indole-3-carbinol has been researched along with Precancerous Conditions in 13 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male Sprague-Dawley rats were treated orally with indole-3-carbinol (13C) for 7 wk at levels of 150, 100, and 50 mg/kg body weight." | 3.71 | Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats. ( Exon, JH; Hendrix, K; Magnuson, BA; South, EH, 2001) |
| "In C33A cervical cancer cells, DIM was more potent than I3C [dose at which the number of viable cells was 50% of that in untreated cultures (LD(50)) = 50-60 micromol/L for DIM and 200 micromol/L for I3C in a mitochondrial function assay] and faster acting." | 1.31 | Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. ( Auborn, KJ; Carter, TH; Chen, DZ; Qi, M, 2001) |
| " Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF)." | 1.30 | Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. ( Dashwood, RH; Xu, M, 1999) |
| " In Experiment 2, a total of 45 female SD rats were dosed with DEN (100 mg/kg, i." | 1.29 | Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. ( Ahn, B; Bae, JH; Han, BS; Jang, JJ; Kim, DJ; Lee, KK, 1994) |
| "The high incidence of endometrial cancer in this strain of rats might be related to increased estrogen/progesterone ratio with aging." | 1.29 | Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. ( Kojima, T; Mori, H; Tanaka, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimamoto, K | 1 |
| Dewa, Y | 1 |
| Ishii, Y | 1 |
| Kemmochi, S | 1 |
| Taniai, E | 1 |
| Hayashi, H | 1 |
| Imaoka, M | 1 |
| Morita, R | 1 |
| Kuwata, K | 1 |
| Suzuki, K | 1 |
| Shibutani, M | 1 |
| Mitsumori, K | 1 |
| Stanley, M | 1 |
| Shukla, Y | 1 |
| Kalra, N | 1 |
| Katiyar, S | 1 |
| Siddiqui, IA | 1 |
| Arora, A | 1 |
| Kim, DJ | 1 |
| Lee, KK | 1 |
| Han, BS | 1 |
| Ahn, B | 1 |
| Bae, JH | 1 |
| Jang, JJ | 1 |
| Kojima, T | 3 |
| Tanaka, T | 3 |
| Mori, H | 3 |
| Xu, M | 2 |
| Bailey, AC | 1 |
| Hernaez, JF | 1 |
| Taoka, CR | 1 |
| Schut, HA | 1 |
| Dashwood, RH | 2 |
| Manson, MM | 1 |
| Hudson, EA | 1 |
| Ball, HW | 1 |
| Barrett, MC | 1 |
| Clark, HL | 1 |
| Judah, DJ | 1 |
| Verschoyle, RD | 1 |
| Neal, GE | 1 |
| Bell, MC | 1 |
| Crowley-Nowick, P | 1 |
| Bradlow, HL | 1 |
| Sepkovic, DW | 1 |
| Schmidt-Grimminger, D | 1 |
| Howell, P | 1 |
| Mayeaux, EJ | 1 |
| Tucker, A | 1 |
| Turbat-Herrera, EA | 1 |
| Mathis, JM | 1 |
| Exon, JH | 1 |
| South, EH | 1 |
| Magnuson, BA | 1 |
| Hendrix, K | 1 |
| Chen, DZ | 1 |
| Qi, M | 1 |
| Auborn, KJ | 1 |
| Carter, TH | 1 |
| Morishita, Y | 2 |
| Mori, Y | 1 |
| Hara, A | 1 |
| Ohno, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)[NCT02483624] | Phase 1 | 6 participants (Actual) | Interventional | 2016-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indole-3-carbinol and Precancerous Conditions
| Article | Year |
|---|---|
Chapter 17: Genital human papillomavirus infections--current and prospective therapies.
Topics: Adjuvants, Immunologic; Anticarcinogenic Agents; Antiviral Agents; Anus Neoplasms; Cancer Vaccines; | 2003 |
1 trial available for indole-3-carbinol and Precancerous Conditions
| Article | Year |
|---|---|
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.
Topics: Administration, Oral; Anticarcinogenic Agents; DNA, Viral; Dose-Response Relationship, Drug; Female; | 2000 |
11 other studies available for indole-3-carbinol and Precancerous Conditions
| Article | Year |
|---|---|
Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Carcinogens; Deoxyguanosine; Diethylnitrosamine; | 2011 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; g | 2004 |
Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Enzyme Inducti | 1994 |
Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Diet; Endometrial Neoplasms; Estradiol; Female; Hy | 1994 |
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cy | 1996 |
Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers.
Topics: Aflatoxin B1; Aldehyde Reductase; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; | 1998 |
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Chlorophyllides; Colon; Colonic Neoplasms; | 1999 |
Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers; Body Weight; Carcinogens; Cell Division; | 2001 |
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; DNA Fragmentati | 2001 |
Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoma, Sq | 1992 |
Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats.
Topics: Animals; Diethylnitrosamine; DNA; Glucosinolates; Indoles; Liver Neoplasms, Experimental; Male; Prec | 1990 |