indole-3-carbinol has been researched along with Melanoma in 7 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer-derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound." | 7.85 | 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. ( Aryana, S; Firestone, GL; Khouri, MG; Kundu, A, 2017) |
| "Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as in vivo in tumor xenografted athymic nude mice." | 7.85 | Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation. ( Firestone, GL; Khouri, MG; Kundu, A; Quirit, JG, 2017) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 7.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| "Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor protein in the antiproliferative response induced by the chemopreventative agent indole-3-carbinol (I3C), a natural indolecarbinol compound derived from the breakdown of glucobrassicin produced in cruciferous vegetables such as broccoli and Brussels sprouts." | 7.80 | The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. ( Aronchik, I; Firestone, GL; Kundu, A; Quirit, JG, 2014) |
| "We investigated the mechanism of indole-3-carbinol (13C)/ultraviolet B (UVB)-induced apoptosis using SK-MEL-2 and SK-MEL-5 human melanoma cells." | 7.77 | Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF. ( Jeong, YM; Kim, SY; Kima, DS; Kwon, SB; Moon, SI; Park, KC, 2011) |
| "Indole-3-carbinol (I3C) has been found to act against several types of cancer, while ultraviolet B (UVB) is known to induce the apoptosis of human melanoma cells." | 7.73 | Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. ( Jeong, YM; Kim, DS; Kim, SY; Kwon, SB; Moon, SI; Park, ES; Park, KC; Youn, SW, 2006) |
| "1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer-derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound." | 3.85 | 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. ( Aryana, S; Firestone, GL; Khouri, MG; Kundu, A, 2017) |
| "Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as in vivo in tumor xenografted athymic nude mice." | 3.85 | Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation. ( Firestone, GL; Khouri, MG; Kundu, A; Quirit, JG, 2017) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 3.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| "Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor protein in the antiproliferative response induced by the chemopreventative agent indole-3-carbinol (I3C), a natural indolecarbinol compound derived from the breakdown of glucobrassicin produced in cruciferous vegetables such as broccoli and Brussels sprouts." | 3.80 | The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. ( Aronchik, I; Firestone, GL; Kundu, A; Quirit, JG, 2014) |
| "We investigated the mechanism of indole-3-carbinol (13C)/ultraviolet B (UVB)-induced apoptosis using SK-MEL-2 and SK-MEL-5 human melanoma cells." | 3.77 | Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF. ( Jeong, YM; Kim, SY; Kima, DS; Kwon, SB; Moon, SI; Park, KC, 2011) |
| "Indole-3-carbinol (I3C) has been found to act against several types of cancer, while ultraviolet B (UVB) is known to induce the apoptosis of human melanoma cells." | 3.73 | Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. ( Jeong, YM; Kim, DS; Kim, SY; Kwon, SB; Moon, SI; Park, ES; Park, KC; Youn, SW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kundu, A | 3 |
| Khouri, MG | 2 |
| Aryana, S | 1 |
| Firestone, GL | 5 |
| Aronchik, I | 3 |
| Quirit, JG | 3 |
| Poindexter, KM | 1 |
| Matthew, S | 1 |
| Lavrenov, SN | 1 |
| Poindexter, K | 1 |
| Xu, J | 1 |
| Kyauk, C | 1 |
| Durkin, KA | 1 |
| Tomasiak, T | 1 |
| Solomatin, YA | 1 |
| Preobrazhenskaya, MN | 1 |
| Kim, SY | 2 |
| Kima, DS | 1 |
| Jeong, YM | 2 |
| Moon, SI | 2 |
| Kwon, SB | 2 |
| Park, KC | 2 |
| Kim, DS | 1 |
| Park, ES | 1 |
| Youn, SW | 1 |
7 other studies available for indole-3-carbinol and Melanoma
| Article | Year |
|---|---|
1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Melanoma; Mic | 2017 |
The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
Topics: Animals; Apoptosis; Calorimetry; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Computer Simulati | 2014 |
Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent K | 2017 |
Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
Topics: Aspirin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Synergism; Gene Exp | 2016 |
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Computer Simulation; | 2017 |
Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF.
Topics: Actins; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Death; Cel | 2011 |
Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Casp | 2006 |