models, Animal; Indoles; Mice; Parasitic Sensitivity | 2018 |
Disorder of gut amino acids metabolism during CKD progression is related with gut microbiota dysbiosis and metagenome change.
Topics: Amino Acids; Animals; Bacteria; Bacterial Physiological Phenomena; Cresols; Disease Models, Animal; | 2018 |
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.
Topics: Animals; Cell Survival; Chalcones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2015 |
Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antioxidants; beta-Cyclodextrins; Biomarkers; Blood Urea | 2016 |
The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Biota; Disease | 2016 |
Synthesis and Evaluation of Novel α-Aminoamides Containing an Indole Moiety for the Treatment of Neuropathic Pain.
Topics: Amides; Analgesics; Animals; Disease Models, Animal; Drug Design; Humans; Indoles; Inhibitory Concen | 2016 |
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
Topics: Animal Feed; Animals; Bacteria; Bacteroides; Diet; Disease Models, Animal; Disease Progression; Gast | 2016 |
Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.
Topics: Acetophenones; Animals; Carbon; Cell Hypoxia; Disease Models, Animal; Disease Progression; Enzyme In | 2010 |
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
Topics: Animals; Azabicyclo Compounds; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Hemody | 2010 |
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Topics: Animals; Cell Line; Disease Models, Animal; Humans; Imidazoles; Indoles; Irritable Bowel Syndrome; M | 2011 |
Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxyg | 2013 |