indole-3-carbinol has been researched along with Lung Neoplasms in 24 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In earlier studies, we demonstrated the efficacy of indole-3-carbinol (I3C) against lung adenocarcinoma in A/J mice." | 7.77 | Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. ( Dagne, A; Kassie, F; Luo, X; Melkamu, T; Qian, X; Schutten, MM; Upadhyaya, P, 2011) |
| "We studied the chemopreventive efficacy of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables, to inhibit tobacco carcinogen-induced lung adenocarcinoma in A/J mice when given following post-initiation or progression protocol." | 7.77 | Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. ( Kassie, F; Melkamu, T; Qian, X; Upadhyaya, P, 2011) |
| " In this paper, we extended our work and examined the effects of I3C (70 or 30 micromol/g diet) and MI (56 micromol/g diet) against vinyl carbamate (VC)-induced lung adenocarcinoma by administering the agents from 1 week after the second of two injections of VC until termination of the study at week 18." | 7.76 | Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. ( Hecht, SS; Kalscheuer, S; Kassie, F; Ma, L; Matise, I; Melkamu, T; Upadhyaya, P, 2010) |
| "We report the history of an 8-year-old girl who was treated for suspected lung lesions of respiratory papillomatosis with Indole-3-Carbinol, local and intravenous injections of Cidofovir for 27 months." | 7.73 | Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. ( Bodart, E; de Bilderling, G; De Clercq, E; Lawson, G; Naesens, L; Remacle, M; Snoeck, R; Tuerlinckx, D, 2005) |
| "Indole-3-carbinol (I3C) is a compound occurring naturally in cruciferous vegetables and has been indicated as a promising agent in preventing breast cancer development and progression." | 7.70 | Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. ( Auborn, K; Chen, DZ; Fan, S; Goldberg, ID; Meng, Q; Qi, M; Rosen, EM; Yuan, R, 2000) |
| "Chronic inflammation is an important risk factor for lung cancer." | 5.42 | Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. ( Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P, 2015) |
| "In earlier studies, we demonstrated the efficacy of indole-3-carbinol (I3C) against lung adenocarcinoma in A/J mice." | 3.77 | Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. ( Dagne, A; Kassie, F; Luo, X; Melkamu, T; Qian, X; Schutten, MM; Upadhyaya, P, 2011) |
| "We studied the chemopreventive efficacy of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables, to inhibit tobacco carcinogen-induced lung adenocarcinoma in A/J mice when given following post-initiation or progression protocol." | 3.77 | Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. ( Kassie, F; Melkamu, T; Qian, X; Upadhyaya, P, 2011) |
| " In this paper, we extended our work and examined the effects of I3C (70 or 30 micromol/g diet) and MI (56 micromol/g diet) against vinyl carbamate (VC)-induced lung adenocarcinoma by administering the agents from 1 week after the second of two injections of VC until termination of the study at week 18." | 3.76 | Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. ( Hecht, SS; Kalscheuer, S; Kassie, F; Ma, L; Matise, I; Melkamu, T; Upadhyaya, P, 2010) |
| "We report the history of an 8-year-old girl who was treated for suspected lung lesions of respiratory papillomatosis with Indole-3-Carbinol, local and intravenous injections of Cidofovir for 27 months." | 3.73 | Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. ( Bodart, E; de Bilderling, G; De Clercq, E; Lawson, G; Naesens, L; Remacle, M; Snoeck, R; Tuerlinckx, D, 2005) |
| "Indole-3-carbinol (I3C) is a compound occurring naturally in cruciferous vegetables and has been indicated as a promising agent in preventing breast cancer development and progression." | 3.70 | Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. ( Auborn, K; Chen, DZ; Fan, S; Goldberg, ID; Meng, Q; Qi, M; Rosen, EM; Yuan, R, 2000) |
| "The effects of indole-3-carbinol (I3C) on lung neoplasia induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were assessed in an A/J mouse pulmonary adenoma bioassay." | 3.68 | Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. ( Amin, SG; Chung, FL; LaGreca, SD; Morse, MA, 1990) |
| "Lung cancer is a prominent cause of cancer-associated mortality worldwide." | 2.52 | Dietary agents for prevention and treatment of lung cancer. ( Khan, N; Mukhtar, H, 2015) |
| "Chronic pulmonary inflammation has been consistently shown to increase the risk of lung cancer." | 1.42 | RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents. ( Dickerson, E; Kassie, F; Khammanivong, A; Qian, X; Song, JM; Teferi, F; Upadhyaya, P, 2015) |
| "Chronic inflammation is an important risk factor for lung cancer." | 1.42 | Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. ( Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P, 2015) |
| "Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use." | 1.36 | The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. ( Dennis, PA; Memmott, RM, 2010) |
| "We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu." | 1.33 | Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. ( Ashok, BT; Chen, YG; Garikapaty, VP; Iatropoulos, M; Mittelman, A; Tiwari, RK, 2005) |
| " The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay." | 1.33 | Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. ( Albershardt, DJ; Bailey, GS; Baird, WM; Fischer, KA; Krueger, SK; Löhr, CV; Louderback, MA; Mahadevan, B; Pereira, CB; Williams, DE; Yu, Z, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shorey, LE | 1 |
| Madeen, EP | 1 |
| Atwell, LL | 1 |
| Ho, E | 1 |
| Löhr, CV | 2 |
| Pereira, CB | 2 |
| Dashwood, RH | 1 |
| Williams, DE | 2 |
| Song, JM | 3 |
| Kirtane, AR | 1 |
| Upadhyaya, P | 9 |
| Qian, X | 5 |
| Balbo, S | 1 |
| Teferi, F | 3 |
| Panyam, J | 1 |
| Kassie, F | 10 |
| Khan, N | 1 |
| Mukhtar, H | 1 |
| Khammanivong, A | 1 |
| Dickerson, E | 1 |
| Molla, K | 1 |
| O Sullivan, G | 1 |
| Luo, X | 3 |
| Matise, I | 2 |
| Negia, M | 1 |
| Hecht, SS | 6 |
| Kalscheuer, S | 1 |
| Ma, L | 1 |
| Melkamu, T | 5 |
| Zhang, X | 1 |
| Tan, J | 1 |
| Zeng, Y | 1 |
| Memmott, RM | 1 |
| Dennis, PA | 1 |
| Choi, HS | 1 |
| Cho, MC | 1 |
| Lee, HG | 1 |
| Yoon, DY | 1 |
| Endalew, A | 1 |
| Dagne, A | 1 |
| Schutten, MM | 1 |
| Xiao, X | 1 |
| Meng, Q | 2 |
| Xu, J | 1 |
| Jiao, Y | 1 |
| Rosen, EM | 2 |
| Fan, S | 2 |
| Carmella, SG | 1 |
| Kenney, PM | 1 |
| Low, SH | 1 |
| Arakawa, K | 1 |
| Yu, MC | 1 |
| Kuang, YF | 1 |
| Chen, YH | 1 |
| Garikapaty, VP | 1 |
| Ashok, BT | 1 |
| Chen, YG | 1 |
| Mittelman, A | 1 |
| Iatropoulos, M | 1 |
| Tiwari, RK | 1 |
| de Bilderling, G | 1 |
| Bodart, E | 1 |
| Lawson, G | 1 |
| Tuerlinckx, D | 1 |
| Remacle, M | 1 |
| Naesens, L | 1 |
| De Clercq, E | 1 |
| Snoeck, R | 1 |
| Yu, Z | 1 |
| Mahadevan, B | 1 |
| Fischer, KA | 1 |
| Louderback, MA | 1 |
| Krueger, SK | 1 |
| Albershardt, DJ | 1 |
| Baird, WM | 1 |
| Bailey, GS | 1 |
| Anderson, LB | 1 |
| Scherber, R | 1 |
| Yu, N | 1 |
| Lahti, D | 1 |
| Chung, FL | 3 |
| Morse, MA | 3 |
| Eklind, KI | 1 |
| Xu, Y | 1 |
| Qi, M | 1 |
| Chen, DZ | 1 |
| Yuan, R | 1 |
| Goldberg, ID | 1 |
| Auborn, K | 1 |
| LaGreca, SD | 1 |
| Amin, SG | 2 |
| Wang, CX | 1 |
2 reviews available for indole-3-carbinol and Lung Neoplasms
| Article | Year |
|---|---|
Dietary agents for prevention and treatment of lung cancer.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phyto | 2015 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catechin; DNA; DNA Damage; Ind | 1993 |
22 other studies available for indole-3-carbinol and Lung Neoplasms
| Article | Year |
|---|---|
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Carcinogens; Diet; Female; Indoles; Isothiocyanates; | 2013 |
Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability.
Topics: Administration, Intranasal; Administration, Oral; Animals; Anticarcinogenic Agents; Biological Avail | 2014 |
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Indol | 2015 |
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Tr | 2015 |
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cell Pr | 2008 |
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Prol | 2010 |
Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Blotting, Western; Female; Gene Expression Profili | 2010 |
The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Topics: Animals; Carcinogens; Humans; Indoles; Inositol; Intracellular Signaling Peptides and Proteins; Lung | 2010 |
Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 8; Cell Cycle; Cell Line, Tumor; Cell | 2010 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be | 2010 |
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; | 2011 |
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Carcinogens; Cell Growth P | 2011 |
[EGFR-dependent impact of indol-3-carbinol on radiosensitivity of lung cancer cells].
Topics: Anticarcinogenic Agents; Brassicaceae; Cell Line, Tumor; Cell Proliferation; Cell Survival; ErbB Rec | 2012 |
Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.
Topics: Aged; Anticarcinogenic Agents; Carcinogens; China; Female; Glucosinolates; Glucuronides; Humans; Ind | 2004 |
Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcino | 2004 |
Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Indoles; Lung Neoplasms; Male; Neoplasm Tr | 2005 |
Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.
Topics: Antiviral Agents; Chemotherapy, Adjuvant; Child; Cidofovir; Cytosine; Drug Therapy, Combination; Fem | 2005 |
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.
Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Biological Availability; Diet; DNA Adducts; Female; | 2006 |
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.
Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chromatography, | 2007 |
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.
Topics: alpha Catenin; Anticarcinogenic Agents; beta Catenin; BRCA1 Protein; Breast Neoplasms; Cadherins; Ce | 2000 |
Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.
Topics: Adenoma; Animals; Carcinogens; DNA; Female; In Vitro Techniques; Indoles; Liver; Lung; Lung Neoplasm | 1990 |
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
Topics: Animals; Carcinogens; Diet; DNA; Glucosinolates; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Met | 1988 |