indole-3-carbinol has been researched along with Malignant Melanoma in 7 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer-derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound." | 7.85 | 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. ( Aryana, S; Firestone, GL; Khouri, MG; Kundu, A, 2017) |
| "Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as in vivo in tumor xenografted athymic nude mice." | 7.85 | Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation. ( Firestone, GL; Khouri, MG; Kundu, A; Quirit, JG, 2017) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 7.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| "Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor protein in the antiproliferative response induced by the chemopreventative agent indole-3-carbinol (I3C), a natural indolecarbinol compound derived from the breakdown of glucobrassicin produced in cruciferous vegetables such as broccoli and Brussels sprouts." | 7.80 | The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. ( Aronchik, I; Firestone, GL; Kundu, A; Quirit, JG, 2014) |
| "We investigated the mechanism of indole-3-carbinol (13C)/ultraviolet B (UVB)-induced apoptosis using SK-MEL-2 and SK-MEL-5 human melanoma cells." | 7.77 | Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF. ( Jeong, YM; Kim, SY; Kima, DS; Kwon, SB; Moon, SI; Park, KC, 2011) |
| "Indole-3-carbinol (I3C) has been found to act against several types of cancer, while ultraviolet B (UVB) is known to induce the apoptosis of human melanoma cells." | 7.73 | Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. ( Jeong, YM; Kim, DS; Kim, SY; Kwon, SB; Moon, SI; Park, ES; Park, KC; Youn, SW, 2006) |
| "1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer-derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound." | 3.85 | 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. ( Aryana, S; Firestone, GL; Khouri, MG; Kundu, A, 2017) |
| "Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as in vivo in tumor xenografted athymic nude mice." | 3.85 | Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation. ( Firestone, GL; Khouri, MG; Kundu, A; Quirit, JG, 2017) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 3.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| "Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor protein in the antiproliferative response induced by the chemopreventative agent indole-3-carbinol (I3C), a natural indolecarbinol compound derived from the breakdown of glucobrassicin produced in cruciferous vegetables such as broccoli and Brussels sprouts." | 3.80 | The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. ( Aronchik, I; Firestone, GL; Kundu, A; Quirit, JG, 2014) |
| "We investigated the mechanism of indole-3-carbinol (13C)/ultraviolet B (UVB)-induced apoptosis using SK-MEL-2 and SK-MEL-5 human melanoma cells." | 3.77 | Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF. ( Jeong, YM; Kim, SY; Kima, DS; Kwon, SB; Moon, SI; Park, KC, 2011) |
| "Indole-3-carbinol (I3C) has been found to act against several types of cancer, while ultraviolet B (UVB) is known to induce the apoptosis of human melanoma cells." | 3.73 | Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. ( Jeong, YM; Kim, DS; Kim, SY; Kwon, SB; Moon, SI; Park, ES; Park, KC; Youn, SW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kundu, A | 3 |
| Khouri, MG | 2 |
| Aryana, S | 1 |
| Firestone, GL | 5 |
| Aronchik, I | 3 |
| Quirit, JG | 3 |
| Poindexter, KM | 1 |
| Matthew, S | 1 |
| Lavrenov, SN | 1 |
| Poindexter, K | 1 |
| Xu, J | 1 |
| Kyauk, C | 1 |
| Durkin, KA | 1 |
| Tomasiak, T | 1 |
| Solomatin, YA | 1 |
| Preobrazhenskaya, MN | 1 |
| Kim, SY | 2 |
| Kima, DS | 1 |
| Jeong, YM | 2 |
| Moon, SI | 2 |
| Kwon, SB | 2 |
| Park, KC | 2 |
| Kim, DS | 1 |
| Park, ES | 1 |
| Youn, SW | 1 |
7 other studies available for indole-3-carbinol and Malignant Melanoma
| Article | Year |
|---|---|
1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Melanoma; Mic | 2017 |
The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
Topics: Animals; Apoptosis; Calorimetry; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Computer Simulati | 2014 |
Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent K | 2017 |
Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
Topics: Aspirin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Synergism; Gene Exp | 2016 |
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Computer Simulation; | 2017 |
Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF.
Topics: Actins; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Death; Cel | 2011 |
Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Casp | 2006 |